期刊
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
卷 32, 期 5, 页码 578-581出版社
WILEY
DOI: 10.1177/0148607108321708
关键词
psychiatric; medications; hyperphagia; apetite; weight gain; obesity
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [U13DK064190]
- National Institutes of Health
This brief review examines hyperphagia and associated weight gain as undesirable side effects of psychiatric medications exploring the scope oil the problem, proposed mechanisms, and potential interventions. Mechanisms of action appear to include durg-mediated effects on hypothalamic appetite pathways that have been implicated in other etiologies of obesity There is great individual variation in response to these medications as well as variation in file degree of weight gain Within drug classes. Gene polymorphisms may be a key factor in determining individual variations in response. Better understanding of the underlying mechanisms can guide useful interventions. Medication selection and dosing appear to be important strategies to minimize adverse weight gain.
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