Article
Pharmacology & Pharmacy
Christopher Ross, Basir Syed, Joanna Pak, Vishal Jhanji, Jason Yamaki, Ajay Sharma
Summary: The study investigated the stability of vancomycin ophthalmic drops prepared in different solutions stored at room temperature or under refrigeration for 28 days. Results showed that vancomycin ophthalmic drops prepared using PBS, BSS, and normal saline were stable up to the tested time point of 28 days, irrespective of their storage temperature.
Article
Pharmacology & Pharmacy
Kushal Vanamala, Ketki Bhise, Hiram Sanchez, Razieh Kebriaei, Duy Luong, Samaresh Sau, Hosam Abdelhady, Michael J. Rybak, David Andes, Arun K. Iyer
Summary: This study aims to improve the efficacy of VAN treatment by identifying the folate receptor for MRSA infected tissues and developing folate decorated lipid nanoparticles containing VAN (LVAN). In comparison to conventional VAN, LVAN showed a higher bactericidal effect and a superior ability to inhibit biofilm in MRSA with an enhanced accumulation in MRSA infected thigh tissues and a reduced accumulation in kidney. The results suggested that LVAN is a promising candidate to overcome the current limitations of bacterial resistance and adverse side effects in kidneys found in VAN.
Review
Infectious Diseases
Alberto Enrico Maraolo, Agnese Giaccone, Ivan Gentile, Annalisa Saracino, Davide Fiore Bavaro
Summary: In the treatment of MRSA infections, daptomycin appears to be associated with a lower risk of clinical failure and treatment-limiting adverse events compared to vancomycin. Further studies are needed to better understand the differences between the two drugs.
Article
Cell & Tissue Engineering
J. Goetz, V Keyssner, F. Hanses, F. Greimel, F. Leiss, T. Schwarz, H-R Springorum, J. Grifka, J. Schaumburger
Summary: This study compared the effectiveness of antibiotics commonly used to treat MRSA-induced PJI. The results showed that rifampin, either as monotherapy or in combination, was effective in reducing bacterial count, while other antibiotics showed limited efficacy. Further research with larger case numbers and varied conditions is needed, possibly within a clinical trial.
BONE & JOINT RESEARCH
(2022)
Article
Microbiology
Yi Li, Fengli Zhu, Adhar C. Manna, Liang Chen, Jason Jiang, Jong-In Hong, Richard A. Proctor, Arnold S. Bayer, Ambrose L. Cheung, Yan Q. Q. Xiong
Summary: Persistent endovascular infections caused by MRSA strains susceptible to anti-MRSA antibiotics represent a unique variant of antibiotic resistance mechanisms and a significant therapeutic challenge. Prophage, a mobile genetic element carried by MRSA isolates, provides metabolic advantages and resistance mechanisms to bacterial hosts. This study demonstrates that the gp05 gene of the novel prophage & phi;SA169 significantly impacts MRSA virulence factors, host immune responses, and vancomycin treatment efficacy, leading to persistent outcomes in MRSA endovascular infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Materials Science, Ceramics
Tatiana Padrao, Joana Dias, Angela Carvalho, Marta T. Pinto, Fernando J. Monteiro, Susana R. Sousa
Summary: This study developed lyophilized vancomycin-loaded heparinized nanohydroxyapatite/collagen granules for clinical application, addressing infection eradication and bone regeneration. The local bone substitute delivery system provided an attractive alternative solution not yet commercially available. The lyophilization process effectively controlled the release of antibiotics, inhibiting the growth of MRSA. Additionally, the material promoted osteoblasts activity and induced neovascularization.
CERAMICS INTERNATIONAL
(2023)
Article
Microbiology
Liang Li, Yi Li, Fengli Zhu, Ambrose L. Cheung, Genzhu Wang, Guangchun Bai, Richard A. Proctor, Michael R. Yeaman, Arnold S. Bayer, Yan Q. Xiong
Summary: The intersection between purine biosynthesis and the second messenger c-di-AMP plays a crucial role in VAN persistence in MRSA endovascular infections. Targeting this pathway may offer a novel and effective strategy for treating these life-threatening infections. In-vivo antibiotic treatment revealed a unique form of antibiotic resistance in MRSA infections, highlighting the urgent need to understand the specific mechanisms of persistence in these infections.
Article
Microbiology
Xin Zhang, Peng Chen, Hao-Yang Wan, Run-Jiu Zhu, Yue Zhou, Ming-Rui Song, Nan Jiang, Bin Yu
Summary: The efficacy of daptomycin and vancomycin against MRSA biofilms was compared in this study. Both combinations of daptomycin + gentamicin and vancomycin + gentamicin showed similar efficacy in preventing and killing MRSA biofilms.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Engineering, Biomedical
Yifu Zhuang, Ling Ren, Shuyuan Zhang, Xiang Wei, Ke Yang, Kerong Dai
Summary: A copper-containing titanium alloy was fabricated for the prevention and treatment of MRSA-induced implant-associated infection, showing stable and continuous release of Cu2+ and effective antibacterial performance. In vivo studies demonstrated the alloy's ability to prevent severe infection in a rat model and its favorable biocompatibility.
ACTA BIOMATERIALIA
(2021)
Review
Infectious Diseases
Xinyang Fu, Zhiqiang Lin, Sumei Chen, Limian Hong, Xueping Yu, Shuifa Wu
Summary: Vancomycin dosing should be based on AUC-guided dosing and monitoring. When the vancomycin MIC of MRSA/MRCoNS is >1 mu g/mL, the target AUC/MIC may not be achieved. In such cases, linezolid can effectively be considered as a good alternative to vancomycin.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Public, Environmental & Occupational Health
Muneeba Wali, Mir Sadiq Shah, Tayyab Ur Rehman, Hammad Wali, Masroor Hussain, Laiq Zaman, Fahim Ullah Khan, Autif Hussain Mangi
Summary: The present study aimed to detect the presence of the cfr gene in clinical MRSA isolates. The results showed that multi-drug resistance among resistant MRSA isolates is largely attributed to the presence of the cfr gene, and the horizontal dissemination of the cfr gene among MRSA strains is facilitated by cfr-carrying transposons and plasmids.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Engineering, Biomedical
Renee L. Tonkin, Anna Klockner, Adrian Najer, Carolina J. Simoes da Silva, Cecile Echalier, Marc S. Dionne, Andrew M. Edwards, Molly M. Stevens
Summary: This study develops a hierarchical microparticle system for bacteria-activated single- and dual-antibiotic drug delivery, effectively killing antibiotic-resistant bacteria.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Microbiology
Shuaishuai Wang, Huiping Liu, Jun Mao, Yu Peng, Yisong Yan, Yaowen Li, Na Zhang, Lifang Jiang, Yanyan Liu, Jiabin Li, Xiaohui Huang
Summary: The combination of linezolid and fosfomycin shows promise in treating severe infections caused by VREfm, producing sustained bactericidal effects and eradicating resistant subpopulations. The study also highlights the relationship between fosfomycin resistance and bacterial virulence in VREfm, showing that the development of fosfomycin resistance may come at the expense of bacterial virulence.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Szu-Ting Huang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Hang, Jann-Tay Wang, Yu-Chung Chuang, Yee-Chun Chen, Shan-Chwen Chang
Summary: This study analyzed the risk factors affecting the treatment outcome of linezolid for vancomycin-resistant Enterococcus bloodstream infection. The study found that the linezolid minimum inhibitory concentration and concentration-time curve/MIC were not associated with mortality, while the linezolid dose per body weight, body height, and the interaction between them were independent risks for mortality. In conclusion, the clinical outcomes of linezolid treatment for vancomycin-resistant Enterococcus bloodstream infection are associated with the dose and body height.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Gulseren Aktas
Summary: Due to the high occurrence and resistance of multi-drug-resistant Gram-positive bacteria, finding alternative treatment options is necessary. Combination antibiotherapies, such as vancomycin combined with linezolid, have shown potential due to their broad spectrum and synergistic effect. In this study, the in vitro activity of this combination against clinical vancomycin-resistant enterococci (VRE) strains was investigated. The results demonstrated a high rate of synergy and no observed antagonism, suggesting that this combination could be effective for treating VRE infections.
ARCHIVES OF MEDICAL SCIENCE
(2023)