期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 3, 页码 1017-1024出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo402492d
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资金
- ANU
- NHMRC [1028092]
Boletopsins 7 (1), 11 (2), and 12 (3) are p-terphenyl dibenzofuran compounds, isolated from the Papua New Guinean medicinal mushroom Boletopsis sp. The first syntheses of these fungal metabolites are reported, allowing for an investigation of their antibiotic activity. The key steps include sequential Suzuki-Miyaura couplings to rapidly form the p-terphenyl backbone and an Ullmann ether synthesis on a formate ester to create the dibenzofuran moiety. Biological evaluation of the synthetic compounds and intermediates against a panel of bacterial nosocomial pathogens was performed.
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