Article
Food Science & Technology
Paulo Sergio Loubet Filho, Thais Otranto Dias, Vitoria Helena de Oliveira Teixeira Reis, Amanda Maria Tomazini Munhoz Moya, Elisvania Freitas dos Santos, Cinthia Bail Betim Cazarin
Summary: The incidence of inflammatory bowel diseases (IBD) has increased and its etiology remains unknown. Risk factors, including food intake, are associated with developing IBD. Functional foods (FF) can modulate the gut microbiota and improve the health quality of IBD patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Ecology
Rachel S. Fitzgerald, Ian R. Sanderson, Marcus J. Claesson
Summary: Paediatric inflammatory bowel disease is a chronic inflammatory disorder of the digestive tract, with increasing global incidence. Genetics, environment, and microbiota are believed to contribute to the development of the disease. Studies have found significant differences in the microbiome of paediatric IBD patients compared to healthy children, with changes in response to treatments and disease severity. Further research into biome differences in paediatric IBD patients may enhance our understanding of the disease's etiology.
Article
Microbiology
Ayelen D. Rosso, Pablo Aguilera, Sofia Quesada, Florencia Mascardi, Sebastian N. Mascuka, Maria C. Cimolai, Jimena Cerezo, Renata Spiazzi, Carolina Conlon, Claudia Milano, Gregorio M. Iraola, Alberto Penas-Steinhardt, Fiorella S. Belforte
Summary: Inflammatory bowel disease (IBD) presents a notable diagnostic challenge due to its clinical heterogeneity and treatment responses, especially in underdeveloped countries. This study characterized epigenetic biomarkers and gut microbial profiles in UC and CD patients in the Buenos Aires Metropolitan area for the first time, revealing differences between non-IBD controls and IBD patients.
Article
Food Science & Technology
Milosz Caban, Urszula Lewandowska
Summary: Polyphenols have the potential to be used in the treatment of inflammatory bowel diseases by suppressing immune cell activity, reducing inflammation, enhancing antioxidant defense, regulating gut microbiota balance, and restoring the epithelial barrier.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Laila Aldars-Garcia, Alicia C. Marin, Maria Chaparro, Javier P. Gisbert
Summary: The gut microbiota plays a crucial role in human health, contributing to the development of the immune system, digestion, metabolism, and barrier against pathogens. Inflammatory bowel disease (IBD) is characterized by an exaggerated immune reaction against intestinal microbiota, with changes in abundance of specific microorganisms associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Youlian Zhou, Yan He, Le Liu, Wanyan Zhou, Pu Wang, Han Hu, Yuqiang Nie, Ye Chen
Summary: The study revealed differences in gut microbiota between Chinese and Western populations, as well as distinct microbial characteristics in UC and cCD patients in China. Gardnerella and Fusobacterium were identified as potential biomarkers for distinguishing between UC and cCD, demonstrating an important association between IBD affected bowel region and gut microbiota.
FRONTIERS IN NUTRITION
(2021)
Review
Pediatrics
Xiaojun Zhuang, Caiguang Liu, Shukai Zhan, Zhenyi Tian, Na Li, Ren Mao, Zhirong Zeng, Minhu Chen
Summary: This systematic review included 41 original studies investigating gut microbiota profiles in pediatric patients with IBD. While some studies reported differences in the abundance of certain bacteria in pediatric patients with IBD compared to those without IBD, inconsistent results and heterogeneous methodologies prevented drawing clear overall conclusions. Further large-sample studies with more rigorous and standardized methodologies are needed.
FRONTIERS IN PEDIATRICS
(2021)
Review
Pharmacology & Pharmacy
Irene Marafini, Giovanni Monteleone
Summary: Recent advances in understanding the pathogenic mechanisms of inflammatory bowel diseases (IBD) have led to an expansion in therapeutic options, including monoclonal antibodies and small molecule inhibitors. However, treatment efficacy varies and some patients may lose response over time due to the complex and evolving nature of the disease. Personalized approaches to identify the most suitable treatment for individual patients at specific time points may improve drug efficacy and minimize adverse reactions, ultimately benefiting patients' quality of life and reducing costs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Wei Xian, Dide Wu, Boyuan Liu, Shubin Hong, Zijun Huo, Haipeng Xiao, Yanbing Li
Summary: Our study used bidirectional 2-sample Mendelian randomization (MR) to infer a potential causal relationship between Graves disease (GD) and inflammatory bowel disease (IBD). The results suggest that genetically predicted IBD may increase the risk of GD, while Crohn disease (CD) may increase the risk of GD and ulcerative colitis (UC) may protect against GD. However, genetically predicted GD may slightly increase the risk of CD, but there is no evidence that GD increases the risk of UC or IBD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Bing Chen, Lauren V. Collen, Craig Mowat, Kim L. Isaacs, Siddharth Singh, Sunanda V. Kane, Francis A. Farraye, Scott Snapper, Hani Jneid, Carl J. Lavie, Chayakrit Krittanawong
Summary: This article reviews the association between chronic inflammatory bowel disease and atherosclerotic cardiovascular diseases, heart failure, and atrial fibrillation. The mechanisms underlying this association may involve shared risk factors and pathophysiology. A multidisciplinary team is needed for optimal care.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Medicine, General & Internal
Zhaobei Cai, Shu Wang, Jiannan Li
Summary: Inflammatory bowel disease (IBD) is a global disease that has attracted significant research interest. Constant research has led to a better understanding of the disease and promoted the development of conventional and novel treatments. From small molecules to cell therapy, diverse therapeutic options are emerging, offering new hope for treating IBD.
FRONTIERS IN MEDICINE
(2021)
Article
Ecology
Jose F. Garcia-Mazcorro, Stephany A. Castillo-Carranza, Blake Guard, Jose P. Gomez-Vazquez, Scot E. Dowd, Donald J. Brigthsmith
Article
Infectious Diseases
Felix D. Guerrero, Anastasia Kellogg, Alexandria N. Ogrey, Andrew M. Heekin, Roberto Barrero, Matthew I. Bellgard, Scot E. Dowd, Ming-Ying Leung
TICKS AND TICK-BORNE DISEASES
(2016)
Article
Gastroenterology & Hepatology
Angela Glassing, Scot E. Dowd, Susan Galandiuk, Brian Davis, Rodrick J. Chiodini
Article
Cell Biology
Feng Wang, Jess L. Kaplan, Benjamin D. Gold, Manoj K. Bhasin, Naomi L. Ward, Richard Kellermayer, Barbara S. Kirschner, Melvin B. Heyman, Scot E. Dowd, Stephen B. Cox, Haluk Dogan, Blaire Steven, George D. Ferry, Stanley A. Cohen, Robert N. Baldassano, Christopher J. Moran, Elizabeth A. Garnett, Lauren Drake, Hasan H. Otu, Leonid A. Mirny, Towia A. Libermann, Harland S. Winter, Kirill S. Korolev
Article
Microbiology
Richard W. McLaughlin, Patricia Lynn Shewmaker, Anne M. Whitney, Ben W. Humrighouse, Ana C. Lauer, Vladimir N. Loparev, Christopher A. Gulvik, P. A. Cochran, Scot E. Dowd
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2017)
Article
Parasitology
Saban Tekin, Scot E. Dowd, Marko Davinic, Ahmet Bursali, Adem Keskin
PARASITOLOGY RESEARCH
(2017)
Article
Infectious Diseases
Shahid Karim, Khemraj Budachetri, Nabanita Mukherjee, Jaclyn Williams, Asma Kausar, Muhammad Jawadul Hassan, Steven Adamson, Scot E. Dowd, Dmitry Apanskevich, Abdullah Arijo, Zia Uddin Sindhu, Muhammad Azam Kakar, Raja Muhammad Dilpazir Khan, Shafiq Ullah, Muhammad Sohail Sajid, Abid Ali, Zafar Iqbal
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Allergy
Jan Hubert, Marta Nesvorna, Pavel Klimov, Scot E. Dowd, Bruno Sopko, Tomas Erban
Article
Microbiology
Jan Hubert, Marta Nesvorna, Pavel B. Klimov, Tomas Erban, Bruno Sopko, Scot E. Dowd, Erin D. Scully
Summary: Through correlations between host and symbiont gene expression profiles, important molecular pathways potentially regulating or facilitating their interactions were identified. Cardinium gene expression explained 95% of the variation in mite gene expression, while mite gene expression explained 76% of Cardinium gene expression variability. Cardinium affects mite metabolic pathways and is correlated with genes associated with terpenoid biosynthesis.
Article
Gastroenterology & Hepatology
Toufic A. Kabbani, Kumar Pallav, Scot E. Dowd, Javier Villafuerte-Galvez, Rohini R. Vanga, Natalia E. Castillo, Joshua Hansen, Melinda Dennis, Daniel A. Leffler, Ciaran P. Kelly
Article
Immunology
Tamar L. Gur, Lena Shay, Aditi Vadodkar Palkar, Sydney Fisher, Vanessa A. Varaljay, Scot Dowd, Michael T. Bailey
BRAIN BEHAVIOR AND IMMUNITY
(2017)
Article
Microbiology
Shukria Akbar, Scot E. Dowd, D. Cole Stevens
GENOME ANNOUNCEMENTS
(2017)
Article
Microbiology
Barbara I. Adaikpoh, Scot E. Dowd, D. Cole Stevens
GENOME ANNOUNCEMENTS
(2017)
Article
Microbiology
Tasha M. Santiago-Rodriguez, Gino Fornaciari, Stefania Luciani, Scot E. Dowd, Gary A. Toranzos, Isolina Marota, Raul J. Cano
FEMS MICROBIOLOGY ECOLOGY
(2016)
Article
Microbiology
Tasha M. Santiago-Rodriguez, Gino Fornaciari, Stefania Luciani, Scot E. Dowd, Gary A. Toranzos, Isolina Marota, Raul J. Cano
FEMS MICROBIOLOGY LETTERS
(2016)