期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 696, 期 3, 页码 772-779出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2010.09.067
关键词
Bioorganometallic chemistry; Anticancer drugs; Click chemistry; Metal-based drugs; Bioinorganic chemistry
资金
- Swiss National Science Foundation
The application of click chemistry to develop libraries of organometallic ruthenium-arene complexes with potential anticancer properties has been investigated. A series of ruthenium-imidazole-triazole complexes, with hydrophobic tails, were prepared from a common precursor via click chemistry. The tail could be attached to the ligand prior to coordination to the ruthenium complex or following coordination, the former giving the product in superior yield. The complexes were screened for cytotoxicity in tumourigenic and non-tumourigenic cell lines, and while the compounds were only moderately cytotoxic, good selectivity for tumourigenic cells was observed. (C) 2010 Elsevier B.V. All rights reserved.
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