期刊
JOURNAL OF PATHOLOGY
卷 217, 期 2, 页码 299-306出版社
WILEY
DOI: 10.1002/path.2478
关键词
prostate; stem cells; neoplasia
资金
- Yorkshire Cancer Research, UK
- Wellcome Trust UK [076612]
- US Department of Defence, USA
Despite the discovery over 60 years ago by Huggins and Hodges [1] that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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