期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 766, 期 -, 页码 86-94出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2014.04.025
关键词
Self-assembly; Flexible pyridyl ligand; Ester functional group; Metallacyclophane; Bromopentacarbonylrhenium(I); Anticancer activity
资金
- Department of Science and Technology, Government of India
- Council of Scientific and Industrial Research, Government of India
- UGC, Government of India
Self-assembly of four components has resulted into the formation of M2L2 type dinuclear metallacyclophanes [Re(CO)(3)Br(mu-L)](2)(1-5), using flexible ester functionalised organic spacers and metal precursor containing fac-Re(CO)(3) corners. The dinuclear metallacyclophanes were synthesized from ReBr(CO) 5 and ditopic pyridyl ligands (L) (L etdp, prdp, budp, pedp and hedp). The self-assembled compounds 1-5 were characterised by elemental analysis, IR, NMR, absorption and emission spectroscopic techniques. Molecular structure of 1 and 2 have been characterised by single crystal X-ray diffraction methods and the molecular masses of 3-5 were evaluated by ESI-MS. Cytotoxicity studies of metallacyclophanes 1, 3 and 5 on six different cancer and normal cells revealed that the metallacyclophanes selectively inhibit certain cancer cells. Especially, compound 5 showed broad-spectrum inhibitory activities in five cancer cells tested with low IC50 value comparable to a reference compound (cisplatin). The anticancer activity of compound 5 is attributed to the induction of early apoptosis. Hence, this class of compounds forms potential anticancer agents. (C) 2014 Elsevier B. V. All rights reserved.
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