Article
Nanoscience & Nanotechnology
Xiaoyan He, Jiandi Dong, Huimin Han, Nan Sun, Wenyu Shi, Xiong Lu, Hui Jia, Xiaoquan Lu
Summary: The newly designed electrochemical aptasensor utilizing DNA-templated copolymers is capable of sensitive detection of ATP, with a wide linear response range and high selectivity, achieving a detection limit as low as 11.5 fM.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Serban F. Peteu, Skye A. Russell, James J. Galligan, Greg M. Swain
Summary: The ATP biosensor described in this paper utilizes glucose oxidase and hexokinase immobilized within the electroactive polymer PEDOT, achieving indirect detection of ATP at different detection potentials with good detection performance.
Article
Materials Science, Biomaterials
Shang-Lin Yeh, Piyush Deval, Jhih-Guang Wu, Shyh-Chyang Luo, Wei-Bor Tsai
Summary: Electrochemical techniques are sensitive and label-free methods for detecting biomarkers, toxins, or pathogens. A one-step electrodeposition method based on pyrogallol polymerization was developed to prepare a nonfouling and biotinylated surface. The platform efficiently fabricates electrochemical biosensors and has the potential for conjugating various biosensing elements for nonfouling biosensors.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Electrochemistry
Kaiyue Hu, Xinxin Ren, Lingxia Qin, Zhiyong Guo, Di Wu, Sui Wang, Yufang Hu
Summary: This study achieved a specific unlocking of the butterfly effect by developing an electrochemical biosensor for the detection of ATP and ALP. The biosensor, based on nanointerfaces, showed low detection limits and could be applied in clinical diagnosis and drug development.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Xiaoyan He, Nan Sun, Hui Jia, Miaomiao Hou, Zheping Tan, Xiaoquan Lu
Summary: An antifouling electrochemical biosensor based on the interpenetrating network of Y-DNA scaffold and polyaniline hydrogel was designed for ATP detection. The sensor exhibited good detection performance and antifouling effect, providing reference value for the detection of other biological small molecules.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Desiree Forstner, Jacqueline Guettler, Beatrice A. Brugger, Freya Lyssy, Lena Neuper, Christine Daxboeck, Gerhard Cvirn, Julia Fuchs, Kristin Kraeker, Alina Frolova, Daniela S. Valdes, Christina Stern, Birgit Hirschmugl, Herbert Fluhr, Christian Wadsack, Berthold Huppertz, Olivia Nonn, Florian Herse, Martin Gauster
Summary: Tissue insults in response to inflammation, hypoxia and ischemia cause the release of ATP, which modulates various pathological processes. CD39 and CD73 are two major enzymes that convert extracellular ATP into adenosine. This study investigated the expression of CD39 and CD73 in placental tissue and their regulation in response to platelet-derived factors and oxygen conditions. The results showed that placental CD39 expression increased in preeclampsia and platelet-derived factors led to deregulated CD39 expression. CD39 overexpression decreased extracellular ATP levels and abolished the upregulation of pro-inflammatory cytokine interleukin-1 beta. These findings suggest that increased placental CD39 could be an important anti-coagulant defense mechanism of the placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ting Wang, Fangzhou Sun, Chunxiao Li, Peng Nan, Yan Song, Xuhao Wan, Hongnan Mo, Jinsong Wang, Yantong Zhou, Yuzheng Guo, Aya Ei Helali, Dongkui Xu, Qimin Zhan, Fei Ma, Haili Qian
Summary: Liver metastasis is the most fatal event of colon cancer patients. The study identifies MTA1 as a new ATP synthase modulator that facilitates colon cancer liver metastasis by driving mitochondrial bioenergetic metabolism reprogramming and enhancing oxidative phosphorylation. MTA1 knockout increases the sensitivity of colon cancer to mitochondrial bioenergetic metabolism-targeted drugs and mTOR inhibitors, and inhibiting ATP5A enhances the sensitivity of liver-metastasized colon cancer to sirolimus in an MTA1-dependent manner.
Review
Endocrinology & Metabolism
Nadine Mundt, Lina Kenzler, Marc Spehr
Summary: Adenosine triphosphate (ATP) is not only the essential source of cellular energy, but also functions as an extracellular signal that activates purinergic receptors. Purinergic signaling plays a crucial role in male reproductive system functions, particularly in spermatogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Estefaniia Delgado-Pinar, Matilde Medeiros, Telma Costa, J. Sergio Seixas de Melo
Summary: Chemical derivatives of PEI with either TPA or Cou can form stable complexes with adenine and guanine nucleotides in water based on noncovalent interactions such as pi-pi stacking and hydrogen bonding. PEI-TPA acts as a chemosensor with recognition based on AIE and pi-pi interaction, while the Cou derivative relies on electrostatic interaction. The study provides valuable insights into designing receptors for selective recognition of nucleotides in water.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Analytical
Amir Khojastehnezhad, Faezeh Taghavi, Elnaz Yaghoobi, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: This article discusses the application of aptamer-based biosensors in the detection of ATP. These sensors, with high specificity, rapid response, and easy construction, can be divided into optical and electrochemical sensors, and further classified into metal-based and carbon-based materials based on QDs.
Article
Biology
Jack Greiner, Thomas Glonek
Summary: The lens and muscle tissues have high concentrations of ATP despite low metabolic requirements, suggesting a non-metabolic function of ATP in cellular and tissue function evolution.
Article
Neurosciences
Yaru Xu, Ge Gao, Xiaoru Sun, Qidong Liu, Cheng Li
Summary: Postoperative delirium (POD) is a major complication after surgery with general anesthesia, and the neurotoxicity of general anesthetics plays a key role. Sevoflurane, a common general anesthetic, is shown to induce inflammatory response and caspase-3 activation through upregulation of ATPIF1 in microglia. ATP supplementation may be a potential therapeutic strategy for alleviating sevoflurane-induced POD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Duo Wang, Zirui Zeng, Mengyue Shen, Ryuji Okazaki, Hironori Miyata, Tomo Yonezawa, Yasuhiro Yoshida
Summary: Neutrophil endocytosis is closely related to ATP-centered energy metabolism. Inhibition of dynamin inhibits ATP consumption triggered by neutrophil endocytosis, while inhibition of ATP synthase and nicotinamide adenine dinucleotide phosphate oxidase suppresses neutrophil endocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Thomas Soranzo, Awatef Ben Tahar, Ayman Chmayssem, Marc Zelsmann, Pankaj Vadgama, Jean-Luc Lenormand, Phillipe Cinquin, Donald K. Martin, Abdelkader Zebda
Summary: In this study, the enzyme aldehyde reductase was synthesized and cloned from a human gene. Spectrophotometric and electrochemical measurements demonstrated that aldehyde reductase can catalyze the reduction of glucose to sorbitol and significantly decrease the electrocatalytic oxidation current of NADPH after glucose addition. This work provides insights into the construction of an efficient electrochemical glucose biosensor.
Article
Chemistry, Analytical
Lina Zhang, Qingkun Kong, Li Li, Yanhu Wang, Shenguang Ge, Jinghua Yu
Summary: A direct-readout photoelectrochemical lab-on-paper device was established for highly sensitive detection of ATP, utilizing a coupled electricity generating system and paper supercapacitors. The device utilized outstanding photoelectric properties and as-generated electricity from electrochemical redox reactions for signal amplification, achieving detection of target ATP concentration with improved signal response efficiency.
Article
Chemistry, Inorganic & Nuclear
Guojun Hu, Ziyue Deng, Yanwei Wang, Dan Yuan, Yong Zhang, Yingming Yao
Summary: A series of rare-earth metal complexes were synthesized and used as efficient initiators for the polymerization of trimethylene carbonate (TMC) and (L)-lactide ((L)-LA).
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Van Ha Nguyen, John H. K. Yip
Summary: In this study, eight PtII-azulene complexes were synthesized to investigate the effect of metalation on the electronic structures, spectroscopy, and luminescence of organic chromophores. The results showed that the attachment of Pt substituents to azulene affected the HOMOs, LUMOs, and luminescence properties. The study provides insights into the role of metalation in modifying the properties of organic chromophores.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Moon Kedia, Virender Singh, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: This study synthesized two types of neutral binuclear metallocycles using a one-pot solvothermal method and characterized their structures. The analysis revealed that these complexes adopt a binuclear heteroleptic cyclic architecture and belong to phosphine oxide donor (P=O)-based supramolecular coordination cyclic complexes.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Radhey S. Srivastava
Summary: This study demonstrates the effectiveness of zero-valent elements as reductants for the deoxydehydration reaction of polyols catalyzed by ONO-pincer ligated molybdenum dioxo. The insolubility and easy separability of the reductants and their oxidized products during the reaction are emphasized. Additionally, the choice of ligand has an impact on the catalytic performance of the reaction.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Hao Zhou, Yajun Sun, Li Deng, Weiran Yang, Yuehui Li
Summary: Efficient Ru-catalyzed hydrogenation of aldehydes was achieved using carbazole-derived phosphine ligands, with the crucial role of N-H moiety in promoting the catalytic reaction. The method was successfully applied in the Co/Ru-catalyzed hydroformylation process, resulting in the production of long-chain alcohols with excellent yields.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Theodor Danescu, Alexandru Lupan, Radu Silaghi-Dumitrescu, R. Bruce King
Summary: The structures and energies of complexes containing (Me2C2N2P)2Ru2(CO)n and (Me2C2N2P)2Fe2(CO)n have been studied. Low-energy structures are characterized by the presence of bridging diazaphospholyl rings, while higher-energy structures involve different ligand structures.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Savannah C. Kapper, Aamani Ponnekanti, Jonas Schaab, Tian-yi Li, Christine L. Chung, Gael Ung, Peter I. Djurovich, Mark E. Thompson
Summary: Organometallic iridium complexes with two cyclometalated ligands and one bis-oxazoline derived ancillary ligand were studied. These complexes have emission spanning across the visible and near-ultraviolet region, with moderate to high photoluminescence quantum yields. The (ppy)2Ir(BOX-CN) complexes were resolved into Delta- and Lambda-diastereomers based on solubility differences.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Zahra Karimi Sangari, Hossein Naeimi
Summary: In this research, a nanostructured CoCuFe2O4 catalyst was prepared using a brief and useful synthetic strategy. This catalyst was used for synthesizing 1,2,4,5-tetrasubstituted imidazole derivatives under ultrasonic irradiation. The approach offers advantages such as high efficiency, short reaction times, simplicity of the reaction medium, accelerated reaction rates, and easier separation and purification of products.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Rukhsana Gul, Wajid Munir, Ebraheem Abdu Musad Saleh, Shaukat Shujah, Muhammad Sirajuddin, Saira Tabassum, Khalil Ur Rehman, Dilfaraz Khan, Sameerah I. Al-Saeedi, Ehab A. Abdelrahman
Summary: Two new Schiff base ligands were synthesized and used to form copper, nickel, and cobalt complexes. The synthesized compounds were characterized and screened for various biological activities. The metal complexes showed better activities in antibacterial, antifungal, antidiabetic, and antioxidant assays.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Review
Chemistry, Inorganic & Nuclear
Ahsan Nazir, Pengwei Huo, Ameena Tur Rasool
Summary: This review explores the potential of g-C3N4-based S-scheme heterojunctions in addressing environmental issues. It summarizes the mechanism and preparation techniques of S-scheme heterojunctions based on g-C3N4, and presents recent studies on their applications in pollutant removal, CO2 reduction, hydrogen production, and bacterial disinfection. The review concludes with an outlook on future challenges for g-C3N4-based S-scheme heterojunctions.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Francois Mazars, Koffi Senam Etse, Guillermo Zaragoza, Lionel Delaude
Summary: The activity of three Pd-PEPPSI catalyst precursors with N-heterocyclic carbene (NHC) ligands derived from caffeine and theophylline in Mizoroki-Heck reactions was tested. The results showed that the catalysts achieved high conversions and yields, especially in the presence of electron-withdrawing substituents.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Bo-Han Wu, Xue Zhou, Lin Liu, Zheng-Bo Han
Summary: Researching carbon dioxide removal from flue gas and natural gas is crucial. Metal-organic frameworks (MOFs) are commonly used in adsorption due to their high surface area, porosity, and chemical properties. An ultra-microporous MOF CPM-20(Co) with mixed ligand was synthesized using inexpensive ligands. The material exhibited high selectivities and low regenerative energy, making it a promising option for CO2 separation in industries.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)