Article
Pharmacology & Pharmacy
Remy Bonnavion, Shangmin Liu, Haruya Kawase, Kenneth Anthony Roquid, Stefan Offermanns
Summary: A recent study discovered that GPR182, a novel chemokine receptor expressed in microvascular and lymphatic endothelial cells, plays a crucial role in immune regulation by binding to various chemokines and regulating their distribution. The study also found that GPR182 has a strong affinity for multiple chemokines, highlighting its importance in chemokine scavenging.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pathology
Clinton P. Turner, Jessica McLay, Ian F. Hermans, Jason Correia, Arnold Bok, Nasim Mehrabi, Stephen Gock, Blake Highet, Maurice A. Curtis, Michael Dragunow
Summary: This study investigated the differences in tumour infiltrating lymphocyte (TIL) density in meningioma and its significance in predicting recurrence. The findings suggested that CD3+ and CD8+ TIL density is prognostically significant in atypical meningioma.
Review
Biochemistry & Molecular Biology
Pedro Bule, Sandra Isabel Aguiar, Frederico Aires-Da-Silva, Joana Nunes Ribeiro Dias
Summary: Chemokines play a crucial role in cancer development by influencing various processes such as angiogenesis, metastasis, and stemness. The chemokine network has emerged as a potential target for immunotherapy and may have therapeutic effects when used alone or in combination with other treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Jia-Bin Wang, You-Xin Gao, Yin-Hua Ye, Tong-Xing Lin, Ping Li, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Ze-Ning Huang, Hua-Long Zheng, Jian-Wei Xie, Chao-Hui Zheng, Chang-Ming Huang
Summary: The study demonstrates that CDK5RAP3 plays a tumor suppressor role in gastric cancer and is related to the infiltration and polarization of macrophages. CDK5RAP3 inhibits TAMs polarization to M2 phenotype and promotes M1 polarization. In addition, CDK5RAP3 reduces monocyte recruitment to tumor tissue by inhibiting the CCL2/CCR2 axis.
CANCER GENE THERAPY
(2023)
Article
Immunology
Serena Melgrati, Oliver J. Gerken, Marc Artinger, Egle Radice, Martyna Szpakowska, Andy Chevigne, Giulia D'Uonnolo, Paola Antonello, Sylvia Thelen, Pawel Pelczar, Daniel F. Legler, Marcus Thelen
Summary: Immune responses rely on immune cell trafficking in secondary lymphoid organs. Atypical chemokine receptors (ACKRs) scavenge chemokines to guide leukocytes. GPR182, a potential novel ACKR, acts as a scavenging receptor for chemokines and does not activate typical intracellular signaling. Cooperation between GPR182 and other ACKRs affects chemokine levels and influences immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mio Yamaguchi, Kiyoshi Takagi, Koki Narita, Yasuhiro Miki, Yoshiaki Onodera, Minoru Miyashita, Hironobu Sasano, Takashi Suzuki
Summary: Chemokines, particularly CCL5, secreted from stromal cells play crucial roles in interaction with carcinoma cells and regulating tumor progression. In human breast carcinoma tissues, the expression of CCL5 and CCR3 is significantly correlated with aggressive phenotype, and patients with positive CCL5 and CCR3 but negative CCR1 and CCR5 have a higher risk of recurrence. These findings suggest that the CCL5-CCR3 axis may contribute to a worse prognosis in breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yihe Yan, Leting Zheng, Qiang Du, Hamza Yazdani, Kun Dong, Yarong Guo, David A. Geller
Summary: IRF-1 regulates anti-tumor immunity in HCC by modulating CXCL10 and CXCR3, inhibiting proliferation and promoting apoptosis. It overcomes proliferation partly through activating the CXCL10/CXCR3 autocrine axis.
Article
Biochemistry & Molecular Biology
Ye Wang, Shimeng Wang, Houshang Wang, Jin Yang, Hongmei Zhou
Summary: This study aimed to establish a C/CR-based risk model for better immunotherapeutic responses and prognosis. A six-gene C/CR-based risk model was developed to stratify patients, and its predictive power was validated in various ways. The low-risk group showed better responses to immunotherapy and had longer overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wenyi Zhang, Pei Xiao, Jiayi Tang, Rui Wang, Xiangdong Wang, Fengxu Wang, Junpu Ruan, Shali Yu, Juan Tang, Rongrong Huang, Xinyuan Zhao
Summary: This study demonstrates the important roles of m6A modification patterns in cervical cancer. Analysis of m6A modification patterns can enhance our understanding of the tumor microenvironment in cervical cancer and facilitate the development of better immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Shi Dong, Wancheng Li, Xin Li, Zhengfeng Wang, Zhou Chen, Huaqing Shi, Ru He, Chen Chen, Wence Zhou
Summary: Metabolic reprogramming and the relationship between glucose metabolism and tumor microenvironment play a crucial role in pancreatic cancer. This study sheds light on the development of new therapies targeting the metabolism of cancer cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
Bin Chen, Guan-Rong Zheng, Cai-Yan Ma, Jian-Jun Huang, Ge Huang, Hai Hua, Shen-Zhong Qiu
Summary: This study analyzed the relationship between serum soluble scavenger receptor A (SRA) concentrations and early neurologic deterioration (END) and poor prognosis after intracerebral hemorrhage (ICH). The results showed that serum soluble SRA concentrations were significantly higher in patients than in healthy controls and were associated with hematoma volume, severity of stroke, and 3-month modified Rankin Scale scores. Serum soluble SRA concentrations independently predicted END and poor 3-month prognosis. Therefore, serum soluble SRA may serve as a promising prognostic biochemical marker of ICH.
CLINICA CHIMICA ACTA
(2023)
Article
Oncology
Mary E. Vail, Rae H. Farnsworth, Linda Hii, Stacey Allen, Sakshi Arora, Robin L. Anderson, Ross A. Dickins, Akira Orimo, Sunny Z. Wu, Alexander Swarbrick, Andrew M. Scott, Peter W. Janes
Summary: We have identified the cell guidance receptor EphA3 on distinct stromal/fibroblast-like cell types in the tumour microenvironment (TME) that promote growth and angiogenesis. Knockdown of EphA3 expression in the TME reduced mesenchymal stromal/fibroblast-like cells in tumours, with corresponding reductions in tumour vasculature and tumour growth, and increased immune infiltrate. Our results highlight the potential of EphA3 as a therapeutic target for tumour angiogenesis and tumour growth.
Article
Immunology
Xiao-Mao Tian, Bin Xiang, Li-Ming Jin, Tao Mi, Jin-Kui Wang, Chenghao Zhanghuang, Zhao-Xia Zhang, Mei-Ling Chen, Qin-Lin Shi, Feng Liu, Tao Lin, Guang-Hui Wei
Summary: A novel immune signature has been established using high-throughput RNA sequencing and analysis of immune-related genes, which can predict prognosis and immunotherapy response in children with Wilms tumour (WT). This signature also reflects immune status and immune cell infiltration in the tumour microenvironment, and is significantly associated with immune checkpoint molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Arezoo Gowhari Shabgah, Farhad Jadidi-Niaragh, Hamed Mohammadi, Farnoosh Ebrahimzadeh, Maziar Oveisee, Abbas Jahanara, Jamshid Gholizadeh Navashenaq
Summary: ACKR2, as an atypical chemokine receptor, plays a crucial role in regulating inflammatory responses and immune reactions. It has the ability to scavenge inflammatory chemokines, maintaining fetal health, inhibiting inflammatory reactions, and resolving inflammation in the body. In cancer, ACKR2 has conflicting effects, either promoting or suppressing tumor development, and can also be used as a biomarker for diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xin-yu Li, Lei Hou, Lu-yu Zhang, Liming Zhang, Deming Wang, Zhenfeng Wang, Ming-Zhe Wen, Xi-tao Yang
Summary: OAS3 plays a significant role in different cancers and is associated with prognosis and immune infiltration levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Surgery
Xiu-Tao Fu, Zheng Tang, Jia-Feng Chen, Ying-Hong Shi, Wei-Ren Liu, Qiang Gao, Guang-Yu Ding, Kang Song, Xiao-Ying Wang, Jian Zhou, Jia Fan, Zhen-Bin Ding
Summary: The study compared laparoscopic and open hepatectomy for patients with solitary HCC and cirrhosis, finding that laparoscopic hepatectomy resulted in better perioperative outcomes, lower complication rates, and reduced postoperative inflammatory responses. This provides evidence for considering routine laparoscopic hepatectomy for carefully selected HCC patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Yingcheng Wu, Shuaixi Yang, Jiaqiang Ma, Zechuan Chen, Guohe Song, Dongning Rao, Yifei Cheng, Siyuan Huang, Yifei Liu, Shan Jiang, Jinxia Liu, Xiaowu Huang, Xiaoying Wang, Shuangjian Qiu, Jianmin Xu, Ruibin Xi, Fan Bai, Jian Zhou, Jia Fan, Xiaoming Zhang, Qiang Gao
Summary: This study presents a single-cell and spatial atlas of colorectal liver metastasis, revealing highly metabolically activated MRCP+ CCL18(+) M2-like macrophages at the metastatic sites. Effective neoadjuvant chemotherapy can slow down this metabolic activation, raising the possibility of targeting metabolic pathways in metastasis.
Article
Oncology
Liangqing Dong, Dayun Lu, Ran Chen, Youpei Lin, Hongwen Zhu, Zhou Zhang, Shangli Cai, Peng Cui, Guohe Song, Dongning Rao, Xinpei Yi, Yingcheng Wu, Nixue Song, Fen Liu, Yunhao Zou, Shu Zhang, Xiaoming Zhang, Xiaoying Wang, Shuangjian Qiu, Jian Zhou, Shisheng Wang, Xu Zhang, Yongyong Shi, Daniel Figeys, Li Ding, Pei Wang, Bing Zhang, Henry Rodriguez, Qiang Gao, Daming Gao, Hu Zhou, Jia Fan
Summary: This study performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA) and revealed important features of iCCA pathogenesis. It identified subgroup-specific biomarkers and provided valuable insights into molecular pathogenesis and therapeutic opportunities in iCCA.
Review
Biochemistry & Molecular Biology
Si-Wei Wang, Chao Gao, Yi-Min Zheng, Li Yi, Jia-Cheng Lu, Xiao-Yong Huang, Jia-Bin Cai, Peng-Fei Zhang, Yue-Hong Cui, Ai-Wu Ke
Summary: The CRISPR/Cas9 gene editing technology has made significant progress in oncological research, providing a powerful tool for exploring the mechanism of cancer, establishing tumor models, and studying drug targets.
Review
Oncology
Fanghua Chen, Junming Wang, Yingcheng Wu, Qiang Gao, Shu Zhang
Summary: Liver cancer is the fourth leading cause of cancer-related death worldwide, predominantly hepatocellular carcinoma (HCC). Only a small percentage of HCC patients are eligible for curative therapy due to the lack of early detection strategies. The integration of multi-omics technology offers the potential for identifying reliable biomarkers for HCC diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chengpan Wang, Jieyi Shi, Jietian Xu, Qiaoyu Fu, Youpeng Ding, Jessie Yang, Binbin Liu, Qiang Gao, Jie Qin, Chunmin Liang
Summary: NLRC3 has been reported as a factor inhibiting inflammatory responses. Its role in hepatocellular carcinoma (HCC) is still unknown. In this study, NLRC3 levels were evaluated using the GEO database and multiple immunohistochemical analysis with tumor tissue microarrays of HCC patients. Tumor-bearing mouse models were also established to assess the effect of NLRC3. The results showed that high NLRC3 expression was associated with favorable overall and disease-free survival. NLRC3 was also found to be involved in CD8(+) T cell infiltration and correlated with increased CCL5 and CXCL9 expressions in the tumor microenvironment. These findings suggest that boosting NLRC3 could be a promising treatment to enhance survival in HCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Yingcheng Wu, Yifei Cheng, Xiangdong Wang, Jia Fan, Qiang Gao
Summary: This article reviews the technological progress of spatial omics in capturing the spatial architecture of tumour microenvironment (TME). It discusses the potential clinical translations of spatial omics in precision oncology and proposes the application of spatial ecological principles to cancer biology. Spatial omics plays a crucial role in decoding the TME ecosystem and may revolutionize current molecular medical research.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Zheng Gao, Jia-Feng Chen, Xiao-Gang Li, Ying-Hong Shi, Zheng Tang, Wei-Ren Liu, Xin Zhang, Ao Huang, Xuan-Ming Luo, Qiang Gao, Guo-Ming Shi, Ai-Wu Ke, Jian Zhou, Jia Fan, Xiu-Tao Fu, Zhen-Bin Ding
Summary: The study shows that ERK signaling inhibition contributes to the reduction of PD-L1 expression through the autophagy pathway in intrahepatic cholangiocarcinoma (iCCA). ERK-targeted therapy may serve as a potentially novel treatment strategy for human KRAS-mutated iCCA.
CANCER CELL INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Zhou Lu, Ronghua Liu, Yining Wang, Mengxia Jiao, Zhongchen Li, Zhiqiang Wang, Cheng Huang, Guoming Shi, Aiwu Ke, Luman Wang, Ying Fu, Jie Xia, Haoyu Wen, Jian Zhou, Xiaoying Wang, Dan Ye, Jia Fan, Yiwei Chu, Jiabin Cai
Summary: This study revealed that TET2 activation in B cells induced by oxidative stress in the HCC microenvironment promoted IL-10 expression, while Tet2-deficient B cells suppressed HCC progression. High levels of IL-10, TET2, and 5hmc in B cells were associated with poor prognosis in patients with HCC. Furthermore, inhibiting TET2 activity in B cells facilitated antitumor immunity and improved the efficacy of anti-PD-1 therapy for HCC.
Article
Gastroenterology & Hepatology
Chuan-Yuan Wei, Meng-Xuan Zhu, Peng-Fei Zhang, Xiao-Yong Huang, Jin-Kai Wan, Xiu-Zhong Yao, Ze-Tao Hu, Xiao-Qiang Chai, Rui Peng, Xuan Yang, Chao Gao, Jian Gao, Si-Wei Wang, Yi-Min Zheng, Zheng Tang, Qiang Gao, Jian Zhou, Jia-Bin Fan, Ai-Wu Ke, Jia Fan
Summary: This study identified ZFP64 as an upregulated gene in tumor tissues from HCC patients with anti-PD1 resistance. Elevated ZFP64 contributes to anti-PD1 resistance by promoting M2 macrophage polarization and creating an inhibitory tumor microenvironment. The PKC alpha/ZFP64/CSF1 axis plays a critical role in immune evasion and anti-PD1 tolerance. Inhibiting this axis can overcome resistance to anti-PD1 in HCC.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Guang-Yu Ding, Jia-Qiang Ma, Jing-Ping Yun, Xing Chen, Yu Ling, Shu Zhang, Jie-Yi Shi, Yu-Qing Chang, Yuan Ji, Xiao-Ying Wang, Wei-Min Tan, Ke-Fei Yuan, Bo Yan, Xiao-Ming Zhang, Fei Liang, Jian Zhou, Jia Fan, Yong Zeng, Mu-Yan Cai, Qiang Gao
Summary: The prognostic value and functional involvement of tertiary lymphoid structures (TLSs) in intrahepatic cholangiocarcinoma (iCCA) were evaluated. The study found that the spatial distribution and abundance of TLSs significantly correlated with prognosis and provided a useful immune classification for iCCA. T follicular helper and regulatory T cells were identified as critical factors in determining the functional orientation of spatially different TLSs.
JOURNAL OF HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Guohe Song, Yang Shi, Lu Meng, Jiaqiang Ma, Siyuan Huang, Juan Zhang, Yingcheng Wu, Jiaxin Li, Youpei Lin, Shuaixi Yang, Dongning Rao, Yifei Cheng, Jian Lin, Shuyi Ji, Yuming Liu, Shan Jiang, Xiaoliang Wang, Shu Zhang, Aiwu Ke, Xiaoying Wang, Ya Cao, Yuan Ji, Jian Zhou, Jia Fan, Xiaoming Zhang, Ruibin Xi, Qiang Gao
Summary: This study characterizes the molecular classification and tumor microenvironment of intrahepatic cholangiocarcinoma (iCCA) using single cell RNA-sequencing. The authors identify S100P and SPP1 as markers for patient classification and demonstrate that different subtypes of iCCA have distinct immune cell infiltration and survival rates.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Chao Gao, Si-wei Wang, Jia-cheng Lu, Xiao-qiang Chai, Yuan-cheng Li, Peng-fei Zhang, Xiao-yong Huang, Jia-bin Cai, Yi-min Zheng, Xiao-jun Guo, Guo-ming Shi, Ai-wu Ke, Jia Fan
Summary: This study reveals the important role of KSR2 in the occurrence and development of HCC, and high expression of KSR2 is associated with poor prognosis. Mechanistically, the interaction between KSR2 and 14-3-3ζ plays a key role in the activation of the MAPK signaling pathway and drug resistance in HCC cells. Therefore, the KSR2-14-3-3ζ interaction may be a therapeutic target to enhance the sensitivity of HCC to sorafenib.
BIOMARKER RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Tiancheng Zhang, Chenhao Zhang, Zile Fu, Qiang Gao
Summary: The fast development of anti-tumor agents reflects a deeper understanding of the mechanisms behind cancer. Chemotherapy, targeted therapy, and immunotherapy are the three pillars of current cancer treatment. While immune checkpoint inhibitors have shown success in controlling tumor growth, only a small fraction of patients benefit from this treatment. Therefore, developing safe therapeutic strategies to improve the response to immunotherapy is crucial. Targeted agents can eliminate cancer cells with specific mutations or targets, and they have been found to have immunostimulatory or immunosuppressive effects. Drug repurposing may be a promising approach to finding combination strategies to enhance the effectiveness of immunotherapy.