期刊
JOURNAL OF PERINATOLOGY
卷 28, 期 3, 页码 233-234出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.jp.7211898
关键词
staphylococcus aureus; neonates; daptomycin; premature; drug concentration
资金
- NICHD NIH HHS [T32 HD-043728-01A2, K23 HD044799, U01 HD037255, U10 HD045962, T32 HD043728, U01 HD037255-06, K23 HD-044799-01, T32 HD043728-01A2, K23 HD044799-01A2, U10 HD037255, U10 HD037255-06, U10 HD045962-03, 5U10 HD045962-03] Funding Source: Medline
We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.
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