Review
Biochemistry & Molecular Biology
Luca Giannella, Jacopo Di Giuseppe, Giovanni Delli Carpini, Camilla Grelloni, Mariasole Fichera, Gianmarco Sartini, Serena Caimmi, Leonardo Natalini, Andrea Ciavattini
Summary: Cervical cancer is a major cause of death in women, particularly in developing countries. Cervical adenocarcinoma, a subtype of the disease, often presents at an advanced stage and has a poorer prognosis compared to squamous lesions. Treatment options and the impact of HPV vaccination and screening in managing these lesions require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Maria Teresa Bruno, Sara Boemi, Giuseppe Caruso, Francesco Sgalambro, Salvatore Ferlito, Antonio Cavallaro, Maria Chiara Sudano, Marco Palumbo
Summary: In recent years, the oral transmission of HPV and the risk of oral cancer have increased. This study aimed to evaluate the coexistence of HPV in the oral and genital mucosa of women with histologically confirmed HPV lesions. It found a high prevalence of oral HPV infection in women with concomitant genital HPV infection and identified several risk factors for HPV infections in the oropharynx and genitals.
Article
Cell Biology
Margareta Strojan Flezar, Neza Nedelko, Mario Poljak, Anja Ostrbenk Valencak, Helena Gutnik
Summary: Stratified mucin-producing intraepithelial lesion (SMILE) is a rare high-grade cervical precancerous lesion, predominantly associated with single high-risk HPV genotypes. SMILE shows typical immunohistochemical features with variable mucin presence and squamous differentiation. The study indicates the characteristics of SMILE in cervical precancerous lesions.
Article
Immunology
Orsolya Rideg, Timea Dergez, Kornelia Farkas, Krisztina Kovacs, Endre Kalman, Tamas Tornoczky, Angela Oszter
Summary: This study compared the HPV genotypes in cytological and FFPE specimens of women diagnosed with HSIL. The results showed a high agreement in HPV genotypes between the two sample types, but multi-infections were more common in cytological specimens while single infections were more common in FFPE specimens. Additionally, nonavalent vaccinated type (VT) HPVs and non-nonavalent VT HPVs were both found in HSIL cases, highlighting the importance of vaccine development.
Article
Microbiology
Laura Conde-Ferraez, Alberto Chan-Mezeta, Jesus Gilberto Gomez-Carballo, Guadalupe Ayora-Talavera, Maria del Refugio Gonzalez-Losa
Summary: The incidence of anal intraepithelial neoplasias associated with HPV is increasing worldwide, with higher risk among individuals living with HIV/AIDS. A study in Mexico found that 59.8% of men and women living with HIV had anal HPV infection, with multiple genotypes identified. Risky behaviors, such as receptive anal intercourse and inconsistent condom use, were associated with HPV infection. Cytology identified low-grade and high-grade squamous intraepithelial lesions in a significant proportion of participants.
Article
Oncology
Anne M. Schultheis, Ino de Bruijn, Pier Selenica, Gabriel S. Macedo, Edaise M. da Silva, Salvatore Piscuoglio, Achim A. Jungbluth, Kay J. Park, David S. Klimstra, Eva Wardelmann, Wolfgang Hartmann, Claus Dieter Gerharz, Mareike von Petersdorff, Reinhard Buettner, Jorge S. Reis-Filho, Britta Weigelt
Summary: The study found that uterine cervix SCCs have a low mutation burden and few copy number alterations, with the majority being HPV-positive, leading to inactivation of the suppressors p53 and RB, which differentiate them from SCLCs.
MOLECULAR ONCOLOGY
(2022)
Review
Health Care Sciences & Services
Camelia Liana Buhas, Andrei Pascalau, Claudia Teodora Judea-Pusta, Ovidiu Laurean Pop, Adrian Sorin Judea, Bianca-Maria Negrutiu, Lavinia Marcut, Bogdan Adrian Buhas, Daniela Gheorghita, Alin Danut Bodog
Summary: This is a rare case of epidermoid cyst in the uterine cervix of a female patient. The patient underwent biopsy and uterine curettage, followed by total hysterectomy. The histopathologic analysis and immunohistochemical assay confirmed the cervical epidermoid cyst. High-risk HPV was only detected in the cervical mucosa. The exact etiopathogenesis is unknown, but implantation of embryonic tissue after childbirth could be involved in the development of these lesions.
Article
Oncology
Karen Braeutigam, Stefanie Meier, Sabina Meneder, Louisa Proppe, Katharina Stroschein, Stephan Polack, Frank Koester, Achim Rody, Sascha Baum
Summary: In this study, HPV subtypes in anogenital and oral samples were investigated, and new HPV subtypes associated with precursors and cancers in these areas were identified.
Article
Pathology
Sigrid Regauer, Olaf Reich, Karl Kashofer
Summary: This study provides a detailed characterization of HPV-negative cervical carcinoma, including the identification of different types of precursor lesions and the analysis of genetic mutations and chromosomal variations. The findings suggest that genetic factors and inflammatory infiltrate may contribute to the development of HPV-negative cervical cancer.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Obstetrics & Gynecology
Neerja Bhatla, Daisuke Aoki, Daya Nand Sharma, Rengaswamy Sankaranarayanan
Summary: Since the publication of the 2018 FIGO Cancer Report, significant progress has been made in reducing the burden of cervical cancer globally, with initiatives such as the WHO's global strategy for cervical cancer elimination, HPV vaccination programs, and wider implementation of HPV testing. While these interventions will take time to show their impact, over half a million new cases of cervical cancer are still added each year.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Health Care Sciences & Services
Angel Yordanov, Mariela Vasileva-Slaveva, Noya Galai, David Faraggi, Milan Paul Kubelac, Irina Tripac-Iacovleva, Neville Calleja, Riccardo Di Fiore, Jean Calleja-Agius
Summary: Eastern Europe, particularly Bulgaria, has high rates of uterine cervix cancer and human papillomavirus infection. This study examined the trends in cervix cancer in Bulgaria, which lacks a population-based screening program and is facing a demographic crisis. The findings showed that although there has been a decrease in cervix cancer incidence, the issue remains significant in Bulgaria, with a decrease in early-stage diagnosis.
Article
Biochemistry & Molecular Biology
Minori Ogawa, Kae Hashimoto, Saki Kitano, Saya Yamashita, Aska Toda, Koji Nakamura, Yasuto Kinose, Michiko Kodama, Kenjiro Sawada, Tadashi Kimura
Summary: High-risk HPV infection is the major cause of cervical cancer. This study found that estrogen/GPR30 signaling induces genomic instability in high-risk HPV-infected endocervical columnar cell lines, leading to carcinogenesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Obstetrics & Gynecology
Frederik A. Stuebs, Paul Gass, Anna K. Dietl, Carla E. Schulmeyer, Werner Adler, Carol Geppert, Arndt Hartmann, Antje Knoell, Matthias W. Beckmann, Martin C. Koch
Summary: This study found that HPV-16 is the most common type of hrHPV in HSIL+ lesions, especially in women aged 35 and below. Therefore, women aged 35 and above with persistent infection with this type of hrHPV need careful surveillance, as they are at high risk of progression to cervical cancer.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Virology
Tomas Rokos, Veronika Holubekova, Zuzana Kolkova, Andrea Hornakova, Terezia Pribulova, Erik Kozubik, Kamil Biringer, Erik Kudela
Summary: This preliminary study investigates the presence of HPV infection and bacterial diversity associated with bacterial vaginosis in women with cervical abnormalities. The study found that HPV16 was the dominant genotype in patients with confirmed cervical precancerous lesions, and there was an increased bacterial diversity in the vaginal microbiome in patients with cervical lesions.
Article
Obstetrics & Gynecology
Julie Hansa John, Ajay Halder, Shashank Purwar, Kameshwarachari Pushpalatha, Priyal Gupta, Pankhuri Dubey
Summary: The study found that urinary HPV detection has good concordance with histopathology for detecting precancerous and cancerous lesions of the cervix. Urinary HPV testing shows moderate sensitivity and high specificity in predicting the presence of high-grade precancerous or cancerous lesions.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Peripheral Vascular Disease
Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C. Aplin, Robert Auerbach, Hellmut G. Augustin, David O. Bates, Judy R. van Beijnum, R. Hugh F. Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C. Boeck, Peter C. Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M. Cimpean, Ondine Cleaver, George Coukos, George E. Davis, Michele De Palma, Anna Dimberg, Ruud P. M. Dings, Valentin Djonov, Andrew C. Dudley, Neil P. Dufton, Sarah-Maria Fendt, Napoleone Ferrara, Marcus Fruttiger, Dai Fukumura, Bart Ghesquiere, Yan Gong, Robert J. Griffin, Adrian L. Harris, Christopher C. W. Hughes, Nan W. Hultgren, M. Luisa Iruela-Arispe, Melita Irving, Rakesh K. Jain, Raghu Kalluri, Joanna Kalucka, Robert S. Kerbel, Jan Kitajewski, Ingeborg Klaassen, Hynda K. Kleinmann, Pieter Koolwijk, Elisabeth Kuczynski, Brenda R. Kwak, Koen Marien, Juan M. Melero-Martin, Lance L. Munn, Roberto F. Nicosia, Agnes Noel, Jussi Nurro, Anna-Karin Olsson, Tatiana V. Petrova, Kristian Pietras, Roberto Pili, Jeffrey W. Pollard, Mark J. Post, Paul H. A. Quax, Gabriel A. Rabinovich, Marius Raica, Anna M. Randi, Domenico Ribatti, Curzio Ruegg, Reinier O. Schlingemann, Stefan Schulte-Merker, Lois E. H. Smith, Jonathan W. Song, Steven A. Stacker, Jimmy Stalin, Amber N. Stratman, Maureen Van de Velde, Victor W. M. van Hinsbergh, Peter B. Vermeulen, Johannes Waltenberger, Brant M. Weinstein, Hong Xin, Bahar Yetkin-Arik, Seppo Yla-Herttuala, Mervin C. Yoder, Arjan W. Griffioen
Article
Oncology
Elisabetta Marangoni, Cecile Laurent, Florence Coussy, Rania El-Botty, Sophie Chateau-Joubert, Jean-Luc Servely, Ludmilla de Plater, Franck Assayag, Ahmed Dahmani, Elodie Montaudon, Fariba Nemati, Justine Fleury, Sophie Vacher, David Gentien, Audrey Rapinat, Pierre Foidart, Nor Eddine Sounni, Agnes Noel, Anne Vincent-Salomon, Marick Lae, Didier Decaudin, Sergio Roman-Roman, Ivan Bieche, Martine Piccart, Fabien Reyal
CLINICAL CANCER RESEARCH
(2018)
Correction
Biochemistry & Molecular Biology
Angela Moncada-Pazos, Alvaro J. Obaya, Maria Llamazares, Ritva Heljasvaara, Maria F. Suarez, Enrique Colado, Agnes Noel, Santiago Cal, Carlos Lopez-Otin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Evelyne Collignon, Annalisa Canale, Clemence Al Wardi, Martin Bizet, Emilie Calonne, Sarah Dedeurwaerder, Soizic Garaud, Celine Naveaux, Whitney Barham, Andrew Wilson, Sophie Bouchat, Pascale Hubert, Carine Van Lint, Fiona Yull, Christos Sotiriou, Karen Willard-Gallo, Agnes Noel, Francois Fuks
Article
Oncology
Pierre Foidart, Cassandre Yip, Jean Radermacher, Silvia Blacher, Mehdi Lienard, Laetitia Montero-Ruiz, Erik Maquoi, Elodie Montaudon, Sophie Chateau-Joubert, Joelle Collignon, Michel Coibion, Veronique Jossa, Elisabetta Marangoni, Agnes Noel, Nor Eddine Sounni, Guy Jerusalem
CLINICAL CANCER RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Cassandre Yip, Pierre Foidart, Agnes Noel, Nor Eddine Sounni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Christelle Sepult, Marine Bellefroid, Natacha Rocks, Kim Donati, Catherine Gerard, Christine Gilles, Andreas Ludwig, Bernard Duysinx, Agnes Noel, Didier Cataldo
Article
Oncology
Charline Dubois, Natacha Rocks, Silvia Blacher, Irina Primac, Anne Gallez, Melissa Garcia-Caballero, Celine Gerard, Laurent Brouchet, Agnes Noel, Francoise Lenfant, Didier Cataldo, Christel Pequeux
ENDOCRINE-RELATED CANCER
(2019)
Article
Respiratory System
Natacha Rocks, Celine Vanwinge, Coraline Radermecker, Silvia Blacher, Christine Gilles, Raphael Maree, Alison Gillard, Brigitte Evrard, Christel Pequeux, Thomas Marichal, Agnes Noel, Didier Cataldo
Review
Biochemistry & Molecular Biology
Florent Morfoisse, Agnes Noel
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2019)
Article
Medicine, Research & Experimental
Irina Primac, Erik Maquoi, Silvia Blacher, Ritva Heljasvaara, Jan Van Deun, Hilde Y. H. Smeland, Annalisa Canale, Thomas Louis, Linda Stuhr, Nor Eddine Sounni, Didier Cataldo, Taina Pihlajaniemi, Christel Pequeux, Olivier De Wever, Donald Gullberg, Agnes Noel
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Oncology
Maureen Van de Velde, Marie Ebroin, Tania Durre, Marc Joiret, Lionel Gillot, Silvia Blacher, Liesbet Geris, Frederic Kridelka, Agnes Noel
Summary: This study revealed a new mechanism by which tumor exposed-LEC promote tumor cell proliferation, showcasing their role in enhancing cancer cell invasion and proliferation in vivo. The analysis of teLEC secretome identified IL6 as a key molecule modulated in teLEC, with neutralization of IL6 abolishing the mitogenic effects mediated by teLEC in vivo. The findings suggest a novel function for teLEC beyond their traditional role in lymphatic vessel formation, emphasizing their potential as key stromal determinants in future studies.
Review
Biochemistry & Molecular Biology
Lionel Gillot, Louis Baudin, Loic Rouaud, Frederic Kridelka, Agnes Noel
Summary: Lymph node metastasis is a significant prognostic factor in various cancers, serving as a gateway for further dissemination. Prior to metastasis, the primary tumor reshapes the draining lymph node by secreting soluble factors or releasing extracellular vesicles, creating a pre-metastatic niche for the survival and growth of metastatic cells. This review highlights the structure of lymph nodes, matrix composition, cellular heterogeneity, and major processes associated with nodal pre-metastatic niche formation, offering insights into potential research directions and clinical implications.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lionel Gillot, Alizee Lebeau, Louis Baudin, Charles Pottier, Thomas Louis, Tania Durre, Remi Longuespee, Gabriel Mazzucchelli, Christophe Nizet, Silvia Blacher, Frederic Kridelka, Agnes Noel
Summary: This study revealed an association between POSTN deposition and lymphangiogenesis in lymph nodes of cervical cancer patients, highlighting the key role of POSTN in promoting lymphatic vessel formation and the seeding of metastatic cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Fabrice Gucciardo, Sebastien Pirson, Louis Baudin, Alizee Lebeau, Agnes Noel
Summary: The urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180) is a key protein involved in collagen internalization and degradation, playing a role in pathologies like fibrosis and cancer. Recent research has also shown its importance in vascular biology and immune system regulation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)