Review
Microbiology
Leila Gholami, Shiva Shahabi, Marzieh Jazaeri, Mahdi Hadilou, Reza Fekrazad
Summary: With the emergence of resistant bacterial strains and novel microorganisms that pose a global threat to human life, there is an urgent need for new treatment modalities for microbial infections. Antimicrobial photodynamic therapy (aPDT) has shown promise as a non-invasive and effective treatment for oral infectious diseases. Many studies have investigated its efficacy in eliminating bacterial, fungal, and viral infections, with a focus on key pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Candida albicans, and Enterococcus faecalis. Clinical studies have also explored methods of enhancing the efficacy of aPDT through the development of natural, nano-based, and targeted photosensitizers. However, further randomized controlled trials are needed to establish effective clinical protocols and parameters for this treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Marwan El Mobadder, Samir Nammour, Kinga Grzech-Lesniak
Summary: This study evaluated the effectiveness of photodynamic therapy (PDT) using tolonium chloride and a 635 nm diode laser as an adjunct to non-surgical periodontitis treatment. The results showed that PDT significantly contributed to the non-surgical treatment of periodontitis, with reductions in plaque index, bleeding on probing, probing pocket depth, and clinical attachment loss. The combination of SRP and PDT resulted in further improvements compared to SRP alone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jun-ichiro Hayashi, Kohta Ono, Yuki Iwamura, Yasuyuki Sasaki, Tasuku Ohno, Ryoma Goto, Eisaku Nishida, Genta Yamamoto, Takeshi Kikuchi, Naoya Higuchi, Akio Mitani, Mitsuo Fukuda
Summary: This study introduced a new aPDT method using transgingival Near-infrared (NIR) wavelength and nanoparticles as a photosensitizer in periodontal therapy. The results showed that this method can effectively reduce bacteria count without pain or discomfort.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qingchao Kong, Manlin Qi, Wen Li, Yujia Shi, Jing Su, Shimeng Xiao, Jiao Sun, Xue Bai, Biao Dong, Lin Wang
Summary: In this study, a novel Z-scheme heterostructured nanocomposite of Bi2S3/Cu-TCPP is developed to enhance the efficiency of porphyrin-based antibacterial photodynamic therapy (aPDT). The nanocomposite exhibits highly efficient light absorption and effective electron-hole separation, promoting enhanced biofilm removal. The synergistic effect of aPDT/photothermal treatment (PTT)/chemodynamic therapy (CDT) demonstrates potent antibacterial activity against periodontal pathogens, resulting in significant therapeutic effects, including inflammation alleviation and bone preservation.
Article
Biotechnology & Applied Microbiology
Enyu Shi, Liya Bai, Lujia Mao, Hanping Wang, Xiaoying Yang, Yinsong Wang, Mingming Zhang, Changyi Li, Yue Wang
Summary: A self-assembled nanosystem containing ICG and polycationic brush has shown promising clinical application for synergistic PTT and PDT against periodontitis, exerting excellent antibacterial and anti-periodontitis actions both in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Oncology
Roopanshi Mehrotra, Sanjay Gupta, Zeba Rahman Siddiqui, Deepti Chandra, Sk Aziz Ikbal
Summary: Both ozone therapy and photodynamic therapy can significantly improve clinical and microbiological parameters in chronic periodontitis, but there is no significant difference in effectiveness between the two treatment methods.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Rafael Drummond Rodrigues, Nara Santos Araujo, Jorge Moreira Pinto Filho, Carolina Leticia Zilli Vieira, Daniel Araki Ribeiro, Jean Nunes dos Santos, Patricia Ramos Cury
Summary: This study aimed to determine the effect of antimicrobial photodynamic therapy (aPDT) on single-rooted teeth of patients with grade C periodontitis. The results showed that the combination of scaling and root planning with aPDT provided slightly better periodontal clinical outcomes compared to scaling and root planning alone. The effect of aPDT was more apparent in sites with deeper initial probing depths. Therefore, aPDT may be considered as an adjunctive treatment for grade C periodontitis affecting single-rooted teeth.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Chemistry, Multidisciplinary
Alessia Pardo, Andrea Butera, Angela Giordano, Simone Gallo, Maurizio Pascadopoli, Andrea Scribante, Massimo Albanese
Summary: The aim of this study was to evaluate the adjunctive effects of photodynamic therapy (aPDT) on nonsurgical mechanical treatment in patients with periodontitis. The results showed that despite the limited number of RCTs and the great heterogeneity between them, it can be concluded that aPDT in association with nonsurgical periodontal treatment improved the clinical parameters at 3 months.
APPLIED SCIENCES-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Pengyu Gao, Guotai Li, Zhiguo Wang, Hui Zhang, Yansheng Shan, Xin Yuan, Qiang Shi, Xue Dou, Qihui Zhou, Quanchen Xu
Summary: Periodontitis is a chronic inflammatory disease caused by a plaque biofilm that can lead to the destruction of periodontal support tissue and tooth loss. Traditional methods of periodontitis treatment, such as antibiotic therapy, are often ineffective due to the presence of impenetrable substances on bacterial biofilms. In this study, a novel nanoparticle, CuS NPs loaded with protease, was developed for the management of periodontitis. The results showed that the designed nanoparticles had strong antibacterial properties and were effective in inhibiting bone resorption and alleviating inflammation in a rat periodontitis model. Hence, the CuS@A NPs hold promise for the treatment of periodontitis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Michael Patyna, Vicky Ehlers, Benjamin Bahlmann, Adrian Kasaj
Summary: All treatment modalities showed clinical improvements in PPD and CAL at 6 months compared to baseline, with no statistically significant difference between groups. The combination of SD + LAD + probiotic treatment in group 3 demonstrated significantly greater reductions in inflammatory parameters and red complex bacteria compared with other groups at 6 months.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Oncology
Leticia Helena Theodoro, Tiago Esgalha da Rocha, Mark Wainwright, Marta Aparecida Alberton Nuernberg, Edilson Ervolino, Eduardo Quintao Manhanini Souza, Daniela Atili Brandini, Valdir Gouveia Garcia
Summary: The BuTB-aPDT group showed the least extent of inflammation throughout the experimental periods, with aPDT treated groups exhibiting better bone structure at 15 days. BuTB also demonstrated lower Alveolar Bone Loss compared to the TBO-aPDT group at 30 days.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Maria-Alexandra Martu, Petra Surlin, Luminita Lazar, George Alexandru Maftei, Ionut Luchian, Dorin-Nicolae Gheorghe, Elena Rezus, Vasilica Toma, Liliana-Georgeta Foia
Summary: This study analyzed the effects of three different periodontal disease treatment possibilities on clinical periodontal indexes and oxidative stress markers in gingival crevicular fluid. The results showed that periodontal therapy improved these measurements, with laser and photodynamic therapy treatment providing additional benefits.
Article
Oncology
Rakasevic Dragana, Marinkovic Jelena, Markovic Jovan, Nikolic Biljana, Markovic Dejan
Summary: The study aimed to determine the antibacterial efficiency of adjuvant photodynamic therapy (PDT) and high-power diode laser (DL) in treating chronic periapical periodontitis (CPP) in young permanent teeth. It was found that both PDT and DL could be performed as adjuvants to standard endodontic treatment, reducing bacterial count and achieving bacterial elimination in a significant percentage of root canals.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Pharmacology & Pharmacy
Snehal Dalvi, Stefano Benedicenti, Tudor Salagean, Ioana Roxana Bordea, Reem Hanna
Summary: This systematic review and meta-analysis evaluated the efficacy of antimicrobial photodynamic therapy (aPDT) in periodontitis, finding no additional benefit in reducing probing pocket depth and increasing clinical attachment level. Well-designed randomized controlled trials are needed to determine the effectiveness of aPDT.
Article
Oncology
Abdulaziz A. Al-Kheraif, Ravish Javed, Mohammed Mahmoud Al-Momani, Aisha Wasi, Badreldin A. Mohamed, Aftab Ahmed Khan
Summary: This study aims to evaluate the clinical, radiographic, immune modulatory biomarkers, and quality of life with the application of PDT as an adjunctive treatment to SRP in patients with chronic periodontitis and Parkinson's disease. The results showed that combined SRP with PDT has significantly improved clinical parameters, cytokine levels, and oral health-related quality of life compared to SRP alone.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)