期刊
JOURNAL OF PEDIATRICS
卷 156, 期 3, 页码 388-392出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2009.10.002
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资金
- British Columbia Children's Hospital Foundation's Telethon Projects Competition New Research Fund
Objective To assess the biophysical properties of the aorta in children born small for gestational age (SGA) with an echo-Doppler method and to determine associations with known perinatal risk factors. Study design In this cross-sectional study, 39 SGA and 41 control subjects aged 8 to 13 years were recruited. Perinatal risk factors were recorded. The aortic diameters and pulse wave transit time around the aortic arch were measured with echo-Doppler and the blood pressure recorded. Pulse wave velocity, aortic input impedance (Zi), characteristic impedance (Zc), arterial pressure-strain elastic modulus (Ep), and arterial wall stiffness index (beta-index) were calculated. Results Pulse wave velocity (374 +/- 46 vs 348 +/- 47cm/sec, P < .02); Zi (177 +/- 39 vs 142 +/- 27 dynes . sec/cm(5), P < .0001); Zc (185 +/- 29 vs 152 +/- 37 dynes . sec/cm(5), P < .0001); Ep (286 +/- 101 vs 216 +/- 41 mm Hg, P < .0001); and beta-index (2.43 +/- 0.32 vs 2.17 +/- 0.15, P < .0001) were all higher in SGA. We found negative associations between the following: birth weight and Zi, Zc, Ep, and beta-index; as well as body mass index and Zi, Zc. Conclusion This simple echo-Doppler method demonstrated abnormal biophysical properties of the aorta in a cohort of pre-adolescent patients born SGA who remain small in stature and continue to have normal blood pressure. (J Pediatr 2010;156:388-92).
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