Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Article
Endocrinology & Metabolism
Kyoung Eun Joung, Camilia R. Martin, Sara Cherkerzian, Mark Kellogg, Mandy Brown Belfort
Summary: Leptin intake in milk was positively associated with weight gain and weight z-scores in preterm infants, while adiponectin intake was associated with length z-scores and negatively with head circumference z-scores after adjusting for protein and calorie intake. Insulin intake did not show significant associations with growth outcomes. Further research regarding the long-term effects of milk hormones is warranted.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Elena Sinkiewicz-Darol, Iwona Adamczyk, Katarzyna Lubiech, Gabriela Pilarska, Magdalena Twaruzek
Summary: Leptin present in breast milk plays a crucial role in regulating appetite and reducing the risk of obesity in infants.
Article
Nutrition & Dietetics
Gabriela E. Leghi, Merryn J. Netting, Ching T. Lai, Ardra Narayanan, Michael Dymock, Alethea Rea, Mary E. Wlodek, Donna T. Geddes, Beverly S. Muhlhausler
Summary: The study found that reducing maternal energy, carbohydrate, fat, and sugar intake over a two-week period significantly decreased concentrations of insulin, leptin, and adiponectin in human milk. However, macronutrient concentrations in human milk were not affected. Additionally, maternal body weight and fat mass were significantly reduced at the end of the dietary intervention, indicating potential benefits for maternal health.
Article
Biotechnology & Applied Microbiology
Thamer Aljutaily, Medhat Rehan, Mahmoud M. A. Moustafa, Hassan Barakat
Summary: This study examined the effects of intermittent fasting, fermented camel milk, and fermented camel milk with Sukkari date on weight loss and health of obese rats. The results showed that these interventions reduced body weight, improved blood profile and antioxidant status. Combining intermittent fasting with fermented camel milk or fermented camel milk with Sukkari date yielded the most effective results.
FERMENTATION-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Majed A. Suwaydi, Zoya Gridneva, Sharon L. Perrella, Mary E. Wlodek, Ching Tat Lai, Donna T. Geddes
Summary: Human milk contains a variety of hormones that may play a significant role in infant growth, development, and metabolic regulation. However, studies of these hormones in human milk are limited and varied in terms of research design, sample collection, and analysis methods. Current methods for quantifying these metabolic hormones in human milk predominantly utilize immunoassay techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Shangang Zhao, Christine M. Kusminski, Philipp E. Scherer
Summary: The discovery of leptin and adiponectin established adipose tissue as an important endocrine organ in cardiovascular health. Normal levels of adiponectin and leptin are crucial for proper cardiovascular function, while both excess and insufficient levels may contribute to cardiovascular disorders. High levels of both adiponectin and leptin are a paradoxical factor in the pathogenesis of cardiovascular diseases.
CIRCULATION RESEARCH
(2021)
Article
Nursing
Lindsay Ellsworth, Julie Sturza, Kate Stanley
Summary: The study revealed that most mothers have limited knowledge about donor human milk and milk banks, and have not received sufficient counseling from medical providers. While participants had positive attitudes towards donor human milk, they tended to choose formula over donor human milk when making decisions. Additionally, if donor human milk was the only option, they preferred milk from a relative or friend over milk banks.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Nutrition & Dietetics
Laura Galante, Clare M. Reynolds, Amber M. Milan, Tanith Alexander, Frank H. Bloomfield, Yannan Jiang, Sharin Asadi, Mariana Muelbert, David Cameron-Smith, Shikha Pundir, Mark H. Vickers
Summary: The concentrations of IGF-1 and leptin in breast milk are associated with the growth and body composition of moderate-late preterm infants up to 4 months corrected age, with varying effects observed in boys and girls. This highlights the importance of sex-specific considerations in the nutritional care of preterm infants in order to optimize their growth outcomes.
FRONTIERS IN NUTRITION
(2021)
Review
Oncology
Xi Pu, Deyu Chen
Summary: Obesity is a global epidemic and closely related to the occurrence and development of various tumors, adipokines secreted by adipocytes and insulin/IGF play important roles in tumors.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Longhua Liu, Zunhan Shi, Xiaohui Ji, Wenqian Zhang, Jinwen Luan, Tarik Zahr, Li Qiang
Summary: Obesity is strongly associated with atherosclerosis, and adipokines secreted by adipose tissue play important roles in the development and treatment of atherosclerosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Nutrition & Dietetics
Blanca Grases-Pinto, Mar Abril-Gil, Paulina Torres-Castro, Margarida Castel, Maria J. Rodriguez-Lagunas, Francisco J. Perez-Cano, Angels Franch
Summary: The study analyzed the content of immunoglobulins and key adipokines and growth factors in rat breast milk throughout the lactation period, comparing them with corresponding plasma levels. Changes were observed in the levels of certain factors, including an increase in TGF-beta 2 and -beta 3 in the first week, and a decrease in FGF21 in the second period. Positive correlations were found between milk and plasma levels of IgM, IgG, and adipokines.
Article
Nutrition & Dietetics
Nelly C. Munoz-Esparza, Edgar M. Vasquez-Garibay, Elizabeth Guzman-Mercado, Alfredo Larrosa-Haro, Oriol Comas-Baste, M. Luz Latorre-Moratalla, M. Teresa Veciana-Nogues, M. Carmen Vidal-Carou
Summary: The study evaluated the influence of different breastfeeding factors on the polyamine levels in human milk, finding that polyamine levels varied significantly between mothers and tended to decrease over time. Spermidine and spermine concentrations were higher in hindmilk compared to foremilk, and decreased significantly as lactation progressed.
Review
Obstetrics & Gynecology
Maria Francisca Juan Castell, Isabel Peraita-Costa, Jose Miguel Soriano, Agustin Llopis-Morales, Maria Morales-Suarez-Varela
Summary: The relationship between leptin in human milk and infant growth is controversial. Some studies suggest an effect on satiety and self-regulation of infant intake, while others find conflicting results. Further research is needed to clarify the impact of leptin in breast milk on infant weight gain.
BREASTFEEDING MEDICINE
(2022)
Review
Nutrition & Dietetics
Elvira Verduci, Maria Lorella Gianni, Giulia Vizzari, Sara Vizzuso, Jacopo Cerasani, Fabio Mosca, Gian Vincenzo Zuccotti
Summary: Human milk has benefits for both mother and infant, linking maternal diet and lifestyle to offspring's health outcomes. This link may be explained in part by epigenetics, and the aim of the paper is to update the association between maternal diet and human milk composition.