Article
Dentistry, Oral Surgery & Medicine
Salwa Farid Ahmed, Mostafa A. Bakr, Amr H. Rasmy
Summary: This study evaluated the effect of different doses of vitamin E on radiation-induced oral mucositis in rat model, finding that higher doses of vitamin E were effective in treating oral mucositis. The results showed improved food intake, reduced weight loss, delayed onset, decreased severity and duration of mucositis, and restored histological structure of lingual tongue papillae in vitamin E treated groups.
Article
Dentistry, Oral Surgery & Medicine
Zeynep Bayramoglu, Behzad Mokhtare, Ali Sefa Mendil, Taha Abdulkadir Coban, Renad Mammadov, Seval Bulut, Zeynep Suleyman, Halis Suleyman
Summary: Taxifolin has been found to have antioxidant, anti-inflammatory, antitumor, and antimicrobial properties. In this study, taxifolin was shown to attenuate methotrexate-induced oral mucosal damage by reducing oxidative stress and inflammation and antagonizing the decrease in glutathione levels.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Steven He, Rajdeep Chakraborty, Shoba Ranganathan
Summary: Oral cancer is a common type of head and neck squamous cell carcinoma, with a high mortality rate. International research on the molecular pathways of oral cancer has implications for early diagnosis, prognosis, and the development of new drugs. This review focuses on the pathways of proliferation and apoptosis in OSCC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jessica Berte Valer, Marina Curra, Amanda de Farias Gabriel, Tuany Rafaeli Schmidt, Maria Beatriz Cardoso Ferreira, Rafael Roesler, Mario Correa Evangelista Junior, Marco Antonio Trevizani Martins, Lauro Gregianin, Manoela Domingues Martins
Summary: This study evaluated the relationship between OM and MTX metabolism time and other toxicities in childhood cancer patients receiving HD-MTX. The results showed that OM is a prevalent complication in these patients, and renal and hepatic toxicity could be considered risk factors for OM, especially in patients with lymphoma.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kani Bilginaylar, Asli Aykac, Serkan Sayiner, Hanife Ozkayalar, Ahmet Ozer Sehirli
Summary: This study demonstrates that chitosan has a protective effect against oral mucosal damage caused by MTX.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Junhua Huang, Alan Yaw Min Hwang, Yuting Jia, Brian Kim, Melania Iskandar, Ali Ibrahim Mohammed, Nicola Cirillo
Summary: This study provides a comprehensive overview of animal models used in the study of chemotherapy-induced mucositis. The results reveal a large variation in the models used to simulate mucositis in animals. Further research is needed to define optimal protocols that improve the applicability of the findings to humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wuying Lang, Min Cheng, Xin Zheng, Yongping Zhao, Yunlong Qu, Zhao Jia, Haizhou Gong, Ihsan Ali, Jingwen Tang, Haihua Zhang
Summary: The study demonstrated that FTA effectively reversed methotrexate-induced intestinal mucositis in rats by reducing inflammation, maintaining intestinal structure, and modulating levels of inflammatory cytokines and immune cells in the bloodstream.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michele Massimino, Laura Sciacca, Nunziatina Laura Parrinello, Nunzio Massimo Scalisi, Antonino Belfiore, Riccardo Vigneri, Paolo Vigneri
Summary: IR isoforms exhibit different effects on cell proliferation and survival. While both IR-A and IR-B can inhibit cell proliferation when unbound to insulin, IR-B is more effective in reducing resistance to DNA damage. In the presence of insulin, IR-A provides a selective growth advantage over IR-B, particularly at high concentrations. Insulin-bound IR-A, but not IR-B, can protect cells from cytotoxicity induced by DNA damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Douglas Magno Guimaraes, Tamara Melo Nunes Ota, Diego Assuncao Calixto Da Silva, Fabio De Lucas Da Silva Almeida, Tatiana Dias Schalch, Alessandro Melo Deana, Jose Miguel Alves Junior, Kristianne Porta Santos Fernandes
Summary: This study compared the efficacy of LLLT and LEDT for prevention and treatment of oral mucositis, finding that LEDT has similar effects to LLLT in reducing symptoms of oral mucositis. Therefore, LEDT could be considered as an alternative option for preventing and treating oral mucositis.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Saori Oku, Toshiko Futatsuki, Yoshiko Imamura, Haruna Hikita, Akemi Inada, Shinsuke Mizutani, Yasuo Mori, Haruhiko Kashiwazaki
Summary: This study found that cryotherapy can effectively prevent oral mucositis (OM) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, especially in cases without methotrexate (MTX) for graft-versus-host disease (GVHD) prophylaxis.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Cell Biology
Moein Ala, Razieh Mohammad Jafari, Mahan Ala, Sedigheh Marjaneh Hejazi, Seyed Mohammad Tavangar, Seied Rabi Mahdavi, Ahmad Reza Dehpour
Summary: This study found that sildenafil can improve radiation-induced oral mucositis by attenuating inflammation and oxidative stress, and reduce the apoptosis of mucosal cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
David Dahlgren, Markus Sjoblom, Per M. Hellstrom, Hans Lennernas
Summary: Chemotherapeutics-induced intestinal mucositis (CIM) is a common gastrointestinal toxicity in cancer patients due to the rapid proliferation of intestinal epithelial cells and complex immunological interactions with gut microbiota. CIM often leads to dose-reduction, decreasing the efficacy of anticancer treatment, and effective strategies for prevention and treatment are still lacking.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Noemi Coppola, Tiziana Cantile, Federica Canfora, Daniela Adamo, Paolo Bucci, Michele Davide Mignogna, Stefania Leuci
Summary: This systematic review aimed to synthesize the available evidence on oral plasma cell mucositis (o-PCM). The clinical phenotypes of o-PCM are diverse, with gingiva being the most frequently involved site and erythema being the main clinical phenotype. Treatment options for o-PCM include irritant removal, corticosteroids, immunosuppressants/immunomodulators, surgery, radiotherapy, and chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Jing Feng, Min Gao, Chengcheng Zhao, Jian Yang, Haiyan Gao, Xin Lu, Rong Ju, Xiuwei Zhang, Yunlei Zhang
Summary: This study conducted a systematic review and meta-analysis on the efficacy of oral probiotics in managing chemotherapy-induced adverse reactions. The results showed that oral probiotic use significantly decreased the risk of chemotherapy-induced diarrhea and oral mucositis. Interestingly, the beneficial effects of probiotics were found to be statistically significant only in Asian patients. Furthermore, the more species of bacteria they took, the lower the incidences of the adverse reactions occurred. However, more clinical trials are needed to further verify the efficacy of oral probiotic use against adverse reactions, and the species and number of probiotics should be optimized and standardized prior to clinical applications.
FRONTIERS IN NUTRITION
(2022)
Review
Oncology
Hedy Maagdenberg, Natanja Oosterom, Jolanda Zanen, Donato Gemmati, Rachael E. Windsor, Sandra G. Heil, Patricia Esperon, Shakila Jabeen, Guillermo J. Ruiz-Arguelles, Oliver Zolk, Susanne Hoerning, Charlotte Sleurs, Elixabet Lopez-Lopez, Monica Moreno-Galvan, Marry M. van den Heuvel-Eibrink, Anke H. van der Zee, Bruce C. Carleton
Summary: Methotrexate-induced mucositis varies greatly among individuals, and genetic variants such as MTHFR c.677C > T and MTRR c.66A > G have been found to have statistically significant associations with the occurrence of mucositis. Further research in this area may help in predicting and managing this common side effect of MTX treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
