Article
Multidisciplinary Sciences
Youqiang Sun, Mengmeng Liang, Yuemeng Xing, Yinfan Duan, Shuangxiao Zhang, Baogui Deng, Xiaobing Xiang, Bengen Zhou
Summary: Cyasterone alleviates apoptosis of rat BMSCs induced by Dexamethasone through the PI3K/AKT signaling pathway and promotes bone repair in SIONFH rats by reducing the percentage of empty bone lacunae.
Article
Food Science & Technology
Puji Peng, Xuezhong Wang, Chen Qiu, Wendi Zheng, Hongjun Zhang
Summary: Extracellular vesicles secreted by human umbilical cord mesenchymal stem cells play an important role in the prevention and treatment of steroid-induced avascular necrosis of the femoral head.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Orthopedics
Guo-Shuang Zheng, Xing Qiu, Ben-Jie Wang, De-Wei Zhao
Summary: This study investigated the collapse mechanism in osteonecrosis of the femoral head (ONFH) by studying the relationship between changes in femoral head blood circulation and histomorphometry characteristics of the collapse area. The results showed that the collapse in ONFH always involved the margin of the necrotic lesion of the lateral column and started at the lateral column, which was ischemic. Preserving a portion of the blood supply to the lateral column improved the prognosis and delayed collapse. Measurement of blood flow in the lateral area of the femoral head can predict collapse and guide clinical therapy.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Qiu-Shi Wei, Zi-Qi Li, Zhi-Nan Hong, Guo-Ju Hong, Feng-Xiang Pang, Peng Yang, Fan Yang, Ying-Jia Yuan, Zhi-Kun Zhuang, Wei He
Summary: In this retrospective study of ONFH patients, the CPA was found to be a stronger predictor of femoral head collapse compared to other factors, with a higher accuracy and sensitivity.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Biotechnology & Applied Microbiology
Sumit Murab, Teresa Hawk, Alexander Snyder, Sydney Herold, Meghana Totapally, Patrick W. Whitlock
Summary: Avascular necrosis (AVN) of the femoral head commonly leads to symptomatic osteoarthritis of the hip. While hip replacement is a viable option for older patients, it poses significant challenges for pediatric, adolescent, and young adult patients. Early detection is vital, but current diagnostic techniques are not sensitive enough. Various surgical techniques exist to prevent disease progression, but their effectiveness is limited, and more research is needed in tissue engineering for a potential long-term solution.
BIOENGINEERING-BASEL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoo Sung Song, Won Woo Lee, Moon Seok Park, Nak Tscheol Kim, Ki Hyuk Sung
Summary: Quantitative bone SPECT/CT is useful in predicting the occurrence of AVN in pediatric patients with SCFE or femoral neck fracture, especially in patients with a decreased mean SUV ratio.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yusong Zhang, Limin Ma, Erhai Lu, Wenhua Huang
Summary: This study found that Ato can alleviate SANFH, inhibit apoptosis, and promote autophagy. miR-186 was significantly upregulated after Ato treatment, targeting TLR4 and inactivating the MAPKs/NF-kappa B pathway. Inhibition of miR-186 reversed the protection of Ato on SANFH rats, while inhibition of TLR4 restored the protective effect of Ato. Ato reduced apoptosis and promoted autophagy of OB-6 cells by upregulating miR-186 and inhibiting the TLR4/MAPKs/NF-kappa B pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Hongliang Wu, Guocheng Chen, Guibao Zhang, Qiang Lv, Di Gu, Minhua Dai
Summary: This study investigated the regulatory effect and molecular mechanism of VEC-derived Exos modified with VEGF in osteogenic and adipogenic differentiation of BMSCs in SANFH. The results showed that VEGF-VEC-Exos promoted osteogenic differentiation and suppressed adipogenic differentiation of BMSCs. Furthermore, VEGF-VEC-Exos activated the MAPK/ERK pathway in BMSCs, thereby promoting osteoblast differentiation and inhibiting adipogenic differentiation. Hence, VEGF-VEC-Exos could be a potential therapeutic approach for treating SANFH.
BIOMEDICAL MATERIALS
(2023)
Review
Medicine, General & Internal
Jeremy T. Hines, Woo Lam Jo, Quanjun Cui, Michael A. Mont, Kyung Hoi Koo, Edward Y. Cheng, Stuart B. Goodman, Yong Chan Ha, Phillippe Hernigou, Lynne C. Jones, Shin Yoon Kim, Takashi Sakai, Nobuhiko Sugano, Takuaki Yamamoto, Mel S. Lee, Dewei Zhao, Wolf Drescher, Tae Young Kim, Young Kyun Lee, Byung Ho Yoon, Seung Hoon Baek, Wataru Ando, Hong Seok Kim, Jung Wee Park
Summary: Non-traumatic osteonecrosis of the femoral head (ONFH) predominantly affects adults younger than 50 years, leading to femoral head collapse and hip arthritis. The use of corticosteroids for leukemia and organ transplantation has contributed to the increasing prevalence of ONFH.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Crim, Lester J. Layfield, James Derek Stensby, Robert L. Schmidt
Summary: Radiography is useful in depicting osteonecrosis in most patients undergoing femoral head resection, but there are false-positive and false-negative findings. Diagnostic difficulty increases in patients with advanced osteoarthritis or subchondral fractures, leading to increased uncertainty for both radiologic and pathologic evaluations. The accuracy of MRI for osteonecrosis evaluation requires further study due to limited patient numbers.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shan Shi, Ping Luo, Li Sun, Limin Xie, Tong Yu, Zhenchang Wang, Xuedong Yang
Summary: The study found that the initial bone resorption lesion in ARCO Stage 2-3A ONFH can predict femoral head collapse progression. A threshold MAC of 49 mm(2) was identified for predicting rapid progression, with higher areas in specific regions indicating a higher likelihood of collapse.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin Huang, Fei Hu, Raphael N. Alolga, Xiaojian Yin
Summary: This study characterized the cartilage protein profiles of patients with AVNFH and identified potential proteins involved in the progression of AVNFH using proteomics technique. The significantly changed proteins were mainly involved in ECM-receptor interaction, focal adhesion, and glycolysis pathways. The marker proteins could help us understand the pathogenesis of AVNFH.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Medicine, General & Internal
Adrian Cardin-Pereda, Daniel Garcia-Sanchez, Nuria Teran-Villagra, Ana Alfonso-Fernandez, Michel Fakkas, Carlos Garces-Zarzalejo, Flor Maria Perez-Campo
Summary: Osteonecrosis of the Femoral Head (ONFH) is a disabling disease with challenging diagnosis and staging, relying on imaging studies and anatomopathological analysis. Disagreements between different healthcare specialists are common. The study found a high degree of histological confirmation for clinico-radiological diagnosis of ONFH, but only moderate agreement between radiologists and orthopedic surgeons.
Article
Orthopedics
Kyung-Hoi Koo, Michael A. Mont, Quanjun Cui, Jeremy T. Hines, Byung-Ho Yoon, Wendy M. Novicoff, Yun Jong Lee, Edward Y. Cheng, Wolf Drescher, Philippe Hernigou, Shin-Yoon Kim, Nobuhiko Sugano, De-Wei Zhao, Yong-Chan Ha, Stuart B. Goodman, Takashi Sakai, Lynne C. Jones, Mel S. Lee, Takuaki Yamamoto, Young-Kyun Lee, Yusuhn Kang, James Burgess, Dennis Chen, Nicole Quinlan, Jian Zhong Xu, Jung-Wee Park, Hong-Seok Kim
Summary: A novel classification for early stage osteonecrosis of the femoral head (ONFH) was developed and compared to three previous classifications. The results demonstrate that the novel classification is more reliable and valid, and has better predictive ability for future femoral head collapse.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Antonin Chochola, Jan Bartonicek, Pavel Dousa, Michal Tucek
Summary: The study evaluates the long-term results of valgus intertrochanteric osteotomy (VITO) in adolescents with avascular necrosis of the femoral head (ANFH) after femoral neck fracture. VITO can improve the function of the hip joint, but cannot completely restore the original shape and structure of the femoral head.
BMC MUSCULOSKELETAL DISORDERS
(2023)