期刊
JOURNAL OF PERIODONTOLOGY
卷 79, 期 12, 页码 2331-2339出版社
WILEY
DOI: 10.1902/jop.2008.080068
关键词
Acute coronary syndrome; endotoxin; high-density lipoprotein; periodontitis; triglycerides; troponin
Background: Recent studies have reported an association between poor dental health and acute coronary syndrome (ACS). The purpose of this study was to correlate the presence of periodontitis with serum endotoxin/lipopolysaccharides (LPS), lipid profiles, troponin, and immunoglobulin G (IgG) antibody to Porphyromonas gingivalis in control patients or patients with ACS or angina at the time of hospital admission. Methods: Blood samples from 194 subjects presenting with ACS, angina, or non-cardiac chest pain were analyzed for endotoxin/LPS (Limulus amebocyte lysate assay), lipid profile, troponin, and IgG antibody to P. gingivalis. Data were collected from hospital charts and dental records, and health questionnaire responses. Results: Subjects with ACS or angina were more likely to have poor oral care, fewer remaining teeth, and increased alveolar radiographic bone loss compared to subjects with chest pain. In all subjects, endotoxin/LPS and IgG antibody to P. gingivalis tended to increase in association with increased radiographic bone loss. Endotoxin/LPS increased directly with triglyceride and troponin levels (P= 0.04 and P= 0.006, respectively) and inversely with high-density lipoprotein (HDL) levels (P= 0.002). IgG antibody to P. gingivalis levels was directly correlated with very low-density lipoprotein (P= 0.03) and triglycerides (P= 0.06) and inversely with low-density lipoprotein (P= 0.01). Conclusions: Results showed more alveolar bone loss in patients with cardiac disease than in patients without cardiac disease, but there was no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis. However, there were associations between endotoxin/LPS and levels of serum triglycerides, troponin, and HDL. J Pedodontol 2008;79:2331-2339.
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