Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Article
Biochemistry & Molecular Biology
Olatunji Anthony Akerele, Sarah Jane Manning, Sarah Emily Dixon, Amelia Estelle Lacey, Sukhinder Kaur Cheema
Summary: The study found that a maternal diet high in Ω-3 PUFA can prevent dyslipidemia in non-pregnant mice and maintain the expected lipid profile during pregnancy, while a very low Ω-3 PUFA diet can lead to hyperlipidemia in mice before pregnancy and during pregnancy. Omega (n)-3 polyunsaturated fatty acids are crucial for maintaining maternal metabolic profile and fetal sustainability during pregnancy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Immunology
Pan-Yen Lin, Chin Cheng, Senthil Kumaran Satyanarayanan, Lu-Ting Chiu, Yu-Chuan Chien, Chih-Pin Chuu, Tsuo-Hung Lan, Kuan-Pin Su
Summary: The study found that n-3 PUFAs supplements did not significantly reduce cognitive, functional, and depressive symptoms outcomes in Alzheimer's disease patients, but showed improvements in spoken language ability and constructional praxis scores. Attention to clinical heterogeneity in dementia is crucial, and CCL4 may be a better indicator for EPA treatment response compared to other inflammatory cytokines.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Clinical Neurology
Marco A. Villaldama-Soriano, Maricela Rodriguez-Cruz, Sthephanie Y. Hernandez-De la Cruz, Tomas Almeida-Becerril, Alan Cardenas-Conejo, Carlos Wong-Baeza
Summary: Supplementation with omega-3 LCPUFA may decrease pro-inflammatory monocytes and their cytokines, while increasing anti-inflammatory monocytes in patients with DMD. Further studies are needed to explore the effects of omega-3 LCPUFA on monocyte populations in this population.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Food Science & Technology
Yi Wang, Ke Liu, Tingting Long, Jieyi Long, Ying Li, Jiaoyuan Li, Liming Cheng
Summary: Through a meta-analysis of observational studies, we found that dietary fish and marine omega-3 PUFA consumption are associated with improved cancer prognosis and reduced mortality in patients.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Biochemistry & Molecular Biology
Claudia Sanfilippo, Angela Patti
Summary: The biocatalytic epoxidation of ethanolamides of omega-3 fatty acids EPA and DHA was investigated in the presence of a peroxygenase-containing preparation from oat flour. Good regio- and steroselectivity were observed, and acetone as cosolvent improved the concentration of starting substrates and selectivity in the epoxidation of DHA-EA. This method offers a valuable strategy for obtaining oxyfunctionalized derivatives of fatty acids due to the easy availability of the enzymatic preparation.
BIOORGANIC CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Flavia M. S. De Branco, Ana Elisa M. Rinaldi, Jaqueline L. Pereira, Hamilton Roschel, Catarina M. Azeredo, Erick P. De Oliveira
Summary: This study evaluated the association between plasma omega-3 (6)-3 fatty acids and appendicular muscle mass index (AMMI) in adults, taking into account protein intake. The results showed a positive correlation between plasma omega-3 (6)-3 fatty acids and AMMI in individuals with low protein intake, indicating potential benefits of omega-3 (6)-3 fatty acid supplementation for muscle mass when protein intake is inadequate.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Qi Sun, Ning Gao, Weiliang Xia
Summary: This study found a negative correlation between omega-3 and omega-6 levels and the risk of cholelithiasis. Individuals with low serum omega-3/6 levels should be aware of the risk of cholelithiasis.
FRONTIERS IN NUTRITION
(2022)