期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 10, 页码 4332-4339出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo500145w
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-
资金
- National Natural Science Foundation of China [21242007]
- Fundamental Research Funds for the Central Universities
The first organocatalytic enantioselective Mannich reaction of pyrazoleamides with isatin-derived N-Boc ketimines has been developed to afford 2-oxindole-based chiral beta-amino amides in good yields (84-97%) with excellent diastereo- and enantioselectivities (up to 99:1 dr and >99% ee).
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