Article
Multidisciplinary Sciences
Harlan L. Pietz, Ata Abbas, Zachary Lee Johnson, Michael L. Oldham, Hiroaki Suga, Jue Chen
Summary: This study identifies a macrocyclic peptide CPI1 that inhibits the function of MRP1 and blocks substrate transport. The findings suggest that CPI1 could be a potential therapeutic candidate.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Absarul Haque, Ghazanfar Ali Baig, Abdulelah Saleh Alshawli, Khalid Hussain Wali Sait, Bilal Bin Hafeez, Manish Kumar Tripathi, Badrah Saeed Alghamdi, Hani S. H. Mohammed Ali, Mahmood Rasool
Summary: This study determined the binding affinity and potential interaction sites of the multidrug resistance protein 1 (MRP1) with various anticancer drugs using homology modelling and molecular docking analysis. The results suggested that Carboplatin could be an appropriate therapeutic choice against MRP1 in ovarian cancer, and combining Carboplatin with Gemcitabine may overcome multidrug resistance phenotype.
Article
Pharmacology & Pharmacy
Tatyana A. Grigoreva, Aleksandra V. Sagaidak, Daria S. Novikova, Vyacheslav G. Tribulovich
Summary: ABC transporters play a crucial role in multidrug resistance and maintaining overall viability. Modulating the activity of these transporters holds promise in overcoming drug delivery challenges and treating diseases caused by genetic polymorphisms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Hee-Jeong Lee, Cheol-Hee Choi
Summary: New resistant breast cancer cell lines overexpressing BCRP were established by gradually increasing SN38 concentration, and genes and mechanisms associated with multidrug resistance were discovered.
Article
Chemistry, Physical
Damian Krzyzanowski, Marcin Kruszewski, Agnieszka Grzelak
Summary: Silver nanoparticles (AgNPs) have unique properties that have attracted significant attention, showing antibacterial, antifungal, and anticancer properties. However, they can also exhibit cytotoxic effects and modulate the activity and expression of ABC transporters.
Article
Pharmacology & Pharmacy
Fang Li, Chengqiong Mao, Stacy Yeh, Yao Sun, Junbo Xin, Qin Shi, Xin Ming
Summary: This study demonstrates that the anti-MRP1 antibody (Mab)-IR700 conjugate shows higher cellular delivery in multidrug resistant SCLC cells, leading to a stronger photokilling effect and tumor suppression.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Oncology
Danijela Mandic, Lana Nezic, Ljiljana Amdzic, Natasa Vojinovic, Radoslav Gajanin, Miroslav Popovic, Jugoslav Deri, Milena Todorovic Balint, Jelena Dumanovic, Zoran Milovanovic, Jelica Grujic-Milanovic, Ranko Skrbic, Vesna Jacevic
Summary: This study aimed to investigate whether the coexpression of ABC transporters and survivin was associated with the response to R-CHOP treatment in DLBCL patients. The results showed that DLBCL might harbor molecular signatures such as MRP1/ABCC1, survivin, and BCRP/ABCC2 overexpression that can predict resistance to R-CHOP.
Article
Oncology
Yunfeng Hu, Jie Cui, Lei Jin, Yani Su, Xiaozhi Zhang
Summary: The study demonstrates that LRPPRC contributes to cisplatin resistance in lung cancer cells by regulating MDR1 transcription. Silencing LRPPRC increases sensitivity to DDP and affects LRPPRC binding with the MDR1 promoter, influencing MDR1 expression.
Article
Chemistry, Multidisciplinary
Arimi Fujita, Saki Noguchi, Rika Hamada, Satoko Inoue, Tsutomu Shimada, Satomi Katakura, Tetsuo Maruyama, Yoshimichi Sai, Tomohiro Nishimura, Masatoshi Tomi
Summary: The functional impact of a single MDR1 molecule at the placental barrier and blood-brain barrier in mice is compared in this study. The findings suggest that murine placental MDR1 has minimal influence on fetal drug concentration, possibly due to bypass transfer via connexin26 gap junctions.
PHARMACEUTICAL RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Zhang Yi, Qu Yong, Chen Yun-Zhong
Summary: The combination treatment of 6-shogaol and 5-fluorouracil (5-FU) was found to inhibit cell proliferation and promote apoptosis in liver cancer cells. This combination treatment also affected the cell cycle of the cancer cells. These effects were achieved through the inhibition of AKT/mTOR/MRP1 signaling pathway, which is involved in multidrug resistance.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Biochemistry & Molecular Biology
Kamila Siedlecka-Kroplewska, Agata Wronska, Zbigniew Kmiec
Summary: Acute myeloid leukemia is characterized by uncontrolled proliferation of abnormal myeloid progenitor cells. Despite recent advances in treatment, prognosis remains poor, driving the search for new chemotherapeutics. Piceatannol shows promise as a chemotherapeutic agent for leukemia, but its use may be associated with the risk of multidrug resistance, suggesting the need for combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Infectious Diseases
Alessandra Romandini, Arianna Pani, Paolo Andrea Schenardi, Giulia Angela Carla Pattarino, Costantino De Giacomo, Francesco Scaglione
Summary: Antibiotic resistance poses a significant public health threat to children, with multiple factors contributing to its emergence, including overuse and misuse of antibiotics, lack of pediatric-specific data and trials. The evolving nature of children's development requires consideration of the diversity in biochemical characteristics and pharmacokinetics in drug treatment.
Article
Pharmacology & Pharmacy
F. Yuan, Z-F Zhou
Summary: This study discovered that DDX53 was highly expressed in Taxol-resistant NPC cells and could be transferred to normal NPC cells through exosome secretion. The transferred DDX53 upregulated the expression of MDR1 in NPC cells to enhance resistance to Taxol, providing a new perspective for understanding NPC and suggesting a potential therapeutic target.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Oncology
Xuan-Yu Chen, Yuqi Yang, Jing-Quan Wang, Zhuo-Xun Wu, Jing Li, Zhe-Sheng Chen
Summary: Betulin is a natural compound with diverse biological and pharmacological activities, but it is prone to resistance. Studies have shown that the interaction between betulin and ABCC1 may play a crucial role in the development of resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Anna G. Manjon, Stefano Giustino Manzo, Stefan Prekovic, Leon Potgeter, Tom van Schaik, Ning Qing Liu, Koen Flach, Daniel Peric-Hupkes, Stacey Joosten, Hans Teunissen, Anoek Friskes, Mila Ilic, Dorine Hintzen, Vinicius H. Franceschini-Santos, Wilbert Zwart, Elzo de Wit, Bas van Steensel, Rene H. Medema
Summary: Acquired drug resistance is a major problem in cancer treatment. The study reveals that dissociation of the nuclear lamina can lead to derepression of the ABCB1 gene, resulting in drug resistance. This finding suggests that disruption of 3D genome topology plays an important role in tumor evolution and the acquisition of drug resistance.
