期刊
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
卷 27, 期 7-8, 页码 717-723出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/jpem-2013-0385
关键词
glucagon-like peptide-1; glucose-dependent insulinotropic polypeptide; leptin; neonates; pancreatic polypeptide; peptide YY; premature infants
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [21791039]
- Grants-in-Aid for Scientific Research [21791039] Funding Source: KAKEN
Aim: To investigate changes of gut hormones in term and preterm infants in the first 2 months after birth, as the role and relationships of gut hormones in premature infants has not been well elucidated. Methods: In 29 preterm and five term infants, fasting serum concentrations of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin, and ghrelin were measured using a bead array system. Results: Serum leptin concentration soon after birth showed a positive correlation with gestational week in all infants (r=0.623, p<0.01). Serum leptin level rapidly decreased in all infants. In preterm infants, serum GLP-1 levels at birth showed negative correlations with gestational week (r=-0.447, p=0.02). Serum GIP, GLP-1, and PYY levels increased after birth and were persistently high until 10 weeks of life. Conclusion: Serum concentrations of different gut hormones changed postnatally in their specific ways in preterm infants.
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