期刊
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
卷 36, 期 8, 页码 E553-E555出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPH.0000000000000215
关键词
Fanconi anemia; unrelated donor cord blood transplantation; donor chimerism
资金
- Chang Gung Memorial Hospital [CMRPG4A0031, CMRPG460013]
To potentially reduce late effects of malignancy and chronic graft-versus-host disease in patients with Fanconi anemia, 3 patients received unmanipulated umbilical cord blood grafts with 0 or 1 HLA antigen mismatch. The conditioning regimen consisted of fludarabine (30 mg/m(2)/d) for 6 days, cyclophosphamide (60 mg/kg/d) for 2 days, and rabbit antithymocyte globulin (ATG) (2.5 mg/kg/d) for 3 days. Radiation was not used in the preparative regimen. None of the patients had significant conditioning-related toxicity. All were engrafted within 10 to 19 days. All patients are well with stable or full donor chimerism after a median follow-up of 64 months (range, 13 to 69 mo).
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