Article
Medicine, General & Internal
Andres Da Silva-Candal, Antonio Dopico-Lopez, Maria Perez-Mato, Manuel Rodriguez-Yanez, Jose M. Pumar, Paulo Avila-Gomez, Jose Castillo, Tomas Sobrino, Francisco Campos, Pablo Hervella, Ramon Iglesias-Rey
Summary: The study showed that ischemic stroke patients with early onset had higher serum glutamate levels and lower IL-6 levels, with a glutamate/IL-6 index serving as an early identification tool for stroke onset.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Inge Kirchberger, Christa Meisinger, Dennis Freuer, Vincenza Leone, Michael Ertl, Philipp Zickler, Markus Naumann, Jakob Linseisen
Summary: This study aimed to identify specific biomarkers associated with fatigue in post-stroke patients and replicate the findings in a population-based study. The results showed an association between the growth factor SCF and fatigue. Future research should focus on a longitudinal design and include a sufficient number of participants to test associations between certain cytokines and sub-groups of chronic fatigue.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jiejie Li, Yuesong Pan, Jie Xu, Shiyu Li, Mengxing Wang, Kehua Quan, Xia Meng, Hao Li, Jinxi Lin, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang
Summary: Residual inflammatory risk only may predict recurrent stroke and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack, especially in those with large-artery atherosclerosis.
Article
Clinical Neurology
Melissa J. Visser, Joseph Yuan-Mou Yang, Fernando Calamante, Michael Kean, Christopher L. Adamson, Gagan Sharma, Vicki Anderson, Bruce C. V. Campbell, Mark T. Mackay
Summary: This study demonstrated the feasibility of rapidly assessing perfusion-diffusion mismatch in childhood AIS using automated software and identified some children with favorable mismatch profiles. The results suggest potential therapeutic benefit of RAPID use beyond the standard 4.5 hours window for thrombolysis. Further research is needed to determine the utility of perfusion-based imaging for guiding clinical decision making, whether adult thresholds need modification in childhood AIS, and the impact of time-delay and cause on mismatch characteristics.
Review
Chemistry, Medicinal
Dan Luo, Baili Yu, Shoukai Sun, Bonan Chen, Harsh Vivek Harkare, Longlong Wang, Jie Pan, Bin Huang, Yang Song, Tianhong Ma, Shihua Shi
Summary: We conducted a meta-analysis on the clinical efficacy of berberine (BBR) in treating acute ischemic stroke (AIS) and its anti-inflammatory effects. The analysis included 17 clinical trials involving 1670 AIS patients. The results showed that BBR in combination with conventional treatment significantly reduced inflammatory markers and improved outcomes compared to conventional treatment alone.
PHYTOTHERAPY RESEARCH
(2023)
Article
Clinical Neurology
Lauren A. Beslow, Shannon C. Agner, Jonathan D. Santoro, Dipak Ram, Jenny L. Wilson, Dana Harrar, Brian Appavu, Stuart M. Fraser, Thomas Rossor, Marcela D. Torres, Manoelle Kossorotoff, Yenny C. Zuniga Zambrano, Marta Hernandez-Chavez, Sahar M. A. Hassanein, Dimitrios Zafeiriou, Michael M. Dowling, Ilona Kopyta, Nicholas Stence, Timothy J. Bernard, Nomazulu Dlamini
Summary: This study investigated the cases of acute arterial ischemic stroke (AIS) caused by SARS-CoV-2 infection among hospitalized children from June to December 2020. The results showed that the risk of AIS in children hospitalized with SARS-CoV-2 remained stable compared to earlier estimates. Inflammatory arteriopathies were found to be the mechanism behind stroke in children where SARS-CoV-2 was considered the main risk factor.
Review
Medicine, Research & Experimental
Shuoqi Zhang, Jinming Zhang, Chunxu Wang, Xiaojing Chen, Xinyi Zhao, Haijiao Jing, Huan Liu, Zhuxin Li, Lihua Wang, Jialan Shi
Summary: During the COVID-19 pandemic, severe patients are prone to develop acute ischemic stroke due to hypercoagulability, but the exact mechanisms remain unclear. Understanding these mechanisms is crucial for effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemical Research Methods
Rong-Fang Gu, Terry Fang, Ashley Nelson, Stefka Gyoneva, Benbo Gao, Joe Hedde, Kate Henry, Emily Peterson, Linda C. Burkly, Ru Wei
Summary: This study utilized proteomic analysis to investigate the dynamic changes in protein expression post-ischemic stroke, identifying potential biomarkers and therapeutic targets associated with immune response, neuronal remodeling, and inflammation-targeting therapies. A subset of proteins showed large and sustained changes post-stroke, indicating their potential as pharmacodynamic biomarker candidates. Additionally, neurophysiologic pathways associated with poststroke recovery were also identified, providing valuable insights for future research and therapy development.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Oncology
Ruth A. Salazar-Camelo, Eder A. Moreno-Vargas, Andres F. Cardona, Hernan F. Bayona-Ortiz
Summary: This article provides guidance on when to suspect and evaluate cancer in stroke patients, highlighting the increased risk of ischemic stroke in active cancer patients. A multidisciplinary approach is recommended for comprehensive evaluation, including neuroimaging and serological biomarkers, with close follow-up for cryptogenic stroke patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Hematology
Jae-Chan Ryu, Jae-Han Bae, Sang Hee Ha, Bum Joon Kim, Sang-Beom Jeon, Dong-Wha Kang, Sun U. U. Kwon, Jong S. S. Kim, Jun Young Chang
Summary: This study investigated the association between thromboelastography (TEG) parameter reaction time (R) and functional outcomes in stroke patients. The results showed that patients with an R of less than 5 minutes were more likely to experience hemorrhagic transformation and early neurological deterioration, and had a lower rate of functional independence. Therefore, TEG parameters may serve as biomarkers for predicting functional outcomes in stroke patients.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Lisa Bartha-Doering, Andreas Gleiss, Sarah Knaus, Maria Theresa Schmook, Rainer Seidl
Summary: The study found that socioeconomic status has a significant impact on cognitive outcomes in children after arterial ischemic stroke, with much greater influence than clinical factors. Future pediatric studies should pay more attention to the treatment of children with lower socioeconomic status.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Review
Clinical Neurology
Lisa R. R. Sun, John K. Lynch
Summary: While rare, stroke in infants and children is a significant cause of mortality and chronic morbidity in the pediatric population. Advances in neuroimaging and stroke care protocols have improved the ability to diagnose and determine the causes of stroke in children. Recent therapeutic developments allow for targeted stroke prevention in high-risk conditions, but important knowledge gaps remain.
Review
Immunology
Hua Zhu, Siping Hu, Yuntao Li, Yao Sun, Xiaoxing Xiong, Xinyao Hu, Junjing Chen, Sheng Qiu
Summary: Ischemic stroke caused by cerebral artery occlusion is a major cause of chronic disability globally. Interleukins (ILs) play a bidirectional role in ischemic stroke by regulating the activation, multiplication, and differentiation of immune cells, as well as the inflammatory reaction. Interactions between different ILs in different immune cells also impact the outcome of ischemic stroke. This overview discusses the role of various ILs in ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Ana Lucia Cruz Furstenberger Lehmann, Daniela Frizon Alfieri, Maria Caroline Martins de Araujo, Emanuelle Roberto Trevisani, Maisa Rocha Nagao, Francisco Spessatto Pesente, Jair Roberto Gelinski, Leonardo Bodner de Freitas, Tamires Flauzino, Marcio Francisco Lehmann, Marcell Alysson Batisti Lozovoy, Jose Wander Bregano, Andrea Name Colado Simao, Michael Maes, Edna Maria Vissoci Reiche
Summary: This study evaluated the prognostic validity of a combination of clinical, imaging, and laboratory biomarkers in predicting 1-year mortality of IS, finding that non-survivors showed significant differences in multiple indicators including IS severity, carotid intima-media thickness, coagulation factors, and inflammatory factors.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Hematology
Jae-Chan Ryu, Seunguk Jung, Jae-Han Bae, Sang Hee Ha, Bum Joon Kim, Sang-Beom Jeon, Dong-Wha Kang, Sun U. Kwon, Jong S. Kim, Jun Young Chang
Summary: Thromboelastography (TEG) can be used to predict functional outcome in acute large vessel occlusive stroke patients undergoing intraarterial thrombectomy (IAT), with decreased reaction time (R) associated with improved functional independence.
THROMBOSIS RESEARCH
(2023)
Article
Clinical Neurology
Scott Demarest, Jeff Calhoun, Krista Eschbach, Hung-Chun Yu, David Mirsky, Katie Angione, Tamim H. Shaikh, Gemma L. Carvill, Tim A. Benke
Summary: This study aimed to identify additional genes associated with infantile spasms using whole-exome sequencing on a cohort of 21 individuals with infantile spasms. Likely pathogenic de novo variants and candidate variants were identified, supporting the utility of WES in uncovering the genetic etiology in undiagnosed individuals with infantile spasms. High-priority candidates were identified, expanding the mutational and phenotypic spectrum of disease-associated genes.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Behavioral Sciences
Logan J. Bigelow, Catherine Fiset, Jack H. M. Jarvis, Sarah Macleod, Markus Wohr, Tim A. Benke, Paul B. Bernard
Summary: Early-life seizures are associated with autism spectrum disorder, and deficits in auditory communication were observed in adult male rats following a single episode of kainic acid-induced early-life seizures, potentially contributing to previously reported social deficits associated with ELS.
EPILEPSY & BEHAVIOR
(2022)
Article
Behavioral Sciences
Peter Jacoby, Andrew Whitehouse, Helen Leonard, Jacinta Saldaris, Scott Demarest, Tim Benke, Jenny Downs
Summary: The objective of this study was to establish an evidence-based rule for handling missing data in the Quality of Life Inventory-Disability questionnaire. A simulation study was conducted, and different criteria for permissible missing items were compared. The study found that according to a stringent criterion, 1 missing item per domain is allowed, while other less strict criteria allowed up to 2 missing items per domain.
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2022)
Article
Pediatrics
Kathleen J. Motil, Suzanne Geerts, Fran Annese, Jeffrey L. Neul, Tim Benke, Eric Marsh, David Lieberman, Steven A. Skinner, Daniel G. Glaze, Peter Heydemann, Arthur Beisang, Shannon Standridge, Robin Ryther, Jane B. Lane, Lloyd Edwards, Alan K. Percy
Summary: This study aimed to characterize growth and anthropometric measurements in females with Rett syndrome and assess their relationship with functional outcomes. The results showed that females with classic and severe atypical Rett syndrome had lower growth and anthropometric measurements compared to those with mild atypical Rett syndrome, indicating clear differences between different types of Rett syndrome. Anthropometric measures were correlated with functional outcomes, suggesting that they could be used as markers to evaluate efficacy in clinical trials.
JOURNAL OF PEDIATRICS
(2022)
Article
Genetics & Heredity
Xiaolan Fang, Kameryn M. Butler, Fatima Abidi, Jennifer Gass, Arthur Beisang, Timothy Feyma, Robin C. Ryther, Shannon Standridge, Peter Heydemann, Mary Jones, Richard Haas, David N. Lieberman, Eric D. Marsh, Tim A. Benke, Steve Skinner, Jeffrey L. Neul, Alan K. Percy, Michael J. Friez, Raymond C. Caylor
Summary: This study analyzed the X-chromosome inactivation (XCI) patterns in individuals with Rett syndrome (RTT) and other syndromes with overlapping phenotypes. The results showed that RTT patients had a slightly higher XCI ratio compared to their mothers, and different syndromes had different preferentially inactivated alleles. Additionally, the study found a correlation between XCI skewing and clinical severity in RTT patients.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Clinical Neurology
Sam Amin, Marie Monaghan, Angel Aledo-Serrano, Nadia Bahi-Buisson, Richard F. Chin, Angus J. Clarke, J. Helen Cross, Scott Demarest, Orrin Devinsky, Jenny Downs, Elia M. Pestana Knight, Heather Olson, Carol-Anne Partridge, Graham Stuart, Marina Trivisano, Sameer Zuberi, Tim A. Benke
Summary: This article presents the characteristics, incidence, and impact of CDKL5 Deficiency Disorder (CDD), as well as recommendations from international healthcare professionals to address the diverse needs of individuals with CDD. Using a Delphi method, a consensus was reached and clinical management recommendations were proposed. These recommendations aim to standardize and improve the medical care for individuals with CDD.
FRONTIERS IN NEUROLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Kingsley Wong, Mohammed Junaid, Scott Demarest, Jacinta Saldaris, Tim A. Benke, Eric D. Marsh, Jenny Downs, Helen Leonard
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Kingsley Wong, Mohammed Junaid, Scott Demarest, Jacinta Saldaris, Tim A. Benke, Eric D. Marsh, Jenny Downs, Helen Leonard
Summary: This study investigated the influence of factors at birth and in infancy on the likelihood of achieving major motor milestones in CDKL5 Deficiency Disorder (CDD). The study found that female gender, late truncating variant, and mosaicism positively impacted the likelihood of independent sitting. Later seizure onset and experiencing a honeymoon period also improved the likelihood of independent sitting.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Education, Special
Helen Leonard, Andrew Whitehouse, Peter Jacoby, Tim Benke, Scott Demarest, Jacinta Saldaris, Kingsley Wong, Dinah Reddihough, Katrina Williams, Jenny Downs
Summary: This study compares the quality of life among different diagnoses associated with intellectual disability, constructs quality of life profiles, and evaluates membership by diagnostic group, function, and comorbidities. The results show variations in quality of life across different diagnostic groups, suggesting interventions can be targeted at improving emotional well-being, social interaction, and independence to enhance quality of life.
RESEARCH IN DEVELOPMENTAL DISABILITIES
(2022)
Article
Genetics & Heredity
Jessica Stansauk, Andrea Fidell, Tim Benke, Michael Schaffer, Scott T. Demarest
Summary: CDKL5 deficiency disorder (CDD) is associated with rare cases of prolonged QTc and other cardiac conduction abnormalities. However, further studies in larger cohorts are needed to confirm these findings.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Behavioral Sciences
Jacinta M. Saldaris, Peter Jacoby, Helen Leonard, Tim A. Benke, Scott Demarest, Eric D. Marsh, Jenny Downs
Summary: This study aimed to evaluate the psychometric properties of the Quality of Life Inventory-Disability (QI-Disability) in CDKL5 Deficiency Disorder (CDD). The results showed that QI-Disability is suitable for assessing the quality of life of children and adults with CDD and may be of value for upcoming clinical trials.
EPILEPSY & BEHAVIOR
(2023)
Article
Neurosciences
Jennifer L. Sanderson, Ronald K. Freund, Anna M. Castano, Timothy A. Benke, Mark L. Dell 'Acqua
Summary: This study provides insights into how alterations in CaV1.2 channel function disrupt basal transmission and plasticity, which are relevant for neurobehavioral alterations in Autism Spectrum Disorders (ASD). Individuals with Timothy Syndrome (TS) and TS2-neo mice exhibit social deficits and cognitive impairments similar to ASD. The synaptic function in the hippocampal CA1 region of TS2-neo mice shows slightly increased excitatory transmission and strongly decreased inhibitory transmission, potentially related to the synaptic dysfunction caused by CaV1.2 channel mutations.
Article
Genetics & Heredity
Xiaolan Fang, Lauren M. Baggett, Raymond C. Caylor, Alan K. Percy, Jeffrey L. Neul, Jane B. Lane, Daniel G. Glaze, Tim A. Benke, Eric D. Marsh, Kathleen J. Motil, Judy O. Barrish, Fran E. Annese, Steven A. Skinner
Summary: This study investigates the association between parental age and the risk and clinical severity of Rett syndrome (RTT). The results suggest that parental age does not appear to be a significant risk factor for the development of RTT or the severity of the condition.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Clinical Neurology
Carolyn Daniels, Caitlin Greene, Lacey Smith, Elia Pestana-Knight, Scott Demarest, Bo Zhang, Timothy A. Benke, Annapurna Poduri, Heather E. Olson
Summary: This study aimed to differentiate individuals with CDKL5 deficiency disorder (CDD) from those with other infantile-onset epilepsies based on their phenotypic features. The results showed that CDD individuals were more likely to have treatment-resistant epilepsy, developmental and epileptic encephalopathy, sequential seizures, spasms without hypsarrhythmia, diffuse hypotonia, paroxysmal movement disorders, cerebral visual impairment, and failure to thrive compared to the comparison group. Defining core phenotypic characteristics can improve precision diagnosis and treatment.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Joni N. Saby, Patrick J. Mulcahey, Alexis E. Zavez, Sarika U. Peters, Shannon M. Standridge, Lindsay C. Swanson, David N. Lieberman, Heather E. Olson, Alexandra P. Key, Alan K. Percy, Jeffrey L. Neul, Charles A. Nelson, Timothy P. L. Roberts, Timothy A. Benke, Eric D. Marsh
Summary: The study quantified electrophysiological measures in individuals with CDKL5 deficiency disorder, identifying reduced visual evoked potential amplitude in this group. Auditory evoked potential amplitude correlated with disease severity, and multiple quantitative EEG features differed between CDKL5 deficiency disorder and typically developing participants. The theta/delta ratio was found to be the strongest predictor of severity and a repeatable measure from baseline to Year 1. These findings highlight the potential utility of evoked potentials and quantitative EEG parameters as objective measures for future clinical trials.
BRAIN COMMUNICATIONS
(2022)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)