Article
Hematology
Sudeep Sastry, Federica Cuomo, Jayaveera Muthusamy
Summary: Severe cases of COVID-19 are associated with an increased risk of thromboembolic events. This article reviews recent studies on COVID-19-related thrombotic events and explores the potential role of hemodynamic factors such as stasis, turbulent flow, and non-physiological shear stress in thrombosis.
THROMBOSIS RESEARCH
(2022)
Article
Physiology
Xudong Jiang, Haoyao Cao, Zijian Zhang, Tinghui Zheng, Xiaoqiang Li, Peng Wu
Summary: By comparing with actual clinical treatments and observations, the old blood volume (OBV) is identified as a more appropriate metric to evaluate the thrombosis risk in occluded coronary arterial fistulas with terminal aneurysms, and it can better reflect the degree of blood stasis compared with hemodynamic parameters.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Changjiao Sun, Xin Yang, Xiaofei Zhang, Qi Ma, Peng Yu, Xu Cai, Yonggang Zhou
Summary: This review evaluated the use of personalized tourniquet inflation pressures (PTIP) versus uniform tourniquet inflation pressures (UTIP) in total knee arthroplasty (TKA). The results showed that PTIP provided less pain intensity, thigh circumference, and rate of thigh ecchymosis, and improved initial recovery of knee flexion. Therefore, using PTIP method in TKA is recommended.
Article
Medical Laboratory Technology
John D. Belcher, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Ruan Conglin, Zalaya K. Ivy, Jason Cummings, Thomas Dudler, Gregory M. Vercellotti
Summary: This study found that both the lectin pathway (LP) and the alternative pathway (AP) play a role in promoting inflammation and vaso-occlusion in sickle cell disease (SCD). Inhibiting complement activation via LP or AP may inhibit inflammation and prevent vaso-occlusive crisis (VOC) in SCD patients.
TRANSLATIONAL RESEARCH
(2022)
Article
Emergency Medicine
Craig Goolsby, Nicole Dacuyan-Faucher, Keke Schuler, Annie Lee, Amit Shah, Jeremy Cannon, Curt Kothera
Summary: This study evaluates the ability of a novel tourniquet, LAVA TQ, to occlude blood flow in human legs compared to the traditional tourniquet, CAT. The study found that LAVA TQ is non-inferior to CAT in terms of occluding blood flow. The findings demonstrate the superior usability of LAVA TQ, making it an acceptable alternative limb tourniquet.
WESTERN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Orthopedics
Anna Trier Heiberg Brix, Tine Nymark, Hagen Schmal, Martin Lindberg-Larsen
Summary: This study aims to investigate the total blood loss and complications after transfemoral amputation in patients operated with or without tourniquet. The findings will provide evidence-based recommendations for best practice in amputation surgery.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Chemistry, Multidisciplinary
Seong Tak Woo, Cheol Woo Park, Ji Hyun Sung, Cheol-Min Park
Summary: The automatic tourniquet is made of high-elasticity biocompatible material and is designed to automatically adjust the strap length according to the body dimensions of patients, showing better performance compared to traditional blood collection support tools.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Sarita Devi, Roshni M. Pasanna, Nikhil Nadiger, Santu Ghosh, Anura V. Kurpad, Arpita Mukhopadhyay
Summary: The study found that the duration of tourniquet application significantly affects the variability in plasma metabolite concentrations, recommending minimizing tourniquet application time and waiting for 5 minutes after removal to reduce variability and false interpretations.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jun Wu, QiWei Fu, HaoBo Li, YaGuang Han, JianHua Deng, Yi Chen, QiRong Qian
Summary: This study compared an estimation formula for tourniquet pressure (TP) based on thigh circumferences and systolic blood pressure (SBP) with two traditional methods in total knee arthroplasty (TKA). The formula-calculated group had lower intraoperative TP values and lower thigh pain scores postoperatively. The estimation method was easy and rapid, providing comparable hemostatic effect.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Xiaoke Xie, Xuanting Liu, Jiazhu Zhu, Yongxian Xu, Xiaojing Li, Yameng Zheng, Shangyue Gong, Xiao Xiao, Yiwen Chen, Jianmin Zhang, Wei Gong, Ke Si
Summary: This study analyses the spatiotemporal dynamics of the microglial inflammatory response during single vessel occlusion and recanalization, revealing four different response phases. The study provides a comprehensive analysis of the potential mechanisms for vascular occlusion-related disease treatments based on the morphological features of microglial phase-specific responses.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takashi Asano, Meiyan Xuan, Naohiro Iwata, Jun Takayama, Kousuke Hayashi, Yosuke Kato, Toshiya Aoyama, Hiroshi Sugo, Hirokazu Matsuzaki, Bo Yuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto, Mari Okazaki
Summary: Tissue plasminogen activator is effective for acute ischemic strokes but has a limited time window. A derivative, FAD012, showed antioxidant properties and potential to cross the blood-brain barrier. It protected cells from oxidative stress and reduced cerebral ischemia/reperfusion injuries in rats. It may be a promising prophylactic drug for stroke patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Orthopedics
David Figueroa
Summary: Lower tourniquet inflation pressures in patients undergoing total knee arthroplasty were found to reduce postoperative pain at the tourniquet inflation site and surgical site for up to 2 weeks compared to higher pressures.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Orthopedics
Songlin Li, Xiangshuai Zhang, Mingxing Liu, Qunshan Lu, Yang Yu, Zhuang Miao, Desu Luo, Kaifei Han, Lei Li, Wenwei Qian, Peilai Liu
Summary: The study found that using tourniquets during high tibial osteotomy did not reduce post-operative blood loss, operation time, or intra-operative complications. However, not using a tourniquet led to a shorter hospital stay, decreased post-operative morphine usage, and reduced tourniquet-related complications, which facilitated early recovery of knee function.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Physiology
Balamurugan Packialakshmi, David M. Burmeister, Joseph A. Anderson, Judah Morgan, Georgetta Cannon, Juliann G. Kiang, Yuanyi Feng, Sang Lee, Ian J. Stewart, Xiaoming Zhou
Summary: Hemorrhage is a major cause of death in trauma, and while tourniquets are effective at controlling bleeding, they can also cause damage to limbs and other organs. This study aimed to develop a new animal model that combines tourniquet-induced lower limb ischemia/reperfusion (TILLIR) with hemorrhage, in order to better understand the pathophysiology and develop treatments. The results showed that hemorrhage exacerbates TILLIR-induced acute kidney injury and damage to the lung and liver.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Orthopedics
Robert Bielitzki, Tom Behrendt, Martin Behrens, Lutz Schega
Summary: Musculoskeletal rehabilitation aims to achieve pre-injury physical function level with low risk of re-injury. Blood flow restriction (BFR) training is a promising alternative that can shorten therapy duration and enhance patient physical functioning. The proposed BFR-assisted rehabilitation program has the potential to accelerate recovery and benefit patients and other healthcare stakeholders.
Review
Sport Sciences
Kyle J. Hackney, Jessica M. Scott, Andrea M. Hanson, Kirk L. English, Meghan E. Downs, Lori L. Ploutz-Snyder
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2015)
Article
Biophysics
Kyle J. Hackney, Meghan E. Downs, Lori Ploutz-Snyder
AEROSPACE MEDICINE AND HUMAN PERFORMANCE
(2016)
Article
Sport Sciences
Christopher J. Kotarsky, Bryan K. Christensen, Jason S. Miller, Kyle J. Hackney
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2018)
Article
Geriatrics & Gerontology
Jessica M. Scott, David S. Martin, Robert Ploutz-Snyder, Timothy Matz, Timothy Caine, Meghan Downs, Kyle Hackney, Roxanne Buxton, Jeffrey W. Ryder, Lori Ploutz-Snyder
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Biophysics
Andrew Taylor, Christopher J. Kotarsky, Colin W. Bond, Kyle J. Hackney
AEROSPACE MEDICINE AND HUMAN PERFORMANCE
(2018)
Article
Public, Environmental & Occupational Health
Jessica M. Scott, Kyle Hackney, Meghan Downs, Jamie Guined, Robert Ploutz-Snyder, James Fiedler, David Cunningham, Lori Ploutz-Snyder
AVIATION SPACE AND ENVIRONMENTAL MEDICINE
(2014)
Article
Physiology
Jeffrey W. Ryder, Roxanne E. Buxton, Elizabeth Goetchius, Melissa Scott-Pandorf, Kyle J. Hackney, James Fiedler, Robert J. Ploutz-Snyder, Jacob J. Bloomberg, Lori L. Ploutz-Snyder
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2013)
Article
Sport Sciences
Lori L. Ploutz-Snyder, Meghan Downs, Jeffrey Ryder, Kyle Hackney, Jessica Scott, Roxanne Buxton, Elizabeth Goetchius, Brent Crowell
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2014)
Article
Sport Sciences
Meghan E. Downs, Kyle J. Hackney, David Martin, Timothy L. Caine, David Cunningham, Daniel P. O'Connor, Lori L. Ploutz-Snyder
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2014)
Article
Geriatrics & Gerontology
Ryan McGrath, S. Al Snih, K. Markides, K. Hackney, R. Bailey, M. Peterson
JOURNAL OF NUTRITION HEALTH & AGING
(2019)
Article
Geriatrics & Gerontology
Ryan P. McGrath, Brian C. Clark, Kristine M. Erlandson, Stephen D. Herrmann, Brenda M. Vincent, Orman T. Hall, Kyle J. Hackney
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2019)
Article
Geriatrics & Gerontology
Nathaniel Johnson, Adam Bradley, Lukus Klawitter, Jane Johnson, Lance Johnson, Grant R. Tomkinson, Kyle J. Hackney, Sherri Stastny, Diane K. Ehlers, Ryan McGrath
Summary: The study found that during the COVID-19 pandemic, older adults participating in telehealth interventions increased computer time, reduced active transport time, and showed a slight increase in moderate-to-vigorous physical activity participation.
Article
Chemistry, Analytical
Vidura Jayasooriya, Nathaniel Johnson, Adam Bradley, Christopher Kotarsky, Lizzy Jepng'etich, Daniel Friesner, Sherri Stastny, Kyle J. Hackney, Dharmakeerthi Nawarathna
Summary: Weight loss through dietary and exercise intervention is not effective for everyone, but recent studies have shown that circulating microRNA (miR) biomarkers could be used to predict who will likely lose weight through diet and exercise. However, detecting miRs in clinical samples is costly and error-prone. To address this, researchers have developed a low-cost and highly sensitive miR sensor called iLluminate for point-of-care testing. In a pilot intervention study, miR biomarkers were evaluated using iLluminate, and miRs-140 and -935 were found to be significantly associated with fat loss. These findings suggest that miRs-140 and -935 provide additional predictive capability for body weight and fat mass alterations.
Article
Orthopedics
Kyle J. Hackney, William J. Brown, Kara A. Stone, David J. Tennent
TECHNIQUES IN ORTHOPAEDICS
(2018)