期刊
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
卷 48, 期 2, 页码 161-167出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPG.0b013e318183e112
关键词
Anti-Saccharomyces cerevisiae antibodies; Crohn disease; Early onset; Indeterminate colitis; Ulcerative colitis
资金
- Wellcome Trust Programme [072789/Z/03/Z]
- GI/Nutrition Research Fund
- Child Life and Health, University of Edinburgh
- MRC [G0800759, G0600329] Funding Source: UKRI
- Chief Scientist Office [CZB/4/540] Funding Source: researchfish
- Medical Research Council [G0800759, G0600329] Funding Source: researchfish
Objectives: To determine anti-Saccharomyces cerevisiae antibodies (ASCA) status and its relation to disease phenotype in patients with inflammatory bowel disease (IBD). Patients and Methods: A total of 301 Scottish patients with early-onset IBD-197 Crohn disease (CD), 76 ulcerative colitis (UC), 28 indeterminate dolitis (IC)-and 78 healthy control individuals were studied. ASCA status (IgA, IgG) was determined by enzyme-linked immunosorbent assay. ASCA status was then analyzed in relation to CD phenotype. Results: Patients with CD had a higher prevalence of ASCA than patients with UC and healthy controls: 82/197 versus 12/76, odds ratio (OR) 3.80 (1.93-7.50) and 82/197 versus 6/78, OR 8.56 (3.55-20.62), respectively. Univariate analysis showed that positive ASCA status was associated with oral CID (17/25 vs 59/153, OR 3.39 [1.38-8.34]), perianal CID (39/77 vs 38/108, OR 1.89 [1.04-3.44]) and the presence of granulomata (63/132 vs 15/52, OR 2.25 [1.13-4.48]) and also with markers of disease severity: raised C-reactive protein (44/90 vs 12/49, OR 2.95[1.36-6.37]), hypoalbuminemia (44/85 vs 20/74, OR 2.28[1.19-4.37]). and Surgery (27/49 vs 54/147, OR 2.11 [1.10-4.06]). From multivariate analysis, the presence of oral disease (adjusted P=0.001, OR 22.22 [3.41-142.86]) and hypoalbuminemia (adjusted P=0.01, OR 4.78 [1.40-16.39]) was found to be independently associated with ASCA status. No association was demonstrated between ASCA and IBD candidate genes. Conclusions: Patients with CID had a higher prevalence of ASCA than did other patients with IBD. ASCA status described patients with CD who had a specific phenotype, showing an association with markers of disease severity and oral CD involvement. JPGN 48:161-167, 2009.
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