期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 715, 期 -, 页码 102-112出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2012.05.042
关键词
Ferrocene; Click reaction; Azide-alkyne cycloaddition reaction; 1H-1,2,3-Triazole; HCC38 cell; MCF-7 cell
资金
- Polish Ministry of Science and Higher Education
A series of monophenols and diphenols containing the ferrocene-C-triazolyl and ferrocene-N-triazolyl bond were prepared in a cycloaddition reaction of ethynylferrocene with aryl and benzyl azides and in a reaction of azidoferrocene with phenylacetylenes, respectively. The anticancer activity of the prepared compounds against hormone-dependent (MCF-7) and hormone-independent (HCC38) breast cancer cell lines was studied. The investigated compounds exhibited moderate anticancer activity against hormone-independent (IC50 similar to 15-48 mu M) cancer cell line and low activity against hormone-dependent cancer cell line (IC50 similar to 84-98 mu M). (C) 2012 Elsevier B. V. All rights reserved.
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