Article
Medicine, General & Internal
Daniel L. Cohen, Anton Bermont, Vered Richter, Narjes Azzam, Haim Shirin, Ram Dickman, Amir Mari
Summary: The study found that integrated relaxation pressure (IRP) can distinguish between the reflux-predominant and dysphagia-predominant phenotypes in patients with absent contractility (AC). This may have important clinical implications, as procedures such as fundoplication may benefit patients with reflux and a low IRP, while procedures like peroral endoscopic myotomy (POEM) may benefit patients with dysphagia and a relatively high IRP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Satsuki Takahashi, Tomoaki Matsumura, Tatsuya Kaneko, Mamoru Tokunaga, Hirotaka Oura, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Naoki Akizue, Yuki Ohta, Atsuko Kikuchi, Mai Fujie, Keiko Saito, Kenichiro Okimoto, Daisuke Maruoka, Tomoo Nakagawa, Makoto Arai, Jun Kato, Naoya Kato
Summary: This study found that different types of EMDs have distinct characteristics. Cigarette smoking and high body mass index were associated with esophageal hypermotility. Assessment of dysphagia symptom scores may help identify patients with EMDs.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, General & Internal
Faiz Tuma, Jafar Aljazeeri, Zhamak Khorgami, Leena Khaitan
Summary: This study reviewed esophageal function testing results over a 12-month period and found that the most likely levels of impaired bolus transit in the esophagus were 15 and 20 cm above the gastroesophageal junction (GEJ). Common symptoms among the study sample included dysphagia, chest pain, and regurgitation. The study suggests that focusing on the levels of impaired bolus transit identified in the esophagus may be important for future research on the pathophysiology of esophageal dysmotility.
ANNALS OF MEDICINE AND SURGERY
(2021)
Review
Pharmacology & Pharmacy
Sawangpong Jandee, Annelies Geeraerts, Hannelore Geysen, Nathalie Rommel, Jan Tack, Tim Vanuytsel
Summary: Esophageal hypomotility, particularly ineffective esophageal motility according to the Chicago criteria, is a common motility disorder diagnosed on high resolution manometry. Most patients present with GERD symptoms or dysphagia. Prokinetic agents are commonly prescribed but their beneficial effects are limited to certain drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yuichiro Ikebuchi, Hiroki Sato, Haruo Ikeda, Hirofumi Abe, Masaki Ominami, Junya Shiota, Chiaki Sato, Hisashi Fukuda, Ryo Ogawa, Tetsuya Tatsuta, Hiroshi Yokomichi, Hajime Isomoto, Haruhiro Inoue
Summary: This study found that high-resolution manometry (HRM) can diagnose esophageal hypomotility disorders such as absent contractility (AC) and ineffective esophageal motility (IEM). AC is often associated with systemic diseases, while IEM is more common. The HRM system can effectively differentiate between AC and achalasia. AC and IEM can transform into each other, but no transition to achalasia was observed.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael Kurin, Syed A. Adil, Sofi Damjanovska, Samuel Tanner, Katarina Greer
Summary: Chicago classification version 4.0 introduced stricter diagnostic criteria for ineffective esophageal motility (IEM) compared to version 3.0. The new criteria resulted in a decreased prevalence of IEM and revealed differences between patients who met the criteria under version 4.0 and those who no longer met the criteria.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, General & Internal
Sergey Morozov, Tatyana Sentsova
Summary: This study aims to explore the gene expression of inflammatory cytokines in esophageal mucosa of patients with EE and NERD, and its association with esophageal MII-pH measurements.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Surgery
Shahin Ayazi, Katrin Schwameis, Ping Zheng, Kirsten Newhams, Brittney M. Myers, Andrew D. Grubic, Toshitaka Hoppo, Blair A. Jobe
Summary: This study evaluated the impact of MSA on the lower esophageal sphincter (LES) and esophageal body using high resolution impedance manometry. The findings showed that MSA improved LES characteristics without affecting esophageal peristaltic progression and bolus clearance.
Article
Critical Care Medicine
Karel Balihar, Jan Kotyza, Lucie Zdrhova, Jana Kozeluhova, Michal Krcma, Martin Matejovic
Summary: Motility disorders of upper gastrointestinal tract are common in critical illness and vary according to gastric emptying status. Metoclopramide reduced esophageal activities but did not affect reflux episodes in critically ill patients.
Article
Pediatrics
Amber Vandecruys, Koen Huysentruyt, Kristel Van De Maele, Yvan Vandenplas
Summary: This study aims to assess the reliability of the KidZ Health Castle formula (KHC-F) in determining the correct probe position of a multichannel intraluminal impedance pH. The results show that the positioning with KHC-F is correct in two-thirds of the participants and has a strong correlation with the target position. Compared with other formulas, KHC-F and KHC-F v2 outperform in terms of positioning accuracy, mean error, and 95% limits of agreement.
JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Qian-Jun Zhuang, Nian-di Tan, Meng-Yu Zhang, Song-Feng Chen, Yu Luo, Ying-Lian Xiao
Summary: The stringent criteria of IEM in CCv4.0 demonstrated a stronger association with abnormal acid exposure compared to CCv3.0, indicating its potential for better predicting esophageal issues in GERD patients.
Article
Otorhinolaryngology
Peter Banovcin, Peter Liptak, Diana Vazanova, Jakub Hoferica, Milos Tatar, Martin Duricek
Summary: Menthol does not significantly affect esophageal motility or lower esophageal sphincter function in both healthy individuals and GERD patients. However, it induces more intense discomfort in GERD patients compared to healthy volunteers.
Article
Gastroenterology & Hepatology
Jeanine Wakim El-Khoury, John E. Pandolfino, Peter J. Kahrilas, Bidemi Godo, Domenico A. Farina, Wenjun Kou, Dustin A. Carlson
Summary: This study aimed to describe the changes in FLIP metrics during FLIP emptying, that is, reduced volume distension. The results showed that isotonic or auxotonic relaxation of the lower esophageal sphincter occurs with reduced volume distension in patients with achalasia and normal motility. The study also supports the importance of utilizing a standardized FLIP motility study protocol to provide reliable and generalizable FLIP metrics to facilitate diagnosis of esophageal motility disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Yanhong Wu, Zihao Guo, Chuan Zhang, Yutao Zhan
Summary: Gastroesophageal reflux disease (GERD) is a common and increasingly prevalent disease worldwide. The diagnosis of GERD is currently challenging due to the lack of definitive criteria. A novel impedance parameter called mean nocturnal baseline impedance (MNBI) has been proposed, which can reflect the burden of longitudinal reflux and the integrity of the esophageal mucosa. MNBI shows great promise in improving the diagnostic rate of multichannel intraluminal impedance-pH (MII-pH) monitoring and in predicting the response to treatment in patients with reflux symptoms.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Sawangpong Jandee, Suriya Keeratichananont, Jan Tack, Tim Vanuytsel
Summary: Manometry, especially high-resolution manometry, is the preferred diagnostic tool for evaluating esophageal motor function. It is useful in dysphagia and gastroesophageal reflux disease (GERD), helping to exclude alternative diagnoses and guide specific treatment.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Maria M. E. Jongsma, Martine A. Aardoom, Martinus A. Cozijnsen, Merel van Pieterson, Tim de Meij, Michael Groeneweg, Obbe F. Norbruis, Victorien M. Wolters, Herbert M. van Wering, Iva Hojsak, Kaija-Leena Kolho, Thalia Hummel, Janneke Stapelbroek, Cathelijne van der Feen, Patrick F. van Rheenen, Michiel P. van Wijk, Sarah T. A. Teklenburg-Roord, Marco W. J. Schreurs, Dimitris Rizopoulos, Michail Doukas, Johanna C. Escher, Janneke N. Samsom, Lissy de Ridder
Summary: In paediatric patients with moderate-to-severe Crohn's disease, starting with infliximab (IFX) as first-line treatment (FL-IFX) is more effective in achieving and maintaining remission compared to conventional treatment.
Article
Gastroenterology & Hepatology
Jasmijn Z. Jagt, Christine D. Pothof, Hans J. C. Buiter, Johan E. van Limbergen, Michiel P. van Wijk, Marc A. Benninga, Nanne K. H. de Boer, Tim G. J. de Meij
Summary: This study retrospectively analyzed the incidence and factors of thiopurine-induced adverse events in pediatric IBD patients, finding that 20% of patients discontinued treatment due to AE; after AE, rechallenge or switch to mercaptopurine is an effective strategy; concentrations of 6-TGN and 6-MMP are associated with biochemical abnormalities.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Taher Omari, Charles Cock, Shu-Wei Liang, Chandra Prakash Gyawali, Chien-Lin Chen
Summary: This study aimed to evaluate the feasibility and usefulness of CSI with SLR in complementing the diagnosis of GERD. Results showed that impedance-based metrics were lower in GERD patients compared to non-GERD patients. Particularly, the SLR maneuver increased diagnostic accuracy of CSI for GERD identification, especially in IEM patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Paul T. Heitmann, Reizal Mohd Rosli, Lyn Maslen, Lukasz Wiklendt, Raghu Kumar, Taher I. Omari, David Wattchow, Marcello Costa, Simon J. Brookes, Phil G. Dinning
Summary: This study utilized high-resolution impedance manometry to investigate colonic motor patterns and gas transit in healthy volunteers. Results showed an increase in the prevalence of the 2-8/minute cyclic motor pattern and propagation of impedance events after a meal or gas insufflation. The temporal association between propagating contractions and gas transit supports the hypothesis that the 2-8/minute cyclic motor pattern acts as a physiological brake modulating rectal filling.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Michal M. Szczesniak, Taher Omari, Thomas Y. Lam, Marc Wong, Vincent C. T. Mok, Justin C. Y. Wu, Philip I. W. Chiu, Margaret T. Y. Yuen, Raymond K. Tsang, Charles Cock, Joseph J. Sung, Peter Wu
Summary: Oropharyngeal dysphagia is common in Parkinson's disease (PD) and its neurophysiology is complex. This study aimed to investigate the changes in oropharyngeal pressure dynamics in PD and their correlation with clinical characteristics. The results showed that PD patients had impaired upper esophageal sphincter relaxation, increased flow resistance, and higher pharyngeal contractility compared to healthy controls. PD severity and dysphagia severity were associated with certain parameters of oropharyngeal function. These findings suggest that UES dysfunction and increased flow resistance may contribute to dysphagia in PD.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jui-Sheng Hung, Shu-Wei Liang, Taher Omari, Ming-Wun Wong, Wei-Yi Lei, Chih-Hsun Yi, Tso-Tsai Liu, Lin Lin, Chien-Lin Chen
Summary: The effects of baclofen on volitional swallowing measures are limited, but it reduces the likelihood of initiation of piecemeal deglutition to large volume challenges.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Taher Omari, Charles Cock, Peter Wu, Michal Marcin Szczesniak, Mistyka Schar, Jan Tack, Nathalie Rommel
Summary: This study aimed to establish a methodology for diagnosing oropharyngeal disorders using P-HRM-I. The results showed that UES relaxation pressure was the best indicator for differentiating patients from controls and diagnosing UES disorders. A diagnostic scheme was also devised to identify patients with UES disorder or propulsive disorder. Additionally, the study found that patients with pharyngeal pressurizations and evidence of reduced UES relaxation and/or distensibility had higher aspiration scores.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Shu-Wei Liang, Taher Omari, Wei-Chuan Chang, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Tso-Tsai Liu, Lin Lin, C. Prakash Gyawali, Chien -Lin Chen
Summary: This study aimed to assess the value of transient hiatal separation during SLR in reflux patients, and found that in patients with ineffective esophageal motility, transient hiatal separation during SLR was associated with higher total acid exposure time, DeMeester scores, total acid reflux events, and longest acid reflux episodes.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Genetics & Heredity
Ilan J. N. Koppen, Leonie A. A. Menke, Wytske M. M. Westra, Femke Struik, Simone Mesman, Michiel P. P. Van Wijk, Sylvia A. A. Huisman
Summary: This article discusses two cases of unexpected deaths due to gastrointestinal complications in individuals with PTHS, highlighting the importance of screening and managing gastrointestinal symptoms in this population. It also provides an overview of the literature on how fatal gastrointestinal complications may be related to PTHS.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Gastroenterology & Hepatology
Chantal A. ten Kate, Nadine M. Teunissen, Joost van Rosmalen, Lieke S. Kamphuis, Michiel P. van Wijk, Maja Joosten, E. Sofie van Tuyll van Serooskerken, Rene Wijnen, Hanneke IJsselstijn, Andre B. Rietman, Manon C. W. Spaander
Summary: This study developed and validated a specific questionnaire (SQEA) to assess health-related quality of life in adults with esophageal atresia. The questionnaire showed good feasibility, reliability, and validity. It is able to discriminate disease burden and serves as an interesting signaling tool for clinicians to identify more severely affected patients.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Gastroenterology & Hepatology
Per Cajander, Taher Omari, Anders Magnuson, Harry Scheinin, Mika Scheinin, Johanna Savilampi
Summary: Dexmedetomidine affects pharyngeal swallowing and esophageal motility, which should be considered in clinical patient management and when choosing sedative agents for procedural sedation or manometric examination.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Letter
Gastroenterology & Hepatology
Per Cajander, Taher Omari, Harry Scheinin, Mika Scheinin, Johanna Savilampi
Summary: It is important to consider the impact of anesthetic agents on esophageal function testing. Dexmedetomidine has been found to affect primary peristalsis in esophageal manometry, and in the case reports by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be due to a specific pharmacodynamic effect, with a transient direct alpha 2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration before sympathetic inhibition begins.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Critical Care Medicine
Sanith S. Cheriyan, Mistyka S. Schar, Charmaine M. Woods, Shailesh Bihari, Charles Cock, Theodore Athanasiadis, Taher I. Omari, Eng H. Ooi
Summary: This study aimed to investigate the mechanistic effects of a tracheostomy on swallowing using pharyngeal high-resolution manometry with impedance (P-HRM-I). The results showed that in tracheostomised patients, there were significant increases in hypopharyngeal intrabolus pressure and upper oesophageal sphincter (UOS) integrated relaxation pressure, as well as reductions in UOS opening extent and relaxation time. Total pharyngeal contractility was also significantly elevated. These findings suggest that tracheostomy may result in UOS dysfunction, but does not contribute to pharyngeal weakness.
CRITICAL CARE AND RESUSCITATION
(2023)
Article
Pediatrics
H. van Braak, R. R. Gorter, M. P. van Wijk, J. R. de Jong
Summary: This study evaluated the outcomes of laparoscopic Roux-en-Y feeding jejunostomy (LRFJ) in children with gastric emptying disorders. The results showed that LRFJ is a safe and effective method of enteral feeding in these patients, with high parenteral satisfaction.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Audiology & Speech-Language Pathology
T. Omari, L. Ferris, M. Schar, C. Cock, S. Doeltgen
Summary: This study utilized high resolution pharyngeal manometry (HRPM) with impedance to detect and characterize multiple swallowing behaviors in healthy subjects. The results showed that while single swallows were the most common behavior, some participants exhibited multiple swallowing behaviors. Using impedance, the multiple swallowing behaviors were further sub-typed as secondary dry swallows, preceding dry swallows, piecemeal swallows, or clearing swallows. These findings are important for further research on the sub-types of multiple swallowing behaviors in patients with swallowing disorders.
SPEECH LANGUAGE AND HEARING
(2022)