Article
Biochemistry & Molecular Biology
Dayana Mesa, Yarelys E. Augusto, Giselle Hernandez, Juan P. Figueroa-Macias, Francisco Coll, Andres F. Olea, Maria Nunez, Hernan Astudillo Campo, Yamilet Coll, Luis Espinoza
Summary: Recent studies have shown that aza-steroids and steroidal sapogenins have antiproliferative and cytotoxic effects on human cancer cell lines, making them potential drug candidates for cancer treatment. This study synthesized new diosgenin oxime derivatives as potential antiproliferative agents and proposed a reaction mechanism to explain their transformation.
Article
Chemistry, Multidisciplinary
Haoying Cao, Shanshan Ma, Yanhong Feng, Yawen Guo, Peng Jiao
Summary: Various beta-nitro ketones, including those with a beta-tertiary carbon, were synthesized through visible light photoredox catalysis, and can be easily converted into different organic compounds.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Lukas Fliegel, Jens Christoffers
Summary: Reacting beta-oxoesters with PIFA yields alpha-(iodophenyl) derivatives, which serve as starting materials for the preparation of [b] annulated benzofurane derivatives through copper-catalyzed C-O coupling reaction. The resulting scaffold shows great potential in medicinal chemistry and can be diversified to obtain various structurally different compounds.
Article
Chemistry, Organic
Kota Muramatsu, Tetsuo Okujima, Shigeki Mori, Shion Kikuchi, Shimpei Ando, Yusuke Okada, Masayoshi Takase, Hidemitsu Uno, Nagao Kobayashi
Summary: Unusual phenanthroporphyrins were synthesized by a stepwise precursor method, and their optical properties and electronic structures were analyzed through experimental and theoretical calculations.
Article
Chemistry, Multidisciplinary
Akito Nakai, Jinseok Kim, Takayuki Tanaka, Dongho Kim, Atsuhiro Osuka
Summary: A novel octaphyrin was synthesized, and its complexation reactions and oxidation were studied, revealing the reaction activity and formation mechanism, showing promise for the development of novel fused porphyrinoids.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Gurpreet Kaur, Mangalampalli Ravikanth
Summary: By synthesizing different compounds, we obtained ligands and conjugates with different functionalities. These compounds have good solubility in organic solvents and were thoroughly characterized using various methods, providing a comprehensive understanding of their properties.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Medicinal
Fostino R. B. Bokosi, Richard M. Beteck, Mziyanda Mbaba, Thanduxolo E. Mtshare, Dustin Laming, Heinrich C. Hoppe, Setshaba D. Khanye
Summary: Several classes of antimalarial drugs are available, but issues of toxicity and drug resistant malaria parasites have reduced their efficiency. Quinoline based antiplasmodial drugs have a long-established history and continue to inspire the design of new antimalarial agents. Among a series of synthesized mono- and bisquinoline methanamine derivatives, compounds 40 and 59 showed the most promising in vitro antiplasmodial activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Chemistry, Multidisciplinary
Jiajie Chen, Yufang Zhu, Stefan Kaskel
Summary: Metal-organic frameworks (MOFs) have received increasing attention in recent years, and the introduction of porphyrin molecules into MOFs has allowed for overcoming the limitations of porphyrins in biomedical applications. Porphyrin-based MOFs have made significant achievements and progress in areas such as tumor therapy and biosensing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Paolo Dognini, Talhat Chaudhry, Giulia Scagnetti, Michele Assante, George S. M. Hanson, Kehinde Ross, Francesca Giuntini, Christopher R. Coxon
Summary: This study presents a method for peptide cyclisation using polyfluorinated aromatic reagents and thiolates through nucleophilic aromatic substitution (SNAr). The resulting peptide scaffolds offer new possibilities for 3D peptide architectures. The method demonstrates chemoselectivity and wide applicability, allowing for stapling and multicyclisation of non-protected peptides. Additionally, a porphyrin-templated stapled peptide with skin cell penetrating ability and intrinsic fluorescence was developed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Noam Zion, John C. Douglin, David A. Cullen, Piotr Zelenay, Dario R. Dekel, Lior Elbaz
Summary: The study reports the synthesis, characterization, and utilization of heat-treated iron porphyrin aerogels as cathode catalysts in AEMFCs. The best performing aerogel reached a peak power density of 580 mW cm(-2) and a limiting current density of 2.0 A cm(-2), considered state-of-the-art for PGM-free based AEMFCs.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yue Wu, Ho-Fai Chau, Yik-Hoi Yeung, Waygen Thor, Hei-Yui Kai, Wai-Lun Chan, Ka-Leung Wong
Summary: In this study, a novel synthetic method for the efficient preparation of prefunctionalized core porphyrins and the controllable construction of various valent porphyrin-peptide conjugates was reported. Compared to traditional methods, this approach is faster, greener, and requires only one final-stage purification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ruslan R. Kashapov, Yuliya S. Razuvayeva, Svetlana S. Lukashenko, Syumbelya K. Amerhanova, Anna P. Lyubina, Alexandra D. Voloshina, Victor V. Syakaev, Vadim V. Salnikov, Lucia Y. Zakharova
Summary: The combined method of photodynamic therapy and chemotherapy for treating malignant neoplasms shows great promise. This study investigates the properties of a supramolecular system based on TSPP and LaSurf in an aqueous medium. The complexes can assemble into nanostructures capable of binding anticancer drugs and their stability and drug binding ability can be controlled by adjusting the molar ratio and concentration of the components.
Article
Biochemistry & Molecular Biology
Frederique Bregier, Vincent Sol, Yves Champavier, Laurent Galmiche, Clemence Allain, Pierre Audebert
Summary: The study presents the synthesis of a porphyrin linked to a heptazine photoactive antenna, demonstrating the activity of both components. While they exhibit independent electrochemical behavior, spectroscopy reveals energy transfer between the two partners.
Article
Polymer Science
Milena B. Boarini, Natalia S. Gsponer, Maria E. Milanesio, Edgardo N. Durantini
Summary: This study synthesized two novel polymeric conjugates that exhibited significant photodynamic effects and tested their photoinactivation abilities against Staphylococcus aureus and Escherichia coli.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Manuela Stefanelli, Gabriele Magna, Corrado Di Natale, Roberto Paolesse, Donato Monti
Summary: Conjugating the porphyrin ring with an amino acid via amide linkage allows for the creation of both amphiphilicity and chirality in the macrocycle. The use of proline residue is advantageous due to its conformational rigidity, which allows for efficient transfer and amplification of molecular chirality in aqueous environments. This article describes the evolution of studies conducted by the authors to achieve chiral systems from porphyrin-proline derivatives, both in solution and in the solid state. The discussion focuses on fundamental aspects that influence the resulting molecular architectures, including the nature of the appended group, the presence of coordinated metal ions, and the properties of the solvent. The fine-tuning of these parameters enables the creation of stereospecific structures with distinct chiroptical and morphological features. Solid films based on these chiral systems are also obtained and their recognition abilities in gaseous and liquid phases are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)