Review
Chemistry, Multidisciplinary
Myuto Kashihara, Yoshiaki Nakao
Summary: Cross-coupling reactions using nitroarenes as electrophiles have gained attention due to their ease of accessibility and potential advantages over haloarenes. Recent research has focused on developing new catalyst systems and reaction conditions to improve the efficiency and practicality of these reactions, with promising results in diversifying bond-forming reactions and reducing catalyst loading. Research in this field is expected to continue growing as the utility of nitroarenes in organic synthesis is reevaluated.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Samuel H. Newman-Stonebraker, Sleight R. Smith, Julia E. Borowski, Ellyn Peters, Tobias Gensch, Heather C. Johnson, Matthew S. Sigman, Abigail G. Doyle
Summary: In this study, a classification workflow using monodentate phosphine ligands was developed to identify reactivity cliffs in 11 Ni- and Pd-catalyzed cross-coupling datasets. The minimum percent buried volume descriptor was found to be a physically meaningful and predictive representation of ligand structure in catalysis.
Article
Chemistry, Multidisciplinary
Justin Y. Wang, Kyoungmin Choi, Stephan J. Zuend, Kailaskumar Borate, Harish Shinde, Roland Goetz, John F. Hartwig
Summary: The study reports the Pd-catalyzed C-N coupling of hydrazine with (hetero)aryl chlorides and bromides to form aryl hydrazines with catalyst loadings as low as 100 ppm of Pd and KOH as base. Mechanistic studies revealed two catalyst resting states: an arylpalladium(II) hydroxide and arylpalladium(II) chloride, which interact in two interconnected catalytic cycles to produce the product. Kinetic studies showed that the coupling process occurs by rate-limiting deprotonation of a hydrazine-bound arylpalladium(II) chloride complex to give an arylpalladium(II) hydrazido complex.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Md. Lutfor Rahman, Mohd Sani Sarjadi, Mohammed Salim Akhter, J. John Hannan, M. Shaheen Sarkar
Summary: A silica-coated magnetically separable Schiff-base palladium nanocatalyst was developed and successfully applied in the Suzuki-Miyaura reaction with excellent recyclability.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jairus L. Lamola, Paseka T. Moshapo, Cedric W. Holzapfel, Munaka Christopher Maumela
Summary: A new family of biaryl phosphacyclic ligands have been developed for efficient Suzuki-Miyaura cross-coupling of aryl bromides and chlorides, with successful coupling of sterically hindered and heterocyclic substrates at room temperature.
Article
Chemistry, Organic
Ruoqian Fan, Meiying Kuai, Dong Lin, Felix Bauer, Weiwei Fang
Summary: A new palladacyclic N-heterocyclic carbene pre-catalyst was designed and successfully applied for Pd-catalyzed C-N cross-coupling reactions of challenging heteroaryl chlorides. The desired aminated products were achieved in good to excellent yields.
Article
Chemistry, Multidisciplinary
Jingru Lu, Sofia Donnecke, Irina Paci, David C. Leitch
Summary: Making accurate predictions of chemical reactivity based on molecular structure is still a challenging task. This article presents an approach to reactivity prediction for catalytic reactions using quantitative structure-reactivity models. The authors demonstrate this approach with a mechanistically based model for a key step in catalytic processes.
Article
Chemistry, Applied
Masahiro Sai
Summary: The tetraarylpyrrole-based phosphine ligand L1 in combination with Pd(dba)(2) serves as an effective catalyst for the Buchwald-Hartwig amination reaction, allowing rapid coupling of a variety of amines with aryl chlorides and selective monoarylation of aliphatic primary amines under specific conditions. Comparison experiments demonstrate the superior catalytic activity of L1 in the Pd-catalyzed C-N coupling of various amines.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Physical
Matthew J. Andrews, Sebastian Brunen, Ruaraidh D. McIntosh, Stephen M. Mansell
Summary: This paper describes the synthesis and catalytic testing of a palladium complex with a 5-membered chelating [N,O] ligand, derived from the condensation of 2,6-diisopropylphenyl aniline and maple lactone. The catalyst was active towards the Suzuki-Miyaura cross-coupling reaction, and its activity was optimised through the selection of base, solvent, catalytic loading and temperature. The catalyst exhibited good activity towards aryl bromides with electron-withdrawing groups, as well as a range of boronic acids and pinacol esters. It was also a capable catalyst for the cross-coupling of aryl chlorides and phenylboronic acid.
Article
Chemistry, Multidisciplinary
Samantha L. Goldschmid, Nicholas Eng Soon Tay, Candice L. Joe, Brendan C. Lainhart, Trevor C. Sherwood, Eric M. Simmons, Melda Sezen-Edmonds, Tomislav Rovis
Summary: Aryl amination plays a crucial role in medicinal, process, and materials chemistry. Blue-light-driven metallaphotoredox catalysis is a valuable tool for C-N cross-coupling, but its limited penetration through reaction media and the formation of unwanted side-products pose challenges for industrial scalability. Using low-energy light, such as deep red or near-infrared, can enhance penetration and suppress unwanted reactions, leading to an enhanced scope of aryl bromides and amine-based nucleophiles.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Xichao Peng, Junhao Zhao, Guojian Ma, Yan Wu, Shiyu Hu, Zhixiong Ruan, Pengju Feng
Summary: The study proposes a sustainable method for the selective synthesis of C-2/C-3 aminated five-membered heteroarenes incorporated with functionalities from aniline derivatives through an electro-oxidative cross coupling process. This approach enables the synthesis of a wide variety of heteroarene derivatives, tolerates functional groups, and is suitable for gram-scale synthesis. Preliminary mechanistic studies suggest a radical cross coupling process between the N-centered radical and indole radical cation may be involved in this amination reaction.
Article
Chemistry, Organic
Tingting Yan, Kaki Raveendra Babu, Yong Wu, Yang Li, Yuhai Tang, Silong Xu
Summary: A phosphine-catalyzed olefinic cross-coupling reaction between benzyl halides and fumarates has been described, providing trisubstituted alkenes with good yields and excellent E-selectivity under metal-free conditions. Mechanistic studies suggest a catalytic cycle involving phosphorus ylide formation, Michael addition, water-assisted hydrogen transfer, and phosphine elimination.
Article
Chemistry, Organic
Yiu-Wai Yeung, Chun-Ming Chan, Yu-Ting Chen, Marco Chan, Mingyu Luo, Xin Gao, Bingnan Du, Wing-Yiu Yu
Summary: We have developed a Cu-catalyzed cross-electrophilic coupling reaction for the synthesis of alpha-amino acid derivatives using alpha diazoesters and O-benzoyl hydroxylamines. Cu(OAc)2 is used as the catalyst and polymethylhydrosilane (PMHS) as the hydride reagent. The reaction demonstrates excellent functional group compatibilities. The formation of a Cuacetoacetate complex was confirmed by ESI-MS analysis, and radical trap experiments suggest the involvement of nitrogen-centered radicals as intermediates. This strategy provides a simple and cost-effective approach for the synthesis of alpha-amino acid derivatives.
Article
Multidisciplinary Sciences
Madeleine C. Deem, Joshua S. Derasp, Thomas C. Malig, Kea Legard, Curtis P. Berlinguette, Jason E. Hein
Summary: Ring walking in Buchwald-Hartwig amination reactions is influenced by the chelating nature of the ligand, while the resting state of the catalyst has no impact. The study also differentiates catalysts that undergo ring walking from diffusion-controlled coupling. The insights gained from this study were used to achieve the desymmetrization of a tetrabrominated precursor.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Pooja Y. Vemuri, Frederic W. Patureau
Summary: In this study, an unprecedented, simple and hetero-selective cross-dehydrogenative N-N coupling of amides and benzotriazoles using a hypervalent iodine species as the terminal oxidant was reported. The scope and mechanistic investigations of this reaction were discussed.
Article
Chemistry, Inorganic & Nuclear
Ya Yin, Zhao Chen, Run-Hao Li, Chang Yuan, Tian-Yin Shao, Kai Wang, Hongwei Tan, Yue Sun
Summary: This study successfully synthesized two coordination-driven metal-lacycles through subtle structure modifications, with the dianthracene-containing hexagon demonstrating mechanochromic and vapochromic characteristics while the monoanthracene-containing hexagon did not. Further investigation indicated that changes in the molecular stacking structure played a key role in the observed behavioral differences.
INORGANIC CHEMISTRY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Yue Sun, Riina Aav, Akihiko Tsuda, Hiroyuki Miyake, Keiji Hirose, Victor Borovkov
FRONTIERS IN CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Shi-Qi Cheng, Xue-Qing Liu, Zhi-Liang Han, Yu Rong, Si-Yong Qin, Yue Sun, Haibing Li
Summary: Researchers have developed a method for designing solid-state nanochannels that can regulate ion transport in response to CO2/N-2 stimuli, by tailoring the nanochannel walls using host-guest chemistry. The CO2-activated ion nanochannels demonstrated stability and repeatability, indicating potential applications in biomimetic nanopore systems and advanced separation processes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yue Sun, Fan Yi, Run-Hao Li, Xuehong Min, Huan Qin, Shi-Qi Cheng, Yi Liu
Summary: The article introduces a membrane technology for purifying water containing antibiotics, which achieves high permeance and rejection rates through the preparation of hybrid nanosheets with large lateral size and regular structure. This membrane technology is expected to be widely used in academia and industry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Cui Wang, Fan Yi, Runhao Li, Xiao-Cui Liang, Qiang He, Xuehong Min, Xiaoyun Hu, Yue Sun
Summary: A simple strategy of combining pillar[5]arene (P5) and MXene was used to prepare functional two-dimensional materials. The resulting MXene-P5 showed high supramolecular recognition, enrichment capability, and electrochemical response towards dye molecules, possibly due to the synergistic effects of high conductivity, high surface area, and host-guest recognition. This study provides a promising prospect for an electrochemical sensing platform based on different types of pillararenes.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Shi-Qi Cheng, Si-Yun Zhang, Xue-Hong Min, Ming-Jie Tao, Xiao-Le Han, Yue Sun, Yi Liu
Summary: Photoresponsive nanochannels, inspired by biological channels, offer precise spatial and temporal regulation and energy source capabilities, showing promise for applications in biosensors, stimuli-responsive smart devices, and nanofluidic devices.
Editorial Material
Chemistry, Multidisciplinary
Zhao Chen, Dian-Dian Deng, Riina Aav, Victor Borovkov, Yue Sun
FRONTIERS IN CHEMISTRY
(2022)
Article
Engineering, Chemical
Ming-jie Tao, Shi-Qi Cheng, Xiao-Le Han, Fan Yi, Run-Hao Li, Yu Rong, Yue Sun, Yi Liu
Summary: Membrane-based separation techniques are crucial for addressing water pollution and scarcity. This study demonstrates the use of supramolecular cyclodextrins to fabricate hybrid membranes with improved water purification performance.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Physical
Huan Qin, Xiaolong Ding, Shi-Qi Cheng, Si-Yong Qin, Xinya Han, Yue Sun, Yi Liu
Summary: In this study, an artificial nanochannel with a conductance value of 2.01 nS was successfully fabricated using a supramolecular coordination strategy. Utilizing the unique H2S-mediated covalent reaction, the nanochannel biosensor was able to switch from ON to OFF states upon the addition of H2S. Furthermore, the nanochannel exhibited high rectification ratio and gating ratio, directing ion transport. Theoretical simulations were conducted to provide insights into the possible mechanism of the functionalized nanochannel.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Zhao Chen, Huan Qin, Ya Yin, Dian-dian Deng, Si-Yong Qin, Nan Li, Kai Wang, Yue Sun
Summary: In this study, a series of multi-functionalized luminophores were designed and synthesized based on a carbazole core with different donor and acceptor units. These compounds exhibited full-color emission covering the entire visible light range in the solid state under UV light illumination. One of the derivatives showed rare aggregation-induced near-infrared emission and red-to-near-infrared mechano-fluorochromism, demonstrating potential applications in cell imaging and photodynamic therapy (PDT). This work not only provides insights for the construction of full-color emissive systems but also opens new avenues for multifunctionalized luminophores in near-infrared mechanical-force sensors and PDT fields.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Lei Yang, Zhongyue Sun, Siyun Zhang, Yue Sun, Haibing Li
Summary: In this study, a facile and feasible strategy was employed to construct chiral-modified nanochannels for the transmembrane transport of chiral drugs. The results showed that the constructed nanochannels exhibited improved chiral selectivity compared to other chiral channels. This study is of significant importance for the basic theory research and the construction of artificial channels for the separation of chiral drugs.
Review
Chemistry, Multidisciplinary
Run-Hao Li, Qian Lin, Shu-Lan Li, Yue Sun, Yi Liu
Summary: This review highlights the preparation and applications of MXene materials based on macrocyclic hosts. Functional membranes, photocatalysis, sensing, and adsorption are the main application areas discussed. The unique structural features and recognition ability of macrocyclic hosts provide new inspiration for the design and improvement of MXene-based materials.
Article
Materials Science, Biomaterials
Xuehong Min, Ming Li, Wenjing Zhang, Run-Hao Li, Zhe Zhang, Pingshan Wang, Weide Su, Feng Li, Yue Sun, Yi Liu
Summary: Different from common anti-tumor drugs, organoplatinum(ii) metallacycles can integrate imaging and therapeutic capabilities by incorporating functional donor ligands, enabling potential applications in biomedicine. In this study, an organoplatinum(ii) metallacycle (PtM) was designed and synthesized for use in chemo-photodynamic combination therapy. The PtM molecules were encapsulated in human heavy chain ferritin (HFn) to prepare the active targeting nanoagent HFn-PtM, which exhibited excellent stability and anti-tumor efficiency with negligible systemic toxicity.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Editorial Material
Chemistry, Multidisciplinary
Zhao Chen, Huan Qin, Ya Yin, Dian-dian Deng, Si-Yong Qin, Nan Li, Kai Wang, Yue Sun
Summary: This study successfully prepared eight multifunctional luminophores based on the same core skeleton, exhibiting various colors covering the whole visible light range. Among them, a novel carbazole derivative with dicyano-functionalized triphenylamine unit showed aggregation-induced near-infrared emission and red-to-near-infrared mechano-fluorochromism, making it a promising candidate for cell imaging and photodynamic therapy. This work provides reference for the construction of full-color emissive systems and offers a new avenue for the preparation of multifunctionalized luminophores with potential applications in near-infrared mechanical-force sensors and PDT fields.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiao-Cui Liang, Shi-Qi Cheng, Qiang He, Zhong-Qiang Zhou, Yanxi Zhao, Yue Sun
Summary: We describe tandem response solid nanochannels tailored with a porphyrin derivative that exhibit excellent zinc and nitric oxide gating behaviors. The coordination of zinc with the porphyrin derivative has been confirmed using EXAFS and fluorescence experiments, with a binding constant of 3.39 x 10(5) M-1. These studies have important implications for simulating physiological functions, designing complex logic circuits, and fabricating novel biosensors.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Guojun Hu, Ziyue Deng, Yanwei Wang, Dan Yuan, Yong Zhang, Yingming Yao
Summary: A series of rare-earth metal complexes were synthesized and used as efficient initiators for the polymerization of trimethylene carbonate (TMC) and (L)-lactide ((L)-LA).
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Van Ha Nguyen, John H. K. Yip
Summary: In this study, eight PtII-azulene complexes were synthesized to investigate the effect of metalation on the electronic structures, spectroscopy, and luminescence of organic chromophores. The results showed that the attachment of Pt substituents to azulene affected the HOMOs, LUMOs, and luminescence properties. The study provides insights into the role of metalation in modifying the properties of organic chromophores.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Moon Kedia, Virender Singh, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: This study synthesized two types of neutral binuclear metallocycles using a one-pot solvothermal method and characterized their structures. The analysis revealed that these complexes adopt a binuclear heteroleptic cyclic architecture and belong to phosphine oxide donor (P=O)-based supramolecular coordination cyclic complexes.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Radhey S. Srivastava
Summary: This study demonstrates the effectiveness of zero-valent elements as reductants for the deoxydehydration reaction of polyols catalyzed by ONO-pincer ligated molybdenum dioxo. The insolubility and easy separability of the reductants and their oxidized products during the reaction are emphasized. Additionally, the choice of ligand has an impact on the catalytic performance of the reaction.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Hao Zhou, Yajun Sun, Li Deng, Weiran Yang, Yuehui Li
Summary: Efficient Ru-catalyzed hydrogenation of aldehydes was achieved using carbazole-derived phosphine ligands, with the crucial role of N-H moiety in promoting the catalytic reaction. The method was successfully applied in the Co/Ru-catalyzed hydroformylation process, resulting in the production of long-chain alcohols with excellent yields.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Theodor Danescu, Alexandru Lupan, Radu Silaghi-Dumitrescu, R. Bruce King
Summary: The structures and energies of complexes containing (Me2C2N2P)2Ru2(CO)n and (Me2C2N2P)2Fe2(CO)n have been studied. Low-energy structures are characterized by the presence of bridging diazaphospholyl rings, while higher-energy structures involve different ligand structures.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Savannah C. Kapper, Aamani Ponnekanti, Jonas Schaab, Tian-yi Li, Christine L. Chung, Gael Ung, Peter I. Djurovich, Mark E. Thompson
Summary: Organometallic iridium complexes with two cyclometalated ligands and one bis-oxazoline derived ancillary ligand were studied. These complexes have emission spanning across the visible and near-ultraviolet region, with moderate to high photoluminescence quantum yields. The (ppy)2Ir(BOX-CN) complexes were resolved into Delta- and Lambda-diastereomers based on solubility differences.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Zahra Karimi Sangari, Hossein Naeimi
Summary: In this research, a nanostructured CoCuFe2O4 catalyst was prepared using a brief and useful synthetic strategy. This catalyst was used for synthesizing 1,2,4,5-tetrasubstituted imidazole derivatives under ultrasonic irradiation. The approach offers advantages such as high efficiency, short reaction times, simplicity of the reaction medium, accelerated reaction rates, and easier separation and purification of products.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Rukhsana Gul, Wajid Munir, Ebraheem Abdu Musad Saleh, Shaukat Shujah, Muhammad Sirajuddin, Saira Tabassum, Khalil Ur Rehman, Dilfaraz Khan, Sameerah I. Al-Saeedi, Ehab A. Abdelrahman
Summary: Two new Schiff base ligands were synthesized and used to form copper, nickel, and cobalt complexes. The synthesized compounds were characterized and screened for various biological activities. The metal complexes showed better activities in antibacterial, antifungal, antidiabetic, and antioxidant assays.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Review
Chemistry, Inorganic & Nuclear
Ahsan Nazir, Pengwei Huo, Ameena Tur Rasool
Summary: This review explores the potential of g-C3N4-based S-scheme heterojunctions in addressing environmental issues. It summarizes the mechanism and preparation techniques of S-scheme heterojunctions based on g-C3N4, and presents recent studies on their applications in pollutant removal, CO2 reduction, hydrogen production, and bacterial disinfection. The review concludes with an outlook on future challenges for g-C3N4-based S-scheme heterojunctions.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Francois Mazars, Koffi Senam Etse, Guillermo Zaragoza, Lionel Delaude
Summary: The activity of three Pd-PEPPSI catalyst precursors with N-heterocyclic carbene (NHC) ligands derived from caffeine and theophylline in Mizoroki-Heck reactions was tested. The results showed that the catalysts achieved high conversions and yields, especially in the presence of electron-withdrawing substituents.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Bo-Han Wu, Xue Zhou, Lin Liu, Zheng-Bo Han
Summary: Researching carbon dioxide removal from flue gas and natural gas is crucial. Metal-organic frameworks (MOFs) are commonly used in adsorption due to their high surface area, porosity, and chemical properties. An ultra-microporous MOF CPM-20(Co) with mixed ligand was synthesized using inexpensive ligands. The material exhibited high selectivities and low regenerative energy, making it a promising option for CO2 separation in industries.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
