期刊
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
卷 51, 期 1, 页码 103-105出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPG.0b013e3181cd26f9
关键词
defensin; mucosal immunity; newborn
资金
- Elan Foundation, University of Erlangen-Nurembert
Objective: Development of the mucosal immune system is essential for controlling antigenic response. External factors are known to influence the immune system, such as breast-feeding or the mode of delivery. The aim of the present study was to investigate maturation of the enteric immune system. Patients and Methods: In stool samples of 59 preterm and term-born infants we measured the concentration of human b-defensin 2 (HBD 2), an endogenous antimicrobial peptide, and tumor necrosis factor-a (TNF-a), a cytokine playing a central role in mucosal inflammation, by enzyme-linked immunosorbent assay. Results: Mode of delivery as well as nutrition (breast-feeding or formula) had no influence on the fecal concentration of HBD-2 or TNF-a, but there was a significant increase in the concentration of HBD-2 in correlation with gestational age. TNF-a showed no change in concentration. Conclusions: Low fecal HBD-2 may be a risk factor in preterm infants to develop neonatal enteric disease, such as necrotizing enterocolitis.
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