Article
Oncology
Laurie E. McLouth, Kaitlyn Weyman, Shannon L. Golden, Jennifer S. Cheavens, Amy Peterman, Vilma Bursac, Jennifer Gabbard, Kathryn E. Weaver
Summary: Lung cancer patients show interest in hope-enhancing interventions, with a preference for nurse-led interventions. Survey and semi-structured interview data indicate that working towards goals is beneficial, patients and caregivers like the intervention concept, and prompts and rating scales on handouts facilitate discussion. Most participants prefer nurse delivery during infusions.
Article
Oncology
Abdel Halim M. El-Kishky, Nermine Moussa, Maged W. Helmy, Medhat Haroun
Summary: This study evaluated the antitumor effects of GANT61 and BI-847325, as well as their combination, on lung cancer cells. The results showed that these drugs could inhibit tumor cell proliferation and angiogenesis, while activating the apoptotic pathway. Additionally, they had a negative impact on the interaction between tumor-related pathways. These findings provide a foundation for further research.
Review
Psychology, Multidisciplinary
David B. Feldman, Benjamin W. Corn
Summary: Two predominant models of hope in cancer literature are Snyder's Hope Theory and Herth's hope model, both of which have produced brief self-report measures. Evidence shows that hope, as defined in these models, is associated with various psychological variables in cancer patients, including depression, distress, coping, symptom burden, and post-traumatic growth. Recent studies suggest that hope may also predict survival probability in advanced cancer. Surveys indicate that patients and families generally prefer healthcare communication that honestly conveys prognosis, which does not decrease hope but may actually foster it. Several interventions have been developed to enhance hope in cancer patients, generally showing moderate effects.
CURRENT OPINION IN PSYCHOLOGY
(2023)
Review
Rheumatology
Mary-Ann Fitzcharles, Daniel J. Clauw, Winfried Haeuser
Summary: CBD, a major metabolite of Cannabis sativa, has potential as a medicinal product for pain and inflammation. However, clinical studies are lacking and there are concerns about manufacturing practices, product quality, and potential drug interactions. Sound scientific research is needed to substantiate the therapeutic use of CBD.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Oncology
Veronica Derricks, Izzy Gainsburg, Cleveland Shields, Kevin Fiscella, Ronald Epstein, Veronica Yu, Jennifer J. J. Griggs
Summary: The purpose of this study is to examine the effects of physician burnout on the quality of physicians' pain assessment and opioid prescribing for patients with advanced lung cancer, and to test whether these relationships are moderated by patient-level factors such as race and activation level. The results showed that higher levels of burnout were associated with a greater likelihood of prescribing opioids and prescribing stronger doses for patients, and these effects were not moderated by patient race or activation level.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Cell Biology
Xihan Li, Yu Chen, Jialun Wang, Chengfei Jiang, Ying Huang
Summary: Cancer-induced bone pain (CIBP) is a serious condition affecting the quality of life among tumor patients, with miRNA potentially playing a role in its development and maintenance, particularly let-7d-5p.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Mohammad Masoudi, Parisa Torabi, Robert L. Judson-Torres, Reza Khodarahmi, Sharif Moradi
Summary: Cancer, as the second leading cause of death, requires further research. Learning from natural resistance and predisposition to cancer can help design future research and develop novel cancer therapeutic strategies.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Yali Wang, Kun Zheng, Yongbiao Huang, Hua Xiong, Jinfang Su, Rui Chen, Yanmei Zou
Summary: Defects in DNA damage response can lead to cancer development, but also sensitize cells to death. PARP plays a central role in DNA repair, with inhibitors found to be effective in cancer therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Bhaskar Kumar, Stephen Lam, Mina Adam, Rachel Gilroy, Mark J. Pallen
Summary: This article discusses the potential importance of the oesophageal microbiome and introduces new research methods that offer hope for a comprehensive description of this microbial community.
TRENDS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kedar Khaparkhuntikar, Indrani Maji, Sunil Kumar Gupta, Srushti Mahajan, Mayur Aalhate, Anitha Sriram, Ujala Gupta, Santosh Kumar Guru, Prachi Kulkarni, Pankaj Kumar Singh
Summary: Drug repurposing is a groundbreaking concept in cancer research that investigates the anti-cancer activity of approved drugs, accelerating drug discovery. ACL, a known drug for hematological malignancies, was evaluated for its therapeutic ability against breast and lung cancer using computational methods.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Natalia Krzyzanowska, Kamila Wojas-Krawczyk, Janusz Milanowski, Pawel Krawczyk
Summary: Immunotherapy with immune checkpoint inhibitors has become a leading treatment for non-small-cell lung cancer. While effective, resistance and adverse events are challenges, leading to the exploration of alternatives and discovery of new drugs and targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Anna Maria Rzewuska, Monika Zybowska, Ilona Sajkiewicz, Izabela Spiechowicz, Klaudia Zak, Monika Abramiuk, Krzysztof Kulak, Rafal Tarkowski
Summary: Endometriosis is a chronic disease characterized by the presence of endometrial-like tissue outside the uterus. These lesions, which can be found in various locations such as the pelvic region and other extragenital areas, cause symptoms like pain and infertility that greatly impact the patient's quality of life. Pharmacological management, particularly through the use of gonadotropin-releasing hormone (GnRH) antagonists, has become increasingly important in treating endometriosis. These antagonists work by regulating the hormonal axis and reducing estrogen levels, thereby preventing disease progression and reducing recurrence after surgical removal. This review highlights the significant role of oral GnRH antagonists as a treatment option for pain reduction in endometriosis patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Alesha A. Thai, Benjamin J. Solomon, Lecia Sequist, Justin F. Gainor, Rebecca S. Heist
Summary: The seminar highlights significant advancements in screening, diagnosis, and treatment of lung cancer in the past two decades, with a specific focus on targeted therapies and immune checkpoint inhibitors. These progressions have transformed outcomes for many patients.
Article
Oncology
Wei Dai, Shuai Chang, Cecilia Pompili, Bin Qiu, Xing Wei, Yunfei Mu, Rui Zhang, Cheng Shen, Qiuling Shi, Qiang Li, Zhong Wu, Guowei Che
Summary: The study found that in patients with small-sized peripheral non-small-cell lung cancer, thoracoscopic segmentectomy and lobectomy resulted in similar symptom burden and functional impairment during the early postoperative period. Short-term clinical outcomes were also comparable between the two surgical procedures.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nicolas Zhou, Jiangong Niu, David Nelson, Hope A. Feldman, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Boris Sepesi, Stephen G. Swisher, Garret L. Walsh, Sharon H. Giordano, Ravi Rajaram
Summary: Robotic and VATS approaches for lung resection can reduce the persistent use of opioids after surgery. Persistent opioid use is common among the entire patient cohort, but patients who undergo robotic and VATS procedures have lower rates of persistent opioid use.
ANNALS OF THORACIC SURGERY
(2023)
Article
Oncology
Yufen Lin, Donald E. Bailey, Sharron L. Docherty, Laura S. Porter, Bruce A. Cooper, Steven M. Paul, Marilyn J. Hammer, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
Summary: This study identified distinct subgroups of patients with gastrointestinal cancers who experience different levels of sleep disturbance, and found differences among these subgroups in demographic, clinical, and sleep characteristics, as well as co-occurring symptoms and quality of life outcomes. This provides new insights into the associations between sleep disturbance and multiple symptoms in these patients.
Article
Health Care Sciences & Services
Joseph G. Winger, Katherine Ramos, Sarah A. Kelleher, Tamara J. Somers, Karen E. Steinhauser, Laura S. Porter, Arif H. Kamal, William S. Breitbart, Francis J. Keefe
Summary: This study examined the feasibility and acceptability of a behavioral pain management intervention, MCPC, for patients with advanced cancer pain. Results showed high completion rates, satisfaction, and improvement in primary and secondary outcomes. The findings suggest further evaluation of MCPC in a randomized controlled trial is warranted.
JOURNAL OF PALLIATIVE MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Shelby L. Langer, Joan M. Romano, Francis Keefe, Donald H. Baucom, Timothy Strauman, Karen L. Syrjala, Niall Bolger, John Burns, Jonathan B. Bricker, Michael Todd, Brian R. W. Baucom, Melanie S. Fischer, Neeta Ghosh, Julie Gralow, Veena Shankaran, S. Yousuf Zafar, Kelly Westbrook, Karena Leo, Katherine Ramos, Danielle M. Weber, Laura S. Porter
Summary: Cancer and its treatment present challenges for patients and their partners, impacting their psychological adjustment and relationship quality. Effective communication between couples plays a crucial role in their well-being. This project aims to examine and compare two conceptual models of couple communication and evaluate different assessment methods. The results will inform theory, measurement, and the development of effective interventions to optimize the well-being of both patients and partners.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Kristina M. Post, David A. Smith, John W. Burns, Laura S. Porter, Francis J. Keefe
Summary: This study examined the associations between depressed affect, criticism, and support among individuals with chronic low back pain and their spouses. The results showed that higher levels of depressed affect were related to more criticism and less support. There were bidirectional relationships between spouse's own depressed affect and criticism. Spouse's depressed affect was also associated with decreased support from individuals with chronic low back pain.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Health Policy & Services
Laura S. Porter, Debra K. Weiner, Katherine Ramos, Deborah E. Barnes, Kenneth E. Schmader, Lisa Gwyther, Christine S. Ritchie, Francis J. Keefe
Summary: The study developed a new caregiver-assisted pain coping skills training protocol tailored for community-dwelling individuals with cognitive impairment, and a single-arm pilot test showed that the intervention was feasible and acceptable. The preliminary findings suggest that the caregiver-assisted pain coping skills intervention may be a promising approach to managing pain in patients with cognitive impairment, with positive feedback from participants and high completion rates.
PALLIATIVE & SUPPORTIVE CARE
(2022)
Article
Medicine, General & Internal
Normarie Torres Blasco, Rosario Costas Muniz, Carolina Zamore, Laura Porter, Maria Claros, Guillermo Bernal, Megan Johnson Shen, William Breitbart, E. M. Castro
Summary: This study aims to culturally adapt a psychosocial intervention protocol called 'Caregivers-Patients Support to Latinx coping advanced-cancer' (CASA) by combining two evidence-based interventions and adapting them to improve the sense of meaning and communication among patients with advanced cancer and their caregivers.
Article
Health Care Sciences & Services
James Gerhart, Katherine Ramos, Laura S. Porter, Scott Ravyts, Sonia Malhotra, Brenna Mossman, Ashley Eaton England, Sarah Alonzi, Tristen Peyser, Seowoo Kim, Sean O'Mahony, John W. Burns, Michael Hoerger
Summary: Seriously ill patients often suffer from persistent pain. Behavioral pain management, a part of comprehensive pain interventions, can be used by palliative care clinicians to reduce pain intensity and improve functional outcomes and quality of life. By promoting helpful behaviors and modifying underlying patterns of thinking, feeling, and communicating, behavioral interventions are effective in managing persistent pain. This article by experts in various fields provides a review of the current evidence and 10 recommendations for behavioral pain management.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Oncology
Joseph G. Winger, Sarah A. Kelleher, Katherine Ramos, Devon K. Check, Justin A. Yu, Victoria D. Powell, Reginald Lerebours, Maren K. Olsen, Francis J. Keefe, Karen E. Steinhauser, Laura S. Porter, William S. Breitbart, Tamara J. Somers
Summary: This study examined the feasibility and initial effects of a cognitive-behavioral pain management intervention called Meaning-Centered Pain Coping Skills Training (MCPC) in patients with advanced cancer. The results showed that participants who received MCPC reported better pain severity, pain interference, and pain self-efficacy scores compared to the control group. Therefore, MCPC appears to be a promising approach for improving pain management in advanced cancer patients.
Article
Psychology, Multidisciplinary
Danielle M. Weber, Brian R. W. Baucom, Donald H. Baucom, Melanie S. Fischer, Katherine Ramos, Joan M. Romano, Laura S. Porter, Shelby L. Langer
Summary: This study examined how couples' emotional arousal in cancer conversations relates to well-being. Couples who started the conversation with higher emotional arousal had better initial well-being, and couples who remained higher in arousal later in the conversation improved in their individual well-being over time. If the non-cancer partner had lower arousal compared with patients, this predicted worse well-being over time.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Yufen Lin, Laura S. Porter, Wonshik Chee, Olatunji B. Alese, Kimberly A. Curseen, Melinda K. Higgins, Laurel Northouse, Canhua Xiao
Summary: The study aims to develop a web-based dyadic intervention for colorectal cancer patients receiving chemotherapy and their caregivers, and evaluate its feasibility, acceptability, and preliminary effects. The findings are expected to guide the development and implementation of interventions for symptom management and palliative care for cancer patients and their caregivers.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Respiratory System
Christopher E. Cox, Sarah A. Kelleher, Alice Parish, Maren K. Olsen, Santos Bermejo, Katelyn Dempsey, Jennie Jaggers, Catherine L. Hough, Marc Moss, Laura S. Porter
Summary: This study examines the feasibility and clinical impact of a self-guided mobile app-based coping skills program called Blueprint for patients with cardiorespiratory failure. The results suggest that Blueprint has the potential to reduce psychological distress symptoms and improve quality of life in this population. Further large-scale trials are needed to confirm its efficacy.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Elias H. Pratt, Levent Hall, Christina Jennings, Maren K. Olsen, Adina Jan, Alice Parish, Laura S. Porter, Christopher E. Cox
Summary: The COVID-19 pandemic has had a negative impact on the mental health of frontline healthcare workers. This study investigated the feasibility and effects of mobile mindfulness in treating psychological distress and burnout among nurses working in COVID-19 units. The intervention showed promising results in reducing depression symptoms, but did not have a significant effect on burnout.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Health Care Sciences & Services
Hailey N. Miller, Corrine Voils, Kate A. Cronin, Elizabeth Jeanes, Jeffrey Hawley, Laura S. Porter, Rachel R. Adler, Whitney Sharp, Samantha Pabich, Kara L. Gavin, Megan A. Lewis, Heather M. Johnson, William S. Yancy, Kristen E. Gray, Ryan J. Shaw
Summary: This study describes the development and use of two REDCap databases to deliver automated intervention content and communication. The approach provides a framework for future behavioral health interventions to create an accessible, reliable, and affordable method for intervention delivery and engagement.
JMIR FORMATIVE RESEARCH
(2022)
Meeting Abstract
Oncology
Zachary Rivers, Veena Shankaran, Laura S. Porter, Shelby Langer
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Zachary Rivers, Veena Shankaran, Laura S. Porter, Shelby Langer
JOURNAL OF CLINICAL ONCOLOGY
(2022)