Article
Genetics & Heredity
Anne Marie Jelsig, Thomas van Overeem Hansen, Lene Bjerring Gede, Niels Qvist, Lise-Lotte Christensen, Charlotte Kvist Lautrup, Jane Huebertz Frederiksen, Lone Sunde, Lilian Bomme Ousager, Ken Ljungmann, Birgitte Bertelsen, John Gasdal Karstensen
Summary: Peutz-Jeghers syndrome (PJS) is a hereditary polyposis syndrome with a high risk of cancer and death. In this study, the genetic etiology of all known PJS patients in Denmark was identified, and the risks of cancer, surveillance effects, and overall survival were estimated. Most cases of cancer were found between scheduled examinations, highlighting the need for improved clinical care.
Article
Gastroenterology & Hepatology
Francesca Ferretti, Federica Branchi, Stefania Orlando, Leda Roncoroni, Giulio Barigelletti, Sabrina Fabiano, Maurizio Vecchi, Roberto Penagini, Luisa Doneda, Luca Elli
Summary: CE and DBE have a high diagnostic yield in identifying and monitoring complicated celiac disease. Patients older than age 50 years with a CD duration shorter than 5 years are more likely to have positive CE results. Some SB lesions are unreachable by upper endoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
A. R. Latchford, S. K. Clark
Summary: The clinical management of GI tract in Peutz-Jeghers syndrome (PJS) patients faces two main problems: long-term cancer risk and complications related to polyps. The evidence base for making recommendations is limited due to the rarity of this condition. Controversies remain regarding the relationship between PJ polyps, cancer development, and cancer risk. This article provides an overview of PJS clinical management and surveillance recommendations, emphasizing the need for further research to address knowledge gaps.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
(2022)
Article
Pediatrics
Jeremy Stewart, Nathan R. Fleishman, Vincent S. Staggs, Mike Thomson, Nicole Stoecklein, Caitlin E. Lawson, Michael P. Washburn, Shahid Umar, Thomas M. Attard
Summary: The management of pediatric Peutz-Jeghers Syndrome (PJS) focuses on preventing intussusception complicating small intestinal polyposis. This study analyzed VCE studies in pediatric PJS patients and found that the polyp burden mainly favored the proximal third of the small intestine, with relatively small numbers and sizes amenable to resection through enteroscopy. Male gender and older age were associated with an increased polyp burden.
Article
Oncology
Masaaki Yamamoto, Kazuya Iwamoto, Rei Suzuki, Yosuke Mukai, Tomohira Takeoka, Kei Asukai, Naoki Shinno, Hisashi Hara, Takashi Kanemura, Nozomu Nakai, Shinichiro Hasegawa, Keijiro Sugimura, Naotsugu Haraguchi, Junichi Nishimura, Hiroshi Wada, Hidenori Takahashi, Chu Matsuda, Masayoshi Yasui, Takeshi Omori, Hiroshi Miyata, Masayuki Ohue, Masaru Murata
Summary: Peutz-Jeghers syndrome is a rare genetic disorder characterized by gastrointestinal polyps and pigmentation. Laparoscopic-assisted disinvagination and polypectomy is a useful, minimally invasive treatment for PJS patients with multiple intussusceptions caused by small intestinal polyps.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Mesut Akarsu, Soner Onem, Zarni Htway, Ozan Cengiz, Suleyman Dolu, Leyla Iyilikci
Summary: Peutz-Jeghers syndrome is an autosomal dominant disorder characterized by multiple hamartomatous polyps in the small intestine. This case report describes the first double balloon enteroscopy during pregnancy for a patient with a history of intestinal resection due to the syndrome. Experienced endoscopists in expert centers should perform the procedure to manage the high-risk complications effectively.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Gastroenterology & Hepatology
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis, Lumir Kunovsky, Deirdre McNamara, Helmut Neumann, Enrique Perez-Cuadrado-Martinez, Enrique Perez-Cuadrado-Robles, Stefania Piccirelli, Bruno Rosa, Jean-Christophe Saurin, Reena Sidhu, Ilja Tacheci, Erasmia Vlachou, Konstantinos Triantafyllou
Summary: According to the recommendations from ESGE, small-bowel capsule endoscopy is the recommended first-line examination for suspected small-bowel bleeding due to its excellent safety profile and patient tolerability. In cases of overt suspected small-bowel bleeding, small-bowel capsule endoscopy should be conducted as soon as possible, ideally within 48 hours after the bleeding episode to maximize diagnostic and therapeutic benefits. Routine second-look endoscopy before small-bowel capsule endoscopy is not recommended for patients with suspected small-bowel bleeding or iron-deficiency anemia. Conservative management is recommended for patients with suspected small-bowel bleeding and negative small-bowel capsule endoscopy. If lesions are identified, device-assisted enteroscopy can be used for confirmation and possibly treatment. Small-bowel capsule endoscopy is recommended as the first-line examination for patients with iron-deficiency anemia when small bowel evaluation is indicated. Small-bowel capsule endoscopy is also recommended in patients with suspected Crohn's disease and negative ileocolonoscopy findings, as well as in patients with unremarkable or nondiagnostic findings from dedicated small-bowel cross-sectional imaging if it is likely to influence patient management. A patency capsule should be used before small-bowel capsule endoscopy in patients with established Crohn's disease to decrease the capsule retention rate. Device-assisted enteroscopy can be used as an alternative to surgery for retrieving foreign bodies in the small bowel in patients without acute intestinal obstruction. Additionally, DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) is recommended as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy, except for Billroth II patients.
Article
Genetics & Heredity
Yu-Liang Jiang, Xiao-Dong Xu, Bai-Rong Li, En-Da Yu, Zi-Ye Zhao, Hong Liu
Summary: Early diagnosis of Peutz-Jeghers syndrome (PJS) is crucial based on selective features in family history among family members and pathological information. The novel mutations also expand the STK11 variant spectrum.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Review
Gastroenterology & Hepatology
Giuseppe Losurdo, Milena Di Leo, Salvatore Rizzi, Ilaria Lacavalla, Francesca Celiberto, Andrea Iannone, Maria Rendina, Enzo Ierardi, Giuseppe Iabichino, Luca De Luca, Alfredo Di Leo
Summary: Hereditary polyposis syndromes are inherited disorders that increase the risk of developing colorectal cancer. The best known ones include familial adenomatous polyposis (FAP), Peutz-Jeghers (PJS), juvenile polyposis, Cowden syndromes, and Lynch syndrome. Some of these disorders are characterized by an increased risk of small bowel polyps.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Margherita Trebbi, Cesare Casadei, Silvia Dari, Andrea Buzzi, Mario Luciano Brancaccio, Valentina Feletti, Alessandro Mussetto
Summary: This study evaluated the indications, diagnostic yield, therapeutic yield, and complications of double-balloon enteroscopy (DBE) in a cohort of consecutive patients according to patients' age. The results showed that DBE had a good diagnostic yield, with vascular lesions and polyps or neoplastic masses being the main findings. Older patients had higher rates of clinically relevant findings and therapeutic intervention. DBE is an efficient and safe diagnostic and therapeutic tool, especially in the elderly population.
Article
Oncology
Lijuan Qian, Yijie Gu, Lu Zheng, Tingting Xia
Summary: In this study, the clinical data of 134 cases of CE and 109 cases of DBE were retrospectively analyzed. The results showed that DBE had a higher disease diagnostic rate and suspected intestinal bleeding rate than CE, but required a longer examination time, had a higher incidence of adverse reactions, and a lower examination tolerance than CE.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Surgery
Lina Cadili, Michael Horkoff, Scott Ainslie, Brian Chai, Jeffrey S. Demetrick, Karl Langer, Kevin Wiseman, Hamish Hwang
Summary: The introduction of a formalized protocol for the management of complex polyps has led to improved documentation, multidisciplinary discussion, and optimized management, particularly for polyps over 3 cm.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Min Ji Kim, Soo Young Na, Joon Sung Kim, Hyun Ho Choi, Dae Bum Kim, Jeong-Seon Ji, Byung-Wook Kim, Hwang Choi
Summary: This study compared the efficacy and safety of cold snare polypectomy (CSP) and cold endoscopic mucosal resection (cold EMR) for small colorectal polyps. The results showed no significant difference in complete resection rate or adverse events between the two methods, but CSP reduced the total procedure time.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Biology
Maria Manuela Estevinho, Rolando Pinho, Adelia Rodrigues, Ana Ponte, Joao Correia, Pedro Mesquita, Teresa Freitas, Manuel Perucho
Summary: Although users have reported subjective differences between capsule endoscopy devices, there is limited research comparing their visualization quality and diagnostic yield. This study compared two widely used systems (Mirocam (R) MC1600 and OMOM (R) HD) and found differences in small bowel cleanliness and diagnostic yield.
Article
Medicine, General & Internal
Serhiy Semenov, Conor Costigan, Mohd Syafiq Ismail, Deirdre McNamara
Summary: This study assessed the false negative rate of CCE and the breakdown of reader/technical errors. The results showed that CCE has a significant false negative rate, which should be taken into consideration in clinical decision making.
Article
Radiology, Nuclear Medicine & Medical Imaging
Steve Connor, Mustafa Anjari, Christian Burd, Amrita Guha, Mary Lei, Teresa Guerrero-Urbano, Irumee Pai, Paul Bassett, Vicky Goh
Summary: The study looked at the impact of HPV OPC status on predicting outcomes of HNSCC CRT with pretreatment DW-MRI, finding that HPV OPC diagnosis was a significant predictor of 2-year survival outcomes, while pretreatment ADC values did not predict survival in the HPV OPC subgroup.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Orthopedics
Metin Tolga Buldu, Catrin Wigley, Smriti Kapoor, Paul Bassett, Craig Gerrand
Summary: This study found a high prevalence of frailty in patients undergoing surgery for musculoskeletal tumors, and frailty scores should be considered in surgical planning as part of holistic care. Frail patients had a median survival greater than 18 months, supporting the decision to offer surgery and potentially improve quality of life. Further research is needed to explore the relationship between frailty and outcomes in musculoskeletal tumor patients.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Stuart A. Taylor
Article
Radiology, Nuclear Medicine & Medical Imaging
Gauraang Bhatnagar, Sue Mallett, Laura Quinn, Rajapandian Ilangovan, Uday Patel, Asif Jaffer, Christopher Pawley, Arun Gupta, Anthony Higginson, Andrew Slater, Damian Tolan, Ian Zealley, Steve Halligan, Stuart A. Taylor
Summary: This study compared the distention quality and patient experience of oral mannitol and polyethylene glycol (PEG) for MRE. The study found that mannitol had better distension quality in the jejunum compared to PEG. However, overall distension quality and side effect profiles were similar between the two agents. Additionally, ingestion of more than 1 L of mannitol did not alter distension quality or side effect profile.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ruaridh M. Gollifer, Stuart A. Taylor, Alex Menys, Natalia Zarate-Lopez, Dave Chatoor, Anton Emmanuel, David Atkinson
Summary: Patients with IBS-C and FABD show reduced terminal ileum (TI) motility and differences in luminal content compared to healthy controls (HCs). This may indicate reflux of colonic contents or delayed clearance of the TI, contributing to symptoms of constipation and bloating.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Jordi Rimola, Joana Torres, Shankar Kumar, Stuart A. Taylor, Torsten Kucharzik
Summary: Endoscopy, the reference standard for inflammatory bowel disease (IBD) diagnosis and assessment, has limitations. Cross-sectional imaging techniques such as magnetic resonance enterography (MRE) and intestinal ultrasound (IUS) are better tolerated, safer, and can examine the entire bowel. They also allow visualization of the small-bowel and assessment of extraintestinal disease, making them viable alternatives to colonoscopy for diagnosing and monitoring Crohn's disease.
Article
Oncology
Alessandro Parente, Joseph P. Thompson, Charlotte Crook, Paul Bassett, Sebastian Aspinall, Ross Melvin, Michael J. Stechman, Helen Perry, Sabapathy P. Balasubramanian, Arslan Pannu, Fausto F. Palazzo, Klaas Van Den Heede, Fiona Eatock, Hannah Anderson, Helen Doran, Kelvin Wang, Johnathan Hubbard, Abdulaziz Aldrees, Susannah L. Shore, Clare Fung, Alison Waghorn, John Ayuk, Davinia Bennett, Robert P. Sutcliffe, UK Phaeo Study Grp
Summary: This study developed a clinical risk score to assess the risk of postoperative hypotension after adrenalectomy for phaeochromocytoma. Female sex, high preoperative catecholamine level, open surgery, and low preoperative mean arterial blood pressure were identified as independent risk factors for postoperative hypotension. Low-risk patients can be managed on a surgical ward, while high-risk patients should undergo invasive monitoring.
Article
Medicine, General & Internal
Shankar Kumar, Andrew Plumb, Sue Mallett, Gauraang Bhatnagar, Stuart Bloom, Caroline S. Clarke, John Hamlin, Ailsa L. Hart, Ilan Jacobs, Simon Travis, Roser Vega, Steve Halligan, Stuart Andrew Taylor
Summary: This study aims to evaluate the ability of magnetic resonance enterography (MRE) features to predict the development of disabling Crohn's disease (CD) within 5 years of diagnosis. By collecting clinical follow-up data from patients already recruited to the METRIC study and a separate group of newly diagnosed patients, the comparative predictive ability of MRE severity scores will be evaluated in predicting disabling CD.
Review
Radiology, Nuclear Medicine & Medical Imaging
Natasha Thorley, Alexis Jones, Coziana Ciurtin, Madhura Castelino, Alan Bainbridge, Maaz Abbasi, Stuart Taylor, Hui Zhang, Margaret A. Hall-Craggs, Timothy J. P. Bray
Summary: Imaging, especially MRI, is crucial in assessing inflammation in rheumatic disease. Quantitative MRI methods can improve the accuracy and precision of inflammation detection, facilitating a more personalized approach to treatment.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Microbiology
Ozge Yetis, Shanom Ali, Kush Karia, Paul Bassett, Peter Wilson
Summary: This study aims to monitor the presence of Pseudomonas aeruginosa in shower waters and drains in augmented and non-augmented healthcare settings every 2 weeks for 7 months. The results show that the current testing frequencies may not be sufficient to detect contamination between sampling and remediation activities. Therefore, thorough disinfection and remediation of contaminated shower waters and drains are necessary.
JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
S. A. Taylor, A. Darekar, V. Goh, S. Neubauer, A. Rockall, J. Solomon
CLINICAL RADIOLOGY
(2023)
Article
Behavioral Sciences
P. Triantafyllopoulou, S. Tromans, H. Newman, P. Triantafyllaopoulou, A. Hassiotis, P. Bassett, I. Sawhney, L. Watkins, L. Griffiths, A. Pullen, A. Roy, H. Angus-Leppan, M. Cooper, R. H. Thomas, M. Kinney, P. Tittensor, R. Shankar
Summary: This study aims to compare professional care groups in terms of their subjective confidence and perceived responsibility when managing the needs of people with intellectual disability (ID) and epilepsy. The results showed that health professionals had better awareness and knowledge of the needs of people with ID and epilepsy, but there were still gaps in role clarity, care pathways, epilepsy-specific knowledge, resources, and multidisciplinary work. Therefore, essential training and national pathways are needed to bridge the awareness gap between health and social care professionals in meeting the epilepsy needs of people with ID.
EPILEPSY & BEHAVIOR
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea G. Rockall, Xingfeng Li, Nicholas Johnson, Ioannis Lavdas, Shalini Santhakumaran, A. Toby Prevost, Shonit Punwani, Vicky Goh, Tara D. Barwick, Nishat Bharwani, Amandeep Sandhu, Harbir Sidhu, Andrew Plumb, James Burn, Aisling Fagan, Georg J. Wengert, Dow-Mu Koh, Krystyna Reczko, Qi Dou, Jane Warwick, Xinxue Liu, Christina Messiou, Nina Tunariu, Peter Boavida, Neil Soneji, Edward W. Johnston, Christian Kelly-Morland, Katja N. De Paepe, Heminder Sokhi, Kathryn Wallitt, Amish Lakhani, James Russell, Miriam Salib, Sarah Vinnicombe, Adam Haq, Eric O. Aboagye, Stuart Taylor, Ben Glocker
Summary: The study aimed to develop a machine learning algorithm to improve radiologists' sensitivity and specificity for metastasis detection in whole-body magnetic resonance imaging (WB-MRI). The results showed that using the algorithm can enhance the detection accuracy and reduce reading times for radiologists.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Urology & Nephrology
Deepak Batura, Anish Patel, Akash Gandhi, Ameena Pradhan, Samsara Bachoo, Alina Alexandra Tetea, Paul Bassett, Giles Hellawell
Summary: This study examines the differences between ethnicities in prostate cancer presentation, progression risk, and PSA testing use. The results show that black men are diagnosed at a younger age, while South Asian patients have the highest proportion of advanced disease. Most ethnicities have a high risk of disease progression, with South Asians having the least PSA test-detected cases.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Rehabilitation
Mohamed Sakel, Karen Saunders, Philip Hodgson, David Stephensen, Chetan P. Phadke, Paul A. Bassett, David Wilkinson
Summary: This study aimed to evaluate the feasibility, safety, and effectiveness of using an exoskeleton device for rehabilitation of patients with multiple sclerosis. The results showed that using the Rex Rehab exoskeleton device for balance rehabilitation had positive effects on balance, joint mobility, spasticity, and quality of life in patients with multiple sclerosis. The majority of participants were satisfied with the device.
JOURNAL OF REHABILITATION MEDICINE
(2022)