期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 78, 期 10, 页码 5031-5037出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo400110m
关键词
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资金
- Spanish Ministerio de Economia y Competitividad (MINECO) [CTQ2007-65218, CTQ2011-24151, Consolider Ingenio 2010-CSD2007-00006]
- Generalitat Valenciana (GV) [PROMETEO/2009/039]
- Fondo Europeo de Desarrollo Regional (FEDER)
- Instituto de Sintesis Organica (ISO) of the Universidad de Alicante
A one-pot protocol for the synthesis of 1,2,3-triazoles has been developed starting from inactivated alkenes and based on two click reactions: the azidosulfenylation of the carbon-carbon double bond and the copper-catalyzed azide-alkyne cycloaddition (CuAAC). High yields of the beta-methylsulfanyl triazoles have been attained using CuNPs/C as catalyst, with other commercial copper catalysts being completely inactive. The versatility of the methylsulfanyl group has been demonstrated through a series of synthetic transformations, including direct access to 1-vinyl and 4-monosubstituted triazoles.
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