Article
Mathematics, Interdisciplinary Applications
Yu Shi, Xiao-Feng Luo, Yong-Xin Zhang, Gui-Quan Sun
Summary: In this paper, a rough pathological index for assessing the severity of Crohn's disease (CD) is proposed based on the pattern dynamics of a reaction-diffusion system involving phagocytes and bacteria. The amplitude equations determining Turing pattern structure with different bacterial biomass are obtained through multi-scale analysis, and similar structures are observed in CD images at different inflammatory stages. This rough indicator from a pathological perspective is consistent with the grading based on imaging features, providing detailed insights into the pathogenesis of CD and potential implications for the prevention and control of other intestinal inflammatory diseases.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Nutrition & Dietetics
Wuli Tang, Gang Xie, Junlin Li, Wei Tan, Rongqi Yi, Ling Yang, Lingqin Zhang, Jiaxing Deng, Yue Zhang, Kang Li
Summary: This study investigated the relationship between body composition parameters and disease severity in Crohn's disease (CD) patients treated with infliximab (IFX). The results showed significant differences in subcutaneous adiposity index (SAI), visceral adiposity index (VAI), and skeletal muscle mass index (SMI) among patients with different disease activity statuses. SMI was identified as a reliable indicator of disease activity status.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Chieh-Li Yen, Pei-Chun Fan, Ming-Shyan Lin, Cheng-Chia Lee, Kun-Hua Tu, Chao-Yu Chen, Ching-Chung Hsiao, Hsiang-Hao Hsu, Ya-Chung Tian, Chih-Hsiang Chang
Summary: This study found that among advanced CKD patients, the use of fenofibrate and statins can reduce the risk of cardiovascular death, while fenofibrate can also reduce the incidence of permanent dialysis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Luis G. Guijarro, David Cano-Martinez, M. Val Toledo-Lobo, Lidia Ruiz-Llorente, Maria Chaparro, Ivan Guerra, Marisa Iborra, Jose Luis Cabriada, Luis Bujanda, Carlos Taxonera, Valle Garcia-Sanchez, Ignacio Marin-Jimenez, Manuel Barreiro-de Acosta, Isabel Vera, Maria Dolores Martin-Arranz, Francisco Mesonero, Laura Sempere, Fernando Gomollon, Joaquin Hinojosa, Sofia Zoullas, Jorge Monserrat, Cesar Menor-Salvan, Melchor Alvarez-Mon, Javier P. Gisbert, Miguel A. Ortega, Borja Hernandez-Breijo
Summary: This study found that levels of serum AIF-1 decrease in Crohn's disease (CD) patients after treatment with anti-TNFs. The study also revealed that active CD patients have higher levels of serum AIF-1 compared to inactive CD patients. The combination of serum AIF-1 and CRP levels improves the predictive ability for classifying CD patients by their severity.
Article
Gastroenterology & Hepatology
Neeraj Narula, Cara Pray, Emily C. L. Wong, Jean-Frederic Colombel, John K. Marshall, Marco Daperno, Walter Reinisch, Parambir S. Dulai
Summary: This study established MM-SES-CD thresholds based on endoscopic scoring of Crohn's disease, which can predict endoscopic remission and clinical remission in patients within one year. These thresholds are helpful in assessing disease severity and treatment efficacy.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Angie L. Schroder, Belal Chami, Yuyang Liu, Chloe M. Doyle, Mary El Kazzi, Golo Ahlenstiel, Gulfam Ahmad, Nimalan Pathma-Nathan, Geoff Collins, James Toh, Andrew Harman, Scott Byrne, Grahame Ctercteko, Paul K. Witting
Summary: The study revealed a significant association between increased NET formation and CD severity, potentially due to excessive MPO-mediated HOCI production in the extracellular domain, causing host tissue damage that exacerbates CD.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pediatrics
Hye-Young Jin, Jae-Sang Lim, Yena Lee, Yunha Choi, Seak-Hee Oh, Kyung-Mo Kim, Han-Wook Yoo, Jin-Ho Choi
Summary: Endocrine complications such as impaired growth, delayed puberty, and low bone mineral density are common in pediatric IBD patients. Vitamin D deficiency and osteoporosis are prevalent, while disease severity is associated with decreased weight-SDS, IGF-1-SDS, and testosterone levels. Optimal pubertal development is crucial for bone health.
Article
Multidisciplinary Sciences
Sangsoo Han, Jiwon Park, Sangun Nah, Hae-Dong Jang, Kyungdo Han, Jae-Young Hong
Summary: Underweight is an important modifiable risk factor for fractures. A large population cohort study found a significant association between the severity of underweight and fracture risk.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Eloi Debourdeau, Chloe Charmard, Isabelle Carriere, Julien Plat, Max Villain, Lucile Boivineau, Romain Altwegg, Vincent Daien
Summary: This study found that the severity of Crohn's disease is associated with alterations in retinal microcirculation. Patients with severe CD showed significantly reduced foveal avascular zone area, superficial macular capillary plexus vessel density, and parafoveal thickness compared to controls. The foveal avascular zone area was also significantly lower in severe CD patients compared to moderate CD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Obstetrics & Gynecology
Emily P. A. Brander, Laura A. Keenahan, Haleh Sangi-Haghpeykar, Madeline Graham, Jennifer E. Dietrich
Summary: Turner syndrome (TS) is a disorder characterized by X-chromosome monosomy and presents with hypogonadism and short stature. Estrogen replacement therapy (ERT) is commonly used in TS patients to achieve pubertal changes, but the effect of ERT duration on bone mineral density (BMD) is still uncertain.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chia-Ter Chao, Hsiang-Yuan Yeh, You-Tien Tsai, Chih-Kang Chiang, Huei-Wen Chen
Summary: This study aimed to uncover biomarkers for evaluating the probability and severity of uremic vascular calcification in patients, using a panel of miRNAs and target proteins. The results showed improved diagnostic accuracy by combining serum miRNAs and SULF1 levels into regression models for vascular calcification.
CARDIOVASCULAR RESEARCH
(2021)
Article
Endocrinology & Metabolism
Xueli Zhang, Kun Peng, Gang Li, Lidi Wan, Tingting Xu, Zhijun Cui, Fuxia Xiao, Li Li, Zhanju Liu, Lin Zhang, Guangyu Tang
Summary: This study investigated the characteristics of bone mineral density (BMD) and body compositions in young and middle-aged male patients with Crohn's disease (CD). The results showed that CD patients had lower BMD and bone geometric parameters compared to the control group. Additionally, Tb. BMD, VAT, Ct. Ar, and LM had significant effects on BMD reduction.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Prathyush Chirra, Anamay Sharma, Kaustav Bera, H. Matthew Cohn, Jacob A. Kurowski, Katelin Amann, Marco-Jose Rivero, Anant Madabhushi, Cheng Lu, Rajmohan Paspulati, Sharon L. Stein, Jeffrey A. Katz, Satish E. Viswanath, Maneesh Dave
Summary: Radiomic features extracted from magnetic resonance enterography are associated with the need for surgery in Crohn's disease patients at risk of complications, and when combined with clinical variables and radiological assessment, they can accurately predict the time to surgery.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yu Yu, Hong Zhao, Youyou Luo, Jingan Lou, Jie Chen, Youhong Fang
Summary: The study revealed weak correlations between PCDAI and CDEIS in evaluating disease severity of pediatric patients with CD, both at initial diagnosis and after induction therapy. Comprehensive assessment involving PCDAI, CDEIS, and multiple laboratory factors is recommended for diagnosis and follow-up of CD patients.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Multidisciplinary Sciences
Noha Bakhsh, Mai Banjar, Mukhtiar Baig
Summary: This retrospective study examined the correlation between bone mineral density (BMD) and COVID-19 severity in patients who had chest CT scans. The results showed that BMD had no prognostic advantage, while the pneumonia severity score (PSS) was a significant factor in predicting the outcome of the disease.
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)