Article
Materials Science, Ceramics
Xinyuan Yuan, Tingting Wu, Teliang Lu, Fupo He, Peng Chen, Ning Ma, Jiandong Ye
Summary: This study incorporated three types of micro nano magnesium-containing silicates into calcium phosphate cement to improve its osteogenic and angiogenic performances. The results showed that all modified cements had good biomineralization and significantly stimulated the differentiation of bone and blood vessel cells. Akermanite was identified as the ideal modifier with appropriate physicochemical properties and better bone regeneration potential.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Zilgma Irbe, Dagnija Loca
Summary: Premixed calcium phosphate cement pastes have been proposed as biomaterials for bone tissue repair and regeneration, with alpha-Tricalcium phosphate (alpha-TCP) based cements setting to form calcium deficient hydroxyapatite. The use of mixture of basic and acidic potassium phosphate salts showed the best overall results in terms of cohesion, pH value, hydrolysis, and compressive strength of the cement.
CERAMICS INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Lijuan Sun, Tongyang Li, Sen Yu, Mengmeng Mao, Dagang Guo
Summary: A novel strontium-substituted calcium phosphate bone cement (Sr-CPC) was developed and its physicochemical properties and hydration mechanism were intensively investigated. The compressive strength of Sr-CPC tended to increase with the extension of hydration time, while cytocompatibility was favorable at low strontium contents. The effect of strontium ions on cytocompatibility of Sr-CPC was not significant.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Eaman T. Karim, Veronika Szalai, Lonnie Cumberland, Alline F. Myers, Shozo Takagi, Stanislav A. Frukhtbeyn, Ileana Pazos, Laurence C. Chow
Summary: In this study, carbonate-containing hydroxyapatite (CHA) was synthesized using a self-hardening calcium phosphate cement (CPC) and its paramagnetic properties following gamma-irradiation were investigated. The results suggest that CHA synthesized via CPC cement is a promising substrate for electron paramagnetic resonance (EPR)-based dosimetry applications.
INORGANIC CHEMISTRY
(2022)
Article
Construction & Building Technology
Ting Zhang, Baoguo Ma, Hongbo Tan, Huahui Qi, Tao Shi
Summary: This study found that sodium carbonate and sodium phosphate have different effects on the hydration of cement based on the structure of the precipitates formed, where calcium carbonate precipitate accelerated cement hydration while calcium phosphate precipitate retarded it. The composition and structure of the precipitates were responsible for these effects, with calcium carbonate providing interspace for easier ion dissolution and calcium phosphate forming a more compact layer structure that hindered the transport of water molecules and ions.
JOURNAL OF BUILDING ENGINEERING
(2022)
Article
Green & Sustainable Science & Technology
Yue Ma, Yunlong Luo, Hongyan Ma, Xintao Zhou, Zhongqiu Luo
Summary: This study utilized steel slag powder (SSP) as the raw material to prepare iron-calcium phosphate cement (ICPC) by reacting with ammonium dihydrogen phosphate (ADP). The effects of the raw material mass ratios on the properties and microstructures of ICPC pastes were investigated. The study found that the compressive strengths of ICPC pastes initially increased and then decreased with the increase of SSP/ADP, and the ratio of 6.0 gave the highest strength. Crystalline mundrabillaite and amorphous phases were formed as the main binding phases through reactions between calcium-containing compounds in the steel slag and ADP, and ADP also reacted with free FeO in the steel slag to yield amorphous iron phosphate phase. BSE analysis showed that hydration products formed and grew on the surface of steel slag particles, forming a continuous, dense microstructure of ICPC paste. The utilization of high-volume steel slag as the base component can bring significant economic and environmental benefits in the manufacture of phosphate cement.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Chemistry, Multidisciplinary
Chao Xu, Yuhao Xia, Pengzhen Zhuang, Wenliang Liu, Congpu Mu, Zhongyuan Liu, Jianglin Wang, Lili Chen, Honglian Dai, Zhiqiang Luo
Summary: To address the challenges of postsurgical tumor recurrence and extensive bone defect in osteosarcoma treatment, researchers have developed an advanced artificial bone substitute that can achieve synergistic bone regeneration and tumor therapy. This multifunctional calcium phosphate composite incorporates bioactive FePSe3-nanosheets within a cryogenic-3D-printed alpha-tricalcium phosphate scaffold (TCP-FePSe3), and demonstrates remarkable tumor ablation ability and the ability to suppress tumor recurrence by releasing selenium element.
Article
Chemistry, Physical
Wu-Jiu Jiang, Yu-Xing Tan, Yang Fu, Yi-Yuan Peng
Summary: Five diorganotin complexes were synthesized and characterized, and it was found that C2 exhibited strong antitumor activity and interacted with DNA through intercalation.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Construction & Building Technology
Danqian Wang, Zhicheng Liu, Changhui Yang
Summary: This study explores the passivation of mild steel embedded in magnesium potassium phosphate cement-calcium sulphoaluminate cement blended paste. The results show that adding 30% calcium sulphoaluminate in magnesium potassium phosphate cement leads to higher passivity of mild steel compared to Portland cement paste. The increased passivity is attributed to the higher pH and phosphate concentration in the pore solution, as well as the formation of iron phosphate and Fe2+ oxide in the passive film of MKPC-30%CSA.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Engineering, Biomedical
Kiana Kiakojoori, Farhood Najafi, Maryam Torshabi, Sohrab Kazemi, Sayed Mahmood Rabiee, Hanieh Nojehdehian
Summary: This study describes the synthesis and characterization of a calcium phosphate cement (CPC) with polyetheretherketone/poly (lactic-co-glycolic) acid (PEEK/PLGA) microparticles containing quercetin. The addition of quercetin-containing microparticles enhanced the compressive strength and controlled the drug release of CPC, while also up-regulating the expression of osteoblastic differentiation genes.
BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Vetharaj HephzibahRajam Arkin, Uttamchand Narendrakumar, Harishkumar Madhyastha, Inderchand Manjubala
Summary: Injectable calcium phosphate cement is a promising biomaterial for hard tissue repair, with recent developments in magnesium and strontium-doped cements showing improved setting time, mechanical strength, and cell attachment. The research aims to develop suitable self-setting cements with good biocompatibility, utilizing synthesized hydroxyapatite and additives for enhanced properties.
Article
Engineering, Biomedical
Yeeun Kim, Kenichi Hamada, Kazumitsu Sekine
Summary: The effects of adding poloxamer to modified beta-tricalcium phosphate on cellular activity were investigated. The results showed that even with the addition of poloxamer, it did not have a negative effect on osteoblast growth.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Environmental Sciences
Maksym Avramenko, Kazunori Nakashima, Chikara Takano, Satoru Kawasaki
Summary: This research investigates the consolidation of sand samples using the enzyme induced calcium phosphate precipitation (EICPP) method, with tuna bones as an alternative source of calcium and phosphorus ions. The results showed increased strength in the soil and significant reduction in ammonia emissions compared to the traditional ureolytic induced calcite precipitation (UICP) method.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Ru Bai, Ju Zhang, Changwang Yan, Shuguang Liu, Xiaoxiao Wang, Zhijie Yang
Summary: This study demonstrates that different replacement rates of CSS can effectively reduce the CH content in cementitious composites and increase the hydration degree of cement. The utilization of CSS provides a new method for the reuse of cement waste.
Article
Chemistry, Multidisciplinary
Meng Yin, Yongsheng Fang, Xiaotong Sun, Minggao Xue, Caimei Zhang, Zhiyun Zhu, Yamiao Meng, Lingmei Kong, Yi Yi Myint, Yan Li, Jingfeng Zhao, Xiaodong Yang
Summary: Three series of podophyllotoxin derivatives were synthesized with various nitrogen-containing heterocycles. The antitumor activity of these derivatives was evaluated against human tumor cell lines in vitro. The results showed that podophyllotoxin-imidazolium salts and podophyllotoxin-1,2,4-triazolium salts a1-a20 exhibited excellent cytotoxic activity, with a6 being the most potent compound. Podophyllotoxin-1,2,3-triazole derivatives b1-b5 showed medium cytotoxic activity, while podophyllotoxin-amine compounds c1-c3 displayed good cytotoxic activity. Further experiments revealed that compound a6 induced G2/M cell cycle arrest and apoptosis in HCT-116 cells.
FRONTIERS IN CHEMISTRY
(2023)
Article
Oncology
Yohei Asano, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Hirotaka Yonezawa, Yoshihiro Araki, Sei Morinaga, Shiro Saito, Takayuki Nojima, Hiroyuki Tsuchiya
Summary: This study found that appendicular skeletal metastases of primary tumors with rapid growth speed have a higher risk of developing pathological fractures early after the diagnosis of skeletal metastases, and the prognosis may be poor.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Yoshihiro Araki, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano, Hiroyuki Tsuchiya
Summary: This study found that a high platelet-lymphocyte ratio and low absolute lymphocyte count were independent risk factors significantly associated with metastasis in osteosarcoma patients. These findings contribute to the identification of new indicators for predicting metastasis risk in osteosarcoma.
ANTICANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Shinji Miwa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Hiroyuki Tsuchiya
Summary: Chondrosarcomas develop resistance to standard anticancer drugs, making it challenging to control the disease. New treatment approaches, such as molecule-targeting agents and immunotherapy, are needed. Recent studies have identified promising biomarkers and therapeutic targets for chondrosarcoma, and various molecule-targeting agents and immunotherapies have shown favorable antitumor activity in clinical studies. This review summarizes recent research on biomarkers and therapeutic targets, as well as clinical studies on the treatment of chondrosarcomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yohei Asano, Shinji Miwa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Hirotaka Yonezawa, Yoshihiro Araki, Sei Morinaga, Takayuki Nojima, Hiroko Ikeda, Hiroyuki Tsuchiya
Summary: This study evaluated the diagnostic accuracy of various examinations for differential diagnosis between atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) and lipoma, and developed a new combined scoring system for preoperative diagnosis. The scoring system based on six predictive factors achieved high diagnostic accuracy without requiring special equipment and reagents.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Sei Morinaga, Akihiko Takeuchi, Norio Yamamoto, Katsuhiro Hayashi, Shinji Miwa, Kentaro Igarashi, Hirotaka Yonezawa, Yohei Asano, Shiro Saito, Takayuki Nojima, Hiroyuki Tsuchiya
Summary: This study analyzed the relationship between various factors, especially tumor location and clinical outcome, in patients with primary soft tissue sarcoma of the thigh. The results showed that soft tissue sarcomas in the medial compartment were associated with postoperative seroma and metastasis, while sarcomas in the anterior compartment correlated with low postoperative function.
ANTICANCER RESEARCH
(2022)
Article
Orthopedics
Akihiko Takeuchi, Norio Yamamoto, Takaaki Ohmori, Katsuhiro Hayashi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Hirotaka Yonezawa, Sei Morinaga, Yoshihiro Araki, Yohei Asano, Shiro Saito, Hiroyuki Tsuchiya
Summary: Giant cell tumor of bone (GCTB) is an intermediate tumor commonly treated with surgery to preserve the joint. Calcium phosphate cement (CPC) is an artificial bone substitute used for defect adjustment and promoting healing. This study presents a case of secondary osteoarthritis after CPC packing for GCTB curettage that was successfully treated with total knee arthroplasty (TKA) using a computed tomography (CT)-free navigation system.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshihiro Araki, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano, Takayuki Nojima, Junichi Taki, Hiroyuki Tsuchiya
Summary: The viability of devitalized bone grafts in frozen autograft reconstruction after malignant bone tumor excision was evaluated using Tc-99m-MDP scans. The results showed that the viability of bone grafts recovered within 60 months postoperatively, and this method can also predict postoperative complications.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yoshihiro Araki, Norio Yamamoto, Yoshikazu Tanzawa, Takahiro Higashi, Aya Kuchiba, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Makoto Endo, Eisuke Kobayashi, Hiroyuki Tsuchiya, Akira Kawai
Summary: Understanding the etiology, lifestyle epidemiology, and treatment circumstances of sarcoma is crucial for effective prevention and treatment. Research suggests that personal and family cancer history, as well as smoking habit, are associated with the development of certain types of sarcoma.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Shinji Miwa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Hiroyuki Tsuchiya
Summary: Surgical site infection (SSI) is a serious complication in the treatment of malignant bone tumors, adversely affecting functional and oncological outcomes. To improve surgical outcomes, preoperative risk assessments for SSIs, new preventive techniques, and optimal use of prophylactic antibiotics are required.
Article
Oncology
Akihiko Takeuchi, Makoto Endo, Akira Kawai, Yoshihiro Nishida, Ryu Terauchi, Akihiko Matsumine, Hisaki Aiba, Tomoki Nakamura, Susumu Tandai, Toshifumi Ozaki, Manabu Hoshi, Daiki Kayano, Miho Okuda, Norio Yamamoto, Katsuhiro Hayashi, Shinji Miwa, Kentaro Igarashi, Kenichi Yoshimura, Akihiro Nomura, Toshinori Murayama, Hiroyuki Tsuchiya
Summary: This study evaluated the safety and efficacy of zaltoprofen in patients with TGCT. There were no significant differences in PFR between the zaltoprofen group and placebo group at 48 weeks. Zaltoprofen treatment significantly improved physical function and was deemed safe for patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Takashi Higuchi, Akihiko Takeuchi, Seiichi Munesue, Norio Yamamoto, Katsuhiro Hayashi, Ai Harashima, Yasuhiko Yamamoto, Hiroyuki Tsuchiya
Summary: The nonsteroidal anti-inflammatory drug zaltoprofen induces the expression of PPAR gamma in human extraskeletal chondrosarcoma cells and inhibits their proliferation. Zaltoprofen treatment also inhibits tumor growth and induces tumor cell apoptosis in a mouse model of extraskeletal myxoid chondrosarcoma. These findings suggest the potential use of zaltoprofen as an effective treatment for sarcomas.
Article
Orthopedics
Akihiko Takeuchi, Hiroyuki Tsuchiya, Nokitaka Setsu, Tabu Gokita, Yasunori Tome, Naofumi Asano, Yusuke Minami, Hiroyuki Kawashima, Suguru Fukushima, Satoshi Takenaka, Hidetatsu Outani, Tomoki Nakamura, Satoshi Tsukushi, Teruya Kawamoto, Teruki Kidani, Munehisa Kito, Hiroshi Kobayashi, Takeshi Morii, Toru Akiyama, Tomoaki Torigoe, Koji Hiraoka, Akihito Nagano, Shigeki Kakunaga, Kazuhiko Hashimoto, Makoto Emori, Hisaki Aiba, Yoshikazu Tanzawa, Takafumi Ueda, Hirotaka Kawano
Summary: Tumor-devitalized autografts are a biological reconstruction option that offers advantages such as reduced immunological response, better site match, and no need for a bone bank. However, they also have limitations including inability to assess tumor margins, limited healing potential, and decreased biomechanical strength. Limited data is available on the outcomes of this procedure, making it important for further research.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Oncology
Yohei Asano, Norio Yamamoto, Satoru Demura, Katsuhiro Hayashi, Akihiko Takeuchi, Satoshi Kato, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Yuta Taniguchi, Sei Morinaga, Takashi Sone, Miho Okuda, Isao Matsumoto, Seiji Yano, Hiroyuki Tsuchiya
Summary: This retrospective study investigated the therapeutic effects of immune checkpoint inhibitors (ICIs) and identified predictors of favorable response and prognosis in advanced non-small-cell lung cancer (NSCLC) patients with bone metastases. The study found a response rate of 30.9% and a median survival time of 9.3 months. Factors such as female sex, use of ICIs as first-line therapy, and pretreatment neutrophil-to-lymphocyte ratio (NLR) less than 2.1 were identified as predictors of therapeutic response, while concomitant use of a bone-modifying agent, Katagiri score <= 6 points, and NLR <2.1 were identified as predictors of good prognosis.
Article
Oncology
Munehisa Kito, Keisuke Ae, Masanori Okamoto, Makoto Endo, Kunihiro Ikuta, Akihiko Takeuchi, Naohiro Yasuda, Taketoshi Yasuda, Yoshinori Imura, Takeshi Morii, Kazutaka Kikuta, Teruya Kawamoto, Yutaka Nezu, Ichiro Baba, Shusa Ohshika, Takeshi Uehara, Takafumi Ueda, Jun Takahashi, Hirotaka Kawano
Summary: This study aimed to analyze the clinical outcomes of patients with low-grade myofibroblastic sarcoma (LGMS). Surgical treatment was the main approach, with radiotherapy considered as a viable option in cases where surgery was not feasible or may cause significant functional impairment.
Article
Pediatrics
Hisaki Aiba, Michi Kamei, Yasuhiko Ito, Risa Takeda, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi, Shinji Miwa, Yohei Kawaguchi, Shiro Saito, Takao Sakai, Hideki Murakami, Hiroaki Kimura
Summary: This study reports the use of carboplatin as a substitute for cisplatin in the treatment of osteosarcoma, and the efficacy of a CBDCA-based regimen in the neoadjuvant setting was found to be limited. Therefore, it was considered insufficient for performing adequate surgery.