Hypervalent Iodine-Promoted α-Fluorination of Acetophenone Derivatives with a Triethylamine•HF Complex

The direct fluorination reaction of acetophenone using iodosylarenes and TEA center dot 5HF was conducted under mild conditions except for use of a HF reagent. The fluorination reaction was applied to acetophenone derivatives, acetonaphthones, benzyl phenyl ketone, propiophenone, butyrophenone, 1-indanone, and phenacyl chloride, giving selectively the corresponding alpha-fluoroketone derivatives in good yields.