Article
Orthopedics
Lin Chen, Shao Cheng, Kanghui Sun, Jing Wang, Xinhua Liu, Yongjian Zhao, Junjie Yang, Dongfeng Zhao, Chunchun Xue, Yuren Tao, Shitian Zhao, Hao Zhang, Sheng Lu, Qi Shi, Yongjun Wang, Bing Shu
Summary: Macrophages and inflammatory cytokines play crucial roles in bone fracture healing. However, their expression patterns are disrupted in ovariectomized mice with postmenopausal osteoporosis, potentially contributing to impaired fracture healing.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cell Biology
Ioannis Stratos, Ann-Kathrin Behrendt, Christian Anselm, Aldebarani Gonzalez, Thomas Mittlmeier, Brigitte Vollmar
Summary: The study found that TNF-alpha blockade may help promote recovery after muscle injury, positively impacting the repair of muscle tissue and reducing tissue degradation.
Article
Health Care Sciences & Services
Yang Hee Hong, Eun Young Jung
Summary: This study used an ovariectomy rat model to investigate the therapeutic effects of yeast hydrolysate (YH) on bone loss induced by postmenopausal osteoporosis. The results showed that YH supplementation restored serum testosterone concentration to normal levels in the ovariectomized rats. YH treatment also affected bone markers and improved trabecular bone microarchitecture parameters, indicating its potential in ameliorating bone loss caused by postmenopausal osteoporosis.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Medicinal
Minjie Li, Weiwei Feng, Wenping Zhang, Zhonghui Pang, Shaokun Pei, Lifeng Xia, Qiang Li, Huixiao Li
Summary: Bisacurone therapy significantly increased calcium content, reduced inflammatory cytokine levels, effectively promoted fracture healing, and improved bone quality in OVX-induced osteoporosis rats.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Endocrinology & Metabolism
Jacopo Antonino Vitale, Veronica Sansoni, Martina Faraldi, Carmelo Messina, Chiara Verdelli, Giovanni Lombardi, Sabrina Corbetta
Summary: The study investigated the relationship between osteocalcin (OC) and body composition, risk of fall, and bone-muscle crosstalk in osteoporotic postmenopausal women. Results showed that serum cOC levels correlated with skeletal muscle mass and function, acting as a mediator in the bone-muscle crosstalk. Circulating levels of cOC and uOC may be differentially regulated in fractured and unfractured osteoporotic women, indicating potential differences in bone metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Amandine Landemaine, Antoine Petitcollin, Charlene Brochard, Celine Miard, Marie Dewitte, Eric Le Balc'h, Thomas Grainville, Eric Bellissant, Laurent Siproudhis, Guillaume Bouguen
Summary: In patients treated with infliximab, the risk of infection is correlated with cumulative increase in drug exposure, rather than with the trough concentration of infliximab.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Ming-Han Chen, Shan-Fu Yu, Jia-Feng Chen, Wei-Sheng Chen, The-Ling Liou, Chung-Tei Chou, Chung-Yuan Hsu, Han-Ming Lai, Ying-Chou Chen, Chang-Youh Tsai, Tien-Tsai Cheng
Summary: The study compared the impact of different treatment regimens for rheumatoid arthritis on patients' bone mineral density, finding that abatacept may have a better effect in preserving bone density. Anti-osteoporosis therapy can prevent systemic bone loss in patients regardless of the type of rheumatoid arthritis treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Gulen Hatemi, Nur Beyza Tukek, Sinem Nihal Esatoglu, Yesim Ozguler, Sitki Safa Taflan, Ugur Uygunoglu, Melike Melikoglu, Serdal Ugurlu, Izzet Fresko, Aksel Siva, Zekayi Kutlubay, Sebahattin Yurdakul, Hasan Yazici, Vedat Hamuryudan
Summary: The objective of the study was to investigate the efficacy and safety of infliximab in BS patients with vascular involvement. Among the 127 patients treated with infliximab, the remission rate was 73% at Month 6 and 63% at Month 12. Patients with pulmonary artery involvement and venous thrombosis had better remission rates compared to those with non-pulmonary artery involvement and venous ulcers.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Shin Ju Oh, Young Nam Kwon, Chang Kyun Lee, Jin San Lee
Summary: This is the first report of infliximab-associated anti-NMDAR encephalitis in Crohn's disease, highlighting the need for clinicians to recognize the possibility of a paradoxical autoimmune response occurring with novel biological therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ammara Arooj, Roshina Rabail, Muhammad Naeem, Gulden Goksen, Baojun Xu, Rana Muhammad Aadil
Summary: Sesame seeds have therapeutic effects on bone-related health issues due to their rich content of calcium, vitamins, proteins, oil, and carbohydrates. This comprehensive review explores the impact of sesame seeds on bone mineralization in postmenopausal women and highlights their positive influence on bone health, particularly for those with osteoporosis and arthritis. The supplementation of sesame seeds in a regular diet is found to have a protective role and improve hormone balance in women experiencing menopause.
Article
Oncology
Anne Montfort, Thomas Filleron, Mathieu Virazels, Carine Dufau, Jean Milhes, Cecile Pages, Pascale Olivier, Maha Ayyoub, Muriel Mounier, Amelie Lusque, Stephanie Brayer, Jean-Pierre Delord, Nathalie Andrieu-Abadie, Thierry Levade, Celine Colacios, Bruno Segui, Nicolas Meyer
Summary: TNF blockers can help manage gastrointestinal inflammatory side effects following nivolumab and/or ipilimumab treatment in patients with advanced melanoma, and may enhance the efficacy of immune checkpoint inhibitors. The combination of certolizumab showed a high response rate in patients, warranting further investigation. Both combinations were found to be safe and showed clinical and biological activities in human patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Karoline Soares Garcia, Matheus Freitas Cardoso de Azevedo, Alexandre de Sousa Carlos, Luisa Leite Barros, Jane Oba, Carlos Walter Sobrado Junior, Aytan Miranda Sipahi, Olivia Duarte de Castro Alves, Tomas Navarro-Rodriguez, Rogerio Serafim Parra, Julio Maria Fonseca Chebli, Liliana Andrade Chebli, Cristina Flores, Andrea Vieira, Christianne Damasceno Arcelino do Ceara, Natalia Sousa Freitas Queiroz, Aderson Omar Mourao Cintra Damiao
Summary: Therapeutic drug monitoring (TDM) is important in optimizing response to anti-tumor necrosis factor drugs and preventing inadequate drug exposure. This study aimed to describe the remission rates of Brazilian inflammatory bowel disease (IBD) patients at six months using a proactive TDM algorithm guided by IFX trough levels (ITL) and antibodies to IFX (ATI) levels. The results showed that proactive TDM was associated with a high persistence rate of 82.9% and favorable remission rates at six months.
Article
Multidisciplinary Sciences
Neven Mohamed Sarhan, Ahmed Essam Abou Warda, Haytham Soliman Ghareeb Ibrahim, Mona Farag Schaalan, Shaimaa Mohamed Fathy
Summary: Coronavirus Disease 2019 (COVID-19) is spreading rapidly and monoclonal antibodies, specifically tocilizumab and infliximab, have shown promise as treatments. A prospective cohort study divided patients into three groups: standard treatment, tocilizumab treatment, and tocilizumab/infliximab treatment. Results showed that the tocilizumab/infliximab group had significantly shorter hospital stays, lower need for non-invasive mechanical ventilation, decreased intensive care admissions, fewer cases of sepsis, and lower mortality rates compared to the other two groups.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Alexie A. Larson, Ahmed S. Shams, Shawna L. McMillin, Brian P. Sullivan, Cha Vue, Zachery A. Roloff, Eric Batchelor, Michael Kyba, Dawn A. Lowe
Summary: The study found that the size of the satellite cell pool is reduced in estradiol (E-2)-deficient female mice and humans. By using a combination of in vivo and in vitro approaches, they identified mechanisms whereby E-2 deficiency impairs satellite cell maintenance.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andy Ruiz, Yadira Palacios, Irene Garcia, Leslie Chavez-Galan
Summary: Tumor necrosis factor (TNF) is a key cytokine regulating inflammatory responses and plays a crucial role in granuloma formation during mycobacterial infections. The interactions between soluble and transmembrane TNF with their receptors influence effector mechanisms, providing insights into potential therapeutic strategies against mycobacterial infections. Understanding the structural and activation pathways of TNF and its receptors can offer valuable knowledge for developing more efficient therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study evaluated the effects of single and combined exposures to BPA and/or DEHP during the prenatal and lactational period on the male reproductive system of rats in later stages of life. The results suggest that prenatal and lactational exposure to BPA and DEHP may have adverse effects on the male reproductive system in later stages of life, especially after combined exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Eda Ciftci Dede, Petek Korkusuz, Elif Bilgic, Mehmet Alper Cetinkaya, Feza Korkusuz
Summary: Boron combined with nano-hydroxyapatite can stimulate new bone formation. Injecting boron-containing nano-hydroxyapatite composites with hyaluronan into rabbit femurs can increase bone mineral density and new bone formation. This treatment shows promise in preventing femoral fractures in osteoporosis patients.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Cell Biology
Ovsen Onay, Sevil Kose, Nilda Suslu, Petek Korkusuz, Emirhan Nemutlu, Canset Aydin, Sefik Hosal
Summary: This study found that the HEp-2 human laryngeal squamous cell carcinoma cell line releases the major endocannabinoids AEA and 2-AG, and their exogenous supplementation inhibits tumor cell proliferation in vitro. 2-AG exhibited a stronger anti-proliferative effect compared to AEA, suggesting that they may function through different pathways.
CELL AND TISSUE BANKING
(2022)
Article
Surgery
Seda Banu Akinci, Fatma Saricaoglu, Melih Akinci, Huseyin Cihad Turgut, Naciye Dilara Zeybek, Sevda Muftuoglu
Summary: This study failed to demonstrate a protective effect of remote ischemic conditioning on septic organ injury, and in fact, it increased organ injury especially when applied later in cecal ligation and perforation induced sepsis in mice.
INDIAN JOURNAL OF SURGERY
(2022)
Article
Sport Sciences
Gurhan Donmez, Serife Seyma Torgutalp, Omer Ozkan, Omer Faruk Ilicepinar, Feza Korkusuz, Savas Kudas
Summary: This study found a high incidence of stoppage time due to field injuries in professional football games, with only a small proportion of injuries resulting in an inability to complete the game. The overall time-loss injury incidence that led players to miss the next game could potentially impact the team's performance.
RESEARCH IN SPORTS MEDICINE
(2022)
Article
Otorhinolaryngology
Onur Ergun, Hatice Celik, Naciye Dilara Zeybek, Jale Karakaya
Summary: This study compared the long-term survival and histological changes of sliced, crushed, and intact cartilage grafts for nasal contour restoration. Sliced cartilages showed advantages in retaining thickness and histological properties, making them an ideal graft material for camouflaging purposes.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Cell Biology
Hilmi Burak Kandilci, Gul Simsek, Tugba Zirapli, Mustafa Celebier
Summary: Iron deficiency is closely associated with mitochondrial dysfunction in heart failure patients. Iron plays a role as a structural component in mitochondria and also as a cofactor for the degradation of hypoxia inducible factor. This study used HL-1 cells to investigate the effects of iron depletion on mitochondrial function and reveal the mechanisms leading to cardiac failure.
Article
Multidisciplinary Sciences
Selin Onen, Sevil Kose, Nilgun Yersal, Petek Korkusuz
Summary: This study established a co-culture system using syngeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) to expand and differentiate spermatogonial stem/progenitor cells (SSPCs) in vitro, leading to improved spermatogenesis. This method has the potential to serve as an alternative treatment for male infertility.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Burak Kahveci, Selin Onen, Fuat Akal, Petek Korkusuz
Summary: In this study, a deep learning method was used to detect and count seminiferous tubules and spermatogonial stem/progenitor cells (SSPCs) in testis sections of newborn mice. This provides a rapid and easy detection method for clinicians dealing with male infertility caused by prepubertal testicular damage.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Multidisciplinary Sciences
Eda Ciftci, Naz Bozbeyoglu, Ihsan Gursel, Feza Korkusuz, Feray Bakan Misirlioglu, Petek Korkusuz
Summary: This study compares the efficiency of magnetically activated cell sorting and ultracentrifugation for isolating exosomes derived from human mesenchymal stem cells. The results show that magnetically activated cell sorting provides higher purity and quantity of exosomes, and offers a quick and reliable method for potential cellular therapeutic approaches.
Article
Cell & Tissue Engineering
Selin Onen, Ali Can Atik, Merve Gizer, Sevil Kose, Onder Yaman, Haluk Kulah, Petek Korkusuz
Summary: A new microfluidic device based on bone marrow-derived mesenchymal stem cells has been found to support the maintenance of stem cells and in vitro spermatogenesis, offering potential protection and expansion of the stem cell pool for future fertility preservation in pediatric cancer survivors.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Engineering, Electrical & Electronic
Fatma Nur Depboylu, Evren Yasa, Ozgur Poyraz, Feza Korkusuz
Summary: The aim of this study is to develop a comprehensive process for the production of Cp-Ti bulk and thin structures using L-PBF technology. By varying the process parameters, the optimal parameters for producing high density Cp-Ti parts were determined. The results showed that L-PBF is a favorable manufacturing technology for Cp-Ti parts with almost full density, good mechanical properties, and good dimensional accuracy, even on thin geometries.
Article
Orthopedics
Eda Ciftci Dede, Merve Gizer, Feza Korkusuz, Zeynep Bal, Hiroyuki Ishiguro, Hideki Yoshikawa, Takashi Kaito, Petek Korkusuz
Summary: In this study, we combined nano-hydroxyapatite-polyethylene glycol/poly(lactic acid) (nHAp-PEG/PLA) with recombinant human bone morphogenetic protein 2 (rhBMP2) and evaluated the effects of 0.5, 1.0, and 3.0 μg/mL rhBMP2 on the proliferation, differentiation, and osteogenic genes of human bone marrow mesenchymal stem cells (hBMMSCs). The results showed that nHAp-PEG/PLA composites with 1.0 μg/mL and 3.0 μg/mL rhBMP2 promoted hBMMSC proliferation and differentiation.
Article
Chemistry, Analytical
Ozge Boyacioglu, Tuba Recber, Sedef Kir, Petek Korkusuz, Emirhan Nemutlu
Summary: Synthetic and natural cannabinoid derivatives have potential as drug candidates for various diseases, including cancer. ACPA, a synthetic cannabinoid, shows anticancer effects on lung, pancreatic, and endometrial cancer. Therefore, it is crucial to quantify ACPA in biological samples for monitoring its effects. However, the short half-life and lack of UV signal of ACPA present challenges in its quantification. In this study, a sensitive and selective LC-MS/MS method was developed for quantification of ACPA in cell culture medium and intracellular matrix.
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Gul Simsek, Hilmi Burak Kandilci
BRITISH JOURNAL OF PHARMACOLOGY
(2023)