Review
Medicine, Research & Experimental
David Dahlgren, Hans Lennernas
Summary: Chemotherapy damages the intestinal barrier by killing gut stem cells, leading to increased bacterial translocation and altered permeability. The mucus layer and epithelium are also affected by chemotherapy, making the barrier more permeable. However, the exact sequence of events and contributions of different barrier components are still unclear, and further research is needed to understand the development of chemotherapy-induced gut toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Waleed A. S. Aldamarany, Liling Deng, Geng Zhong
Summary: Bacterial translocation (BT) induced by antibiotics is associated with increased risk of inflammatory disorders, and intestinal barrier integrity plays a vital role in this process. In this study, the prebiotic effects of deacetylated konjac glucomannan (DKGM) and konjac oligo-glucomannan (KOGM) were investigated in a mouse model. The results showed that these derivatives showed potential in inhibiting BT and alleviating colon tissue lesions. Additionally, they improved short-chain fatty acid production and reduced inflammation response.
Article
Biochemistry & Molecular Biology
Annette Brandt, Anja Baumann, Angelica Hernandez-Arriaga, Finn Jung, Anika Nier, Raphaela Staltner, Dragana Rajcic, Christian Schmeer, Otto W. Witte, Barbara Wessner, Bernhard Franzke, Karl-Heinz Wagner, Amelia Camarinha-Silva, Ina Bergheim
Summary: Aging is associated with low grade inflammation, called "inflammaging". Maintaining intestinal homeostasis may help extend the healthy status of older adults. In this study, it was found that even in healthy older men, low grade bacterial endotoxemia is common. Additionally, while intestinal microbiota composition changes significantly during aging, fecal microbiota transplantation does not protect against aging-associated intestinal barrier dysfunction in mice.
Article
Oncology
Yu Wang, Huan He, Jingwen Chen, Zijing Song, Xuediao Pan, Tian Lan, Guixiang Wang
Summary: Studies on colorectal cancer tumor growth and tumor polyamine metabolism have found that the expression level of HIF1α affects the growth rate of tumors and intestinal mucosal permeability, with higher HIF1α expression promoting tumor growth and increasing intestinal mucosal permeability.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohammed A. Elmetwally, Xilong Li, Gregory A. Johnson, Robert C. Burghardt, Cassandra M. Herring, Avery C. Kramer, Cynthia J. Meininger, Fuller W. Bazer, Guoyao Wu
Summary: Dietary supplementation with l-arginine during early pregnancy can promote embryonic survival and placental vascular development by increasing the expression of genes and proteins related to angiogenesis.
Article
Agriculture, Dairy & Animal Science
Cassandra M. Herring, Fuller W. Bazer, Gregory A. Johnson, Heewon Seo, Shengdi Hu, Mohammed Elmetwally, Wenliang He, Daniel B. Long, Guoyao Wu
Summary: Supplementing L-arginine (Arg) during early gestation in gilts improves the survival and development of conceptuses. This is achieved by increasing the number of viable fetuses, enhancing placental blood vessel development, improving embryonic survival, increasing placental weight and fetus weight, and promoting the growth of amniotic and allantoic fluids. Arg supplementation also stimulates the syntheses of nitric oxide (NO) and polyamines in the placenta, increases the transportation of water and amino acids, and upregulates the expression of angiogenic factors and aquaporins.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Water Resources
Jamie English, Lisa Connolly, Linda D. Stewart
Summary: The intestinal epithelium is the first line of defence against pathogens in the gastrointestinal tract and its structure and function are important for maintaining a healthy gut environment. Tight junction complexes between intestinal epithelial cells play a key role in maintaining the integrity of the gut barrier. Genetic and environmental factors can impact the effectiveness of these tight junction complexes and increase the permeability of the intestine, which has been associated with autoimmune diseases.
EXPOSURE AND HEALTH
(2023)
Article
Urology & Nephrology
Hoang Thuy Linh, Yasunori Iwata, Yasuko Senda, Yukiko Sakai-Takemori, Yusuke Nakade, Megumi Oshima, Shiori Nakagawa-Yoneda, Hisayuki Ogura, Koichi Sato, Taichiro Minami, Shinji Kitajima, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Miho Shimizu, Kengo Furuichi, Norihiko Sakai, Hiroyuki Yamada, Katsuhiko Asanuma, Kouji Matsushima, Takashi Wada
Summary: Impairment of intestinal barrier function is associated with the progression of diabetic kidney disease, and abnormal MAVS signaling in the kidney and intestine contributes to disrupted intestinal homeostasis. Controlling intestinal homeostasis may offer a novel therapeutic approach for diabetic kidney disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Nutrition & Dietetics
Katia Martinez-Gonzalez, Leonor Serrano-Cuevas, Eduardo Almeida-Gutierrez, Salvador Flores-Chavez, Juan Manuel Mejia-Arangure, Paola Garcia-delaTorre
Summary: In this study, citrulline oral supplementation significantly improved memory function in an AD murine model, with an increase in arginine levels in cerebrospinal fluid. This suggests that NO may be an effective therapeutic target for memory dysfunction in AD.
Article
Immunology
Yan-hua Wang
Summary: Bacterial translocation can lead to multiple organ dysfunction syndrome, and ensuring the integrity of the intestinal mucosal barrier is crucial for prevention. Early diagnosis, intervention, or prevention of bacterial translocation may be a new avenue in the treatment of various diseases. Elimination of the primary disease, maintaining blood and oxygen supply to the intestine, and selective digestive decontamination are key in treatment.
MICROBIAL PATHOGENESIS
(2021)
Article
Medicine, Research & Experimental
Haishan Wu, Rong Huang, Jinjin Fan, Ning Luo, Xiao Yang
Summary: Low potassium diet may increase intestinal permeability, leading to bacterial translocation, suspected to be due to impaired intestinal epithelial barrier and biological barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Irina Efremova, Roman Maslennikov, Aliya Alieva, Elena Poluektova, Vladimir Ivashkin
Summary: The aim of this study was to determine whether the presence of small intestinal bacterial overgrowth (SIBO) affects the prognosis in cirrhosis. A total of 50 patients were included in this prospective cohort study and underwent lactulose hydrogen breath test for SIBO. The results showed that SIBO is associated with poor prognosis in cirrhosis.
Review
Cell Biology
Raquel Linares, Ruben Frances, Ana Gutierrez, Oriol Juanola
Summary: This review explores the impact of bacterial antigen translocation, intestinal barrier permeability, host immune response, and genetic predisposition on the inflammatory response observed in CD patients. Evidence suggests that bacterial products translocating leads to uncontrolled inflammation in CD patients, with gut bacterial genomic fragments serving as a marker for increased risk of relapse.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Nutrition & Dietetics
Adam M. Gonzalez, Jeremy R. Townsend, Anthony G. Pinzone, Jay R. Hoffman
Summary: This article summarizes the use of nitric-oxide-stimulating dietary supplements to improve muscle performance and training adaptations by increasing NO production and improving blood flow.
Article
Food Science & Technology
Chaiyavat Chaiyasut, Bhagavathi Sundaram Sivamaruthi, Narissara Lailerd, Sasithorn Sirilun, Suchanat Khongtan, Pranom Fukngoen, Sartjin Peerajan, Manee Saelee, Khontaros Chaiyasut, Periyanaina Kesika, Phakkharawat Sittiprapaporn
Summary: This study investigated the effects of supplementing a probiotic mixture (Lactobacillus paracasei HII01, Bifidobacterium breve, and Bifidobacterium longum) on intestinal permeability, lipid profile, obesity index, and metabolic biomarkers in elderly Thai subjects. The results showed that the supplementation of probiotics improved intestinal barrier function, increased high-density lipoprotein cholesterol levels, and improved obesity-related anthropometric biomarkers and short-chain fatty acid levels in human subjects.
Article
Food Science & Technology
Caroline Liboreiro Paiva, Dea A. M. Netto, Valeria A. V. Queiroz, Maria Beatriz A. Gloria
Summary: This study quantified the levels of free bioactive amines during germination of tannin and tannin-free sorghum seeds and seedlings. It was found that tannin-free sorghum seeds had higher levels of spermidine, spermine, putrescine, and total amines compared to tannin sorghum. Throughout germination, putrescine was prevalent followed by spermidine. Spermine was only detected in the 7th germination day in tannin sorghum. The findings suggest that by selecting different genotypes, the polyamine contents in germinated sorghum can be modulated for specific food applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
Brenda de Nazare do Carmo Brito, Renan Campos Chiste, Alessandra Santos Lopes, Maria Beatriz Abreu Gloria, Gilson Celso Albuquerque Chagas Junior, Rosinelson da Silva Pena
Summary: This study aimed to isolate and identify lactic acid bacteria (LAB) during manipueira fermentation for tucupi and investigate their impact on biogenic amine formation. The results showed that only two LAB species were identified during fermentation, and there was a positive correlation between LAB counts and putrescine and histamine levels.
Review
Nutrition & Dietetics
Gustavo Diaz, Maria Isabel T. D. Correia, Maria Cristina Gonzalez, Mariana Reyes
Summary: This study investigated the use and validity of the Global Leadership Initiative on Malnutrition (GLIM) criteria in adult patients admitted to the intensive care unit (ICU). The results showed that 15%-68% of patients were diagnosed with malnutrition using the GLIM criteria, while 48%-75% of malnourished patients were identified with the Subjective Global Assessment (SGA). However, the use and validity of the GLIM criteria in the ICU is still limited and further studies are needed for validation.
CLINICAL NUTRITION
(2023)
Article
Microbiology
Michele M. Moraes, Thiago T. Mendes, Leandro Borges, Alice L. Marques, Cristian Nunez-Espinosa, Dawit A. P. Goncalves, Carolina B. Simoes, Tales S. Vieira, Roberto V. P. Ladeira, Talita G. B. Lourenco, Danielle V. Ribeiro, Elaine Hatanaka, Debora Heller, Rosa M. E. Arantes
Summary: Antarctic camps, with their isolated, confined, and extreme (ICE) conditions, can affect the microbiome and inflammatory responses. A 7-week expedition to Nelson Island resulted in fluctuations in the microbiome, a reduction in disease-associated microbes, and changes in inflammation markers. These findings suggest that Antarctic environments and behaviors play a role in modulating oral microbiome and inflammation.
Article
Food Science & Technology
Paulo Tulio de Souza Silveira, Maria Beatriz Abreu Gloria, Isabela Portelinha Tonin, Marina Oliveira Paraiso Martins, Priscilla Efraim
Summary: The presence and levels of bioactive amines during the processing of cocoa were investigated in this study. The fermentation time, pulp content, and cocoa variety were found to influence the content of bioactive amines. Cadaverine was detected during drying in all cocoa varieties, reaching levels of up to 17.96 mg/kg dwb. Most bioactive amines decreased during roasting, except for phenylethylamine, which increased.
Editorial Material
Nutrition & Dietetics
Diana Cardenas, M. Isabel T. D. Correia, Gil Hardy, Leah Gramlich, Tommy Cederholm, Annemieke Van Ginkel-Res, Wineke Remijnse, Albert Barrocas, Juan B. Ochoa Gautier, Olle Ljungqvist, Winnai Ungpinitpong, Rocco Barazzoni
Summary: To promote a human rights-based approach in the field of clinical nutrition, the International Working Group for Patient's Right to Nutritional Care launched the International Declaration on the Human Right to Nutritional Care in Vienna. This non-legally binding document sets a shared vision and five principles for actions that would promote access to nutritional care. Implementation programs should be based on international normative frameworks such as the UN 2030 Agenda for Sustainable Development, the Rome Declaration, and the Working Plan of the Decade of Action on Nutrition.
CLINICAL NUTRITION
(2023)
Article
Chemistry, Applied
Geisiane Santos Silva, Bruno M. Dala-Paula, Eliete S. Bispo, Maria Beatriz A. Gloria
Summary: The influence of under-fermented cocoa on bioactive amines in chocolate and their in vitro bioaccessibility was investigated. Adding different proportions of under-fermented cocoa during chocolate production can modulate the levels and bioaccessibility of amines.
Editorial Material
Nutrition & Dietetics
Diana Cardenas, M. Isabel T. D. Correia, Gil Hardy, Leah Gramlich, Tommy Cederholm, Annemieke Van Ginkel-Res, Wineke Remijnse, Albert Barrocas, Juan B. Ochoa Gautier, Olle Ljungqvist, Winnai Ungpinitpong, Rocco Barazzoni
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Chemistry, Applied
Roberto Cesar Santos de Sousa, Maria Beatriz Abreu Gloria
Summary: Brazil is facing a growing problem of overweight and obesity, and various measures have been taken to address this issue, such as reducing sugar intake and implementing new packaging labeling. As a result, the use of low or non-caloric sweeteners (LNCS) has increased. This study examined the presence of LNCS in six food groups in Brazil, and found that 17.7% of the included products contained at least one LNCS, with an average of 2.21 LNCS per sweetened product. Non-alcoholic beverages and dairy products had the highest occurrence of LNCS.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Food Science & Technology
Douglas Evangelista Braga, Rafael von Sperling de Souza, Fabiano Narciso Paschoal, Raquel Eduardo Bickel, Daniela Peralva Lima, Jose Eduardo Goncalves, Maria Beatriz Abreu Gloria
Summary: The presence of mycotoxins in meat and meat products can result from contaminated feed carry-over, processing and storage contamination, and contaminated spices and ingredients. The occurrence of mycotoxins in dry fermented sausage is described worldwide, but little information is available for Brazilian products. This study investigated the occurrence of aflatoxins (B1, B2, G1, and G2) and ochratoxin A (OTA) in dry fermented sausage using a validated dilute and shoot method.
FOOD ANALYTICAL METHODS
(2023)
Article
Engineering, Biomedical
Joana Lobato Barbosa, Mariane Izabella Abreu de Melo, Pricila da Silva Cunha, Marcelo Coutinho de Miranda, Breno Rocha Barrioni, Cheisy Daiana Freitas Moreira, Andrea da Fonseca Ferreira, Rosa Maria Esteves Arantes, Marcos Augusto de Sa, Marivalda de Magalhaes Pereira, Michele Angela Rodrigues, Silviene Novikoff, Dawidson Assis Gomes, Alfredo Miranda de Goes
Summary: In this study, a new bilayer scaffold composed of a chitosan-gelatin membrane and a chitosan-polyhydroxybutyrate (PHB) porous matrix was synthesized and populated with human adipose-derived mesenchymal stem cells (hASCs) to be potentially used for wound dressing applications. The results demonstrate that this scaffold has the potential to promote tissue regeneration in wound healing studies.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Food Science & Technology
Evelyn Mayumi H. Konagano, Nelson R. Ferreira, Gilson C. A. Chagas-Junior, Maria Beatriz A. Gloria, Eloisa Helena De Aguiar Andrade, Lidiane D. Do Nascimento, Luiza Helena Da Silva Martins, Alessandra S. Lopes
Summary: This study investigated the influence of Cladosporium cladosporioides on cocoa fermentation. It was found that the use of C. cladosporioides starter culture led to changes in the physico-chemical characteristics, phenolic compounds, free bioactive amines, and volatile compounds in fermented and dried cocoa.
JOURNAL OF FOOD AND NUTRITION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Rubio S. Bruzzi, Michele M. Moraes, Ygor A. T. Martins, Alexandre S. R. Hudson, Roberto V. P. Ladeira, Cristian Nunez-Espinosa, Samuel P. Wanner, Rosa M. E. Arantes
Summary: Short-term diving in Antarctic waters affects physiological parameters including thyroid hormone concentration, autonomic cardiac control, and body temperature, and reduces sleepiness.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Biotechnology & Applied Microbiology
Gilson Celso Albuquerque Chagas Junior, Nelson Rosa Ferreira, Maria Beatriz A. Gloria, Rubens Menezes Gobira, Felipe de Andrade Maia, Alessandra Santos Lopes
Summary: This study identified LAB in Amazonian cocoa prior to fermentation, and found five species that may contribute to enhancing the quality of chocolate.
FERMENTATION-BASEL
(2022)
Article
Multidisciplinary Sciences
Ygor A. T. Martins, Renata L. F. Passos, Alice L. Marques, Dawit A. P. Goncalves, Thiago T. Mendes, Cristian Nunez-Espinosa, Luiz O. C. Rodrigues, Samuel P. Wanner, Michele M. Moraes, Rosa M. E. Arantes, Danusa D. Soares
Summary: This study evaluated the influence of camping in Antarctica on physical performance and exercise-induced thermoregulatory responses. The results showed that camping in Antarctica improved participants' performance and elicited heat-related adaptations. Despite the acclimatization, participants did not report differences in thermal sensation and comfort.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
