Article
Health Care Sciences & Services
Andrea Foppiani, Fabiana Ciciriello, Arianna Bisogno, Silvia Bricchi, Carla Colombo, Federico Alghisi, Vincenzina Lucidi, Maria Ausilia Catena, Mariacristina Lucanto, Andrea Mari, Giorgio Bedogni, Alberto Battezzati
Summary: This study aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population. The results showed the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity for patients 35 years of age.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Tanicia Daley, Benjamin Cousineau, Paula-Dene Nesbeth, Elizabeth Ivie, Moriah Bellissimo, Kirk Easley, Priyathama Vellanki, Miriam Vos, William Hunt, Arlene Stecenko, Thomas Ziegler, Jessica Alvarez
Summary: This study aimed to investigate the relationship between dietary macronutrient quality and glucose homeostasis in adults with cystic fibrosis (CF). The results showed that individuals with cystic fibrosis-related diabetes (CFRD) consumed less total fat and monounsaturated fatty acids (MUFA), and higher unsaturated dietary fat, higher plant protein, and higher carbohydrate quality were associated with better glucose tolerance indicators in adults with CF.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Amy Darukhanavala, Filia Van Dessel, Jannifer Ho, Megan Hansen, Ted Kremer, David Alfego
Summary: This study aimed to evaluate whether HbA1c is suitable for screening patients with pre-CFRD dysglycemia, and the results showed a lack of association between HbA1c and glycemic states. Further studies are needed to explore more efficient screening methods to reduce the burden of annual OGTTs.
Article
Endocrinology & Metabolism
Claudia Piona, Sonia Volpi, Chiara Zusi, Enza Mozzillo, Antonella Tosco, Adriana Franzese, Valeria Raia, Maria Linda Boselli, Maddalena Trombetta, Marco Cipolli, Riccardo C. Bonadonna, Claudio Maffeis
Summary: In patients with cystic fibrosis, each of the 5 glucose tolerance stages demonstrates a distinct pattern of defects in the direct determinants of glucose regulation. Early elevation of AGT140 patients significantly differ from NGT and are similar to IGT.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Enza Mozzillo, Roberto Franceschi, Claudia Piona, Stefano Passanisi, Alberto Casertano, Dorina Pjetraj, Giulio Maltoni, Valeria Calcaterra, Vittoria Cauvin, Valentino Cherubini, Giuseppe D'Annunzio, Adriana Franzese, Anna Paola Frongia, Fortunato Lombardo, Donatella Lo Presti, Maria Cristina Matteoli, Elvira Piccinno, Barbara Predieri, Ivana Rabbone, Andrea Enzo Scaramuzza, Sonia Toni, Stefano Zucchini, Claudio Maffeis, Riccardo Schiaffini
Summary: Cystic Fibrosis Related Diabetes (CFRD) is a comorbidity of cystic fibrosis (CF) that can have negative impacts on the clinical course. Prediabetes is an important predictor of CFRD development and unfavorable prognosis of CF. International guidelines recommend insulin only in cases of CFRD diagnosis. The debate continues over whether early detection and treatment of prediabetes can improve the clinical course of CF.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Review
Biochemistry & Molecular Biology
Vera Dora Izsak, Alexandra Soos, Zsolt Szakacs, Peter Hegyi, Mark Felix Juhasz, Orsolya Varannai, Agnes Rita Martonosi, Maria Foldi, Alexandra Kozma, Zsolt Vajda, James A. M. Shaw, Andrea Parniczky
Summary: Early recognition and prompt treatment of cystic fibrosis-related diabetes (CFRD) are crucial for improved outcomes. Two-day continuous glucose monitoring (CGM) appears to be a promising screening test for CFRD, showing the highest sensitivity and specificity among available screening tools.
Article
Environmental Sciences
Qiang Ma, Houguo Xu, Samwel Mchele Limbu, Yuliang Wei, Mengqing Liang
Summary: In this study, the ability of fish to utilize carbohydrates was evaluated by intraperitoneal injection or oral administration of glucose or fructose to tiger puffer and turbot. The results showed that glucose and fructose stimulated insulin secretion and improved hypoxia tolerance in the two marine fishes.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Endocrinology & Metabolism
Kathryn J. Potter, Quitterie Reynaud, Valerie Boudreau, Florence Racine, Francois Tremblay, Annick Lavoie, Maite Carricart, Genevieve Mailhot, Isabelle Durieu, Peter A. Senior, Remi Rabasa-Lhoret
Summary: Patients meeting both criteria of indeterminate glycemia and impaired glucose tolerance have an increased risk of developing diabetes, suggesting the need for closer monitoring.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Ming-Jun Chen, Jing Leng, Jian-Ping Ni, Ai-Ling Xiong, Man-Yun Hu
Summary: This study examined the association between fasting plasma C-peptide levels and sarcopenia, revealing a U-shaped relationship with lower risk in the range of 774-939 pmol/L.
Article
Endocrinology & Metabolism
Rebecca Hicks, Katie Larson Ode, Tim Vigers, Christine L. Chan
Summary: A study was conducted to examine the screening practices for cystic fibrosis related diabetes (CFRD) and identify barriers and strategies for improvement. Surveys were conducted among CF center directors and endocrinologists, and the results showed low screening rates and practice variations. Use of systematic reminders and further research are recommended to improve CFRD screening.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tao Yuan, Shuoning Song, Tianyi Zhao, Yanbei Duo, Shihan Wang, Junxiang Gao, Shixuan Liu, Yingyue Dong, Rui Li, Yong Fu, Weigang Zhao
Summary: The study identified two different patterns of FPIS among subjects with normal glucose tolerance, indicating that individuals with later time to glucose peak during FPIS may have a lower risk of developing type 2 diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Claudia Piona, Enza Mozzillo, Antonella Tosco, Sonia Volpi, Francesco Maria Rosanio, Chiara Cimbalo, Adriana Franzese, Valeria Raia, Chiara Zusi, Federica Emiliani, Maria Linda Boselli, Maddalena Trombetta, Riccardo Crocina Bonadonna, Marco Cipolli, Claudio Maffeis
Summary: Treatment with CFTR modulators does not significantly improve glucose homeostasis and its direct determinants in CF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Bibi Uhre Nielsen, Inger Hee Mabuza Mathiesen, Rikke Moller, Rikke Krogh-Madsen, Terese Lea Katzenstein, Tacjana Pressler, James A. M. Shaw, Christian Ritz, Michael R. Rickels, Darko Stefanovski, Thomas Peter Almdal, Daniel Faurholt-Jepsen
Summary: The study aims to further understand the pathophysiology of CF-related diabetes and explore potential factors causing hypoglycaemia. The results indicate that there is an association between beta cell stress and abnormal alpha cell function in adults with CF. Hypoglycaemia in CF patients may be due to a temporal mismatch between glucose and insulin levels rather than an impaired glucagon response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Respiratory System
Aurelie Hatton, Anne Bergougnoux, Katarzyna Zybert, Benoit Chevalier, Myriam Mesbahi, Jean Pierre Alteri, Katarzyna Walicka-Serzysko, Magdalena Postek, Magali Taulan-Cadars, Aleksander Edelman, Alexandre Hinzpeter, Mireille Claustres, Emmanuelle Girodon, Caroline Raynal, Isabelle Sermet-Gaudelus, Dorota Sands, Dorota Sands
Summary: This study demonstrates the usefulness of combining genetic and functional investigations to assess the possibility of evolving to CF or CFTR-RD in babies with inconclusive diagnosis at neonatal screening.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Respiratory System
Agathe Lepissier, Charlotte Addy, Kate Hayes, Sabrina Noel, Stephanie Bui, Pierre-Regis Burgel, Lieven Dupont, Olaf Eickmeier, Michael Fayon, Teresinha Leal, Carlos Lopes, Damian G. Downey, Isabelle Sermet-Gaudelus
Summary: This study aimed to evaluate the clinical reliability, validity, and clinical relevance of sputum biomarkers in cystic fibrosis. The results showed that sputum biomarkers have potential as outcome measures in clinical trials, but further research is needed to standardize processing and validate the reliability and validity of these biomarkers.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Review
Pharmacology & Pharmacy
Isabelle Fajac, Isabelle Sermet-Gaudelus
Summary: Cystic fibrosis (CF) is a severe genetic disorder characterized by pancreatic insufficiency and bronchiectasis. CFTR modulators have emerged as a new treatment option, benefiting the majority of CF patients. However, a significant proportion of CFTR mutations do not respond to these modulators. Current research is focusing on alternative therapies, such as DNA- and RNA-based treatments, readthrough agents, and cell-based therapies.
EXPERT OPINION ON EMERGING DRUGS
(2022)
Article
Biochemistry & Molecular Biology
Benoit Chevalier, Nesrine Baatallah, Matthieu Najm, Solene Castanier, Vincent Jung, Iwona Pranke, Anita Golec, Veronique Stoven, Stefano Marullo, Fabrice Antigny, Ida Chiara Guerrera, Isabelle Sermet-Gaudelus, Aleksander Edelman, Alexandre Hinzpeter
Summary: In this study, the interaction of CFTR and its mutants with other proteins was investigated using various experimental approaches. Proximity labeling methods based on TurboID and APEX2 were evaluated and compared to existing databases. The results revealed new protein partners and provided a more comprehensive understanding of the CFTR interactome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Siobhan B. Carr, Elliot McClenaghan, Alexander Elbert, Albert Faro, Rebecca Cosgriff, Olzhas Abdrakhmanov, Keith Brownlee, Pierre-Regis Burgel, Catherine A. Byrnes, Stephanie Y. Cheng, Carla Colombo, Harriet Corvol, Geraldine Daneau, Christopher H. Goss, Vincent Gulmans, Hector Gutierrez, Satenik Harutyunyan, Meagan Helmick, Andreas Jung, Nataliya Kashirskaya, Edward McKone, Joel Melo, Peter G. Middleton, Pedro Mondejar-Lopez, Isabelle de Monestrol, Lutz Naehrlich, Rita Padoan, Megan Parker, M. Dolores Pastor-Vivero, Samar Rizvi, Rasa Ruseckaite, Marco Salvatore, Luiz Vicente R. F. Da Silva-Filho, Nick Versmessen, Marco Zampoli, Bruce C. Marshall, Anne L. Stephenson
Summary: This international study aimed to investigate the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and identify factors associated with severe outcomes. The study found that the use of CFTR modulator therapy had a protective effect, and individuals with cystic fibrosis from ethnic minorities were at a higher risk of severe infection with SARS-CoV-2.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Biochemistry & Molecular Biology
Kusumika Saha, Benoit Chevalier, Stephane Doly, Nesrine Baatallah, Thomas Guilbert, Iwona Pranke, Mark G. H. Scott, Herve Enslen, Chiara Guerrera, Cerina Chuon, Aleksander Edelman, Isabelle Sermet-Gaudelus, Alexandre Hinzpeter, Stefano Marullo
Summary: The exit of certain plasma membrane proteins from the endoplasmic reticulum is regulated by arginine-based retention motifs. PRAF2, a gatekeeper protein, recognizes these motifs and retains specific proteins in the ER. It has been found that PRAF2 can interact with mutant CFTR, preventing it from reaching the ER exit sites. Pharmacological chaperones have also been shown to rescue CFTR-F508del retention by PRAF2 through various mechanisms. These findings provide new therapeutic perspectives for diseases caused by impaired cell surface trafficking of mutant proteins.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Respiratory System
Kevin W. Southern, Carlo Castellani, Elise Lammertyn, Alan Smyth, Donald VanDevanter, Silke van Koningsbruggen-Rietschel, Juerg Barben, Amanda Bevan, Edwin Brokaar, Sarah Collins, Gary J. Connett, Thomas W. V. Daniels, Jane Davies, Dimitri Declercq, Silvia Gartner, Andrea Gramegna, Naomi Hamilton, Jenny Hauser, Nataliya Kashirskaya, Laurence Kessler, Jacqueline Lowdon, Halyna Makukh, Clemence Martin, Lisa Morrison, Dilip Nazareth, Jacquelien Noordhoek, Ciaran O'Neill, Elizabeth Owen, Helen Oxley, Karen S. Raraigh, Caroline Raynal, Karen Robinson, Jobst Roehmel, Carsten Schwarz, Isabelle Sermet, Michal Shteinberg, Ian Sinha, Constance Takawira, Peter van Mourik, Marieke Verkleij, Michael D. Waller, Alistair Duff
Summary: Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic variants in the CFTR gene, and CFTR modulators, the first available therapy, have transformed CF management. Interim standards have been produced to guide healthcare professionals in providing variant-specific therapy for CF patients using evidence-based guidance and stakeholder consultation.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Letter
Critical Care Medicine
Agathe Lepissier, Anne Sophie Bonnel, Nathalie Wizla, Laurence Weiss, Marie Mittaine, Katia Bessaci, Eitan Kerem, Veronique Houdouin, Philippe Reix, Christophe Marguet, Isabelle Sermet-Gaudelus
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Chemistry, Analytical
Waqar Ahmed, Emmanuelle Bardin, Michael D. Davis, Isabelle Sermet-Gaudelus, Stanislas Grassin Delyle, Stephen J. Fowler
Summary: Early detection of lung infection is crucial, and measuring VOCs in exhaled breath has shown potential as a rapid and accurate method. This study investigated VOCs in ALI cultures and identified potential biomarkers for S. aureus lung infection. By analyzing VOCs, we found significant changes in infected cells compared to uninfected cells, suggesting VOC analysis as a highly sensitive and specific test for S. aureus infection.
Editorial Material
Respiratory System
Iwona M. Pranke, Jessica Varilh, Aurelie Hatton, Caroline Faucon, Emmanuelle Girodon, Elise Dreano, Benoit Chevalier, Sabrina Karri, Philippe Reix, Isabelle Durieu, Laure Bidou, Olivier Namy, Magali Taulan, Alexandre Hinzpeter, Isabelle Sermet-Gaudelus
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Respiratory System
Pierre-Regis Burgel, Isabelle Sermet-Gaudelus, Isabelle Durieu, Reem Kanaan, Julie Macey, Dominique Grenet, Michele Porzio, Nathalie Coolen-Allou, Raphael Chiron, Christophe Marguet, Benoit Douvry, Nadine Dufeu, Isabelle Danner-Boucher, Pierre Foucaud, Lydie Lemonnier, Emmanuelle Girodon, Jennifer Da Silva, Clemence Martin, French CF Reference Network Study Grp
Summary: The European Medicines Agency has approved the CFTR modulator combination elexacaftor/tezacaftor/ivacaftor for CF patients carrying certain variants. An observational study evaluated the effectiveness of this treatment in CF patients with advanced lung disease who did not meet the eligibility criteria in Europe. The results showed significant clinical benefits in a subset of patients.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Urology & Nephrology
Marina Avramescu, Pierre Isnard, Sarah Temmam, Agnes Chevalier, Paul Bastard, Mikael Attia, Romain Berthaud, Marc Fila, Claire Dossier, Julien Hogan, Tim Ulinski, Damia Leguevaques, Ferielle Louillet, Edouard Martinez Casado, Jean-Michel Halimi, Sylvie Cloarec, Ariane Zaloszyc, Camille Faudeux, Caroline Rousset-Rouviere, Stephanie Clave, Jerome Harambat, Edouard Rollot, Thomas Simon, Megan Nallet-Amate, Bruno Ranchin, Justine Bacchetta, Florence Porcheret, Josselin Bernard, Amelie Ryckewaert, Anne Jamet, Jacques Fourgeaud, Nicolas Da Rocha, Philippe Perot, Nicolas Kuperwasser, Naim Bouazza, Marion Rabant, Jean-Paul Duong Van Huyen, Matthieu P. Robert, Julien Zuber, Jean-Laurent Casanova, Marc Eloit, Isabelle Sermet-Gaudelus, Olivia Boyer
KIDNEY INTERNATIONAL
(2023)
Article
Immunology
Xiongqi Ding, Xiali Fu, Daniel Euphrasie, Agnes Ferroni, Isabelle Sermet-Gaudelus, Alain Charbit, Mathieu Coureuil, Anne Jamet
Summary: This study investigated the virulence and antimicrobial resistance-associated genes and within-host evolution polymorphisms in 14 persistent clones of Staphylococcus aureus from chronically infected children with cystic fibrosis. The study identified convergent mutations in genes involved in intracellular invasion and persistence, which play an important role in the long-term persistence ability of S. aureus.
MICROBES AND INFECTION
(2023)
Article
Biochemical Research Methods
Anita Golec, Iwona Pranke, Paolo Scudieri, Kate Hayes, Elise Dreano, Fiona Dunlevy, Aurelie Hatton, Damian G. Downey, Luis Galietta, Isabelle Sermet
Summary: In this study, we describe a standardized protocol for isolating, maintaining, and polarizing respiratory epithelial primary cells from patient samples. The protocol involves obtaining samples from nasal brushing, polyp specimens, or lung explants. The resulting polarized layer of epithelial cells on filters exhibits a good number of ciliated cells and a thin layer of mucus. We provide detailed steps for preparing samples from patients with and without cystic fibrosis.
Article
Respiratory System
Aurelie Hatton, Anne Bergougnoux, Katarzyna Zybert, Benoit Chevalier, Myriam Mesbahi, Jean Pierre Alteri, Katarzyna Walicka-Serzysko, Magdalena Postek, Magali Taulan-Cadars, Aleksander Edelman, Alexandre Hinzpeter, Mireille Claustres, Emmanuelle Girodon, Caroline Raynal, Isabelle Sermet-Gaudelus, Dorota Sands
Summary: This study demonstrates the usefulness of combining genetic and functional investigations to assess the possibility of evolving to CF or CFTR-RD in babies with inconclusive diagnosis at neonatal screening.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)