Article
Plant Sciences
Sungha Kim, Muhack Yang, Boncho Ku, Eunhye Cha, Wookcheol Seo, Ilhong Son, Hyungwon Kang, Dongwoung Kim, Bongkeun Song, Chang-Sop Yang, Sungchul Kim
Summary: This study aimed to evaluate the efficacy and safety of Mecasin in patients with ALS. Patients were randomized to receive daily doses of 1.6 g or 2.4 g Mecasin, or placebo for 12 weeks. The results showed that Mecasin can slow down the progression of symptoms in ALS patients without major adverse effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Lei Qiao, Luo-Jia Wang, Yang Wang, Ying Chen, Hai-Lan Zhang, Shu-Cheng Zhang
Summary: XiaojiDaozhi Decoction, a Chinese Herbal Medicine prescription, has been shown to be a safe and effective method for the treatment of childhood constipation, improving bowel movements significantly without serious adverse effects.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Chemistry, Medicinal
Julie Schjodtz Hansen, Stefan Gustavsen, Homayoun Roshanisefat, Matthias Kant, Fin Biering-Sorensen, Claus Andersen, Anna Olsson, Helene Hojsgaard Chow, Nasrin Asgari, Julie Richter Hansen, Helle Hvilsted Nielsen, Rikke Middelhede Hansen, Thor Petersen, Annette Bang Oturai, Finn Sellebjerg, Eva Aggerholm Saedder, Helge Kasch, Peter Vestergaard Rasmussen, Nanna Brix Finnerup, Kristina Bacher Svendsen
Summary: This study investigated the effect of cannabis-based medicine (CBM) on central neuropathic pain (NP) and spasticity in patients with multiple sclerosis (MS) and spinal cord injury (SCI). The results showed that THC, CBD, or their combination did not have a significant effect on pain and spasticity. The study was limited by a smaller sample size due to COVID-19 and recruitment challenges.
Article
Plant Sciences
Yihe Chi, Lin Lin, Xin Guo, Jingmin Xiao, Feiting Fan, Changli Yu, Hanrong Xue, Suyun Li, Dongwei Guo, Lei Liu, Yaoyong Wang, Xiao Ma, Jianguo Pang, Jincheng Wang, Zhiying Zhao, Xianping Zhao, Guangen Wang, Dongwei Gu, Hui Zhen, Hongping Chen, Junping Ding, Mingjuan Zhou, Zhenhu Wu, Yun Han, Yuanbin Chen, Lei Wu
Summary: XBZK granules are a promising therapy for postinfectious cough, effectively reducing the severity of cough, shortening the time for cough recovery, and decreasing the viscosity of sputum.
Article
Medicine, General & Internal
Jia-Hui Zhu, Yang-Yang Qian, Jun Pan, Chen He, Yu Lan, Wei-Na Chen, Bang-Mao Wang, Wei Zhao, Jing-Nan Li, Xiao-Qing Li, Bin Lv, Yi-Hong Fan, Xiu-Li Zuo, Zhen Li, Duo-Wu Zou, Zhao-Shen Li, Zhuan Liao
Summary: This study aimed to assess the efficacy and safety of the newly developed smartphone-controlled vibrating capsule (VC) in patients with functional constipation (FC). The results demonstrated that VC can promote defecation, ameliorate symptoms, and improve the quality of life in patients with FC with sustained efficacy.
Article
Biochemistry & Molecular Biology
Tine L. Dohlmann, Anja B. Kuhlman, Thomas Morville, Maria Dahl, Magnus Asping, Patrick Orlando, Sonia Silvestri, Luca Tiano, Jorn W. Helge, Flemming Dela, Steen Larsen
Summary: This study investigated whether concurrent administration of CoQ10 with statins increases muscle CoQ10 levels and improves mitochondrial function, as well as whether changes in muscle CoQ10 levels correlate with changes in the intensity of myalgia. The results showed that CoQ10 supplementation had no effect on muscle CoQ10 levels or mitochondrial function, and individual changes in muscle CoQ10 levels were not correlated with changes in intensity of myalgia.
Article
Cardiac & Cardiovascular Systems
Ole Frobert, Matthias Gotberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Jorg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: This study found that early influenza vaccination after myocardial infarction or in patients with high-risk coronary heart disease significantly reduced the risk of death, myocardial infarction, or stent thrombosis, and also decreased the risk of all-cause death and cardiovascular death within 12 months compared to placebo.
Article
Gastroenterology & Hepatology
Daisuke Morishita, Toshihiko Tomita, Sumire Mori, Takeshi Kimura, Tadayuki Oshima, Hirokazu Fukui, Hiroto Miwa
Summary: This study evaluated the safety and efficacy of a stimulant laxative compared with an osmotic agent for treating chronic idiopathic constipation. The results showed that senna and MgO significantly improved symptoms and quality of life score in constipated patients, suggesting their effectiveness in constipation treatment.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Hao Lai, Yunfeng Li, Yafang He, Fangyao Chen, Baibing Mi, Junqi Li, Jiawen Xie, Guoqing Ma, Jinzhao Yang, Kun Xu, Xia Liao, Yan Yin, Junrong Liang, Liyun Kong, Xinyan Wang, Zhongxia Li, Yuan Shen, Shaonong Dang, Lei Zhang, Qian Wu, Lingxia Zeng, Lin Shi, Xuguang Zhang, Tian Tian, Xin Liu
Summary: Dietary fibers/probiotics may relieve constipation symptoms by optimizing gut microbiome. In a 4-week trial involving 250 adults with functional constipation, different formulas containing dietary fibers or probiotics were compared with placebo. No significant differences were observed in bowel movement frequency, Bristol stool scale score, and degree of defecation straining, but the intervention groups showed improvements in stool consistency. The intervention groups also showed changes in gut microbiota, with specific microbial genera associated with increased bowel movement frequency.
Article
Critical Care Medicine
Bonnie E. Lonze, Peter Spiegler, Russell N. Wesson, Nada Alachkar, Eva Petkova, Elaina P. Weldon, Rebecca A. Dieter, Yi Li, Max Quinn, Aprajita Mattoo, Irfana Soomro, Steven M. Cohen, Sherry Leung, Cecilia L. Deterville, B. Mark Landrum, Muhammad Imran Ali, David J. Cohen, Andrew L. Singer, Ayan Sen, Edward Chong, Judith S. Hochman, Andrea B. Troxel, Robert A. Montgomery
Summary: The study demonstrates that clazakizumab can improve clinical outcomes, such as survival rate and clinical status, for hospitalized COVID-19 patients with hyperinflammation.
CRITICAL CARE MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Palwasha Momand, Jonas P. Becktor, Aron Naimi-Akbar, Gunnar Tobin, Bengt Gotrick
Summary: Antibiotic prophylaxis in dental implant surgery is often used to prevent infection and early implant failure, but the benefits are unclear. This study compared the effects of antibiotic and placebo regimens and found that antibiotic prophylaxis has minimal benefits and should be avoided in most cases, considering the growing issue of antibiotic resistance.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Carol Angela Howell, Anu Kemppinen, Victoria Allgar, Matthew Dodd, Charles H. Knowles, John McLaughlin, Preeti Pandya, Peter Whorwell, Elena Markaryan, Yan Yiannakou
Summary: This study demonstrates that Enterosgel is safe and effective in patients with IBS-D, improving stool consistency, abdominal pain, stool frequency, and urgency. This provides an alternative to the limited current treatment options.
Article
Integrative & Complementary Medicine
Xuedong An, Bo Peng, Xiaodong Huang, Hongmei Jiang, Zhang'e Xiong, Hong Zhang, Fengmei Lian, Yuanming Ba, Xiaolin Tong
Summary: The study suggests that Ludangshen oral liquid treatment for two weeks may have certain effects on improving digestive and respiratory symptoms in convalescent COVID-19 patients, including fatigue, anorexia, loose stools, and shortness of breath.
Article
Endocrinology & Metabolism
Ida E. E. Jepsen, Malene Hviid Saxtorph, Anne Lis Mikkelsen Englund, Kathrine Birch Petersen, Marie Louise Muff Wissing, Thomas Vauvert F. Hviid, Nicholas Macklon
Summary: This study aimed to investigate the effectiveness of proprietary lactobacilli-loaded vaginal capsules in improving an unfavorable vaginal microbiome. The results suggest that administering vaginal probiotics may not be an effective means of modulating the vaginal microbiome for clinical purposes in an infertile population. However, the study also found a spontaneous improvement rate of 34.2% over a period of one to three months, indicating the dynamic nature of the vaginal microbiota and suggesting that postponing further IVF treatment to await microbiota improvement may be relevant in some patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Sven Olaf Skouby, Agnieszka Katarzyna Warzecha, Hanne Udengaard, Claus Yding Andersen, Marianne Dreyer Holt, Marie Louise Grondahl, Anders Nyboe Andersen, Negjyp Sopa, Anne Lis Englund Mikkelsen, Anja Pinborg, Nicholas Stephen Macklon
Summary: The use of letrozole during ovarian stimulation for IVF did not significantly decrease the proportion of women with premature progesterone levels above 1.5 ng/ml at the time of triggering final oocyte maturation. However, letrozole did significantly increase the proportion of women with mid-luteal progesterone levels above 30 ng/ml.
HUMAN REPRODUCTION
(2022)
Editorial Material
Pediatrics
Neil L. Schechter, Rachael Coakley, Samuel Nurko
Summary: This Viewpoint explores how patient and clinician expectations and biases influence feedback discussions following assessments for pediatric chronic pain.
Article
Gastroenterology & Hepatology
Julie Khlevner, Rachel Rosen, Lusine Ambartsumyan, Sarah Shrager Lusman, John M. Rosen, Desale Yacob, Hayat Mousa, Samuel Nurko, Carlo Di Lorenzo, Mary Boruta, Elyanne M. Ratcliffe, Laurence Feinstein, Julie Snyder, Richard J. Wood, Kahleb Graham, Miguel Saps, C. Prakash Gyawali, Leonel Rodriguez, Jaime Belkind-Gerson
Summary: This article discusses the commonality of neurogastroenterology and motility disorders in children and the lack of training in this area. Guidelines for training in North America are outlined, covering clinical knowledge, skills, and management elements across various anatomical regions. The aim is to break barriers to pursuing a career in NGM and provide uniform training expectations for pediatric gastroenterology fellows.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Lusine Ambartsumyan, Michele Shaffer, Kristen Carlin, Samuel Nurko
Summary: The study found that children with anorectal malformations had abnormal sensation and lower pressures longitudinally and radially along all quadrants of the anal canal. Manometric properties at rest were not associated with reported predictors of fecal continence.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Letter
Gastroenterology & Hepatology
Thomas S. C. Ng, Niharika Putta, Neha S. Kwatra, Laura A. Drubach, Rachel Rosen, Frederic H. Fahey, Alejandro Flores, Samuel Nurko, Stephan D. Voss
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Marc A. Benninga, Sunny Z. Hussain, Manu R. Sood, Samuel Nurko, Paul Hyman, Robert A. Clifford, Molly O'Gorman, Taryn Losch-Beridon, Shadreck Mareya, Peter Lichtlen, Carlo Di Lorenzo
Summary: In pediatric patients with functional constipation, lubiprostone did not show statistically significant effectiveness over placebo, but exhibited a safety profile similar to that in adults. Both doses of lubiprostone were well tolerated in children and adolescents.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jeng-Jung Chen, R. N. Kitzia Colliard, Samuel Nurko, Leonel Rodriguez
Summary: Melanosis coli is associated with the use of sennosides, but it does not affect colonic motility or increase the need for surgery in pediatric functional constipation.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ricardo A. Arbizu, Maureen Amicangelo, Leonel Rodriguez, Samuel Nurko
Summary: This study investigated the changes in intra-anal pressure and characteristics of the rectoanal inhibitory reflex during anorectal manometry in patients undergoing anesthesia induction with propofol. The results showed that propofol can be used to assess the presence of the rectoanal inhibitory reflex in uncooperative children. Additionally, propofol significantly reduces resting intra-anal pressure and increases the percentage of internal anal sphincter relaxation.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Miguel Saps, Samuel Nurko, M. A. Benninga, Carlo Di Lorenzo, Jose M. Garza, Nikhil Thapar, Kelly Richards, Jessica J. Lee, Tara Altepeter
Summary: Pediatric functional gastrointestinal disorders such as irritable bowel syndrome with constipation and functional constipation are common in children, but there are no FDA-approved drugs for chronic use. Challenges persist in conducting pediatric clinical trials to support drug approval, as discussed in a 2018 workshop which highlighted the need for further research efforts.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Caterina Strisciuglio, Massimo Martinelli, Peter Lu, Michal Rozenfeld Bar Lev, Beate Beinvogl, Marc A. Benninga, Carlo Di Lorenzo, Francesca Fiori Nastro, Samuel Nurko, Haley Pearlstein, Rachel Rosen, Raanan Shamir, Annamaria Staiano
Summary: During the first phase of the COVID-19 pandemic, children with FAPDs experienced improved symptoms, with a decrease in abdominal pain episodes over time, and showed increased quality of life and anxiety levels.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Jessica L. Yasuda, Steven J. Staffa, Samuel Nurko, Madeline Kane, Stephanie Wall, Edward B. Mougey, James P. Franciosi, Michael A. Manfredi, Rachel Rosen
Summary: Regardless of the CYP2C19 metabolizer phenotype, patients with esophageal atresia (EA) are more likely to experience PPI-refractory, non-allergic esophagitis, suggesting that factors other than CYP2C19 genetics, including dysmotility, play a primary role in esophagitis in EA.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Pediatrics
Beate Beinvogl, Alexandra Cohen, Courtney DiFilippo, Madeline Kane, Samuel Nurko, Rachel Rosen
Summary: This study aimed to examine the effects of the COVID-19 quarantine on pediatric patients with aerodigestive disease, including their baseline health, medication use, health anxiety, and healthcare utilization. The results showed that despite increased health-related anxiety, patients with aerodigestive disease experienced improvements in airway symptoms and decreased medication use during the pandemic. Additionally, all patient groups continued to access healthcare despite the challenges of the lockdown.
JOURNAL OF PEDIATRICS
(2022)
Review
Gastroenterology & Hepatology
Michael Camilleri, Samuel Nurko
Summary: Bile acids play a central role in the diagnosis of BAD, with idiopathic BAD potentially being caused by reduced synthesis of FGF-19 by the ileal mucosa or genetic variation in hepatocyte proteins. Diagnosis of BAD in adults and adolescents primarily involves serum and fecal testing.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Pediatrics
Suzanna Hirsch, Samuel Nurko, Paul Mitchell, Rachel Rosen
Summary: In a retrospective study of children prescribed prucalopride for upper GI symptoms at a single tertiary care center, 65% of patients showed symptomatic improvement at their first follow-up after prucalopride initiation. Patients with enteral tubes, pulmonary comorbidities, and neurologic comorbidities were more likely to experience improvement. Among patients with feeding difficulties, 79% showed improvements in oral or tube feeding.
Article
Gastroenterology & Hepatology
Claudio Morera, Samuel Nurko, Leonel Rodriguez
Summary: The study evaluated the utility of motility studies in pediatric functional constipation, finding that patients with fecal incontinence had higher frequency of normal motility parameters than those without, but overall interpretation was not different. Colonic manometry helped predict therapy response in functional constipation without fecal incontinence, while anorectal manometry showed no added benefit in the evaluation of functional constipation with/without fecal incontinence.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Leonel Rodriguez, Nicole Heinz, Kitzia Colliard, Maureen Amicangelo, Samuel Nurko
Summary: This study evaluated the utility of wireless motility capsule (WMC) in children with functional gastrointestinal symptoms, finding no association between WMC and symptoms, fair agreement with NMGET and strong agreement with CROM. WMC increases the yield of finding gastrointestinal transit abnormalities, and capsule retention in children is associated with prolonged colon transit. Larger studies are needed to further validate these findings.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)