Article
Genetics & Heredity
Claude Stoll, Y. Alembick, M. P. Roth
Summary: In a study conducted in northeastern France, the types and prevalence of anomalies co-occurring with Pierre Robin sequence (PRS) were examined. The study found that 69.7% of PRS cases had associated non-PRS anomalies. Chromosomal abnormalities were present in 11.2% of cases, and other diagnoses included Stickler syndrome, Treacher Collins syndrome, short stature, and other syndromes.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vikram Shetty, Sripada G. Mehendale, Muralishankar Bhat, Anirudh Yadav, Devyani Bahl, Hermann Sailer
Summary: This study reviewed the usefulness of I-gel as an airway management device for infants with Pierre robin sequence (PRS) undergoing glossopexy. The results showed that I-gel was a reliable and secure alternative for managing difficult airways during the procedure, with no postoperative complications.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Obstetrics & Gynecology
ChunYan Zhong, Zhaopeng Xie, Hongmei Dong, Ting Chen, Xiaohang Zhang, SuZhen Ran
Summary: This study found that prenatal ultrasound (US) examination is highly efficient in diagnosing and predicting the prognosis of Pierre Robin sequence (PRS). All 18 fetuses with PRS were found to have cleft palate, glossoptosis, and micrognathia by prenatal US. Compared with the control group of isolated micrognathia, the PRS group had significantly lower measures in inferior facial angle, jaw index, and frontal nasal-mental angle. 12 fetuses were found to have other associated malformations, with ear malformations being the most common. All 18 cases were confirmed with PRS after delivery or autopsy.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Polymer Science
Andrej Thurzo, Barbora Sufliarsky, Wanda Urbanova, Martin Cverha, Martin Strunga, Ivan Varga
Summary: This paper introduces a complex novel concept and methodology for the creation of personalized biomedical appliances 3D-printed from certified biocompatible photopolymer resin Dental LT Clear (V2). The explained workflow includes intraoral and CT scanning, patient virtualization, digital appliance design, additive manufacturing, and clinical application with evaluation of the appliance intended for patients with cranio-facial syndromes. The presented concept defines virtual 3D fusion of intraoral optical scan and segmented CT as sufficient and accurate data defining the 3D surface of the face, intraoral and airway morphology necessary for the 3D design of complex personalized intraoral and extraoral parts of the orthopedic appliance. A central aspect of the concept is a feasible utilization of composite resin for biomedical prototyping of the sequence of marginally different appliances necessary to keep the pace with the patient rapid growth. Affordability, noninvasiveness, and practicality of the appliance update process shall be highlighted. The methodology is demonstrated on a particular case of two-year-old infant with Pierre Robin sequence. Materialization by additive manufacturing of this photopolymer provides a highly durable and resistant-to-fracture two-part appliance similar to a Tubingen palatal plate, for example. The paper concludes with the viability of the described method and material upon interdisciplinary clinical evaluation of experts from departments of orthodontics and cleft anomalies, pediatric pneumology and phthisiology, and pediatric otorhinolaryngology.
Article
Genetics & Heredity
K. Nicole Weaver, Bonnie R. Sullivan, Stephanie A. Balow, Sara Hopkin, Barbara A. Chini, Brian S. Pan, Rolf W. Stottmann, Patricia L. Bender, Robert J. Hopkin, Xue Zhang, Howard M. Saal
Summary: Our study found that Robin sequence patients without cleft palate are more likely to have additional medical or developmental problems, while those with cleft palate are less likely. Among Robin sequence patients, the presence or absence of cleft palate did not have a significant impact on the severity of airway obstruction, surgical intervention rate, or feeding outcomes.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Review
Engineering, Multidisciplinary
Martin Cverha, Ivan Varga, Tereza Trencanska, Barbora Sufliarsky, Andrej Thurzo
Summary: This article reviews the development of management strategies for the Robin sequence, using advanced techniques from the past to the present. Inspired by nature and individual human anatomy, appliances are designed to be more efficient, comfortable, sustainable, and safe. Current treatment strategies include both nonsurgical and surgical interventions, as well as the use of biomimetic biocompatible personalized appliances.
Article
Dentistry, Oral Surgery & Medicine
Vera de Vreugt, Jungwhan John Choi, Ryan M. Caprio, Snigdha Jindal, Maarten J. Koudstaal, Judy A. Estroff, Cory M. Resnick
Summary: This study aimed to determine if dynamic cine magnetic resonance imaging (MRI) can improve the reliability of prenatal diagnosis for Robin sequence (RS) compared to current static imaging techniques. The results showed that cine imaging sequences on prenatal MRI were superior to static images in discerning complete collapse of the smallest airway space, an important marker of RS. Therefore, adding dynamic MRI evaluation may have a benefit for prenatal diagnosis of RS.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Andreas Naros, Michael Krimmel, Franziska Zengerle, Margit Bacher, Bernd Koos, Ulrich Mack, Cornelia Wiechers, Christian F. Poets, Siegmar Reinert
Summary: Our study evaluated perioperative complications in cleft palate repair for Robin sequence patients. The use of the Tuebingen palatal plate (TPP) treatment showed positive effects on minimizing perioperative complications, effectively correcting upper airway obstruction. After adjustment of the anesthesiology protocol in 2014, there was a reduction in perioperative events.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Chunyi Wang, Bing Shi, Jingtao Li
Summary: Pierre Robin Sequence (PRS) is a congenital craniofacial anomaly characterized by micrognathia, glossoptosis, and upper airway obstruction. Cleft palate is a common complication in PRS patients. The wide U-shape cleft and airway dysfunction present challenges in treatment. There are disputes regarding the treatment protocol and prognosis.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2023)
Article
Surgery
Samuel H. Payne, Colin M. Brady, Oblaise A. Mercury, Magdalena Soldanska, Stefanie E. Hush, Yijin Xiang, Joseph K. Williams
Summary: Immediate extubation following neonatal mandibular distraction is feasible in Pierre Robin sequence patients who are not intubated preoperatively. However, careful consideration should be given to patients who require significant respiratory support preoperatively and in those with certain comorbidities.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Hailiang Zuo, Jing Gao, Yu Mu, Fang Zhang, Yang Liu
Summary: This case report presents a successful treatment of neonatal PRS micrognathia using modified mandible traction with wires, which effectively relieved airway obstruction with minimal complications observed during follow-up.
FRONTIERS IN SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
P. Cascone, V. Quinzi, F. Maffia, E. Trebbi, G. Marzo
Summary: The aim of this paper is to discuss the peculiar findings of Pierre Robin sequence (PRS), a rare congenital anomaly with significant complications after birth. Treating PRS requires specialized centers and highly qualified specialists to provide the best therapeutic strategy. Early diagnosis and parental counseling are crucial in managing PRS, as early treatment activation leads to better outcomes and prevents complications. This paper presents a case of a newborn with PRS, outlining the treatment strategy and final outcome.
EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY
(2023)
Article
Surgery
Hannes Prescher, Jill R. Froimson, Pranav N. Haravu, Russell R. Reid
Summary: This study aimed to analyze the impact of cleft palate (CP) on upper airway obstruction in patients with Pierre Robin Sequence (PRS) undergoing mandibular distraction osteogenesis (MDO) and subsequent CP repair. The study found that patients with CP had higher oxygen parameters, which helped to decrease the severity of obstructive sleep apnea. However, palatal fistulas and relapse of respiratory difficulties were common complications of CP repair.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Medicine, General & Internal
Mohammad Ashraful Amin, Taraque Ahamed Shawon, Naushad Khan Shaon, Sabrina Nahin, Jannatul Fardous, Mohammad Delwer Hossain Hawlader
Summary: Children with Pierre Robin syndrome frequently experience respiratory and feeding difficulties at birth. Surgical intervention may be necessary if conservative therapy is ineffective in relieving airway obstruction. Multidisciplinary approaches are essential for managing patients with PRS.
CLINICAL CASE REPORTS
(2023)
Article
Clinical Neurology
Caroline Duchatsch Ribeiro de Souza, Leticia Faccim Padovani, Grace Cristina Ferreira-Donati, Marcia Cristina Almendros Fernandes Moraes, Camila de Castro Correa, Luciana Paula Maximino
Summary: This study evaluated and associated the neuropsychomotor development of infants aged zero to 12 months with Pierre Robin sequence (PRS), and found that these babies were at risk for developmental delay in language, gross motor, fine motor-adaptive, and personal-social aspects. These findings are important for setting goals in family orientation and intervention.
PEDIATRIC NEUROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Wei Xin Cai, Li Wu Zheng, Li Ma, Hong Zhang Huang, Ru Qing Yu, Roger A. Zwahlen
BIOMED RESEARCH INTERNATIONAL
(2016)
Article
Dentistry, Oral Surgery & Medicine
Yasas S. N. Jayaratne, Curtis K. Deutsch, Roger A. Zwahlen
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2013)
Letter
Dentistry, Oral Surgery & Medicine
Yasas S. N. Jayaratne, Curtis K. Deutsch, Roger A. Zwahlen
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2014)
Article
Dentistry, Oral Surgery & Medicine
P. R. Schmidlin, F. Nicholls, A. Kruse, R. A. Zwahlen, F. E. Weber
CLINICAL ORAL IMPLANTS RESEARCH
(2013)
Article
Dentistry, Oral Surgery & Medicine
Yasas S. N. Jayaratne, Nina K. Anderson, Roger A. Zwahlen
CLINICAL ORAL IMPLANTS RESEARCH
(2014)
Letter
Dentistry, Oral Surgery & Medicine
Nina K. Anderson, Yasas S. N. Jayaratne, Roger A. Zwahlen
EUROPEAN JOURNAL OF ORTHODONTICS
(2013)
Article
Engineering, Chemical
H. C. K. Cheng, J. K. -H. Tsoi, R. A. Zwahlen, J. P. Matinlinna
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2014)
Letter
Dentistry, Oral Surgery & Medicine
Su Keng Tan, John Lo, Roger A. Zwahlen
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2012)
Article
Dentistry, Oral Surgery & Medicine
Zhiyong Zhang, Yi Zhang, Yang He, Jinggang An, Roger Arthur Zwahlen
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2012)
Meeting Abstract
Oncology
Stephan Studer, Jeannette von Jackow, Roger Zwahlen, Gabriella Studer, Gerhard Huber, Klaus Graetz, Marius Bredell
Review
Multidisciplinary Sciences
Su Keng Tan, Wai Keung Leung, Alexander Tin Hong Tang, Roger A. Zwahlen
Article
Oncology
Gabriela Studer, Claudia Linsenmeier, Oliver Riesterer, Yousef Najafi, Michelle Brown, Bita Yousefi, Marius Bredell, Gerhard Huber, Stephan Schmid, Stephan Studer, Roger Zwahlen, Tamara Rordorf, Christoph Glanzmann
RADIATION ONCOLOGY
(2013)
Article
Surgery
Yasas S. N. Jayaratne, Curtis K. Deutsch, Roger A. Zwahlen
SURGICAL INNOVATION
(2014)
Article
Biotechnology & Applied Microbiology
Yasas S. N. Jayaratne, Curtis K. Deutsch, Roger A. Zwahlen
BIOMED RESEARCH INTERNATIONAL
(2013)
Article
Dentistry, Oral Surgery & Medicine
Su Keng Tan, Wai Keung Leung, Alexander T. H. Tang, Roger A. Zwahlen
Summary: This study investigated and compared the esthetic perceptions of different facial profiles among Hong Kong Chinese laypersons and orthognathic patients. The results showed that the dentoskeletal Class I facial profile was considered the most attractive, while a concave facial profile was perceived as the least attractive.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)