Article
Biochemistry & Molecular Biology
Erik R. P. Zuiderweg, David A. Case
Summary: There is computational and experimental evidence suggesting that proteins in solution exhibit pico-ns motions with 1 angstrom amplitude, which have a significant impact on protein function and entropy. Existing NMR relaxation experiments primarily focus on azimuthal angle variations of covalently-linked atoms, and are not sensitive to distance fluctuations. A novel NMR relaxation experiment was conducted to measure amide proton transverse relaxation rates, which depend on fluctuations of dipolar interactions between (HN)-H-1 and nearby protons on both the backbone and sidechains, providing experimental evidence of widespread motions in proteins.
Article
Physics, Fluids & Plasmas
S. V. Grigoriev, O. D. Shnyrkov, P. M. Pustovoit, E. G. Iashina, K. A. Pshenichnyi
Summary: This paper discusses Leonardo da Vinci's area-preserving rule for botanical trees, focusing on its connection to a specific fractal structure called a logarithmic fractal. Using numerical Fourier analysis, the researchers analyze the logarithmic fractal properties of the branching system of real trees in two-dimensional space, based on photographs. They find that different species of trees exhibit a Q(-2) decay in the spectral intensity, indicating a logarithmic fractal structure in the two-dimensional space. Additionally, the experiments involving the side view of the trees suggest that a rule involving the product of branch diameter and length complements Leonardo's area-preserving rule. The findings suggest that while a tree as a three-dimensional object is not a logarithmic fractal, its projection onto a two-dimensional plane is.
Article
Neurosciences
Jonathan D'Arcy Rudge
Summary: The Lipid Invasion Model (LIM) proposes that Alzheimer's disease (AD) is caused by external lipid invasion to the brain following damage to the blood-brain barrier (BBB). This hypothesis explains the observed neuropathologies and risk factors associated with AD, emphasizing the role of cholesterol and fatty acids instead of amyloid-beta. The LIM offers new perspectives for the diagnosis, prevention, and treatment of AD, and may also shed light on other neurodegenerative diseases.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Physics, Multidisciplinary
C. Schmitt, A. Lemasson, K-H Schmidt, A. Jhingan, S. Biswas, Y. H. Kim, D. Ramos, A. N. Andreyev, D. Curien, M. Ciemala, E. Clement, O. Dorvaux, B. De Canditiis, F. Didierjean, G. Duchene, J. Dudouet, J. Frankland, B. Jacquot, C. Raison, D. Ralet, B-M Retailleau, L. Stuttge, I Tsekhanovich
Summary: The isotopic distributions of fragments from the fission of neutron-deficient 178 Hg nuclide were studied, revealing a surprising dominance of the proton subsystem with atomic numbers between Z = 28 and 50. The study also compared the average fragment N/Z ratio and prompt neutron multiplicity with current knowledge from actinide fission, showing a striking consistency. Discussions on the origin of nuclear charge polarization in fission and fragment deformation at scission were also included.
PHYSICAL REVIEW LETTERS
(2021)
Article
Astronomy & Astrophysics
Zhu-Fang Cui, Daniele Binosi, Craig D. Roberts, Sebastian M. Schmidt, D. N. Triantafyllopoulos
Summary: Theory suggests that the t-channel exchange of odderon may generate differences between pp and pp over bar cross-sections. Through robust comparisons using a mathematical approach, we find significant differences between pp and pp over bar elastic differential cross-sections. Combining these results with other experiment-theory comparisons, we obtain a significant signal for the existence of odderon at the (4.0 - 5.2)sigma level.
Article
Polymer Science
Guozhang Wu, Yuanbiao Liu, Gaopeng Shi
Summary: This study explores the relationship between enthalpy hysteresis and excess enthalpy related to the glass transition temperature in glass-forming polymers. The experimental results provide a possible routine for estimating the alpha-related excess entropy of noncrystallizable polymers and validate the thermodynamic link to the kinetic fragility of glass-forming polymers.
Article
Physics, Nuclear
Manoj Kumar Sharma, Mamta Sarswat, Sushant Arora, Satyendra Kumar, Mohd Shuaib, Ishfaq Majeed, M. Shariq Asnain, B. P. Singh, R. Prasad, Vijay Raj Sharma, Abhishek Yadav, Pushpendra P. Singh, Devendra P. Singh
Summary: A systematic analysis of experimental data reveals a novel mass-energy systematics for pre-compound emission of fast neutrons in alpha-induced reactions at low energies. This analysis provides precise estimations of pre-compound contributions for nuclei within a wide range of mass numbers and emphasizes the subtle interconnection between nuclear structure and reaction mechanism at low energies.
Article
Astronomy & Astrophysics
A. Vogt, N. Eugene Engelbrecht, B. Heber, A. Kopp, K. Herbst
Summary: The aim of this study is to investigate the relationship between Jovian electron residence times and energy, in order to deepen our understanding of adiabatic energy changes during charged particle transport and validate simulation approaches. By calculating residence times and analyzing the magnetic connection between the observer and the source, as well as the distribution of exit times and resulting residence times, we found a linear relationship between residence time and kinetic energy. We also developed an improved analytical estimation that agrees with numerical residence time and observed longitudinal shift.
ASTRONOMY & ASTROPHYSICS
(2022)
Article
Chemistry, Physical
Marco Sirotti, Brice Delsaute, Stephanie Staquet
Summary: This study investigates the drying shrinkage behavior of six AAS/sodium hydroxide mortar compositions and the main factors affecting their drying shrinkage. The results show that the shrinkage magnitude is not directly correlated with the molarity of the activating solution, but increases with an increase in the solution-to-binder ratio.
Article
Biochemistry & Molecular Biology
Elmira Mohammadi, Karim Mahnam, Ali Jahanian-Najafabadi, Hamid Mir Mohammad Sadeghi
Summary: Plasminogen activators (PAs) are commonly used for treating clot-related disorders. Newer generations of PAs like tenecteplase, reteplase and desmoteplase aim to improve specificity and affinity to fibrin, resulting in safer drugs. This study introduces two new chimeric reteplase with enhanced fibrin affinity and other beneficial properties, showing better interaction between M1-chr and fibrin compared to M2-chr. Experimental assessments confirmed the mutants' appropriate enzymatic activity and increased fibrin binding ability, indicating potential cost-effective production of promising thrombolytic drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Multidisciplinary Sciences
Mathias Lechelon, Yoann Meriguet, Matteo Gori, Sandra Ruffenach, Ilaria Nardecchia, Elena Floriani, Dominique Coquillat, Frederic Teppe, Sebastien Mailfert, Didier Marguet, Pierre Ferrier, Luca Varani, James Sturgis, Jeremie Torres, Marco Pettini
Summary: In this study, the activation of resonant electrodynamic intermolecular forces was experimentally demonstrated using two independent experiments based on different physical effects detected by fluorescence correlation spectroscopy and terahertz spectroscopy, respectively. This discovery has significant implications for our understanding of biomolecular interactions and cellular dynamics.
Review
Nutrition & Dietetics
Priyanshu Bhargava, Debajit Mahanta, Ashish Kaul, Yoshiyuki Ishida, Keiji Terao, Renu Wadhwa, Sunil C. Kaul
Summary: Propolis, a resinous material produced by honeybees, has been extensively studied for its therapeutic potentials such as improving cognitive functions, antioxidant properties, and anticancer potential. The New Zealand and Brazilian green propolis are the two main types that have been widely researched. Experimental evidence has shown that propolis and its active components have the potential to be candidate drugs for different ailments, enhancing the quality of life.
Article
Multidisciplinary Sciences
Shoh Tagawa, Naoya Sakamoto, Kei Hirose, Shunpei Yokoo, John Hernlund, Yasuo Ohishi, Hisayoshi Yurimoto
Summary: This experimental study shows that hydrogen exhibits a strong siderophile behavior under conditions of core formation, and may explain a significant portion of the density deficit and sound velocity excess of the Earth's outer core compared to pure iron. Additionally, hydrogen could be an important constituent in the metallic cores of terrestrial planets or moons with a mass exceeding approximately 10% of the Earth.
NATURE COMMUNICATIONS
(2021)
Article
Physics, Nuclear
Bo Mei, Jiajun Tu, Xueheng Zhang, Shitao Wang, Yutian Guan, Ziying Mai, Ningxin Zeng, Xiaolin Tu, Zhiyu Sun, Shuwen Tang, Yuhong Yu, Fang Fang, Duo Yan, Shuya Jin, Yixuan Zhao, Shaobo Ma, Yongjie Zhang
Summary: This study validates the universality of odd-even staggering in different reaction systems and finds significant discrepancies between predicted and measured results.
Article
Multidisciplinary Sciences
Paul J. Blanchfield, John W. M. Rudd, Lee E. Hrenchuk, Marc Amyot, Christopher L. Babiarz, Ken G. Beaty, R. A. Drew Bodaly, Brian A. Branfireun, Cynthia C. Gilmour, Jennifer A. Graydon, Britt D. Hall, Reed C. Harris, Andrew Heyes, Holger Hintelmann, James P. Hurley, Carol A. Kelly, David P. Krabbenhoft, Steve E. Lindberg, Robert P. Mason, Michael J. Paterson, Cheryl L. Podemski, Ken A. Sandilands, George R. Southworth, Vincent L. St Louis, Lori S. Tate, Michael T. Tate
Summary: The 15-year experiment conducted to reduce fish MeHg concentrations by decreasing Hg additions to a boreal lake and its watershed demonstrated that any reduction in Hg loadings to lakes, whether from direct deposition or runoff, will have immediate benefits to fish consumers.
Article
Geography, Physical
James W. Hagadorn, Warren D. Allmon
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY
(2019)
Article
Geography, Physical
Katherine N. Marenco, James W. Hagadorn
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY
(2019)
Article
Geosciences, Multidisciplinary
Arturo J. Barron-Diaz, Francisco A. Paz-Moreno, James W. Hagadorn
JOURNAL OF SOUTH AMERICAN EARTH SCIENCES
(2019)
Article
Geography, Physical
Breandan Anraoi MacGabhann, James D. Schiffbauer, James W. Hagadorn, Peter Van Roy, Edward P. Lynch, Liam Morrison, John Murray
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY
(2019)
Article
Geology
Robert B. MacNaughton, James W. Hagadorn, Robert H. Dott
Article
Multidisciplinary Sciences
T. R. Lyson, I. M. Miller, A. D. Bercovici, K. Weissenburger, A. J. Fuentes, W. C. Clyde, J. W. Hagadorn, M. J. Butrim, K. R. Johnson, R. F. Fleming, R. S. Barclay, S. A. Maccracken, B. Lloyd, G. P. Wilson, D. W. Krause, S. G. B. Chester
Article
Geology
K. E. Karlstrom, M. T. Mohr, M. D. Schmitz, F. A. Sundberg, S. M. Rowland, R. Blakey, J. R. Foster, L. J. Crossey, C. M. Dehler, J. W. Hagadorn
Article
Geosciences, Multidisciplinary
Setareh Shahkarami, Luis A. Buatois, M. Gabriela Mangano, James W. Hagadorn, John Almond
PRECAMBRIAN RESEARCH
(2020)
Article
Geology
Eben B. Hodgin, Lyle L. Nelson, Corey J. Wall, Arturo J. Barron-Diaz, Lucy C. Webb, Mark D. Schmitz, David A. Fike, James W. Hagadorn, Emily F. Smith
Summary: By analyzing chemostratigraphy, biostratigraphy, and geochronology of a succession in Sonora, Mexico, researchers identified key markers of the Ediacaran-Cambrian boundary and proposed a potential link between volcanic activity and biological turnover.
Article
Geochemistry & Geophysics
Jesus Fernando Tapia-Trinidad, Arturo Joaquin Barron-Diaz, Francisco Abraham Paz-Moreno, Christopher Holm-Denoma, James W. Hagadorn
Summary: Mafic-ultramafic subvolcanic metabasalt sills in the La Cienega Formation of Sonora, Mexico, display low-grade greenschist facies metamorphism, hydrothermal alteration, and similarities to volcanic rocks of the Cerro Rajon Formation. The geological and geochemical characteristics suggest a Cambrian continental rift event and a low viscosity feeder system for the volcanic rocks.
APPLIED GEOCHEMISTRY
(2022)
Article
Geosciences, Multidisciplinary
John R. Foster, Steven D. Sroka, Thomas F. Howells, Hannah R. Cothren, Carol M. Dehler, James W. Hagadorn
Summary: We report new occurrences of scalidophorans, enteropneusts, and other soft-bodied taxa in several middle Cambrian formations of the western United States. These findings expand the geographic distribution of scalidophorans and suggest a greater diversity of scalidophorans and enteropneusts in the Wheeler ecosystems.
BULLETIN OF GEOSCIENCES
(2022)
Article
Geosciences, Multidisciplinary
Holger Petermann, Tyler R. Lyson, Ian M. Miller, James W. Hagadorn
Summary: This study introduces a new method that uses fossil turtle shells to estimate the timing and depth of fossilization and lithification. By pairing the attributes of turtle shells with geochronologic and stratigraphic data, it is possible to determine the burial histories of continental settings. The study also confirms previous hypotheses about the shallow Cenozoic burial histories of two basins.
Article
Paleontology
Simon J. Braddy, Kenneth C. Gass
Summary: This study redescribes the new combination of Palmichnium gallowayi, a trace fossil from the Middle Ordovician Martinsburg Formation, and provides insights into its behavior and life cycle. It also supports the 'mass-molt-mate' hypothesis with the earliest ichnological evidence.
JOURNAL OF PALEONTOLOGY
(2023)
Article
Paleontology
Roy E. Plotnick, Graham A. Young, James W. Hagadorn
Summary: Sea anemones, particularly Essexella asherae, have been identified as an infaunal or semi-infaunal species in the fossil-rich Mazon Creek Lagerstatte. This finding challenges previous beliefs that Essexella was a medusa and reassigns it to the order Actiniaria. The study also suggests that Essexella may have been responsible for the creation of Conostichus, a plug-shaped trace fossil found in the same region.
PAPERS IN PALAEONTOLOGY
(2023)
Article
Paleontology
Graham A. Young, James W. Hagadorn
BOLLETTINO DELLA SOCIETA PALEONTOLOGICA ITALIANA
(2020)