期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 729, 期 -, 页码 20-27出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2013.01.009
关键词
Bioorganometallic chemistry; Poly(propyleneimine); Rhodium; Iridium; Dendrimers; Anticancer drugs
资金
- University of Cape Town
- National Research Foundation (NRF) of South Africa
- South African Medical Research Council (MRC)
- MRC
- Swiss-South African Joint Research Programme
The development of multinuclear pentamethylcyclopentadienyl (Cp*) rhodium and iridium complexes from first- and second-generation 2-iminopyridyl and salicylaldimine based poly(propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)(n) (n = 4 or 8, DAB = diaminobutane) has been accomplished. Eight compounds were synthesised, viz. (Cp*MCl)(4)G(n) (1-8), by first reacting DAB-(NH2)(n) with either 2-pyridinecarboxaldehyde or salicylaldehyde and subsequently metallating the Schiff-base dendrimers with [Cp*MCl2](2) (where M = Rh, Ir). Related mononuclear complexes [Cp*MCl(L)] (L = iminopyridyl or salicylaldimine) (9-12) were obtained in a similar manner. The molecular structures of 9-12 have been determined by single-crystal X-ray diffraction analysis and the in vitro anticancer activities of 1-12 were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines. (C) 2013 Elsevier B.V. All rights reserved.
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