Article
Medicine, General & Internal
Anna Engell Holm, Hans Henrik Lawaetz Schultz, Helle Krogh Johansen, Tania Pressler, Thomas Kromann Lund, Martin Iversen, Michael Perch
Summary: This study monitored the time of bacterial re-colonization in lung transplant patients with cystic fibrosis and found that 70% of patients were re-colonized by bacteria after 2 years, with no observed impact on survival rates from re-colonization or different bacterial species.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Rocio Castillo-Larios, Naga Swati Gunturu, Jorge Cornejo, Spencer W. Trooboff, Abhishek Ramgir Giri, Steven P. Bowers, Enrique F. Elli
Summary: This study aimed to report and compare the outcomes of different revisional techniques for failed anti-reflux surgery. By retrospectively analyzing patients who underwent revisional surgery between 2016 and 2021, it was found that conversion to RYGB may offer better resolution of reflux than RF, especially for obese patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
S. E. Aragona, G. Ciprandi
Summary: Gastroesophageal reflux disease (GERD) is a common condition in the Western population and the most frequent reason for gastroenterology consultation. Pharmacists play a crucial role in advising on the management of GERD, and their knowledge update significantly affects their recommendations. Proton pump inhibitors (PPIs) and alginates are commonly used medications, with combined therapy being the most common approach.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Endocrinology & Metabolism
S. E. Aragona, M. E. Baldassarre, S. Lazzaro, G. Ciprandi
Summary: Gastric reflux, such as GERD, has seen an increasing prevalence worldwide. The guidelines for diagnosing and treating GERD have been well consolidated and frequently updated. Extra-esophageal manifestations of reflux, such as LPR, have been considered from a multidisciplinary perspective. However, treatment options for LPR are still poorly specified.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Surgery
Riccardo Coletta, Elisa Mussi, Adrian Bianchi, Antonino Morabito
Summary: M-OGD surgery is a less complex technical modification that reduces difficulties in redo oesophageal surgery for neurologically impaired children, with a good long-term outcome.
UPDATES IN SURGERY
(2021)
Review
Immunology
Veronica Roxana Flores-Vega, Silvia Yalid Vargas-Roldan, Jose Luis Lezana-Fernandez, Ricardo Lascurain, Jose Ignacio Santos-Preciado, Roberto Rosales-Reyes
Summary: Cystic fibrosis is a genetic disease caused by a mutation in the cftr gene, affecting chloride ion and water transport and leading to bacterial infections in the lungs. Autophagy plays a crucial role in pathogen clearance, but P. aeruginosa and B. cenocepacia have strategies to evade this pathway, resulting in chronic inflammatory immune responses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
M. Dziekiewicz, M. Mielus, A. Lisowska, J. Walkowiak, D. Sands, A. Radzikowski, A. Banaszkiewicz
Summary: In children with CF, treatment of GERD does not seem to have a stronger effect than a placebo on the severity of cough and abdominal pain. It may be necessary to be more cautious in intensively treating suspected atypical GERD symptoms in patients with CF.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
S. E. Aragona, M. E. Baldassarre, G. Ciprandi
Summary: Gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) are common reasons for physician consultation worldwide. An educational program helped update pediatricians' knowledge, leading to a shift towards monotherapy in managing infants and children with reflux.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Pediatrics
Emilia da Silva Goncalves, Jose Dirceu Ribeiro, Fernando Augusto Lima Marson, Ciro Garcia Montes, Antonio Fernando Ribeiro, Jochen Georg Mainz, Adyleia Aparecida Dalbo Contrera Toro, Juliana Helena Zamariola, Daniela Souza Paiva Borgli, Elizete Aparecida Lomazi, Maria de Fatima Correa Pimenta Servidoni
Summary: The prevalence of GERD in children with CF was assessed using multichannel intraluminal impedanciometry associated with pH monitoring (MIIpH) and compared with respiratory symptoms. It was found that MIIpH detected 30% more GERD patients than pHmetry.
JORNAL DE PEDIATRIA
(2023)
Article
Surgery
Anna N. Ibele, Peter Nau, Carlos Galvani, J. Scott F. Roth, Ross S. Goldberg, Marina Kurian, Leena Khaitan, Jon K. Gould, Yagnik Pandya, SAGES Foregut Taskforce
Summary: In this study, it was found that many surgeons choose RYGB surgery to treat refractory GERD. However, insurance coverage for RYGB surgery is often restricted due to policy limitations, making it difficult for patients to access the procedure. Therefore, advocacy is necessary to improve the accessibility of surgical treatment for GERD in obese patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Nutrition & Dietetics
Imashi Fernando, Kelsey A. Schmidt, Gail Cromer, Maggie S. Burhans, Jessica N. Kuzma, Derek K. Hagman, Kristina M. Utzschneider, Sarah Holte, Jana Kraft, Thomas L. Vaughan, Mario Kratz
Summary: This exploratory analysis suggests that increasing the consumption of low-fat or full-fat dairy foods to at least three servings per day does not affect common symptoms of GERD, such as heartburn and acid regurgitation, in men and women with metabolic syndrome.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Surgery
Seung Joon Choi, Seong Min Kim
Summary: The study found that the mean total sleeve volume was not significantly correlated with %TWL at 12 months postop. The presence of intrathoracic sleeve migration indicated more frequent gastroesophageal reflux symptoms and a higher probability of suboptimal weight loss.
Article
Gastroenterology & Hepatology
Jun Nakamura, Hiroki Sato, Manabu Onimaru, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Hikichi Takuto, Haruhiro Inoue
Summary: This retrospective study analyzed the characteristics and efficacy of peroral endoscopic myotomy (POEM) in patients with esophageal motility disorders (EMDs) who had previous gastric surgery. The results showed that patients with gastric surgery often presented severe disease manifestations, with gastric cancer being the main surgical indication. POEM was found to be safe and effective in these patients, although it increased the incidence of reflux esophagitis.
DIGESTIVE ENDOSCOPY
(2022)
Article
Cardiac & Cardiovascular Systems
Misbah Baqir, Amit Vasirreddy, Ann N. Vu, Teng Moua, Alanna M. Chamberlain, Ryan D. Frank, Jay H. Ryu
Summary: The study found that patients with IPF were more likely to have GERD compared to controls with non-IPF ILD or no diagnosed lung disease. This suggests that GERD may be an important factor contributing to the development of lung fibrosis.
RESPIRATORY MEDICINE
(2021)
Article
Surgery
Rodrigo C. L. Edelmuth, Maria Cristina Riascos, Hala Al Asadi, Jacques A. Greenberg, Ileana C. Miranda, Haythem Najah, Carl V. Crawford, Felice H. Schnoll-Sussman, Brendan M. Finnerty, Thomas J. Fahey, Rasa Zarnegar
Summary: This study, using a rat model, found that administration of Vonoprazan can lead to morphological changes in the gastrointestinal tract, specifically causing alterations in certain cell types, such as PACM. The duration and dosage of Vonoprazan administration were shown to play a significant role in the development of PACM.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)