Article
Endocrinology & Metabolism
Katharina Maruszczak, Konrad Radzikowski, Sebastian Schuetz, Harald Mangge, Peter Bergsten, Anders Forslund, Hannes Manell, Thomas Pixner, Hakan Ahlstrom, Joel Kullberg, Katharina Moerwald, Daniel Weghuber
Summary: Children and adolescents with NAFLD have significantly higher fasting plasma glucagon values, which were best predicted by hepatic insulin resistance and visceral adipose tissue, but not average liver fat content.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Susie Ruqun Wu, Lindo Wang
Summary: Transparency is crucial for supporting scientific claims in Life Cycle Assessment (LCA) studies, but the disclosure of secondary datasets and analysis scripts of models is still relatively low. The use of open-source programming languages can enhance transparency and reproducibility. It is also important to disclose secondary datasets and provide justifications for their selection to ensure accurate interpretation of LCA results.
JOURNAL OF CLEANER PRODUCTION
(2022)
Review
Genetics & Heredity
Xiaoqing Lu, Yuxin Jin, Dexin Li, Jingxin Zhang, Jingyan Han, Yin Li
Summary: Obesity is a global epidemic with significant impact on metabolism and health, leading to financial burden on healthcare systems. The treatment of obesity and its associated diseases is an urgent problem that needs to be addressed.
Article
Chemistry, Multidisciplinary
Philip G. Jessop, Alex R. Macdonald
Summary: The life cycle of a product contains hotspots, which are the steps causing the majority of harm. Traditional practice often overlooks the importance of identifying these hotspots. Therefore, the utilization of life cycle assessments to identify hotspots and drive the selection of research projects is necessary to maximize environmental benefits.
Review
Microbiology
Stephanie L. Rager, Melody Y. Zeng
Summary: There is increasing interest in understanding the interactions between the human gut and microorganisms, and how these interactions affect overall health and disease. The liver, as a vital organ for metabolism, is closely connected to the gut microbial environment through the portal venous system. Although there is extensive research on the gut-liver axis in adults, our understanding of this axis in children, who have unique physiology and gut microbiota, remains limited. This study provides a comprehensive overview of common pediatric hepatobiliary conditions and recent research on the role of gut microbiota in these conditions, as well as the changes in gut microbiota caused by these conditions. The study also explores potential therapeutic approaches that involve modulating the gut microbiota and gut-liver axis to prevent the progression of pediatric liver disease.
Article
Surgery
Anna M. Banc-Husu, Elizabeth A. Moulton, Henry Shiau, Luz Helena Gutierrez Sanchez, Moreshwar S. Desai, Dana Cerminara, Flor M. Munoz, Leanne M. Buffaloe, Kristen G. Valencia-Deray, N. Thao N. Galvan, Julu Bhatnagar, Lindsey Estetter, Negar Rassaei, Sarah Reagan -Steiner, Jason Wicker, James J. Dunn, Carl E. Allen, Kalyani R. Patel, Sanjiv Harpavat, John A. Goss, Daniel H. Leung
Summary: Investigation into a recent cluster of acute hepatitis in children from the southeastern United States found human adenovirus (HAdV) DNAemia in all 9 cases. HAdV type 41 was identified in all cases, and two children progressed to pediatric acute liver failure (PALF) and required liver transplantation. This report highlights the importance of early multidisciplinary medical management and the feasibility of liver transplantation in children with PALF and HAdV DNAemia.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cell Biology
Marco Raffaele, Kristina Kovacovicova, Jan Frohlich, Oriana Lo Re, Sebastiano Giallongo, Jude A. Oben, Martin Faldyna, Lenka Leva, Antonino Giulio Giannone, Daniela Cabibi, Manlio Vinciguerra
Summary: The study showed that senolytic drugs dasatinib and quercetin (D + Q) did not have a positive impact on NAFLD-induced HCC in an age and obesity-related HCC model.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Gastroenterology & Hepatology
Kara Wegermann, Catherine Howe, Ricardo Henao, Ying Wang, Cynthia D. Guy, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan
Summary: This study aimed to determine if serum metabolite profiles in patients with NAFLD associate with future liver-related events. Results showed metabolites of a primary bile acid, vitamin E, and serotonin were associated with future liver-related events, suggesting metabolite pathways may be useful for predicting higher risk for hepatic decompensation in patients with NAFLD.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Roberto Carlos A. Frias-Soler, Natalie Kelsey, Lilian Villarin Pildain, Michael Wink, Franz Bairlein
Summary: This study investigated the liver transcriptome of the Northern Wheatear at different migratory stages and identified molecular processes related to migration adaptation. The findings showed significant enhancement in the liver's metabolic capacities during migration, and genes related to oxidative stress, detoxification, immune responses, lipid metabolism, inflammation, and angiogenesis were regulated.
Review
Endocrinology & Metabolism
Vandana Raman, Anshu Gupta, Ambika P. Ashraf, Emily Breidbart, Evgenia Gourgari, Manmohan Kamboj, Brenda Kohn, Sowmya Krishnan, Amit Lahoti, Kristal Matlock, Shilpa Mehta, Sejal Mistry, Ryan Miller, Laura Page, Danielle Reynolds, Joan C. Han
Summary: This review focuses on recent advances in pharmacotherapy for pediatric obesity, including medications for rare monogenic forms of obesity. In addition to approved medications for weight reduction in children, off-label medications also have a broad safety margin. The review aims to provide guidance for clinicians and encourage further research into pharmacotherapy and other interventions for pediatric obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Amber Hager, Diana Mager, Cheri Robert, David Nicholas, Susan Gilmour
Summary: The study found that there is a certain consistency in parental and child perceptions of HRQOL in pediatric liver transplant recipients, but it is related to age and ethnicity. When children have comorbidities related to mental and neurocognitive development, there may be differences in how parents and children perceive HRQOL.
Article
Pediatrics
Farhad Hosseinpanah, Amirhosein Seyedhoseinpour, Maryam Barzin, Maryam Mahdavi, Erfan Tasdighi, Pooneh Dehghan, Amin Momeni Moghaddam, Fereidoun Azizi, Majid Valizadeh
Summary: The study aimed to compare different childhood body mass index cut-offs in predicting carotid intima media thickness, with results suggesting that IOTF may be a better tool for defining overweight and obesity.
Article
Cardiac & Cardiovascular Systems
Christoph Hochsmann, James L. Dorling, Corby K. Martin, Robert L. Newton, John W. Apolzan, Candice A. Myers, Kara D. Denstel, Emily F. Mire, William D. Johnson, Dachuan Zhang, Connie L. Arnold, Terry C. Davis, Vivian Fonseca, Carl J. Lavie, Eboni G. Price-Haywood, Peter T. Katzmarzyk
Summary: A pragmatic ILI delivered in primary care setting produced clinically relevant improvements in cardiometabolic health in underserved population over 24 months, including significant weight loss and improvements in blood glucose, cholesterol levels.
Article
Nutrition & Dietetics
Stephan C. Bischoff, Johann Ockenga, Ahad Eshraghian, Rocco Barazzoni, Luca Busetto, Marjo Campmans-Kuijpers, Vincenzo Cardinale, Irit Chermesh, Haluk Tarik Kani, Wafaa Khannoussi, Laurence Lacaze, Miguel Leon-Sanz, Juan M. Mendive, Michael W. Mueller, Frank Tacke, Anders Thorell, Darija Vranesic Bender, Arved Weimann, Cristina Cuerda
Summary: This practical guideline focuses on the diagnosis and treatment of obesity in patients with chronic gastrointestinal diseases, with a particular emphasis on metabolic associated liver disease. The guideline provides evidence-based advice in a condensed format, with 100 recommendations covering a multidisciplinary approach to care.
CLINICAL NUTRITION
(2023)
Review
Pediatrics
Valeria Calcaterra, Vittoria Carlotta Magenes, Matteo Vandoni, Clarissa Berardo, Luca Marin, Alice Bianchi, Erika Cordaro, Giustino Simone Silvestro, Dario Silvestri, Vittoria Carnevale Pellino, Cristina Cereda, Gianvincenzo Zuccotti
Summary: Non-alcoholic fatty liver disease is an important health concern in childhood, and there are currently no valid pharmacological therapies for children affected by this condition. Physical exercise plays a positive role in the treatment of non-alcoholic fatty liver disease in obese children and adolescents. However, further research is needed to understand the underlying mechanisms.