Review
Medicine, General & Internal
Saraswathi Lakkasani, Deeksha Seth, Imran Khokhar, Masara Touza, Theodore Dacosta
Summary: This paper provides an overview of the structure and function of the adult small intestine and the development of short bowel syndrome (SBS) resulting from intestine resection. The main treatment approach is personalized dietary management, which focuses on addressing malabsorption issues through proper nutrition to facilitate patient recovery.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Article
Surgery
Isamu Saeki, Sho Kurihara, Masato Kojima, Hiroki Ohge, Shinya Takahashi, Eiso Hiyama
Summary: The study reports a new surgical technique, the Saeki-Spiral-Shark (3S) method, for treating short bowel syndrome (SBS) using biomimetics of shark intestine. The 3S method involves the formation of a spiral valve inside the intestine, enabling intestinal rehabilitation. Compared to traditional intestinal repair procedures, the 3S method offers less invasive surgery and better surgical cleanliness.
Article
Gastroenterology & Hepatology
S. Coughlan, A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: The study conducted metagenomic sequencing of fecal Virus-Like Particles (VLPs) from 55 patients with IBS and 51 control individuals. It found significantly lower alpha diversity of viral clusters in IBS, identified core viromes in both IBS and control groups, and noted no significant covariation between the virome and the bacteriome, IBS clinical subtype, or Bile Acid Malabsorption status.
Article
Multidisciplinary Sciences
Shinya Sugimoto, Eiji Kobayashi, Masayuki Fujii, Yuki Ohta, Kazuya Arai, Mami Matano, Keiko Ishikawa, Kentaro Miyamoto, Kohta Toshimitsu, Sirirat Takahashi, Kosaku Nanki, Yoji Hakamata, Takanori Kanai, Toshiro Sato
Summary: The study successfully generated a functional small intestinalized colon (SIC) by replacing the native colonic epithelium with ileum-derived organoids, which markedly ameliorated intestinal failure in a rat model of short bowel syndrome (SBS). This provides proof of principle for the regenerative use of intestinal organoids and offers a feasible strategy for SBS treatment.
Article
Emergency Medicine
Shunsuke Saito, Izumi Nakayama, Ryutaro Nishie, Tetsushi Higa, Shojiro Oka
Summary: This article presents a case of severe coagulopathy secondary to short bowel syndrome (SBS) and emphasizes the importance of awareness among emergency physicians. SBS is a rare but serious condition that can lead to unexplained coagulopathy and acute bleeding in patients.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Kai-Yue Huang, Feng-Yun Wang, Mi Lv, Xiang-Xue Ma, Xu-Dong Tang, Lin Lv
Summary: In the past decade, research on irritable bowel syndrome (IBS) has focused on the results of epidemiology, overlap disorders, pathophysiology, and treatment. With the upcoming release of Rome V revision, it is necessary to review recent research results on IBS in order to highlight future concerns.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fritz G. Rathjen, Rene Juettner
Summary: The immunoglobulin-like cell adhesion molecule CLMP, a member of the CAR family of cell adhesion proteins, is involved in the development of human congenital short-bowel syndrome (CSBS), which is characterized by defective intestinal elongation and impaired peristalsis. This review compares data from CSBS patients and a mouse knockout model, revealing the role of CLMP in the coordination of calcium signaling via gap junctions and the reduction of connexin43 levels in the intestine. Additionally, the mutations in the CLMP gene also affect other organs and tissues, including the ureter, leading to severe bilateral hydronephrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Celeste Witting, Craig B. Langman, Dean Assimos, Michelle A. Baum, Annamaria Kausz, Dawn Milliner, Greg Tasian, Elaine Worcester, Meaghan Allain, Melissa West, Felix Knauf, John C. Lieske
Summary: Enteric hyperoxaluria, a unique condition caused by gastrointestinal disorders, can lead to kidney stones and even kidney failure. Current treatments involve correcting underlying gastrointestinal issues, modifying diet, and using calcium salts to bind oxalate, but there is still a lack of clinical evidence regarding their efficacy. Further research is necessary to understand the risk factors for adverse outcomes and evaluate the long-term effectiveness of existing treatments, as well as develop new therapeutic approaches.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Medicine, General & Internal
Giusi Desire Sciume, Ginevra Berti, Christian Lambiase, Italia Paglianiti, Vincenzo Villanacci, Francesco Rettura, Antonio Grosso, Angelo Ricchiuti, Nicola de Bortoli, Paolo Usai Satta, Gabrio Bassotti, Massimo Bellini
Summary: Irritable bowel syndrome with predominant diarrhea (IBS-D) and functional diarrhea (FD) are disorders of gut-brain interaction that have a significant impact on the patient's quality of life. Bile acid malabsorption (BAM) and microscopic colitis (MC) are often responsible for the lack of response to conventional treatments in these patients. Therefore, considering these factors and finding appropriate treatments should be part of the diagnostic process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Joelle BouSaba, Wassel Sannaa, Sanna McKinzie, Priya Vijayvargiya, Victor Chedid, Xiao Jing Wang, Jessica Atieh, Ting Zheng, Justin Brandler, Ann L. Taylor, Irene Busciglio, W. Scott Harmsen, Michael Camilleri
Summary: Bile acid diarrhea (BAD) has a significant impact on the demographics, bowel and somatic symptoms, and quality of life of patients with irritable bowel syndrome with diarrhea (IBS-D). Patients with BAD are older, have a higher body mass index, experience more severe bowel dysfunction, and have a greater impact on quality of life. They are more likely to receive medication and are more prone to depression.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pediatrics
Tom Jaksic
Summary: Prior to the late 1960s, pediatric short bowel syndrome had high mortality rates. However, current reports from pediatric interdisciplinary bowel rehabilitation centers show significant improvement in survival rates. This article reviews the trends, definitions, incidence, causes, and clinical manifestations of short bowel syndrome, emphasizing the advances in nutrition, medicine, and surgery that have contributed to better outcomes for pediatric patients. The article also highlights recent findings and remaining challenges.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
Nina N. Sainath, Christina Bales, Jefferson N. Brownell, Octavia Pickett-Blakely, Aisha Sattar, Virginia A. Stallings
Summary: The study aimed to investigate the impact of pancreatic enzyme replacement therapy on enteral absorption in patients with short bowel syndrome (SBS). The results showed that overall, there was no significant improvement in enteral fat and protein absorption after pancreatic enzyme medication therapy, although some subjects demonstrated improvement. This suggests that some SBS patients may benefit from treatment with pancreatic enzymes.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Review
Medicine, General & Internal
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Francesca Falangone, Davide Montanari, Federica Capuani, Giada Mastel, Vincenzo Stanghellini, Giovanni Barbara
Summary: Bile acid malabsorption (BAM) is a common cause of chronic diarrhea, but its prevalence is not well studied. Bile acid diarrhea (BAD) occurs due to dysregulation of the enterohepatic recirculation of bile acids. The gold standard for diagnosing and assessing the severity of BAD is currently the selenium homotaurocholic acid test, but other serum markers are being validated for clinical use. The first-line treatment for BAD is bile acid sequestrants, but further diagnostics are needed for patients who do not respond to this treatment. Early and accurate diagnosis of BAD can improve patients' quality of life and reduce the burden on healthcare systems. More research is needed to explore alternative therapeutic approaches for BAD, such as gut microbiota modulating therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. M. Quigley
Summary: The concept of small intestinal bacterial overgrowth (SIBO) explains the cause of maldigestion and malabsorption. With the development of diagnostic testing, the methods for diagnosing SIBO have evolved from small bowel culture to breath tests and culture-independent microbial analytics. The availability of breath tests has led to an expansion in the diagnosis of SIBO and the associated clinical symptoms. However, issues with the specificity of breath tests have raised doubts about the role of SIBO in certain clinical scenarios. The hope is to use modern molecular microbiology to study the human small intestinal microbiome in order to provide an objective basis for diagnosing SIBO.
Article
Nutrition & Dietetics
Jane K. Naberhuis, Andrew S. Deutsch, Kelly A. Tappenden
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2017)
Letter
Nutrition & Dietetics
Nicolaas E. Deutz, Eric M. Matheson, Laura E. Matarese, Geraldine E. Baggs, Jeffrey L. Nelson, Refaat A. Hegazi, Menghua Luo, Kelly A. Tappenden, Thomas R. Ziegler
CLINICAL NUTRITION
(2016)
Article
Gastroenterology & Hepatology
Hannah D. Holscher, Lars Bode, Kelly A. Tappenden
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2017)
Review
Medicine, General & Internal
Carla M. Prado, Sarah A. Purcell, Carolyn Alish, Suzette L. Pereira, Nicolaas E. Deutz, Daren K. Heyland, Bret H. Goodpaster, Kelly A. Tappenden, Steven B. Heymsfield
ANNALS OF MEDICINE
(2018)
Article
Nutrition & Dietetics
T. Cederholm, G. L. Jensen, M. I. T. D. Correia, M. C. Gonzalez, R. Fukushima, T. Higashiguchi, G. Baptista, R. Barazzoni, R. Blaauw, A. Coats, A. Crivelli, D. C. Evans, L. Gramlich, V. Fuchs-Tarlovsky, H. Keller, L. Llido, A. Malone, K. M. Mogensen, J. E. Morley, M. Muscaritoli, I. Nyulasi, M. Pirlich, V. Pisprasert, M. A. E. de van der Schueren, S. Siltharm, P. Singer, K. Tappenden, N. Velasco, D. Waitzberg, P. Yamwong, J. Yu, A. Van Gossum, C. Compher
CLINICAL NUTRITION
(2019)
Article
Nutrition & Dietetics
Gordon L. Jensen, Tommy Cederholm, M. Isabel T. D. Correia, M. Christina Gonzalez, Ryoji Fukushima, Takashi Higashiguchi, Gertrudis Adrianza de Baptista, Rocco Barazzoni, Renee Blaauw, Andrew J. S. Coats, Adriana Crivelli, David C. Evans, Leah Gramlich, Vanessa Fuchs-Tarlovsky, Heather Keller, Luisito Llido, Ainsley Malone, Kris M. Mogensen, John E. Morley, Maurizio Muscaritoli, Ibolya Nyulasi, Matthias Pirlich, Veeradej Pisprasert, Marian de van der Schueren, Soranit Siltharm, Pierre Singer, Kelly A. Tappenden, Nicolas Velasco, Dan L. Waitzberg, Preyanuj Yamwong, Jianchun Yu, Charlene Compher, Andre Van Gossum
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2019)
Letter
Nutrition & Dietetics
T. Cederholm, C. Compher, M. I. T. D. Correia, M. C. Gonzalez, R. Fukushima, T. Higashiguchi, A. Van Gossum, G. L. Jensen
CLINICAL NUTRITION
(2019)
Article
Geriatrics & Gerontology
T. Cederholm, G. L. Jensen, M. I. T. D. Correia, M. C. Gonzalez, R. Fukushima, T. Higashiguchi, G. Baptista, R. Barazzoni, R. Blaauw, A. J. S. Coats, A. N. Crivelli, D. C. Evans, L. Gramlich, V. Fuchs-Tarlovsky, H. Keller, L. Llido, A. Malone, K. M. Mogensen, J. E. Morley, M. Muscaritoli, I. Nyulasi, M. Pirlich, V. Pisprasert, M. A. E. de van der Schueren, S. Siltharm, P. Singer, K. Tappenden, N. Velasco, D. Waitzberg, P. Yamwong, J. Yu, A. Van Gossum, C. Compher
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Biographical-Item
Nutrition & Dietetics
Kelly A. Tappenden, Stanley J. Dudrick, Lingtak-Neander Chan, John M. Daly, Ezra Steiger, Albert Barrocas, Charlene Compher, Marion F. Winkler, Ruben Gustavo Kliger, Jianchun Yu, Stanislaw Klek, Gil Hardy, Jose M. Pimiento, Joan Bishop, Bettemarie Bond, Emma M. Tillman
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2020)
Article
Nutrition & Dietetics
Kishore Iyer, Marjorie Nisenholtz, David Gutierrez, Marion Winkler, Kelly Tappenden, Douglas Seidner, Donald F. Kirby, Michelle Spangenburg, Ronald Potts, Anthony Bonagura, Joan Bishop, Lisa Metzger, Sanjeev Arora
Summary: This study reviewed the initial experience of using the ECHO model to disseminate knowledge in IF, and found that the LIFT-ECHO program has achieved significant geographic reach and clinician engagement, with clinician participation growing exponentially. Further studies are underway to demonstrate direct benefits to patients.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Marion F. Winkler, Kelly A. Tappenden, Michelle Spangenburg, Kishore Iyer
Summary: Intestinal failure is a rare chronic disease that requires specialized care, and the LIFT-ECHO online videoconferencing project aims to improve healthcare for these patients through remote mentoring and case-based learning.
NUTRITION IN CLINICAL PRACTICE
(2021)
Review
Nutrition & Dietetics
Maria Isabel T. D. Correia, Kelly A. Tappenden, Ainsley Malone, Carla M. Prado, David C. Evans, Abby C. Sauer, Refaat Hegazi, Leah Gramlich
Summary: Despite various published diagnostic criteria, the diagnosis of malnutrition remains a challenge. In 2018, the Global Leadership Initiative on Malnutrition (GLIM) published evidence-based criteria for the diagnosis of malnutrition in adults. This scoping review examined how the GLIM criteria have been used in published literature and compared the reported validation methods to published validation guidance.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Emily Belcher, David Mercer, Bram P. Raphael, Gregory D. Salinas, Sylvie Stacy, Kelly A. Tappenden
Summary: This study aimed to identify unmet educational needs related to the management of patients with SBS-IF. The survey results showed disparities in knowledge and practice among healthcare professionals regarding SBS-IF, including diagnosis, management goals, medications prescribed, and nutrition practices. Future educational interventions should aim to improve awareness and understanding of the disease, facilitate timely diagnosis, and standardize management practices.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Kelly A. A. Tappenden
Summary: Short bowel syndrome-associated intestinal failure is a complex and life-threatening condition that requires comprehensive care to address the multiple factors affecting the patient's long-term prognosis.
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Nutrition & Dietetics
Kelly Tappenden
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)