Article
Medicine, General & Internal
Hun-Ju Yu, Meng-Ni Chuang, Chiao-Lun Chu, Pei-Lin Wu, Shu-Chen Ho, Ho-Chang Kuo
Summary: Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5, with significant complications such as coronary artery lesions. Recent studies have shown an increasing incidence of myopia among KD patients, indicating that IVIG treatment may decrease the risk of myopia in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pediatrics
Yan Pan, Qihong Fan, Luoyi Hu
Summary: This study aimed to gather evidence on the efficacy and safety of available treatments for IVIG-resistant Kawasaki disease in children. A network meta-analysis was performed, and infliximab was found to be the best option against IVIG-resistant KD. Infliximab showed remarkable antipyretic activity, but was more prone to causing hepatomegaly. Second IVIG infusions were more likely to result in haemolytic anaemia, and IVMP treatment was associated with bradycardia, hyperglycaemia, hypertension, and hypothermia. The three treatment options showed no significant differences in the risk of developing CAA.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Yaheng Lu, Tingting Chen, Yizhou Wen, Feifei Si, Xindan Wu, Yanfeng Yang
Summary: This study found that predictors PCT and CRP can be used to predict resistance to repeated IVIG treatment in patients with Kawasaki disease.
Article
Immunology
Yinan Yang, Chao Yang, Lixia Wang, Shuting Cao, Xiaomin Li, Yana Bai, Xiaobin Hu
Summary: A predictive model based on gradient boosting decision tree (GBDT) was constructed to identify children with IVIG resistance in Kawasaki disease (KD) and to actively provide additional treatment to prevent adverse events.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Review
Medicine, General & Internal
Pallavi L. Nadig, Vibhu Joshi, Rakesh Kumar Pilania, Rajni Kumrah, Jayakanthan Kabeerdoss, Saniya Sharma, Deepti Suri, Amit Rawat, Surjit Singh
Summary: Kawasaki disease (KD) is a childhood vasculitis that primarily affects medium vessels, particularly the coronary arteries. Coronary artery aneurysm occurs in about 25-30% of untreated cases, leading to significant morbidity. Intravenous immunoglobulin (IVIg) has been consistently shown to reduce the risk of coronary artery aneurysms to less than 5%, but the mechanism of immunomodulation is still unclear. Studies suggest that IVIg may modulate the innate immune system by affecting toll-like receptor pathways, autophagy, apoptosis, neutrophil extracellular trap, dendritic cell modulation, T-cell differentiation, cytokine release, and regulatory T-cell function. This review discusses the potential mechanisms underlying the immunomodulatory actions of IVIg in KD patients and summarizes the evidence regarding infusion protocols and dosages used in treatment.
Article
Pediatrics
Jie Liu, Jian Zhang, Haodong Huang, Yunting Wang, Zuyue Zhang, Yunfeng Ma, Xiangqian He
Summary: The study identified total bilirubin (TBIL), procalcitonin (PCT), alanine aminotransferase (ALT), and platelet count (PLT) as independent risk factors for intravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD) patients. The LightGBM prediction model, based on these risk factors, showed superior performance in predicting IVIG resistance compared to previous models.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Shuran Shao, Kaiyu Zhou, Xiaoliang Liu, Lei Liu, Mei Wu, Yuxin Deng, Hongyu Duan, Yifei Li, Yimin Hua, Chuan Wang
Summary: This study found that lipid profiles were significantly dysregulated in KD patients with IVIG resistance and CALs. Some of them, such as LDL-C and Apo A, could serve as complementary laboratory markers for predicting both IVIG resistance and CALs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Gang Li, Xiumei Xu, Pengyuan Chen, Rumeng Zeng, Bin Liu
Summary: The study demonstrated that the pretreatment PNI may serve as a novel predictor for IVIG-resistant KD. Lower PNI values were associated with IVIG resistance and related biochemical parameters. PNI, NLR, and PLR were identified as independent predictive factors for IVIG resistance.
Article
Medicine, Research & Experimental
Hongbiao Huang, Lei Xu, Yueyue Ding, Jie Qin, Chengcheng Huang, Xuan Li, Yunjia Tang, Guanghui Qian, Haitao Lv
Summary: The study revealed that IVIG treatment affects myeloid cells and neutrophils in patients with Kawasaki disease, and pathway analysis indicated that hematopoietic cell lineages and osteoclast differentiation may play important roles in the mechanism of action of IVIG treatment. Furthermore, immune cell analysis showed significant changes in levels of monocytes, M1 macrophages, neutrophils, and platelets in patients with Kawasaki disease following IVIG treatment, suggesting the involvement of these cells in the treatment mechanism.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Fengchuan Jing, Haobo Weng, Qiongfei Pei, Jing Zhang, Ruixi Liu, Qijian Yi
Summary: miR-221-3p may be involved in the pathogenesis of KD and IVIG resistance, and miR-221-3p can be used as a new potential biomarker to predict IVIG resistance in children with KD.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Pediatrics
Nobuaki Michihata, Takanori Suzuki, Tetsushi Yoshikawa, Kazuyoshi Saito, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
Summary: This study analyzed a national inpatient database to determine the appropriate dosage of intravenous immunoglobulin (IVIG) for preventing coronary artery abnormalities (CAAs) in patients with acute Kawasaki disease (KD). It found a U-shaped association between IVIG dose and the proportion of CAAs, with the optimal dosage being 2 g/kg.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Changjian Li, Shu Wu, Yuanyuan Shi, Ying Liao, Yan Sun, Hui Yan, Qingyou Zhang, Jia Fu, Dan Zhou, Yong Zhang, Hongfang Jin, Junbao Du
Summary: A scoring model was constructed to predict IVIG-resistant Kawasaki disease, and its predictive ability was validated externally.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Xi Chen, Lu Gao, Zhen Zhen, Ying Wang, Jia Na, Wen Yu, Xinyuan Chu, Yue Yuan, Suyun Qian
Summary: The purpose of this study was to explore the risk factors and develop predictive models for intravenous immunoglobulin (IVIG) resistance in children with recurrent KD. The study found that age and IVIG resistance at the first episode, as well as some laboratory variables, may be risk factors for IVIG resistance. Two predictive models for IVIG resistance with excellent performance were established.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pediatrics
Jiang Hui Cai, Mi Tang, Hong Xi Zhang, Er Dan Luo, Rui Zhang, Shu Ping Shuai, Hua Liang, Wan Jun Tao, Meng Jun Wu, Yang Wen, Yan Feng Yang
Summary: This study investigated the optimal timing of initial intravenous immunoglobulin (IVIG) treatment in Kawasaki disease (KD) patients. It was found that IVIG therapy within 7 days of illness is more effective for reducing the risk of coronary artery abnormalities compared to treatment after 7 days.
JORNAL DE PEDIATRIA
(2023)
Article
Medicine, General & Internal
Hongbiao Huang, Jiaqi Jiang, Xiaosong Shi, Jie Qin, Jinfeng Dong, Lei Xu, Chengcheng Huang, Ying Liu, Yiming Zheng, Miao Hou, Qin Shen, Bihe Zeng, Guanghui Qian, Fang Yang, Haitao Lv
Summary: A nomogram was developed to predict the risk of resistance to intravenous immunoglobulin (IVIG) in children with Kawasaki disease in eastern China, using retrospective data analysis and external and prospective data validation. The nomogram showed satisfactory discriminatory power and could help reduce the risk of coronary artery lesions.
ANNALS OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ming He, Zhen Chen, Marcy Martin, Jin Zhang, Panjamaporn Sangwung, Brian Woo, Adriana H. Tremoulet, Chisato Shimizu, Mukesh K. Jain, Jane C. Burns, John Y. -J. Shyy
CIRCULATION RESEARCH
(2017)
Article
Pediatrics
Cassidy Y. Huang, Jane C. Burns, Chisato Shimizu
PEDIATRIC RESEARCH
(2017)
Review
Rheumatology
Jane C. Burns, Isabelle Kone-Paut, Taco Kuijpers, Chisato Shimizu, Adriana Tremoulet, Moshe Arditi
ARTHRITIS & RHEUMATOLOGY
(2017)
Article
Pharmacology & Pharmacy
Niels Vande Casteele, Jun Oyamada, Chisato Shimizu, Brookie M. Best, Edmund V. Capparelli, Adriana H. Tremoulet, Jane C. Burns
CLINICAL PHARMACOKINETICS
(2018)
Article
Immunology
Alessandra Franco, Jeetendra Kumar, Gene Lin, Negar Behnamfar, Li-En Hsieh, Chisato Shimizu, Adriana H. Tremoulet, Jane C. Burns, Joel Linden
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Pediatrics
Shannon M. Skochko, Sonia Jain, Xiaoying Sun, Nipha Sivilay, John T. Kanegaye, Joan Pancheri, Chisato Shimizu, Robert Sheets, Adriana H. Tremoulet, Jane C. Burns
JOURNAL OF PEDIATRICS
(2018)
Article
Pediatrics
Victoria J. Wright, Jethro A. Herberg, Myrsini Kaforou, Chisato Shimizu, Hariklia Eleftherohorinou, Hannah Shailes, Anouk M. Barendregt, Stephanie Menikou, Stuart Gormley, Maurice Berk, Long Truong Hoang, Adriana H. Tremoulet, John T. Kanegaye, Lachlan J. M. Coin, Mary P. Glode, Martin Hibberd, Taco W. Kuijpers, Clive J. Hoggart, Jane C. Burns, Michael Levin
Article
Cardiac & Cardiovascular Systems
Jun Oyamada, Chisato Shimizu, Jihoon Kim, Matthew R. Williams, Eileen Png, Martin L. Hibberd, Adriana H. Tremoulet, James C. Perry, Jane C. Burns
CONGENITAL HEART DISEASE
(2019)
Article
Pediatrics
Jane C. Burns, Laurel L. DeHaan, Chisato Shimizu, Emelia Bainto, Adriana H. Tremoulet, Daniel R. Cayan, Jennifer A. Burney
Summary: The study found that cases of Kawasaki disease within a temporal cluster exhibit more similar patterns of host response, demographic characteristics, and clinical features, which may be related to different triggers or intensities of exposure leading to clusters of cases that share a similar response pattern.
JOURNAL OF PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Clive Hoggart, Chisato Shimizu, Rachel Galassini, Victoria J. Wright, Hannah Shailes, Evan Bellos, Jethro A. Herberg, Andrew J. Pollard, Daniel O'Connor, Shing Wan Choi, Eleanor G. Seaby, Stephanie Menikou, Martin Hibberd, Neneh Sallah, David Burgner, Paul Brogan, Harsita Patel, Jihoon Kim, Adriana H. Tremoulet, Eeva Salo, Diana van Stijn, Taco Kuijpers, Jane C. Burns, Michael Levin
Summary: The study identified a novel locus for CAA in KD patients of European descent and confirmed the association of susceptibility loci such as ITPKC and FCGR2A with KD. Meta-analysis with Japanese GWAS validated consistent effects of these loci across different populations.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Multidisciplinary Sciences
Pradipta Ghosh, Gajanan D. Katkar, Chisato Shimizu, Jihoon Kim, Soni Khandelwal, Adriana H. Tremoulet, John T. Kanegaye
Summary: Multisystem inflammatory syndrome in children (MIS-C) emerged during the COVID-19 pandemic and shares similarities with Kawasaki disease (KD). Both syndromes exhibit similar host immune responses, but differ in other laboratory parameters and cardiac phenotypes.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Li-En Hsieh, Jaeyoon Song, Alba Grifoni, Chisato Shimizu, Adriana H. Tremoulet, Kirsten B. Dummer, Jane C. Burns, Alessandro Sette, Alessandra Franco
Summary: In this study, SARS-CoV-2-specific T cell responses were analyzed in 22 subacute MIS-C children. CD4+ and CD8+ T cell responses were detected in some subjects, and a subset of DN T cells recognizing SARS-CoV-2 peptides was observed. T cell epitope spreading and increased magnitude of Th and CTL responses were noted during the follow-up period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Multidisciplinary Sciences
Pradipta Ghosh, Gajanan D. Katkar, Chisato Shimizu, Jihoon Kim, Soni Khandelwal, Adriana H. Tremoulet, John T. Kanegaye, Joseph Bocchini, Soumita Das, Jane C. Burns, Debashis Sahoo
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Chisato Shimizu, Jihoon Kim, Ming He, Adriana H. Tremoulet, Hal M. Hoffman, John Y-J Shyy, Jane C. Burns
Summary: This study investigated the transcriptional changes in peripheral arterial endothelial cells (ECs) during the treatment of acute Kawasaki disease (KD), and found that atorvastatin treatment can improve EC health, reduce the production of inflammatory mediators, and block myofibroblast proliferation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemical Research Methods
Feng Chen, Shuang Wang, Xiaoqian Jiang, Sijie Ding, Yao Lu, Jihoon Kim, S. Cenk Sahinalp, Chisato Shimizu, Jane C. Burns, Victoria J. Wright, Eileen Png, Martin L. Hibberd, David D. Lloyd, Hai Yang, Amalio Telenti, Cinnamon S. Bloss, Dov Fox, Kristin Lauter, Lucila Ohno-Machado
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)