Review
Immunology
Mobina Jalalvand, Samaneh Enayati, Maryam Akhtari, Elham Madreseh, Ahmadreza Jamshidi, Elham Farhadi, Mahdi Mahmoudi, Aliakbar Amirzargar
Summary: This meta-analysis aimed to determine the frequency of peripheral blood regulatory T cells (Tregs) in inflammatory bowel disease (IBD) patients. The results showed no significant difference in the frequency of PB Tregs between IBD cases and control subjects. However, the frequency of CD4+CD25+CD127- and CD4+CD25+FoxP3+ Tregs were significantly lower in IBD cases. Additionally, UC cases and active IBD cases showed a significantly lower frequency of Treg cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
C. R. H. Hedin, E. Sonkoly, M. Eberhardson, M. Stahle
Summary: Psoriasis and inflammatory bowel disease (IBD) are immune-mediated diseases with higher prevalence in northern Europe. Changes in gut microbiota play a key role in IBD pathogenesis, while genetic susceptibility has a greater impact on psoriasis.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Article
Immunology
Masaya Yokoyama, Motoko Y. Kimura, Toshihiro Ito, Koji Hayashizaki, Yukihiro Endo, Yangsong Wang, Ryoji Yagi, Tomoo Nakagawa, Naoya Kato, Hisahiro Matsubara, Toshinori Nakayama
Summary: This study found that Myl9/12 were highly expressed in patients with inflammatory bowel disease and mice with DSS-induced colitis. Administration of anti-Myl9/12 Ab alleviated inflammation and prolonged survival, indicating Myl9/12 may be a new therapeutic target for patients with IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Wei Xian, Dide Wu, Boyuan Liu, Shubin Hong, Zijun Huo, Haipeng Xiao, Yanbing Li
Summary: Our study used bidirectional 2-sample Mendelian randomization (MR) to infer a potential causal relationship between Graves disease (GD) and inflammatory bowel disease (IBD). The results suggest that genetically predicted IBD may increase the risk of GD, while Crohn disease (CD) may increase the risk of GD and ulcerative colitis (UC) may protect against GD. However, genetically predicted GD may slightly increase the risk of CD, but there is no evidence that GD increases the risk of UC or IBD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Amy Yu, Sonia Friedman, Ashwin N. Ananthakrishnan
Summary: This study analyzed patients with pregnancy-onset IBD, and found that they were more likely to develop ulcerative colitis and had a higher risk of disease-related hospitalizations.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Medicine, General & Internal
Zhaobei Cai, Shu Wang, Jiannan Li
Summary: Inflammatory bowel disease (IBD) is a global disease that has attracted significant research interest. Constant research has led to a better understanding of the disease and promoted the development of conventional and novel treatments. From small molecules to cell therapy, diverse therapeutic options are emerging, offering new hope for treating IBD.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Jacob R. Sweeney, Carl Crawford, Rhonda K. Yantiss
Summary: Patients with inflammatory bowel disease (IBD) are at increased risk for Clostridioides difficile infection, although clinically important infections can be difficult to recognise. This study found that patients with C. difficile infection have symptoms and endoscopic findings that are indistinguishable from active IBD.
Review
Biochemistry & Molecular Biology
Qiuyun Xu, Xiaorong Zhou, Warren Strober, Liming Mao
Summary: Inflammasomes play a crucial role in the pathogenesis of inflammatory bowel disease by regulating immune responses in the gut. Enhanced NLRP3 inflammasome activation can lead to colitis, while blocking NLRP3 activation or its downstream cytokine IL-1 beta may alleviate colonic inflammation. Proper regulation of inflammasomes could be a promising therapeutic approach for IBD.
Article
Gastroenterology & Hepatology
Filippos Koutroumpakis, Anna Evans Phillips, Dhiraj Yadav, Jorge D. Machicado, Maaz Ahsan, Claudia Ramos Rivers, Xiaoqing Tan, Marc Schwartz, Siobhan Proksell, Elyse Johnston, Jeffrey Dueker, Jana G. Hashash, Arthur Barrie, Janet Harrison, Michael A. Dunn, Liza Konnikova, Douglas J. Hartman, Hasieb Din, Dmitriy Babichenko, Gong Tang, David G. Binion
Summary: The study identified that IgG4 subclass deficiency is common in patients with IBD and associated with markers of disease severity. Treatment with intravenous Ig replacement therapy was beneficial in patients with IgG4-deficient severe IBD. Further research is needed to understand the mechanistic role of IgG4 deficiency in this subset of severe IBD patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Medicine, General & Internal
Claudia Veltkamp, Shuai Lan, Eleni Korompoki, Karl-Heinz Weiss, Hartmut Schmidt, Helmut K. Seitz
Summary: IBD patients often develop liver problems such as hepatic steatosis and fibrosis. Factors associated with hepatic steatosis include age, BMI, disease duration, and specific serum activities. Hepatic fibrosis is more common in CD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Wasuwit Wanchaitanawong, Nithi Thinrungroj, Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Summary: Inflammatory bowel disease (IBD) is a group of intestinal disorders with increasing global incidence. Despite existing treatments not being effective for all patients, metformin has shown significant benefits for IBD and could be a promising therapeutic option.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Paulo Sergio Loubet Filho, Thais Otranto Dias, Vitoria Helena de Oliveira Teixeira Reis, Amanda Maria Tomazini Munhoz Moya, Elisvania Freitas dos Santos, Cinthia Bail Betim Cazarin
Summary: The incidence of inflammatory bowel diseases (IBD) has increased and its etiology remains unknown. Risk factors, including food intake, are associated with developing IBD. Functional foods (FF) can modulate the gut microbiota and improve the health quality of IBD patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Medicine, General & Internal
Ugo Grossi, Gaetano Gallo, Gian Luca Di Tanna, Umberto Bracale, Mattia Ballo, Elisa Galasso, Andrea Kazemi Nava, Martino Zucchella, Francesco Cinetto, Marcello Rattazzi, Carla Felice, Giacomo Zanus
Summary: The safety and effectiveness of surgical treatment for hemorrhoidal disease in patients with inflammatory bowel disease (IBD) is currently poorly supported by evidence. However, cautious surgical management of non-responsive CD patients with inactive disease is still recommended, though further studies are needed to assess the potential benefits of non-excisional techniques in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Salvatore Oliva, Danila Volpe, Giusy Russo, Silvio Veraldi, Paola Papoff, Carla Giordano, Cosimo Ruggiero, Chiara Maria Trovato, Gianluca Terrin, Danilo Rossetti
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Oncology
Giuseppe Broggi, Francesca Gianno, Doron Theodore Shemy, Maura Massimino, Claudia Milanaccio, Angela Mastronuzzi, Sabrina Rossi, Antonietta Arcella, Felice Giangaspero, Manila Antonelli
Summary: Adult AT/RT predominantly arises in female patients and in supratentorial location. Midline structures, including the sellar region, are the most affected sites, especially among females aged > 40 years. Male gender is more prevalent between the age of 18 and 40 years and more frequently associated with non-midline tumors. Factors significantly associated with better prognosis are patient's age (< 40 years), combined radio-chemotherapy adjuvant approach and Ki-67 score < 40%.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Giovanni Di Nardo, Cesare Cremon, Annamaria Staiano, Vincenzo Stanghellini, Osvaldo Borrelli, Caterina Strisciuglio, Claudio Romano, Saverio Mallardo, Elena Scarpato, Giovanni Marasco, Silvia Salvatore, Letizia Zenzeri, Enrico Felici, Licia Pensabene, Simona Sestito, Ruggiero Francavilla, Paolo Quitadamo, Mariella Baldassarre, Valentina Giorgio, Renato Tambucci, Chiara Ziparo, Pasquale Parisi, Maria Raffaella Barbaro, Giovanni Barbara
Summary: Functional gastrointestinal disorders, such as IBS, affect many children worldwide due to disturbed neuroimmune function. Low-grade inflammation and mucosal immune activation play a significant role in symptom generation among pediatric patients with IBS, potentially influencing new therapeutic strategies.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Medicine, General & Internal
Guglielmo Salvatori, Domenico Umberto De Rose, Anna Claudia Massolo, Neil Patel, Irma Capolupo, Paola Giliberti, Melania Evangelisti, Pasquale Parisi, Alessandra Toscano, Andrea Dotta, Giovanni Di Nardo
Summary: Newborn infants with congenital heart disease face various nutritional challenges, leading to inadequate energy intake, sub-optimal growth, increased morbidity, and mortality. To optimize their nutrition and growth, standardized protocols, regular assessment, and multidisciplinary teamwork are essential.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Cristina Capuano, Chiara Pighi, Simone Battella, Fabio Pulcinelli, Cristina Santoro, Antonietta Ferretti, Ombretta Turriziani, Davide De Federicis, Cinzia Fionda, Giuseppe Sciume, Ricciarda Galandrini, Gabriella Palmieri
Summary: The in vivo establishment and long-term persistence of a heterogeneous memory or an adaptive NK cell pool play a functional adaptation role to human cytomegalovirus infection in humans. The FcεRIγ(-) NKG2C(+)CD57(+) memory NK cell subset, whose abundance is associated with anti-HCMV antibody levels, expands robustly and selectively in response to mAb-opsonized targets or ITP-derived platelets, demonstrating superior CD16-dependent IFNγ production. The lack of FcεRIγ chain contributes to the higher responsivity to CD16 engagement in NKG2C(+)CD57(+) memory cells.
Article
Gastroenterology & Hepatology
Giovanni Di Nardo, Enrico Felici, Letizia Zenzeri, Maurizio Mennini, Melania Evangelisti, Pasquale Parisi, Anna Claudia Massolo, Cesare Hassan, Marisa Piccirillo, Livia Lucchini, Silvia Furio, Giovanna Quatrale, Caterina Strisciuglio
Summary: This study aimed to assess the superiority of split-dose regimen of SPMC compared with SPMC day-before regimen for bowel cleansing before colonoscopy in children. The results showed that the rate of successful cleansing level was significantly higher in the split-dose group. The BBPS scores were significantly higher in the split-dose group for the whole colon, right colon, and transverse colon. Patient acceptability was better in the split-dose group and the percentage of children needing nasogastric tube placement was lower.
DIGESTIVE ENDOSCOPY
(2023)
Review
Nutrition & Dietetics
Sabrina Cenni, Veronica Sesenna, Giulia Boiardi, Marianna Casertano, Giovanni Di Nardo, Susanna Esposito, Caterina Strisciuglio
Summary: The Mediterranean diet, rich in antioxidants and anti-inflammatory nutrients, has been recognized as one of the healthiest dietary patterns worldwide. Numerous studies have shown a strong correlation between the Mediterranean diet and chronic gastrointestinal diseases. This narrative review aims to analyze the effectiveness of the Mediterranean diet in preventing and managing these disorders, providing a useful overview.
Review
Pediatrics
Angela Mauro, Teresa Giani, Clelia Di Mari, Martina Sandini, Antonella Talenti, Valentina Ansuini, Luigi Biondi, Giovanni Di Nardo, Luca Bernardo
Summary: Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder. When it presents before the age of 18 years (childhood-onset systemic lupus erythematosus, cSLE), the disease course tends to be more severe with a higher rate of organ involvement and requires an early diagnosis. Gastrointestinal involvement in cSLE is rare and scarcely reported in the literature. This manuscript provides a narrative review of gastrointestinal manifestations in cSLE, focusing on hepatic, pancreatic, and intestinal involvement, based on a comprehensive literature search using the PubMed database.
Article
Oncology
Pietro Familiari, Pierfrancesco Lapolla, Veronica Picotti, Mauro Palmieri, Alessandro Pesce, Giulia Carosi, Michela Relucenti, Stefania Nottola, Francesca Gianno, Simone Minasi, Manila Antonelli, Alessandro Frati, Antonio Santoro, Giancarlo D'andrea, Placido Bruzzaniti, Biagia La Pira
Summary: This study analyzed DLGG patients who underwent surgery at Sant'Andrea University Hospital and found that 1p/19q co-deletion is associated with survival and time to malignant transformation in DLGG patients, and the extent of surgical resection is an important prognostic factor, although its predictive value is influenced by the presence of 1p/19q co-deletion.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Maura Massimino, Sabina Vennarini, Francesca Romana Buttarelli, Manila Antonelli, Francesca Colombo, Simone Minasi, Emilia Pecori, Paolo Ferroli, Carlo Giussani, Marco Schiariti, Elisabetta Schiavello, Veronica Biassoni, Alessandra Erbetta, Luisa Chiapparini, Olga Nigro, Luna Boschetti, Francesca Gianno, Evelina Miele, Piergiorgio Modena, Loris De Cecco, Bianca Pollo, Francesco Barretta
Summary: This study reports the experience, timing, and outcomes of re-irradiation for relapsed medulloblastoma. The results suggest that re-surgery and re-RT can prolong survival, and a significant fraction of patients with worse outcomes belong to the SHH subgroup.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Medicine, General & Internal
Alessandro Ferretti, Mattia Gatto, Margherita Velardi, Giovanni Di Nardo, Thomas Foiadelli, Gianluca Terrin, Manuela Cecili, Umberto Raucci, Massimiliano Valeriani, Pasquale Parisi
Summary: The relationship between migraines and allergies is still not well understood, although there is an epidemiological link between them. Genetic and biological factors contribute to both migraines and allergic disorders. The histaminergic system, particularly the H3 and H4 receptors, may play a role in the pathophysiology of both conditions. Antihistamine drugs could potentially be helpful in treating migraines and allergic disorders. Further research is needed to fully understand the mechanistic link between these two common and debilitating conditions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Pascal D. Johann, Lea Altendorf, Emma-Maria Efremova, Till Holsten, Mona Steinbuegl, Karolina Nemes, Alicia Eckhardt, Catena Kresbach, Michael Bockmayr, Arend Koch, Christine Haberler, Manila Antonelli, John DeSisto, Martin U. Schuhmann, Peter Hauser, Reiner Siebert, Susanne Bens, Marcel Kool, Adam L. Green, Martin Hasselblatt, Michael C. Fruehwald, Ulrich Schueller
Summary: This study investigated the molecular characteristics of recurrent AT/RT tumors compared to their matched primary tumors. It found that there were subtle molecular changes, with chromosome 1q gain and chromosome 10 loss being the most common alterations in recurrences. These findings may help identify novel therapeutic targets for AT/RT recurrences.
ACTA NEUROPATHOLOGICA
(2023)
Article
Gastroenterology & Hepatology
Giulia D'Arcangelo, Giusy Russo, Marina Aloi, Cosimo Ruggiero, Francesca Maccioni, Cesare Hassan, Paola Papoff, Stanley Allen Cohen, Salvatore Oliva
Summary: It remains uncertain whether a treat-to-target approach could effectively improve outcomes in children with Crohn's disease. Results from a 104-week follow-up study showed that mucosal healing (MH) was maintained in 93% of patients who had MH at 52 weeks. The study also found that complete MH at 52 weeks was associated with reduced need for steroids, treatment escalation, hospitalization, and clinical relapses.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Pietro Familiari, Michela Relucenti, Pierfrancesco Lapolla, Mauro Palmieri, Manila Antonelli, Loredana Cristiano, Claudio Barbaranelli, Myriam Catalano, Luca D'Angelo, Giuseppe Familiari, Antonio Santoro, Alessandro Frati, Placido Bruzzaniti
Summary: In this study, the ultrastructure of glioblastoma tissue from 9 patients with the same molecular profile was investigated to find possible ultrastructural features as biomarkers correlated with Ki-67 labeling index (LI). The main findings include anatomical basis of astrocyte-endothelial cells crosstalk, ultrastructural imaging of hyperactivated microglia cells (MsEVs) and microglia cells storing lipid vesicles (MsLVs), and ultrastructural imaging of neoplastic cells mitophagy (NCsM). Statistical analysis showed that MsEVs and MsLVs correlate with Ki-67 LI, indicating their potential as morphological biomarkers. However, further research with larger sample sizes is needed to validate these findings and fully utilize the potential of ultrastructural analysis in managing glioblastoma.
Meeting Abstract
Oncology
Gunther Nussbaumer, Martin Benesch, Yura Grabovska, Alan Mackay, David Castel, Jacques Grill, Marta M. Alonso Roldan, Manila Antonelli, Simon Bailey, Joshua N. Baugh, Alberto Broniscer, Shauna Crampsie, Natacha Entz-Werle, Matthias Eyrich, Maria L. Garre, Nicolas U. Gerber, Felice Giangaspero, Maria J. Gil-da-Costa, Darren Hargrave, Peter Hauser, Ulrich Herrlinger, Marion Hoffmann, Sandra Jacobs, Michael Karremann, Antonis Kattamis, Rejin Kebudi, Robert Kwiecien, Maura Massimino, Angela Mastronuzzi, Virve Pentikainen, Thomas Perwein, Stefan M. Pfister, Torsten Pietsch, Dominik Sturm, David Sumerauer, Dannis van Vuurden, Andre O. von Bueren, Pascale Varlet, Sophie E. M. Veldhuijzen van Zanten, Maria Vinci, Monika Warmuth-Metz, Pieter Wesseling, Maria Wiese, Josef Zamecnik, Andres Morales La Madrid, Brigitte Bison, Gerrit H. Gielen, David T. W. Jones, Chris Jones, Christof M. Kramm