Article
Veterinary Sciences
Vivian G. Quam, Nadine N. Altmann, Matthew T. Brokken, Sushmitha S. Durgam
Summary: This study aimed to isolate and characterize tendon-derived cells from DDFT in horses, identifying potential cells in the podotrochlear bursa that may enhance healing of DDFT injuries. Promoting chondrogenic properties in cells administered for intrasynovial tendon regeneration could be beneficial.
BMC VETERINARY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Min-Seob Kim, Se-Eun Ha, Moxin Wu, Hannah Zogg, Charles F. Ronkon, Moon-Young Lee, Seungil Ro
Summary: The composition and changes of the cellular microenvironment play a crucial role in cancer development, with alterations in the ECM significantly impacting the tumor microenvironment. ECM components are important in colorectal cancer and have potential roles as biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Shichen Zhang, Wei Ju, Xiaoyi Chen, Yanyan Zhao, Lingchong Feng, Zi Yin, Xiao Chen
Summary: This review summarizes recent research on the structure and function of the extracellular matrix (ECM) components of tendons and highlights the application of multiple detection methodologies concerning the structure of ECMs. The focus is on macro to micro detection methods for tendons, and current techniques for evaluating the extracellular matrix of tendons at the micro level are introduced in detail. The review also emphasizes future ECM detection methods and the potential for fabricating biomimetic tendons.
BIOACTIVE MATERIALS
(2022)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Subhajit Konar, Scott M. Bolam, Brendan Coleman, Nicola Dalbeth, Sue R. McGlashan, Sophia Leung, Jillian Cornish, Dorit Naot, David S. Musson
Summary: Tendinopathy is characterized by pathological changes in tendon matrix composition, architecture, and stiffness, with inflammation also playing an important role. This study found that substrate stiffness affects tendon-derived cells and macrophages. Tendon-derived cells showed minor responses to substrate stiffness, while macrophages exhibited a more inflammatory phenotype on non-physiological stiffness substrates. These subtle variations in matrix stiffness may contribute to the onset and progression of tendinopathy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Stefanie H. Korntner, Aniket Jana, Elizabeth Kinnard, Emily Leo, Timothy Beane, Xianmu Li, Rohit Sengupta, Lauren Becker, Catherine K. Kuo
Summary: Using chick embryos as a model, this study identified markers involved in limb tendon formation present in jaw tendons during embryonic development. Results suggest potential therapeutic approaches for CF tendon injuries and disorders by understanding the extracellular matrix development of jaw tendons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Takenori Omoto, Dilimulati Yimiti, Yohei Sanada, Minoru Toriyama, Chenyang Ding, Yuta Hayashi, Yasunari Ikuta, Tomoyuki Nakasa, Masakazu Ishikawa, Masayuki Sano, Minjung Lee, Takayuki Akimoto, Chisa Shukunami, Shigeru Miyaki, Nobuo Adachi
Summary: This study investigated the role of DICER in tendon maturation using Dicer conditional knockout (cKO) mice and identified key miRNAs in tendon maturation. The findings suggest that DICER plays an important role in tendon development, and miR-135a may be a crucial miRNA for tendon maturation and healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-dan Xia, Govind Gill, Haiming Lin, Daniela M. Roth, Xiang-jiang Wang, Feng-yi Su, Adekunle Alabi, Maria Alexiou, Ziyang Zhang, Gui-qing Wang, Daniel Graf, Da-wei Zhang
Summary: Membrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, including severe inflammatory arthritis. The deficiency of MT1-MMP leads to noticeable joint swelling and severe arthritis in adult mice. Targeting specific cell types for MT1-MMP inhibition may be crucial for potential therapeutic use in arthritis.
Article
Biochemistry & Molecular Biology
Danielle Steffen, Michael J. Mienaltowski, Keith Baar
Summary: The effect of mechanical load on tendinopathic tissue varies depending on the type of load. Dynamic loading increases fibrocartilage markers, while long isometric loads stimulate markers of tendon regeneration.
Article
Engineering, Multidisciplinary
Rong Bao, Shi Cheng, Jianyu Zhu, Feng Hai, Wenli Mi, Shen Liu
Summary: This study aims to create a simplified model for tendon adhesion without sutures in the murine flexor tendon. The experimental results show that this model can mimic classical tendon repair models without significant side effects on biomechanics.
Article
Chemistry, Medicinal
Mathilde Fourniere, Gilles Bedoux, Nicolas Lebonvallet, Raphael Leschiera, Claudie Le Goff-Pain, Nathalie Bourgougnon, Thomas Latire
Summary: This study investigated the regulation of ECM by poly- and oligosaccharide fractions from Ulva sp. on human dermal fibroblasts, showing an enhancement in cell proliferation and synthesis of key ECM components without cytotoxic effects. The findings suggest the potential use of Ulva sp. fractions in skin renewal and anti-aging dermo-cosmetic applications.
Article
Environmental Sciences
Carlos Ramos, Rebeca Canedo-Mondragon, Carina Becerril, Georgina Gonzalez-Avila, Ana Laura Esquivel, Ana Lilia Torres-Machorro, Martha Montano
Summary: Exposure to short-term wood smoke was found to significantly increase total cells, macrophages, neutrophils, and collagen in the respiratory system of guinea pigs, leading to overexpression of pro-inflammatory cytokines, MMPs, and TIMPs in lung tissue.
Article
Medicine, General & Internal
S. Holm Nielsen, A. Edsfeldt, C. Tengryd, H. Gustafsson, A. C. Shore, A. Natali, F. Khan, F. Genovese, E. Bengtsson, M. Karsdal, D. J. Leeming, J. Nilsson, I Goncalves
Summary: The study found that PRO-C6 can be localized in atherosclerotic plaques, and it is predictive of future cardiovascular events, cardiovascular death, and all-cause mortality.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biophysics
R. J. Leiphart, S. N. Weiss, M. S. DiStefano, A. A. Mavridis, S. A. Adams, N. A. Dyment, L. J. Soslowsky
Summary: This study investigates the role of collagen V in tendon healing using knockdown models. The results show that Col5a1 knockdown affects tendon gene expression and collagen fibril size and shape, with heterozygous knockdown resulting in improved stiffness of healing tendons.
JOURNAL OF BIOMECHANICS
(2022)
Article
Engineering, Biomedical
Debora Mara Fortes Bartoli, Airton Luiz Felizatti, Fernando Russo Costa do Bomfim, Julia Leme Bovo, Andrea Aparecida de Aro, Maria Esmeria Corezzola do Amaral, Marcelo Augusto Marretto Esquisatto
Summary: The experimental results showed that InGaAlP-670 nm laser therapy had a good therapeutic effect on rats with experimental arthritis, reducing the inflammatory process and tissue injuries, indicating its potential in clinical treatment for acute arthritis recovery.
LASERS IN MEDICAL SCIENCE
(2021)
Review
Anatomy & Morphology
Nicholas White, Shelly E. Sakiyama-Elbert
DEVELOPMENTAL DYNAMICS
(2019)
Review
Neurosciences
Ze Zhong Wang, Shelly E. Sakiyama-Elbert
EXPERIMENTAL NEUROLOGY
(2019)
Article
Endocrinology & Metabolism
Jennifer McKenzie, Craig Smith, Kannan Karuppaiah, Joshua Langberg, Matthew J. Silva, David M. Ornitz
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Genetics & Heredity
Wei Zou, Nidhi Rohatgi, Jonathan R. Brestoff, Yan Zhang, Erica L. Scheller, Clarissa S. Craft, Michael D. Brodt, Nicole Migotsky, Matthew J. Silva, Charles A. Harris, Steven L. Teitelbaum
Review
Orthopedics
Russell P. Main, Sandra J. Shefelbine, Lee B. Meakin, Matthew J. Silva, Marjolein C. H. van der Meulen, Bettina M. Willie
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Correction
Biochemical Research Methods
Jessica C. Butts, Nisha Iyer, Nick White, Russell Thompson, Shelly Sakiyama-Elbert, Todd C. McDevitt
Article
Biophysics
Brandon A. Coates, Matthew J. Silva
JOURNAL OF BIOMECHANICS
(2020)
Article
Endocrinology & Metabolism
Christopher J. Chermside-Scabbo, Taylor L. Harris, Michael D. Brodt, Ingrid Braenne, Bo Zhang, Charles R. Farber, Matthew J. Silva
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
Brandon A. Coates, Jennifer A. McKenzie, Susumu Yoneda, Matthew J. Silva
Summary: IL-6 plays a role in the inflammatory phase of fracture repair, but its impact on successful repair is not fully understood. In experiments using IL-6 KO mice, it was found that IL-6 knockout enhanced callus formation and bone response after stress fracture injury, possibly through direct action on osteoblast function.
Article
Endocrinology & Metabolism
Pei Hu, Jennifer A. McKenzie, Evan G. Buettmann, Nicole Migotsky, Michael J. Gardner, Matthew J. Silva
Summary: Type 1 diabetes impairs bone formation and fracture healing in humans. Akita mice, with a mutation in the insulin-2 gene, showed reduced bone mass and weaker bones, as well as impaired fracture healing. Akita mice exhibited osteopenia and decreased bone mechanical properties, mimicking some skeletal features of T1DM in humans.
Article
Endocrinology & Metabolism
Taylor L. Harris, Matthew J. Silva
Summary: Using Laser Capture Microdissection, osteocytes enriched intracortical bone tissues were analyzed for gene expression, revealing differential regulation of genes like Ngf, Wnt1, and MMP13 under mechanical loading. This method provided insights into the molecular changes in osteocytes in response to mechanical stimuli.
Article
Endocrinology & Metabolism
Lisa Y. Lawson, Michael D. Brodt, Nicole Migotsky, Christopher J. Chermside-Scabbo, Ramya Palaniappan, Matthew J. Silva
Summary: The secretion of Wnt ligands is essential for adult bone homeostasis, and inhibiting their secretion results in decreased bone formation and increased resorption. Additionally, osteoblast-derived Wnts play a crucial role in mediating the bone anabolic response to tibial loading.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Jennifer Pardieck, Manwal Harb, Shelly Sakiyama-Elbert
Summary: Researchers have developed an induction protocol using mouse embryonic stem cells (mESCs) and specific growth factors to derive V0 interneurons (INs) from pluripotent sources. The final protocol yielded the highest percentage of cells expressing V0 IN markers, providing an important tool for further studies.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Endocrinology & Metabolism
Mingming Yan, Xin Duan, Lei Cai, Weili Zhang, Matthew J. Silva, Robert H. Brophy, Muhammad Farooq Rai
Summary: The study revealed that KIF26B plays a crucial role in injury-induced ectopic calcification. It was found that KIF26B represses osteogenesis by modulating Wnt/β-catenin signaling, making it a potential target for mitigating ectopic calcification.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Taylor L. Harris, Matthew J. Silva
Summary: This study assessed the contribution of osteoblast lineage cells to bone formation induced by mechanical loading. Preexisting Osx and Dmp1 lineage cells were found to play a predominant role in lamellar bone formation, while recruitment of earlier osteoprogenitors and increased cell proliferation supported robust woven bone formation.