Review
Pediatrics
Arimatias Raitio, Adeline Salim, Paul D. Losty
Summary: This study suggests that newborns with a hernia sac in congenital diaphragmatic hernia (CDH) have significant survival benefits compared to those without a sac. This may be due to more favorable physiology, less severe pulmonary hypertension, and smaller anatomical defects requiring primary closure only in infants with a hernia sac.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Felicitas Schulz, Ekkehart Jenetzky, Nadine Zwink, Charlotte Bendixen, Florian Kipfmueller, Neysan Rafat, Andreas Heydweiller, Lucas Wessel, Heiko Reutter, Andreas Mueller, Thomas Schaible
Summary: Evidence from a case-control study suggests an association between CDH and maternal periconceptional alcohol intake and maternal periconceptional use of hairspray. The study also highlights the multifactorial background of isolated CDH, identifying novel and confirming previously described parental risk factors.
Article
Pediatrics
Matias Luco, Gisela Salas, Alejandro Zavala, Jesica Otano, Alberto Toso, Aixa Reusmann, Claudia Cannizzaro, Felipe Santelices, Diana Farina, Pam Lally, Javier Kattan
Summary: Mortality related to CDH is high in South America, but the outcomes can vary widely among different centers. This study compares the outcomes of CDH in high-volume quaternary centers in South America with those of the CDH Study Group (CDHSG). It also identifies the factors associated with lower mortality in their population.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Surgery
Vikas S. Gupta, Matthew T. Harting, Pamela A. Lally, Charles C. Miller, Ronald B. Hirschl, Carl F. Davis, MelvinIII S. Dassinger, Terry L. Buchmiller, Krisa P. Van Meurs, Bradley A. Yoder, Michael J. Stewart, Kevin P. Lally
Summary: This study examines the risk-adjusted survival rates of CDH patients over the past 25 years in long-term participants of the CDH Study Group. The results show that the risk-adjusted and observed-to-expected mortality rates for CDH have improved over time.
Review
Surgery
Xiao-Yue Han, Leigh Taryn Selesner, Marilyn W. Butler
Summary: Congenital diaphragmatic hernia (CDH) is a surgical disease primarily affecting newborn infants, requiring timely diagnosis and treatment. Management involves interventions such as endotracheal intubation, fluid resuscitation, and echocardiographic evaluation. After surgical repair, infants may experience various morbidities.
SURGICAL CLINICS OF NORTH AMERICA
(2022)
Review
Pediatrics
Gabriela G. Edel, Gerben Schaaf, Rene M. H. Wijnen, Dick Tibboel, Gabrielle Kardon, Robbert J. Rottier
Summary: Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by diaphragmatic defect, lung hypoplasia, and structural vascular defects. Despite recent developments, the pathogenesis of CDH remains poorly understood. It is a complex congenital disorder with multifactorial etiology involving genetic, cellular, and mechanical factors.
FRONTIERS IN PEDIATRICS
(2021)
Review
Pediatrics
Kylie I. Holden, Matthew T. Harting
Summary: Congenital diaphragmatic hernia (CDH) is a complex cardiopulmonary anomaly requiring intense critical care management. New approaches in thinking and management, including risk stratification, ECLS, and novel therapies, offer hope for high-risk CDH patients. Further research and guidelines are essential for optimizing the care of these infants.
TRANSLATIONAL PEDIATRICS
(2023)
Review
Genetics & Heredity
Przemyslaw Kosinski, Milena Greczan, Aleksandra Jezela-Stanek
Summary: Fryns syndrome is an autosomal recessive multiple congenital anomaly syndrome characterized by diaphragmatic defects and secondary lung hypoplasia. Despite being first reported in 1979, the exact etiology of the syndrome remains uncertain, and prenatal presentation of these anomalies may require consideration of defects in glycosylphosphatidylinositol anchor synthesis.
FRONTIERS IN GENETICS
(2021)
Article
Pediatrics
James M. Prieto, Matthew T. Harting, Richard Y. Calvo, Jeanne M. Carroll, Alicia G. Sykes, Romeo C. Ignacio, Ashley H. Ebanks, David A. Lazar
Summary: This study evaluated the characteristics of neonates with congenital diaphragmatic hernia undergoing enteral access procedures during their initial hospitalization and established a clinical scoring system based on these characteristics to stratify patients into different risk groups for enteral access.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Armin-Johannes Michel, Ulrike Metzger, Steven Alan Rice, Roman Metzger
Summary: This study describes a minimally invasive technique for the repair of larger type B defects of congenital diaphragmatic hernia (CDH) using primary closure and strong suture connection. The technique allows for the transformation of circular defects into tension-free lines with strong compound and can be applied to defects of different sizes.
Article
Surgery
Tim Jancelewicz, Max R. Langham, Mary E. Brindle, Zachary E. Stiles, Pamela A. Lally, Lei Dong, Jim Y. Wan, Yigit S. Guner, Matthew T. Harting
Summary: The use of ECMO is associated with excess mortality for low- and intermediate-risk neonates with CDH. However, it provides a significant survival advantage for high-risk infants, and this advantage is strongly influenced by center CDH volume and ECMO experience.
Review
Pediatrics
Linda Gaillard, Anne Goverde, Quincy C. C. van den Bosch, Fernanda S. Jehee, Erwin Brosens, Danielle Veenma, Frank Magielsen, Annelies de Klein, Irene M. J. Mathijssen, Marieke F. van Dooren
Summary: A study found that variants in the BCL11B gene may be associated with craniosynostosis and CDH, but further research is needed to confirm if they are causative mutations.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Maria Eugenia Gulino, Giuseppe Martucciello, Elio Biffali, Patrizia Morbini, Roberta Patti, Marco Borra, Maria Grazia Scuderi
Summary: This study aimed to evaluate the role of TITF1 gene in the pathogenesis of congenital diaphragmatic hernia (CDH) in humans. The results showed that TITF1 gene mutations do not play a key role in the etiopathogenesis of CDH.
Article
Engineering, Electrical & Electronic
Stefano Robbiani, Francesco Tarantini, Lorenzo Ventura, Chiara Veneroni, Lorenza Draghi, Mar Janna Dahl, J. Jane Pillow, Raffaele L. Dellaca
Summary: Tracheal occlusion (TO) is a fetal treatment option for congenital diaphragmatic hernia, aiming to reduce lung hypoplasia and hypertension. However, the effect of TO on lung pressure was unknown. In this study, an implantable device was developed for real-time wireless monitoring and long-term logging of lung pressure in ovine fetuses. The device showed high accuracy and stability, successfully detecting pressure changes caused by TO.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Pediatrics
Judith Leyens, Lukas Schroeder, Annegret Geipel, Christoph Berg, Bartolomeo Bo, Lotte Lemloh, Neil Patel, Andreas Mueller, Florian Kipfmueller
Summary: This study aims to describe the early course of pulmonary hypertension (PH) in infants with congenital diaphragmatic hernia (CDH) and its relation to prognostic markers and outcome measures. The severity of PH varied significantly in the first 48 hours of life. Patients with mild/no PH had a better prognosis, while patients with severe PH had a higher risk of mortality and ECMO. Assessing PH within 2-6 hours is crucial in the care for CDH neonates.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Francesca Landolfo, Domenico Umberto De Rose, Claudia Columbo, Laura Valfre, Anna Claudia Massolo, Annabella Braguglia, Irma Capolupo, Pietro Bagolan, Andrea Dotta, Francesco Morini
Summary: The study found a significant correlation between lung volume and growth at 12 and 24 months in CDH survivors, with infants with pulmonary hypoplasia showing lower growth parameters.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Andrea Conforti, Chiara Pellegrino, Laura Valfre, Chiara Iacusso, Paolo Maria Salvatore Schingo, Irma Capolupo, Stefania Sgro, Lars Rasmussen, Pietro Bagolan
Summary: The aim of this study was to report the preliminary experience with magnamosis in treating LGEA. The results showed that magnamosis was a safe and effective minimally invasive option for these patients, with successful outcomes in all cases. The main outcomes considered were demographic and surgical features, postoperative complications, and feeding within 6 months of follow-up.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Acoustics
A. Romiti, F. Moro, L. Ricci, C. Codeca, F. Pozzati, M. Viggiano, R. Vicario, I. Fabietti, G. Scambia, P. Bagolan, A. C. Testa, L. Caforio
Summary: This retrospective study examined 51 fetal ovarian cysts in 48 fetuses and reclassified the cysts using IOTA terminology. The results showed that anechoic cysts and cysts with low-level content often resolved spontaneously, while cysts with ground-glass, hemorrhagic, mixed, or undefined content were frequently associated with postoperative necrosis.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Isabella Fabietti, Chiara Vassallo, Domenico Umberto De Rose, Agnese Maria Chiara Rapisarda, Anita Romiti, Milena Viggiano, Roberta Vicario, Federico Scorletti, Marco Bonito, Pietro Bagolan, Leonardo Caforio
Summary: Introduction: The study aims to determine the effectiveness and safety of intrafetal laser (IFL) therapy in managing various prenatal conditions. Methods: A systematic review of 41 articles was conducted, covering a 20-year period (2001-2021) and including cases of twin reversed arterial perfusion (TRAP) sequence, bronchopulmonary sequestrations (BPS), placental chorioangiomas (PCA), sacrococcygeal teratoma (SCT), and embryo reduction (ER) managed using IFL. Results: Successful outcomes were observed in the disruption of acardiac twin perfusion in TRAP, IFL treatment of BPS with no significant complications, and PCA with no cases of preterm premature rupture of membranes (p-PROM) reported. However, the rate of preterm birth (PTB) varied among different conditions, reaching 87.5% in SCT. Discussion: IFL is shown to be a feasible technique for managing fetal conditions, but the risk of PTB and its related morbidity and mortality should be considered during prenatal counseling.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Obstetrics & Gynecology
Patrizio Moras, Luciano Pasquini, Giuseppe Rizzo, Cosimo Marco Campanale, Marco Masci, Luca Di Chiara, Giulio Falasconi, Pietro Bagolan, Alessandra Toscano
Summary: This study aimed to assess the impact of ventricular disproportion and two-dimensional speckle-tracking echocardiography (2D-STE) on the prenatal prediction accuracy of Shone's complex (SC). The study found that SC fetuses had a more severe degree of ventricular disproportion and lower LV GLS, and both MV/TV and LV GLS were predictors of SC. These findings are important for improving the quality of prenatal counseling.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Flaminia Pugnaloni, Irma Capolupo, Neil Patel, Paola Giliberti, Andrea Dotta, Pietro Bagolan, Florian Kipfmueller
Summary: This review highlights the importance of miRNAs in CDH-related PH and summarizes the findings from animal and human CDH studies. The focus on epigenetic modulators of CDH-PH offers potential for developing innovative diagnostic tools and treatment approaches, and enhances researchers' understanding of CDH pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Isabel C. Hageman, Hendrik J. J. van der Steeg, Ekkehart Jenetzky, Misel Trajanovska, Sebastian K. King, Ivo de Blaauw, ARM Net Consortium
Summary: The quality of the Anorectal Malformation Network (ARM-Net) registry was assessed, and it was found that while the collected data are valuable, they are susceptible to error and user variability. Continuous evaluations are needed to maintain relevant and high-quality data and achieve long-term sustainability.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Genetics & Heredity
Isabella Fabietti, Giulia Grassini, Sara Savelli, Roberta Vicario, Anita Romiti, Milena Viggiano, Chiara Vassallo, Laura Valfre, Paola Giliberti, Irma Capolupo, Marco Bonito, Pietro Bagolan, Francesco Morini, Leonardo Caforio
Summary: This study aimed to evaluate fetal brain development in CDH using MRI. The results showed that CDH fetuses had a smaller fronto-occipital diameter, reduced insular depth, deeper cingulate and insular fissure, and greater third ventricle width compared to controls. These findings suggest that CDH may impact fetal brain development with an overall reduction in brain volume.
PRENATAL DIAGNOSIS
(2023)
Article
Pediatrics
Irma Capolupo, Domenico Umberto De Rose, Francesca Mazzeo, Francesca Monaco, Paola Giliberti, Francesca Landolfo, Alessandra Di Pede, Alessandra Toscano, Andrea Conforti, Pietro Bagolan, Andrea Dotta
Summary: This study analyzed the changes in clinical and hemodynamic variables in congenital diaphragmatic hernia (CDH) infants treated with vasopressin. The results showed that after vasopressin infusion, the oxygenation index decreased, the balance between oxygen supply and consumption improved, heart rate decreased, arterial oxygen partial pressure/fraction of inspired oxygen ratio increased, and sodium levels decreased. These findings suggest that early vasopressin infusion may improve oxygenation index and near-infrared spectroscopy in CDH infants. These pilot data provide a basis for future larger randomized trials to evaluate the efficacy and safety of vasopressin in the CDH population.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Angelo Zarfati, Renato Tambucci, Pietro Bagolan, Andrea Conforti
Summary: In this study, the safety and efficacy of Isoperistaltic Gastric Tube (IGT) as an alternative to esophageal replacement in long gap esophageal atresia (LGEA) were evaluated. The results showed that IGT is a viable option for LGEA patients, even with longer gaps, with positive perioperative, post-operative, and middle-term outcomes.
FRONTIERS IN PEDIATRICS
(2023)
Editorial Material
Pediatrics
Dick Tibboel, Anne Greenough, Neil Patel, Pietro Bagolan, Thomas Schaible
FRONTIERS IN PEDIATRICS
(2023)
Article
Infectious Diseases
Marilena Agosta, Daniela Bencardino, Marta Argentieri, Laura Pansani, Annamaria Sisto, Marta Luisa Ciofi Degli Atti, Carmen D'Amore, Pietro Bagolan, Barbara Daniela Iacobelli, Mauro Magnani, Massimiliano Raponi, Carlo Federico Perno, Francesca Andreoni, Paola Bernaschi
Summary: A rapid and unexpected spread of NDM-1 carbapenemase-producing Klebsiella pneumoniae and Escherichia coli cases were reported in a neonatal surgical unit in Rome, Italy. A total of 20 strains (8 K. pneumoniae and 12 E. coli) with NDM-1 gene were isolated from 17 out of 230 stool samples collected from neonates admitted in the ward. Infection control interventions prevented the dissemination of the strains in the ward.
Article
Medicine, General & Internal
Chiara Maddaloni, Domenico Umberto De Rose, Sara Ronci, Iliana Bersani, Ludovica Martini, Stefano Caoci, Irma Capolupo, Andrea Conforti, Pietro Bagolan, Andrea Dotta, Flaminia Calzolari
Summary: This observational cross-sectional study explores the changes in LUS score patterns in neonates with congenital diaphragmatic hernia (CDH) and proposes a specific CDH-LUS score. The study reveals a significant improvement in CDH-LUS scores from the immediate postoperative period, with normal ultrasonographic evaluations a week after surgery in most patients.
Editorial Material
Pediatrics
Costanza Renata Neri, Sara Torresi, Valentina Chiavaroli, Eleonora Coclite, Daniele Galasso, Gianluca Brancaccio, Matteo Trezzi, Fabio Fusaro, Pietro Bagolan, Francesco Chiarelli, Susanna Di Valerio
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2023)
Article
Pediatrics
Matteo Busti, Angelo Zarfati, Laura Valfre, Andrea Conforti, Pietro Bagolan
Summary: This study aimed to assess the long-term pulmonary and orthopaedic outcomes of surgically treated CCAML in newborns, infants, and toddlers. Despite pulmonary symptoms and musculoskeletal sequelae, patients operated for CCAML had good overall outcomes. A structured multidisciplinary follow-up is necessary to manage these issues.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2023)
